Published in Mol Biol Cell on July 18, 2007
gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. Blood (2009) 2.07
Accessory molecules for Toll-like receptors and their function. Nat Rev Immunol (2012) 2.00
Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential. Nat Rev Cancer (2014) 1.83
The stress of protein misfolding: from single cells to multicellular organisms. Cold Spring Harb Perspect Biol (2011) 1.48
GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum. Biochim Biophys Acta (2011) 1.42
GRP94 in ER quality control and stress responses. Semin Cell Dev Biol (2010) 1.29
Protein folding in the endoplasmic reticulum. Cold Spring Harb Perspect Biol (2013) 1.26
TRAP-1, the mitochondrial Hsp90. Biochim Biophys Acta (2011) 1.22
Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway. Proc Natl Acad Sci U S A (2013) 1.19
The chaperone activity of GRP94 toward insulin-like growth factor II is necessary for the stress response to serum deprivation. Mol Biol Cell (2009) 1.18
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat Chem Biol (2013) 1.16
Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex. Blood (2011) 1.12
An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells. Proc Natl Acad Sci U S A (2009) 1.10
The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche. PLoS One (2011) 1.07
Development of a Grp94 inhibitor. J Am Chem Soc (2012) 1.06
Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling. PLoS One (2010) 1.05
ER Stress Proteins in Autoimmune and Inflammatory Diseases. Front Immunol (2012) 1.04
Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis. J Cell Physiol (2015) 1.04
The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery? Br J Pharmacol (2011) 1.02
Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response. Proc Natl Acad Sci U S A (2012) 1.01
In utero exposure to low doses of environmental pollutants disrupts fetal ovarian development in sheep. Mol Hum Reprod (2008) 0.99
Orchestration of secretory protein folding by ER chaperones. Biochim Biophys Acta (2013) 0.98
Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors. Biochim Biophys Acta (2009) 0.97
Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. Dev Biol (2010) 0.97
Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus. Proc Natl Acad Sci U S A (2010) 0.96
The Hsp90 mosaic: a picture emerges. Nat Struct Mol Biol (2009) 0.95
Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production. FASEB J (2012) 0.95
Myofiber stress-response in myositis: parallel investigations on patients and experimental animal models of muscle regeneration and systemic inflammation. Arthritis Res Ther (2010) 0.94
Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response. J Cell Sci (2012) 0.93
An essential role for chloroplast heat shock protein 90 (Hsp90C) in protein import into chloroplasts. Proc Natl Acad Sci U S A (2013) 0.92
Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. J Hepatol (2014) 0.90
Calreticulin induces dilated cardiomyopathy. PLoS One (2013) 0.90
Endoplasmic reticulum stress and diabetic cardiomyopathy. Exp Diabetes Res (2011) 0.89
Representing ontogeny through ontology: a developmental biologist's guide to the gene ontology. Mol Reprod Dev (2010) 0.89
OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation. Mol Biol Cell (2014) 0.85
Oocyte-targeted deletion reveals that hsp90b1 is needed for the completion of first mitosis in mouse zygotes. PLoS One (2011) 0.83
Curcumin counteracts loss of force and atrophy of hindlimb unloaded rat soleus by hampering neuronal nitric oxide synthase untethering from sarcolemma. J Physiol (2014) 0.81
Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasis. Cell Mol Life Sci (2012) 0.80
Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94. Curr Top Med Chem (2016) 0.79
Protein quality control in the endoplasmic reticulum. F1000Prime Rep (2014) 0.79
Endoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport. J Biol Chem (2016) 0.78
The stress protein/chaperone Grp94 counteracts muscle disuse atrophy by stabilizing subsarcolemmal neuronal nitric oxide synthase. Antioxid Redox Signal (2013) 0.78
Identification and characterization of novel ER-based hsp90 gene in the red flour beetle, Tribolium castaneum. Cell Stress Chaperones (2013) 0.77
Grp94 Protein Delivers γ-Aminobutyric Acid Type A (GABAA) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation. J Biol Chem (2016) 0.76
A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein. PLoS Genet (2016) 0.76
Tauroursodeoxycholic acid inhibits endoplasmic reticulum stress, blocks mitochondrial permeability transition pore opening, and suppresses reperfusion injury through GSK-3ß in cardiac H9c2 cells. Am J Transl Res (2016) 0.75
Serum Gp96 is a chaperone of complement-C3 during graft-versus-host disease. JCI Insight (2017) 0.75
A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production. Endocrinology (2016) 0.75
Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90. PLoS One (2017) 0.75
Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development. Oncotarget (2016) 0.75
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell (1991) 14.23
Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle. Nature (1978) 11.49
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell (1993) 10.36
Role of insulin-like growth factors in embryonic and postnatal growth. Cell (1993) 8.22
