Published in J Biol Chem on July 23, 2008
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet (2011) 3.46
Glycosylation in immune cell trafficking. Immunol Rev (2009) 1.61
A systematic study of site-specific GalNAc-type O-glycosylation modulating proprotein convertase processing. J Biol Chem (2011) 1.40
Treatment strategies targeting amyloid β-protein. Cold Spring Harb Perspect Med (2012) 1.37
Regulation of the metastatic cell phenotype by sialylated glycans. Cancer Metastasis Rev (2012) 1.32
Emerging role of alpha2,6-sialic acid as a negative regulator of galectin binding and function. J Biol Chem (2010) 1.23
Sialylation of the Fas death receptor by ST6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cells. J Biol Chem (2011) 1.19
ST6Gal-I protein expression is upregulated in human epithelial tumors and correlates with stem cell markers in normal tissues and colon cancer cell lines. Cancer Res (2013) 1.15
Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system. J Neurosci (2011) 1.06
ST6Gal-I regulates macrophage apoptosis via α2-6 sialylation of the TNFR1 death receptor. J Biol Chem (2011) 0.99
The role of protein N-glycosylation in neural transmission. Glycobiology (2014) 0.95
β-Galactoside α2,6-sialyltranferase 1 promotes transforming growth factor-β-mediated epithelial-mesenchymal transition. J Biol Chem (2014) 0.91
Dendritic cells: a spot on sialic Acid. Front Immunol (2013) 0.91
β-Secretase: its biology as a therapeutic target in diseases. Trends Pharmacol Sci (2013) 0.88
Role for hepatic and circulatory ST6Gal-1 sialyltransferase in regulating myelopoiesis. J Biol Chem (2010) 0.88
The role of integrin glycosylation in galectin-8-mediated trabecular meshwork cell adhesion and spreading. Glycobiology (2008) 0.88
N-glycosylation in regulation of the nervous system. Adv Neurobiol (2014) 0.83
Sialic acid associated with αvβ3 integrin mediates HIV-1 Tat protein interaction and endothelial cell proangiogenic activation. J Biol Chem (2012) 0.83
The phagocytic capacity and immunological potency of human dendritic cells is improved by α2,6-sialic acid deficiency. Immunology (2013) 0.83
Remodeling of marrow hematopoietic stem and progenitor cells by non-self ST6Gal-1 sialyltransferase. J Biol Chem (2014) 0.82
ST6Gal-I modulates docetaxel sensitivity in human hepatocarcinoma cells via the p38 MAPK/caspase pathway. Oncotarget (2016) 0.78
TNF-α regulates the proteolytic degradation of ST6Gal-1 and endothelial cell-cell junctions through upregulating expression of BACE1. Sci Rep (2017) 0.75
Inhibitory role of α2,6-sialylation in adipogenesis. J Biol Chem (2016) 0.75
Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain. J Biol Chem (2016) 0.75
Genetic Determinants of Type 2 Diabetes in Asians. Int J Diabetol Vasc Dis Res (2015) 0.75
Integrins: bidirectional, allosteric signaling machines. Cell (2002) 36.25
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science (1999) 13.19
Structural basis of integrin regulation and signaling. Annu Rev Immunol (2007) 8.60
Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation. Science (2006) 8.13
Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature (1999) 5.77
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci (2001) 4.54
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci (2001) 3.85
Integrin regulation. Curr Opin Cell Biol (2005) 3.80
Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat Immunol (2007) 3.07
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A (2000) 2.96
BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet (2001) 2.76
Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions. J Exp Med (2000) 2.21
Molecular mechanisms of leukocyte recruitment in the inflammatory process. Cardiovasc Res (1996) 2.12
Integrin modulation and signaling in leukocyte adhesion and migration. Immunol Rev (2007) 2.10
Hypersialylation of beta1 integrins, observed in colon adenocarcinoma, may contribute to cancer progression by up-regulating cell motility. Cancer Res (2005) 2.08
Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am J Pathol (2007) 2.05
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem (2005) 2.03
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. J Biol Chem (2003) 1.99
In vitro granulocyte adherence and in vivo margination: two associated complement-dependent functions. Studies based on the acute neutropenia of filtration leukophoresis. J Exp Med (1977) 1.94
Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases. Med Res Rev (2002) 1.89
Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease. Prog Neurobiol (2006) 1.75
Emerging and diverse roles of protein kinase C in immune cell signalling. Biochem J (2003) 1.69
Sweet 'n' sour: the impact of differential glycosylation on T cell responses. Nat Immunol (2002) 1.65
The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death. J Biol Chem (2002) 1.61
Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J Neurosci (2003) 1.56
Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the beta 1 subunit. FEBS Lett (1995) 1.54
Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation. J Biol Chem (2001) 1.51
Method for large scale isolation, culture and cryopreservation of human monocytes suitable for chemotaxis, cellular adhesion assays, macrophage and dendritic cell differentiation. J Immunol Methods (2004) 1.49
The in vivo quantitation and kinetics of monocyte migration into acute inflammatory tissue. Am J Pathol (1981) 1.42
Novel mechanistic concepts for the control of leukocyte transmigration: specialization of integrins, chemokines, and junctional molecules. J Mol Med (Berl) (2002) 1.41
Ras oncogene directs expression of a differentially sialylated, functionally altered beta1 integrin. Oncogene (2003) 1.40
Variant glycosylation: an underappreciated regulatory mechanism for beta1 integrins. Biochim Biophys Acta (2004) 1.39
High affinity very late antigen-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM-1 in shear flow. J Immunol (1999) 1.35
High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus. Exp Neurol (2006) 1.31
Hyposialylation of integrins stimulates the activity of myeloid fibronectin receptors. J Biol Chem (2002) 1.25
Regulation of integrin functions by N-glycans. Glycoconj J (2004) 1.25
The sialyl-alpha2,6-lactosaminyl-structure: biosynthesis and functional role. Glycoconj J (2000) 1.23
The selective binding and transmigration of monocytes through the junctional complexes of human endothelium. J Exp Med (1988) 1.23
BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time. Neurobiol Dis (2003) 1.20
Cell-cell interactions: leukocyte-endothelial interactions. Curr Opin Hematol (2003) 1.19
A protein kinase C/Ras/ERK signaling pathway activates myeloid fibronectin receptors by altering beta1 integrin sialylation. J Biol Chem (2005) 1.15
Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines. Leukemia (2002) 1.04
Integrins in the immune system. Adv Immunol (1999) 1.03
In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase. J Biol Chem (2004) 1.02
The Src kinase p56(lck) up-regulates VLA-4 integrin affinity. Implications for rapid spontaneous and chemokine-triggered T cell adhesion to VCAM-1 and fibronectin. J Biol Chem (2000) 1.02
Prolonged activation of the mitogen-activated protein kinase pathway is required for macrophage-like differentiation of a human myeloid leukemic cell line. Cell Growth Differ (2000) 0.99
Increased alpha2,6-sialylation of surface proteins on tolerogenic, immature dendritic cells and regulatory T cells. Exp Hematol (2006) 0.98
Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells. J Biol Chem (1994) 0.95
Minimal structural and glycosylation requirements for ST6Gal I activity and trafficking. Glycobiology (2000) 0.90
A disulfide-bonded dimer of the Golgi beta-galactoside alpha2,6-sialyltransferase is catalytically inactive yet still retains the ability to bind galactose. J Biol Chem (1996) 0.90
Phorbol ester-induced mononuclear cell differentiation is blocked by the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059. Cell Growth Differ (1999) 0.89
