Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways.

PubWeight™: 3.18‹?› | Rank: Top 1%

🔗 View Article (PMC 21111)

Published in Proc Natl Acad Sci U S A on July 21, 1998

Authors

Y W Jiang1, P Veschambre, H Erdjument-Bromage, P Tempst, J W Conaway, R C Conaway, R D Kornberg

Author Affiliations

1: Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Articles citing this

Suppression of inflammation by a synthetic histone mimic. Nature (2010) 8.80

Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell (2013) 8.37

Super-enhancers in the control of cell identity and disease. Cell (2013) 7.50

A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition. Mol Cell Biol (2000) 4.27

Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol Cell Biol (2008) 3.74

Transcription factor and polymerase recruitment, modification, and movement on dhsp70 in vivo in the minutes following heat shock. Mol Cell Biol (2003) 3.65

The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation. Microbiol Mol Biol Rev (2006) 3.44

The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Mol Cell Biol (2011) 3.01

Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4. Mol Cell Biol (2002) 2.85

BET domain co-regulators in obesity, inflammation and cancer. Nat Rev Cancer (2012) 2.80

A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase. Mol Cell Biol (2002) 2.51

Bromodomain factor 1 corresponds to a missing piece of yeast TFIID. Genes Dev (2000) 2.47

The mechanisms behind the therapeutic activity of BET bromodomain inhibition. Mol Cell (2014) 2.47

The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains. Genes Dev (2015) 2.28

BET bromodomains mediate transcriptional pause release in heart failure. Cell (2013) 2.17

RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. Cell Growth Differ (2000) 2.13

Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev (2002) 2.02

The Mediator complex: a central integrator of transcription. Nat Rev Mol Cell Biol (2015) 1.97

Cell numbers and leaf development in Arabidopsis: a functional analysis of the STRUWWELPETER gene. EMBO J (2002) 1.92

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle (2012) 1.88

Interaction of bovine papillomavirus E2 protein with Brd4 stabilizes its association with chromatin. J Virol (2005) 1.87

TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family. Proc Natl Acad Sci U S A (1999) 1.86

Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. Mol Cell Biol (2002) 1.86

Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function. J Virol (2006) 1.81

Structural organization of yeast and mammalian mediator complexes. Proc Natl Acad Sci U S A (2000) 1.76

A regulatory shortcut between the Snf1 protein kinase and RNA polymerase II holoenzyme. Proc Natl Acad Sci U S A (2000) 1.69

Mediator protein mutations that selectively abolish activated transcription. Proc Natl Acad Sci U S A (1999) 1.65

The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol (2013) 1.64

Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines. J Proteome Res (2006) 1.64

Brd2/RING3 interacts with a chromatin-binding domain in the Kaposi's Sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (LANA-1) that is required for multiple functions of LANA-1. J Virol (2005) 1.51

E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia. Blood (2003) 1.51

Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization. Mol Cell Biol (2004) 1.47

Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA. Oncogene (2013) 1.44

Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem (2011) 1.43

The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. Mol Cell Biol (2000) 1.38

The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J (2002) 1.38

Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A. Biochem J (2005) 1.38

Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Proc Natl Acad Sci U S A (2002) 1.36

Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Genes Dev (2000) 1.34

Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails. BMC Struct Biol (2007) 1.32

Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice. Genes Dev (1999) 1.31

TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. Mol Cell Biol (2002) 1.31

Activation domain-mediator interactions promote transcription preinitiation complex assembly on promoter DNA. Proc Natl Acad Sci U S A (2003) 1.28

BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones. Nat Struct Mol Biol (2014) 1.25

The Mediator complex and transcription elongation. Biochim Biophys Acta (2012) 1.24

Origins and activity of the Mediator complex. Semin Cell Dev Biol (2011) 1.23

Activator-independent functions of the yeast mediator sin4 complex in preinitiation complex formation and transcription reinitiation. Mol Cell Biol (2003) 1.22

Replication and partitioning of papillomavirus genomes. Adv Virus Res (2008) 1.21

Brd4-independent transcriptional repression function of the papillomavirus e2 proteins. J Virol (2007) 1.19

Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29. J Virol (2008) 1.18

Drosophila Mediator complex is broadly utilized by diverse gene-specific transcription factors at different types of core promoters. Mol Cell Biol (2001) 1.16

CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation. Cell Cycle (2010) 1.16

Human mediator enhances activator-facilitated recruitment of RNA polymerase II and promoter recognition by TATA-binding protein (TBP) independently of TBP-associated factors. Mol Cell Biol (2003) 1.16

Mediator-dependent nuclear receptor function. Semin Cell Dev Biol (2011) 1.12

The Mediator complex in plants: structure, phylogeny, and expression profiling of representative genes in a dicot (Arabidopsis) and a monocot (rice) during reproduction and abiotic stress. Plant Physiol (2011) 1.09

A double-bromodomain protein, FSH-S, activates the homeotic gene ultrabithorax through a critical promoter-proximal region. Mol Cell Biol (2007) 1.09

Characterization of mediator complexes from HeLa cell nuclear extract. Mol Cell Biol (2001) 1.09

Targeting STAT5 in hematologic malignancies through inhibition of the bromodomain and extra-terminal (BET) bromodomain protein BRD2. Mol Cancer Ther (2014) 1.09

Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation. Nucleic Acids Res (2011) 1.08

Purification of transcription cofactor complex CRSP. Proc Natl Acad Sci U S A (1999) 1.07

Activation-induced nuclear translocation of RING3. J Cell Sci (2000) 1.06

RNA polymerase II (Pol II)-TFIIF and Pol II-mediator complexes: the major stable Pol II complexes and their activity in transcription initiation and reinitiation. Mol Cell Biol (2004) 1.05

Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells. Proc Natl Acad Sci U S A (2001) 1.04

The Ras/PKA signaling pathway of Saccharomyces cerevisiae exhibits a functional interaction with the Sin4p complex of the RNA polymerase II holoenzyme. Genetics (2001) 0.99

Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs. Cancer Cell (2016) 0.98

The Ras/PKA signaling pathway may control RNA polymerase II elongation via the Spt4p/Spt5p complex in Saccharomyces cerevisiae. Genetics (2003) 0.98

Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation. Proc Natl Acad Sci U S A (1999) 0.95

MYC and transcription elongation. Cold Spring Harb Perspect Med (2014) 0.95

Elevated MED28 expression predicts poor outcome in women with breast cancer. BMC Cancer (2010) 0.94

The role of bromodomain proteins in regulating gene expression. Genes (Basel) (2012) 0.93

An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis. FEBS Lett (2010) 0.89

Targeting epigenetic regulations in cancer. Acta Biochim Biophys Sin (Shanghai) (2015) 0.88

The proliferating cell nuclear antigen regulates retinoic acid receptor transcriptional activity through direct protein-protein interaction. Nucleic Acids Res (2005) 0.88

Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module. Mol Cell Biol (2003) 0.87

Clinical trials for BET inhibitors run ahead of the science. Drug Discov Today Technol (2016) 0.86

BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements. Cell Rep (2016) 0.85

Chromatin targeting drugs in cancer and immunity. Genes Dev (2013) 0.84

Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150). Arch Biochem Biophys (2007) 0.83

BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell. PLoS One (2016) 0.83

Sequence and expression analyses of KIX domain proteins suggest their importance in seed development and determination of seed size in rice, and genome stability in Arabidopsis. Mol Genet Genomics (2013) 0.82

Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor. J Clin Invest (2014) 0.82

Drosophila Med6 is required for elevated expression of a large but distinct set of developmentally regulated genes. Mol Cell Biol (2001) 0.81

Evolution of disorder in Mediator complex and its functional relevance. Nucleic Acids Res (2015) 0.79

Mechanism and factors that control HIV-1 transcription and latency activation. J Zhejiang Univ Sci B (2014) 0.79

Mediator independently orchestrates multiple steps of preinitiation complex assembly in vivo. Nucleic Acids Res (2015) 0.78

Med8, Med18, and Med20 subunits of the Mediator head domain are interdependent upon each other for folding and complex formation. Proc Natl Acad Sci U S A (2009) 0.77

BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma. Oncotarget (2016) 0.76

Epigenetic mechanisms in heart failure pathogenesis. Circ Heart Fail (2014) 0.76

Small molecule probes to target the human Mediator complex. Isr J Chem (2013) 0.76

