Published in J Virol on July 11, 2007
The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Mol Cell Biol (2011) 3.01
Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Proc Natl Acad Sci U S A (2010) 1.57
Destabilization of TIP60 by human papillomavirus E6 results in attenuation of TIP60-dependent transcriptional regulation and apoptotic pathway. Mol Cell (2010) 1.34
The papillomavirus E2 proteins. Virology (2013) 1.30
Abrogation of the Brd4-positive transcription elongation factor B complex by papillomavirus E2 protein contributes to viral oncogene repression. J Virol (2010) 1.22
NCoR1 mediates papillomavirus E8;E2C transcriptional repression. J Virol (2010) 1.02
Perturbation of BRD4 protein function by BRD4-NUT protein abrogates cellular differentiation in NUT midline carcinoma. J Biol Chem (2011) 1.02
Brd4 regulation of papillomavirus protein E2 stability. J Virol (2009) 1.02
The interaction of the gammaherpesvirus 68 orf73 protein with cellular BET proteins affects the activation of cell cycle promoters. J Virol (2009) 1.01
Papillomavirus genomes associate with BRD4 to replicate at fragile sites in the host genome. PLoS Pathog (2014) 1.00
Brd4 is displaced from HPV replication factories as they expand and amplify viral DNA. PLoS Pathog (2013) 1.00
HPV-16 E2 contributes to induction of HPV-16 late gene expression by inhibiting early polyadenylation. EMBO J (2012) 1.00
Papillomavirus interaction with cellular chromatin. Biochim Biophys Acta (2009) 0.96
Mining RNA-seq data for infections and contaminations. PLoS One (2013) 0.93
Tumor suppressor or oncogene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression. Am J Cancer Res (2011) 0.91
Dimerization of the papillomavirus E2 protein is required for efficient mitotic chromosome association and Brd4 binding. J Virol (2008) 0.91
The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle. Viruses (2015) 0.89
Current understanding of the role of the Brd4 protein in the papillomavirus lifecycle. Viruses (2013) 0.89
Modification of papillomavirus E2 proteins by the small ubiquitin-like modifier family members (SUMOs). Virology (2008) 0.89
Dimerization of the human papillomavirus type 16 E2 N terminus results in DNA looping within the upstream regulatory region. J Virol (2008) 0.86
Virology and molecular pathogenesis of HPV (human papillomavirus)-associated oropharyngeal squamous cell carcinoma. Biochem J (2012) 0.86
The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response. Cell Death Dis (2014) 0.83
Topography of bovine papillomavirus E2 protein on the viral genome during the cell cycle. Virology (2009) 0.83
The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters. J Virol (2015) 0.82
Analysis of the papillomavirus E2 and bromodomain protein Brd4 interaction using bimolecular fluorescence complementation. PLoS One (2013) 0.81
Tandemly Integrated HPV16 Can Form a Brd4-Dependent Super-Enhancer-Like Element That Drives Transcription of Viral Oncogenes. MBio (2016) 0.80
Cell-type specific transcriptional activities among different papillomavirus long control regions and their regulation by E2. Virology (2009) 0.79
Brd4 Activates Early Viral Transcription upon Human Papillomavirus 18 Infection of Primary Keratinocytes. MBio (2016) 0.79
The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVs. J Virol (2013) 0.79
Papillomaviruses: a systematic review. Genet Mol Biol (2017) 0.75
Failure to interact with Brd4 alters the ability of HPV16 E2 to regulate host genome expression and cellular movement. Virus Res (2015) 0.75
Transcriptional elongation control of the HBV cccDNA transcription by Super Elongation Complex (SEC) and BRD4. Mol Cell Biol (2017) 0.75
Global cancer statistics, 2002. CA Cancer J Clin (2005) 119.22
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell (1990) 20.60
The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science (1989) 16.54
Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature (1985) 11.11
Controlling the elongation phase of transcription with P-TEFb. Mol Cell (2006) 9.95
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol Cell (2005) 8.95
Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol Cell (2005) 8.92
Breaking barriers to transcription elongation. Nat Rev Mol Cell Biol (2006) 8.18
Papillomavirus infections--a major cause of human cancers. Biochim Biophys Acta (1996) 7.79
Bovine papillomavirus contains multiple transforming genes. Proc Natl Acad Sci U S A (1985) 6.73
Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J Virol (1987) 6.65
Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames. EMBO J (1991) 6.00
The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis. Proc Natl Acad Sci U S A (2003) 5.59
A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO J (1991) 5.39
Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator. Science (1990) 4.92
The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumours. J Gen Virol (1985) 4.82
NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II. Mol Cell (2001) 4.55
Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes. Cell (2004) 4.38
A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition. Mol Cell Biol (2000) 4.27
Something about SUMO inhibits transcription. Curr Opin Genet Dev (2005) 4.05
The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region. EMBO J (1987) 3.86
Bovine papillomavirus transcriptional regulation: localization of the E2-responsive elements of the long control region. J Virol (1987) 3.66
Trans-activation of an upstream early gene promoter of bovine papilloma virus-1 by a product of the viral E2 gene. EMBO J (1987) 3.65