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature (1990) 5.47
Embryonic stem cells express neuronal properties in vitro. Dev Biol (1995) 5.03
Expression pattern of the mouse T gene and its role in mesoderm formation. Nature (1990) 4.97
The insulin-like growth factor system and cancer. Cancer Lett (2003) 4.91
Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages. Immunity (2007) 4.17
Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol (1994) 3.88
Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability. Nat Cell Biol (2001) 3.60
Eomesodermin is required for mouse trophoblast development and mesoderm formation. Nature (2000) 3.53
Differentiation of pluripotent embryonic stem cells into cardiomyocytes. Circ Res (2002) 3.52
nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development (1997) 3.15
A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. EMBO J (1993) 2.73
Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum. Nature (1994) 2.60
Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development (1998) 2.59
Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos. Development (1997) 2.41
Activation of an unfolded protein response during differentiation of antibody-secreting B cells. J Biol Chem (2002) 2.38
Differentiation of embryonic stem cells into adipocytes in vitro. J Cell Sci (1997) 2.33
Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell (1985) 2.22
BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo. Development (1999) 2.16
Transcriptional regulation of two genes specifically induced by glucose starvation in a hamster mutant fibroblast cell line. J Biol Chem (1983) 1.96
Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. Proc Natl Acad Sci U S A (1998) 1.94
The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development (1998) 1.85
Mice lacking HSP90beta fail to develop a placental labyrinth. Development (2000) 1.83
Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately. J Cell Biol (1990) 1.74
Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. Dev Biol (1994) 1.71
In vitro differentiation of embryonic stem cells into hepatocyte-like cells identified by cellular uptake of indocyanine green. Stem Cells (2002) 1.62
Generation of a mammalian cell line deficient in glucose-regulated protein stress induction through targeted ribozyme driven by a stress-inducible promoter. J Biol Chem (1995) 1.61
Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. Mol Endocrinol (1999) 1.58
Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis. Dev Biol (1999) 1.55
Depletion of intracellular calcium stores by calcium ionophore A23187 induces the genes for glucose-regulated proteins in hamster fibroblasts. J Biol Chem (1987) 1.55
The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse. Genes Dev (1998) 1.52
Competitive inhibition of a set of endoplasmic reticulum protein genes (GRP78, GRP94, and ERp72) retards cell growth and lowers viability after ionophore treatment. Mol Cell Biol (1991) 1.41
Structure and assembly of the endoplasmic reticulum. The synthesis of three major endoplasmic reticulum proteins during lipopolysaccharide-induced differentiation of murine lymphocytes. J Biol Chem (1985) 1.36
Pattern of the insulin-like growth factor II gene expression during early mouse embryogenesis. Development (1990) 1.30
Overexpression of the stress protein Grp94 reduces cardiomyocyte necrosis due to calcium overload and simulated ischemia. FASEB J (2003) 1.29
Establishment of a Chinese hamster ovary cell line that expresses grp78 antisense transcripts and suppresses A23187 induction of both GRP78 and GRP94. J Cell Physiol (1992) 1.27
SHEPHERD is the Arabidopsis GRP94 responsible for the formation of functional CLAVATA proteins. EMBO J (2002) 1.26
Expression of the T-box gene Eomesodermin during early mouse development. Mech Dev (1999) 1.25
Biology of insulin-like growth factors in development. Birth Defects Res C Embryo Today (2003) 1.23
Radicicol-sensitive peptide binding to the N-terminal portion of GRP94. J Biol Chem (2002) 1.15
Cardiac-specific expression of calcineurin reverses embryonic lethality in calreticulin-deficient mouse. J Biol Chem (2002) 1.14
Regulation of the glucose-regulated protein genes by beta-mercaptoethanol requires de novo protein synthesis and correlates with inhibition of protein glycosylation. J Cell Physiol (1987) 1.13
Post-translational processing of the insulin-like growth factor-2 precursor. Analysis of O-glycosylation and endoproteolysis. J Biol Chem (1998) 1.12
Phylogenetic conservation of the molecular and immunological properties of the chaperones gp96 and hsp70. Eur J Immunol (2001) 1.11
Differential expression of BMP receptors in early mouse development. Int J Dev Biol (1997) 1.10
Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. I. Evidence for allosteric regulation of ligand binding. J Biol Chem (2000) 1.09
Histochemical localization of IGF-I and -II mRNA in the developing rat embryo. Development (1987) 1.08
Reduced amount of the glucose-regulated protein GRP94 in skeletal myoblasts results in loss of fusion competence. FASEB J (2000) 1.01
MyoD cannot compensate for the absence of myogenin during skeletal muscle differentiation in murine embryonic stem cells. Dev Biol (2001) 1.01
The bHLH class protein pMesogenin1 can specify paraxial mesoderm phenotypes. Dev Biol (2000) 0.95
Chromosomal assignment of the gene encoding the mouse tumor rejection antigen gp96. Immunogenetics (1988) 0.92