Molecular mechanism of the priming by jasmonic acid of specific dehydration stress response genes in Arabidopsis. Epigenetics Chromatin (2016) 0.75

Regulation of the human papillomavirus type 16 late promoter by transcriptional elongation. Virology (2017) 0.75

Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental Signaling. Genes (Basel) (2017) 0.75

Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture. Genes Dev (2016) 0.75

Genomic alterations in fatal forms of non-anaplastic thyroid cancer: Identification of MED12 and RBM10 as novel thyroid cancer genes associated with tumor virulence. Clin Cancer Res (2017) 0.75

The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes. Mol Cell (2017) 0.75

The Essential Transcriptional Function of BRD4 in Acute Myeloid Leukemia. Cold Spring Harb Symp Quant Biol (2017) 0.75

Articles cited by this

Basic local alignment search tool. J Mol Biol (1990) 659.07

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30

A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell (1994) 8.44

Mechanism of transcriptional activation by Sp1: evidence for coactivators. Cell (1990) 8.18

Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID. Nature (1990) 7.11

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell (1992) 6.11

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell (1992) 5.39

Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter. Genes Dev (1992) 4.85

A human RNA polymerase II complex associated with SRB and DNA-repair proteins. Nature (1996) 3.50

TBP-associated factors are not generally required for transcriptional activation in yeast. Nature (1996) 3.45

A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias. Nat Genet (1992) 3.43

Transcription activation in cells lacking TAFIIS. Nature (1996) 3.04

A mediator required for activation of RNA polymerase II transcription in vitro. Nature (1991) 3.00

Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme. Proc Natl Acad Sci U S A (1995) 2.96

The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes Dev (1998) 2.91

RNA polymerase II C-terminal domain required for enhancer-driven transcription. Nature (1995) 2.78

Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae. Mol Cell Biol (1992) 2.39

The Drosophila fsh locus, a maternal effect homeotic gene, encodes apparent membrane proteins. Dev Biol (1989) 2.35

In utero rearrangements in the trithorax-related oncogene in infant leukaemias. Nature (1993) 2.19

Yeast TAF(II)145 functions as a core promoter selectivity factor, not a general coactivator. Cell (1997) 2.17

A mammalian SRB protein associated with an RNA polymerase II holoenzyme. Nature (1996) 2.16

Rapid and reversible translocation of the catalytic subunit of cAMP-dependent protein kinase type II from the Golgi complex to the nucleus. EMBO J (1985) 2.02

A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID. Cell (1992) 1.98

A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator. Genes Dev (1996) 1.97

Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations. Cancer Res (1991) 1.88

A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC. DNA Seq (1992) 1.85

Structure and molecular analysis of RGR1, a gene required for glucose repression of Saccharomyces cerevisiae. Mol Cell Biol (1990) 1.68

Type 3 protein kinase C localization to the nuclear envelope of phorbol ester-treated NIH 3T3 cells. J Cell Biol (1989) 1.48

Requirement for RGR1 and SIN4 in RME1-dependent repression in Saccharomyces cerevisiae. Genetics (1994) 1.46

Signal transduction and nuclear targeting: regulation of transcription factor activity by subcellular localisation. J Cell Sci (1993) 1.45

Identification and characterization of BRDT: A testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh. Genomics (1997) 1.43

Interplay of positive and negative effectors in function of the C-terminal repeat domain of RNA polymerase II. Proc Natl Acad Sci U S A (1994) 1.41

Methodical analysis of protein-nitrocellulose interactions to design a refined digestion protocol. Anal Biochem (1996) 1.38

Microbore reversed-phase high-performance liquid chromatographic purification of peptides for combined chemical sequencing-laser-desorption mass spectrometric analysis. J Chromatogr A (1994) 1.34

A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans. Mol Cell Biol (1997) 1.29

High-sensitivity sequencing of large proteins: partial structure of the rapamycin-FKBP12 target. Protein Sci (1994) 1.24

Genes induced in programmed cell death of neuronal PC12 cells and developing sympathetic neurons in vivo. Dev Biol (1997) 1.05