Mediator of transcriptional regulation. Annu Rev Biochem (2000) 3.51
The papillomavirus E2 regulatory proteins. J Biol Chem (1991) 3.27
Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. Proc Natl Acad Sci U S A (1998) 3.18
The bromodomain revisited. Trends Biochem Sci (1997) 2.95
Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters. J Virol (1990) 2.90
Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4. Mol Cell Biol (2002) 2.85
A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase. Mol Cell Biol (2002) 2.51
Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation. Proc Natl Acad Sci U S A (1998) 2.50
The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes. J Virol (1989) 2.50
Transient replication of human papillomavirus DNAs. J Virol (1992) 2.43
Enhancers and trans-acting E2 transcriptional factors of papillomaviruses. J Virol (1987) 2.36
Brd4 links chromatin targeting to HPV transcriptional silencing. Genes Dev (2006) 2.36
Bovine papillomavirus type 1 genomes and the E2 transactivator protein are closely associated with mitotic chromatin. J Virol (1998) 2.35
The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression. Genes Dev (2005) 2.29
Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Cell (2002) 2.24
You bet-cha: a novel family of transcriptional regulators. Front Biosci (2001) 2.20
The yeast Mediator complex and its regulation. Trends Biochem Sci (2005) 2.15
Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association. Mol Cell (2006) 2.11
Suppression of cellular proliferation by the papillomavirus E2 protein. J Virol (1995) 2.05
Cis and trans requirements for stable episomal maintenance of the BPV-1 replicator. EMBO J (1996) 2.03
Functional analysis of E2-mediated repression of the HPV18 P105 promoter. New Biol (1991) 2.02
Ras induces mediator complex exchange on C/EBP beta. Mol Cell (2004) 1.98
Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene. J Virol (1993) 1.92
Brd4 is required for e2-mediated transcriptional activation but not genome partitioning of all papillomaviruses. J Virol (2006) 1.92
The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II. Proc Natl Acad Sci U S A (2006) 1.91
Human papillomavirus type 11 E2 proteins repress the homologous E6 promoter by interfering with the binding of host transcription factors to adjacent elements. J Virol (1994) 1.90
Interaction of bovine papillomavirus E2 protein with Brd4 stabilizes its association with chromatin. J Virol (2005) 1.87
The mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4. J Virol (2005) 1.86
Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis. EMBO J (1997) 1.85
Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function. J Virol (2006) 1.81
Initiation of DNA replication: lessons from viral initiator proteins. Nat Rev Mol Cell Biol (2003) 1.76
Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions. J Virol (1996) 1.76
Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways. EMBO J (2000) 1.73
Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells. J Virol (2000) 1.71
Kaposi's sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a BRD4- and BRD2/RING3-induced G1 cell cycle arrest. J Virol (2006) 1.68
Phosphorylation sites of the E2 transcriptional regulatory proteins of bovine papillomavirus type 1. J Virol (1989) 1.65
A recurrent phospho-sumoyl switch in transcriptional repression and beyond. Mol Cell (2006) 1.60
Different mechanisms contribute to the E2-mediated transcriptional repression of human papillomavirus type 18 viral oncogenes. J Virol (1997) 1.56
Identification of a novel constitutive enhancer element and an associated binding protein: implications for human papillomavirus type 11 enhancer regulation. J Virol (1989) 1.52
Bovine papillomavirus type 1 E2 transcriptional regulators directly bind two cellular transcription factors, TFIID and TFIIB. J Virol (1995) 1.48
Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4. Virology (2006) 1.47
Brd4 is involved in multiple processes of the bovine papillomavirus type 1 life cycle. J Virol (2006) 1.47
Reconstitution of papillomavirus E2-mediated plasmid maintenance in Saccharomyces cerevisiae by the Brd4 bromodomain protein. Proc Natl Acad Sci U S A (2005) 1.34
cAMP response element-binding protein-binding protein binds to human papillomavirus E2 protein and activates E2-dependent transcription. J Biol Chem (2000) 1.28
Mechanisms of human papillomavirus E2-mediated repression of viral oncogene expression and cervical cancer cell growth inhibition. J Virol (2000) 1.27
Inhibition of E2 binding to Brd4 enhances viral genome loss and phenotypic reversion of bovine papillomavirus-transformed cells. J Virol (2005) 1.27
Functional interaction of a novel cellular protein with the papillomavirus E2 transactivation domain. Mol Cell Biol (1997) 1.24
Enhanced transcriptional activation by E2 proteins from the oncogenic human papillomaviruses. J Virol (1996) 1.19
Direct interaction between nucleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription. Mol Cell Biol (2004) 1.14
Runx1 binds positive transcription elongation factor b and represses transcriptional elongation by RNA polymerase II: possible mechanism of CD4 silencing. Mol Cell Biol (2005) 1.10
Functional interaction of the bovine papillomavirus E2 transactivation domain with TFIIB. J Virol (1998) 1.08
Functional interaction between p/CAF and human papillomavirus E2 protein. J Biol Chem (2001) 1.04