Sialidase treatment exposes the beta1-integrin active ligand binding site on HL60 cells and increases binding to fibronectin. Cell Adhes Commun (2000) 0.87
Biochemical engineering of the acyl side chain of sialic acids stimulates integrin-dependent adhesion of HL60 cells to fibronectin. J Mol Med (Berl) (2002) 0.86
Effects of acute endotoxemia and glucose administration on circulating leukocyte populations in normal and diabetic subjects. Metabolism (1978) 0.84
Involvement of proteases in glycosyltransferase secretion: Alzheimer's beta-secretase-dependent cleavage and a following processing by an aminopeptidase. Glycoconj J (2004) 0.83
Sialylation regulates peripheral tolerance in CD4+ T cells. Int Immunol (2005) 0.83
VLA-4 antagonists: potent inhibitors of lymphocyte migration. Med Res Rev (2003) 0.82
Allostery and proteolysis: two novel modes of regulating integrin function. Matrix Biol (1997) 0.78
Hypersialylation of beta1 integrins, observed in colon adenocarcinoma, may contribute to cancer progression by up-regulating cell motility. Cancer Res (2005) 2.08
Engineering nanocages with polyglutamate domains for coupling to hydroxyapatite biomaterials and allograft bone. Biomaterials (2013) 1.47
Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration. Mol Cell Biol (2003) 1.44
Sialylation of beta1 integrins blocks cell adhesion to galectin-3 and protects cells against galectin-3-induced apoptosis. J Biol Chem (2008) 1.40
p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association. J Biol Chem (2005) 1.34
Regulation of the metastatic cell phenotype by sialylated glycans. Cancer Metastasis Rev (2012) 1.32
ST6Gal-I expression in ovarian cancer cells promotes an invasive phenotype by altering integrin glycosylation and function. J Ovarian Res (2008) 1.26
The effect of RGD peptides on osseointegration of hydroxyapatite biomaterials. Biomaterials (2008) 1.26
Hyposialylation of integrins stimulates the activity of myeloid fibronectin receptors. J Biol Chem (2002) 1.25
Emerging role of alpha2,6-sialic acid as a negative regulator of galectin binding and function. J Biol Chem (2010) 1.23
Sialylation of the Fas death receptor by ST6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cells. J Biol Chem (2011) 1.19
Identification of a HoxA10 activation domain necessary for transcription of the gene encoding beta3 integrin during myeloid differentiation. J Biol Chem (2007) 1.18
A protein kinase C/Ras/ERK signaling pathway activates myeloid fibronectin receptors by altering beta1 integrin sialylation. J Biol Chem (2005) 1.15
The effect of adsorbed serum proteins, RGD and proteoglycan-binding peptides on the adhesion of mesenchymal stem cells to hydroxyapatite. Biomaterials (2006) 1.15
ST6Gal-I protein expression is upregulated in human epithelial tumors and correlates with stem cell markers in normal tissues and colon cancer cell lines. Cancer Res (2013) 1.15
Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma. Clin Cancer Res (2013) 1.13
Increasing the pore sizes of bone-mimetic electrospun scaffolds comprised of polycaprolactone, collagen I and hydroxyapatite to enhance cell infiltration. Biomaterials (2011) 1.11
The effect of collagen I mimetic peptides on mesenchymal stem cell adhesion and differentiation, and on bone formation at hydroxyapatite surfaces. Biomaterials (2009) 1.10
Tumor cell migration and invasion are regulated by expression of variant integrin glycoforms. Exp Cell Res (2008) 1.09
Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. BMC Musculoskelet Disord (2011) 1.06
Mesenchymal stem cell responses to bone-mimetic electrospun matrices composed of polycaprolactone, collagen I and nanoparticulate hydroxyapatite. PLoS One (2011) 1.05
Osteogenic differentiation of human mesenchymal stem cells directed by extracellular matrix-mimicking ligands in a biomimetic self-assembled peptide amphiphile nanomatrix. Biomacromolecules (2009) 1.04
Osteoblast adhesion and matrix mineralization on sol-gel-derived titanium oxide. Biomaterials (2005) 1.04