Articles by these authors

SNAP receptors implicated in vesicle targeting and fusion. Nature (1993) 18.57

Chromatin structure: a repeating unit of histones and DNA. Science (1974) 13.18

Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol (2001) 9.82

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell (1994) 9.48

Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell (1990) 9.24

Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Science (2001) 8.92

Structure of chromatin. Annu Rev Biochem (1977) 8.91

A cellular gene encodes scrapie PrP 27-30 protein. Cell (1985) 8.86

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell (1994) 8.71

A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell (1994) 8.44

Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution. Science (2001) 8.24

Chromatin structure; oligomers of the histones. Science (1974) 7.85

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev (1999) 7.58

An octamer of histones in chromatin and free in solution. Proc Natl Acad Sci U S A (1975) 7.35

Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae. Mol Cell Biol (1988) 7.10

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science (1998) 6.79

DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell (1991) 6.63

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science (1999) 6.38

RSC, an essential, abundant chromatin-remodeling complex. Cell (1996) 6.17

A single gene from yeast for both nuclear and cytoplasmic polyadenylate-binding proteins: domain structure and expression. Cell (1986) 5.99

Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell (1997) 5.83

A single domain of yeast poly(A)-binding protein is necessary and sufficient for RNA binding and cell viability. Mol Cell Biol (1987) 5.66

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat Genet (1999) 5.61

Action of micrococcal nuclease on chromatin and the location of histone H1. J Mol Biol (1977) 5.61

Synthetic peptides as nuclear localization signals. Nature (1986) 5.35

Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science (2001) 5.25

COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A (2001) 5.19

Architecture of RNA polymerase II and implications for the transcription mechanism. Science (2000) 5.12

Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol Cell (2001) 5.04

Nucleosomes inhibit the initiation of transcription but allow chain elongation with the displacement of histones. Cell (1987) 5.00

The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell (1997) 4.99

Specific protein binding to far upstream activating sequences in polymerase II promoters. Proc Natl Acad Sci U S A (1985) 4.85

Inside-outside transitions of phospholipids in vesicle membranes. Biochemistry (1971) 4.84

A human telomeric protein. Science (1995) 4.77

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature (1993) 4.68

Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. Science (1999) 4.65

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem (1999) 4.56

Preparation of native chromatin and damage caused by shearing. Science (1975) 4.49

Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol Cell (1999) 4.49

A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell (1994) 4.47

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci U S A (2000) 4.41

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature (1999) 4.40

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci U S A (1992) 4.32

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev (1998) 4.29

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. Genes Dev (1991) 4.28

Inhibition of transcription elongation by the VHL tumor suppressor protein. Science (1995) 4.23

A multisubunit complex containing the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated from yeast. Proc Natl Acad Sci U S A (1994) 4.21

I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell (1995) 3.95

A Drosophila Polycomb group complex includes Zeste and dTAFII proteins. Nature (2001) 3.90

Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK. Cell (1994) 3.81

A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol Cell (1999) 3.80

Statistical positioning of nucleosomes by specific protein-binding to an upstream activating sequence in yeast. J Mol Biol (1988) 3.80

SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell (1998) 3.76

Rel-associated pp40: an inhibitor of the rel family of transcription factors. Science (1991) 3.76

A novel mediator between activator proteins and the RNA polymerase II transcription apparatus. Cell (1990) 3.74

Connections between transcriptional activators, silencers, and telomeres as revealed by functional analysis of a yeast DNA-binding protein. Mol Cell Biol (1988) 3.69

General initiation factors for RNA polymerase II. Annu Rev Biochem (1993) 3.69

Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex. Genes Dev (2001) 3.67

Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis. J Chromatogr A (1998) 3.64

Cloning and characterization of PSF, a novel pre-mRNA splicing factor. Genes Dev (1993) 3.63

Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. Science (1995) 3.53

Mediator of transcriptional regulation. Annu Rev Biochem (2000) 3.51

An RNA polymerase II elongation factor encoded by the human ELL gene. Science (1996) 3.46

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc Natl Acad Sci U S A (1999) 3.43

Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits. EMBO J (1992) 3.33

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. Mol Cell Biol (1998) 3.30