Conserved interaction of the papillomavirus E2 transcriptional activator proteins with human and yeast TFIIB proteins. J Virol (1997) 0.98
Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes. Cell (2004) 4.38
Human papillomavirus immortalization and transformation functions. Virus Res (2002) 3.58
The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Mol Cell Biol (2011) 3.01
Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600. Proc Natl Acad Sci U S A (2005) 2.51
Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a. Biochemistry (2002) 2.29
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. J Virol (2006) 2.11
CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol Cell (2008) 1.94
Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function. J Virol (2006) 1.81
Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding. Proc Natl Acad Sci U S A (2005) 1.76
Interaction of tSNARE syntaxin 18 with the papillomavirus minor capsid protein mediates infection. J Virol (2005) 1.61
Regulation of aurora B expression by the bromodomain protein Brd4. Mol Cell Biol (2009) 1.60
Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Proc Natl Acad Sci U S A (2010) 1.57
Interferon regulatory factor-3 is an in vivo target of DNA-PK. Proc Natl Acad Sci U S A (2002) 1.42
DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a. Proc Natl Acad Sci U S A (2003) 1.39
Ubiquitin recognition by the DNA repair protein hHR23a. Biochemistry (2003) 1.38
Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses. Proc Natl Acad Sci U S A (2012) 1.33
The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome. Mol Biol Cell (2003) 1.32
Bromodomain protein Brd4 associated with acetylated chromatin is important for maintenance of higher-order chromatin structure. J Biol Chem (2012) 1.30
Merkel cell polyomavirus large T antigen disrupts host genomic integrity and inhibits cellular proliferation. J Virol (2013) 1.28
Comprehensive analysis of host cellular interactions with human papillomavirus E6 proteins identifies new E6 binding partners and reflects viral diversity. J Virol (2012) 1.28
Inhibition of E2 binding to Brd4 enhances viral genome loss and phenotypic reversion of bovine papillomavirus-transformed cells. J Virol (2005) 1.27
Abrogation of the Brd4-positive transcription elongation factor B complex by papillomavirus E2 protein contributes to viral oncogene repression. J Virol (2010) 1.22
Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein. J Biol Chem (2004) 1.20
E6AP ubiquitin ligase mediates ubiquitylation and degradation of hepatitis C virus core protein. J Virol (2006) 1.19
Identification of TRAIL as an interferon regulatory factor 3 transcriptional target. J Virol (2005) 1.13
Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication. PLoS Pathog (2012) 1.11
Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling. Proc Natl Acad Sci U S A (2012) 1.09
Recruitment of Brd4 to the human papillomavirus type 16 DNA replication complex is essential for replication of viral DNA. J Virol (2013) 1.07
Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells. Proc Natl Acad Sci U S A (2003) 1.05
E6AP and calmodulin reciprocally regulate estrogen receptor stability. J Biol Chem (2005) 1.04
Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. Mol Cell Biol (2012) 1.03
NCoR1 mediates papillomavirus E8;E2C transcriptional repression. J Virol (2010) 1.02
Perturbation of BRD4 protein function by BRD4-NUT protein abrogates cellular differentiation in NUT midline carcinoma. J Biol Chem (2011) 1.02
Brd4 regulation of papillomavirus protein E2 stability. J Virol (2009) 1.02
The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability. J Virol (2009) 1.00
WHAT do viruses BET on? Front Biosci (Landmark Ed) (2010) 0.99
Host DNA damage response factors localize to merkel cell polyomavirus DNA replication sites to support efficient viral DNA replication. J Virol (2014) 0.96
Ubiquitin family proteins and their relationship to the proteasome: a structural perspective. Biochim Biophys Acta (2004) 0.94
Proteomic approaches to the study of papillomavirus-host interactions. Virology (2013) 0.94
Human herpesvirus 8: biology and role in the pathogenesis of Kaposi's sarcoma and other AIDS-related malignancies. Curr HIV/AIDS Rep (2004) 0.89
Bovine papillomavirus E7 oncoprotein inhibits anoikis. J Virol (2007) 0.89
Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins. BMC Biochem (2008) 0.88
Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus. J Gen Virol (2007) 0.88
Requirement of E7 oncoprotein for viability of HeLa cells. Microbes Infect (2006) 0.86
Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. J Proteome Res (2014) 0.85
Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice. J Immunol (2012) 0.83
The ER-lumenal domain of the HHV-7 immunoevasin U21 directs class I MHC molecules to lysosomes. Traffic (2003) 0.82
Analysis of the papillomavirus E2 and bromodomain protein Brd4 interaction using bimolecular fluorescence complementation. PLoS One (2013) 0.81
Human Herpesvirus 8: Biology and Role in the Pathogenesis of Kaposi's Sarcoma and Other AIDS-related Malignancies. Curr Infect Dis Rep (2003) 0.81
Characterization of papillomavirus E1 helicase mutants defective for interaction with the SUMO-conjugating enzyme Ubc9. Virology (2009) 0.79
Cell-type specific transcriptional activities among different papillomavirus long control regions and their regulation by E2. Virology (2009) 0.79
Loss-of-function mutations identified in the Helical domain of the G protein alpha-subunit, G alpha2, of Dictyostelium discoideum. Biochim Biophys Acta (2005) 0.77