An in vitro regenerated functional human endothelium on a nanofibrous electrospun scaffold. Biomaterials (2010) 1.03
Production of trans-lentiviral vector with predictable safety. Methods Mol Med (2003) 1.02
Ubiquitous GFP expression in transgenic chickens using a lentiviral vector. Development (2005) 1.01
ST6Gal-I regulates macrophage apoptosis via α2-6 sialylation of the TNFR1 death receptor. J Biol Chem (2011) 0.99
Primary human marrow stromal cells and Saos-2 osteosarcoma cells use different mechanisms to adhere to hydroxylapatite. J Biomed Mater Res A (2004) 0.99
Low temperature induces the delivery of mature and immature CFTR to the plasma membrane. Biochem Biophys Res Commun (2007) 0.98
Inverse relationship between matrix remodeling and lipid metabolism during osteoarthritis progression in the STR/Ort mouse. Arthritis Rheum (2007) 0.95
ST6Gal-I sialyltransferase confers cisplatin resistance in ovarian tumor cells. J Ovarian Res (2013) 0.95
Mesenchymal stem cell interaction with ultra-smooth nanostructured diamond for wear-resistant orthopaedic implants. Biomaterials (2008) 0.94
Delivery of platelet-derived growth factor as a chemotactic factor for mesenchymal stem cells by bone-mimetic electrospun scaffolds. PLoS One (2012) 0.94
p21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112. PLoS One (2011) 0.93
Engineering an antiplatelet adhesion layer on an electrospun scaffold using porcine endothelial progenitor cells. J Biomed Mater Res A (2011) 0.92
Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. Bone (2012) 0.91
Enhancement of peptide coupling to hydroxyapatite and implant osseointegration through collagen mimetic peptide modified with a polyglutamate domain. Biomaterials (2010) 0.91
Effect of altered glycosylation on the structure of the I-like domain of beta1 integrin: a molecular dynamics study. Proteins (2008) 0.91
Microporous dermal-like electrospun scaffolds promote accelerated skin regeneration. Tissue Eng Part A (2014) 0.87
Mesenchymal stem cell adhesion and spreading on microwave plasma-nitrided titanium alloy. J Biomed Mater Res A (2006) 0.86
Polyglutamate directed coupling of bioactive peptides for the delivery of osteoinductive signals on allograft bone. Biomaterials (2012) 0.85
Working group report: the roles of glycans in hemostasis, inflammation and vascular biology. Glycobiology (2008) 0.84
Mesenchymal stem cell adhesion and spreading on nanostructured biomaterials. J Nanosci Nanotechnol (2004) 0.82
Comparison of mesenchymal stem cell and osteosarcoma cell adhesion to hydroxyapatite. J Mater Sci Mater Med (2008) 0.81
M-CSF induces the stable interaction of cFms with alphaVbeta3 integrin in osteoclasts. Int J Biochem Cell Biol (2006) 0.80
Tunable delivery of bioactive peptides from hydroxyapatite biomaterials and allograft bone using variable-length polyglutamate domains. J Biomed Mater Res A (2013) 0.79
Self-association of arrestin family members. Handb Exp Pharmacol (2014) 0.78
The prevalence and determinants of drug-resistance-associated mutations in the HIV-1-infected MSM population of Henan Province in China. Arch Virol (2015) 0.78
Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice. PLoS One (2011) 0.78
Comparing variable-length polyglutamate domains to anchor an osteoinductive collagen-mimetic peptide to diverse bone grafting materials. Int J Oral Maxillofac Implants (2014) 0.77
Doxycycline up-regulates the expression of IL-6 and GM-CSF via MAPK/ERK and NF-κB pathways in mouse thymic epithelial cells. Int Immunopharmacol (2011) 0.77
The functional role of SUMO E3 ligase Mms21p in the maintenance of subtelomeric silencing in budding yeast. Biochem Biophys Res Commun (2013) 0.77
Role of the repressor Oaf3p in the recruitment of transcription factors and chromatin dynamics during the oleate response. Biochem J (2013) 0.76
Enhanced Skin Regeneration Using a Novel Amniotic-derived Tissue Graft. Wounds (2017) 0.75
Doxycycline Protects Thymic Epithelial Cells from Mitomycin C-Mediated Apoptosis In Vitro via Trx2-NF-x03BA;B-Bcl-2/Bax Axis. Cell Physiol Biochem (2016) 0.75