IGF-II promotes mesoderm formation. Dev Biol (2000) 0.90
Immunolocalization and heart levels of GRP94 in the mouse during post-implantation development. Anat Embryol (Berl) (1997) 0.87
Mapping of the genes for human endoplasmic reticular heat shock protein gp96/grp94. Somat Cell Mol Genet (1993) 0.87
Expression of the glucose-regulated proteins (GRP94 and GRP78) in differentiated and undifferentiated mouse embryonic cells and the use of the GRP78 promoter as an expression system in embryonic cells. Differentiation (1990) 0.86
The Toll/IL-1 receptor binding protein MyD88 is required for Xenopus axis formation. Mech Dev (2000) 0.84
A protein kinase isolated from porcine brain microvessels is similar to a class of heat-shock proteins. Eur J Biochem (1994) 0.82
Developmentally regulated expression of insulin-like growth factors by differentiated murine teratocarcinomas and extraembryonic mesoderm. J Embryol Exp Morphol (1986) 0.82
Ontogenic changes in the circulating concentrations of insulin-like growth factor (IGF)-I, IGF-II, and IGF-binding proteins in the chicken embryo. Gen Comp Endocrinol (1997) 0.78
Expression of a glucose-regulated cell surface protein in early mouse embryos. Dev Biol (1984) 0.78
Expression levels of stress protein gp96 are not limiting for major histocompatibility complex class I-restricted antigen presentation. Eur J Immunol (1996) 0.77
Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing. Sci Transl Med (2009) 4.71
Assuring the quality of next-generation sequencing in clinical laboratory practice. Nat Biotechnol (2012) 3.62
Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients. J Infect Dis (2009) 3.08
Increased islet apoptosis in Pdx1+/- mice. J Clin Invest (2003) 2.91
Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements. J Immunol (2010) 2.36
Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. J Exp Med (2011) 1.97
Low-abundance HIV drug-resistant viral variants in treatment-experienced persons correlate with historical antiretroviral use. PLoS One (2009) 1.91
Minority variants associated with transmitted and acquired HIV-1 nonnucleoside reverse transcriptase inhibitor resistance: implications for the use of second-generation nonnucleoside reverse transcriptase inhibitors. J Acquir Immune Defic Syndr (2009) 1.73
The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies. PLoS Pathog (2013) 1.67
Convergent antibody signatures in human dengue. Cell Host Microbe (2013) 1.64
Protein homeostasis in models of aging and age-related conformational disease. Adv Exp Med Biol (2010) 1.48
GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum. Biochim Biophys Acta (2011) 1.42
High-resolution antibody dynamics of vaccine-induced immune responses. Proc Natl Acad Sci U S A (2014) 1.39
Characterization of Mauritian cynomolgus macaque major histocompatibility complex class I haplotypes by high-resolution pyrosequencing. Immunogenetics (2010) 1.31
Gene expression profiling in postmortem prefrontal cortex of major depressive disorder. J Neurosci (2007) 1.30
GRP94 in ER quality control and stress responses. Semin Cell Dev Biol (2010) 1.29
The chaperone activity of GRP94 toward insulin-like growth factor II is necessary for the stress response to serum deprivation. Mol Biol Cell (2009) 1.18
Radicicol-sensitive peptide binding to the N-terminal portion of GRP94. J Biol Chem (2002) 1.15
An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells. Proc Natl Acad Sci U S A (2009) 1.10
High-throughput sequencing of PCR products tagged with universal primers using 454 life sciences systems. Curr Protoc Mol Biol (2011) 1.07
IL-4 suppresses dendritic cell response to type I interferons. J Immunol (2007) 1.06
Development of a Grp94 inhibitor. J Am Chem Soc (2012) 1.06
The peptide-binding activity of GRP94 is regulated by calcium. Biochem J (2007) 1.05
Identification of the N-terminal peptide binding site of glucose-regulated protein 94. J Biol Chem (2004) 1.04
Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation. Hum Mol Genet (2007) 1.03
Escherichia coli interaction with human brain microvascular endothelial cells induces signal transducer and activator of transcription 3 association with the C-terminal domain of Ec-gp96, the outer membrane protein A receptor for invasion. Cell Microbiol (2008) 1.01
Next generation sequencing reveals the association of DRB3*02:02 with type 1 diabetes. Diabetes (2013) 0.98
Orchestration of secretory protein folding by ER chaperones. Biochim Biophys Acta (2013) 0.98
Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors. Biochim Biophys Acta (2009) 0.97
Prevalence of low-level HIV-1 variants with reverse transcriptase mutation K65R and the effect of antiretroviral drug exposure on variant levels. Antivir Ther (2011) 0.97
Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production. FASEB J (2012) 0.95
Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response. J Cell Sci (2012) 0.93
Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells. J Immunol (2011) 0.91
Deficient SUMO attachment to Flp recombinase leads to homologous recombination-dependent hyperamplification of the yeast 2 microm circle plasmid. Mol Biol Cell (2008) 0.91
Use of dried-blood-spot samples and in-house assays to identify antiretroviral drug resistance in HIV-infected children in resource-constrained settings. J Clin Microbiol (2011) 0.90
The Ras/cAMP pathway and the CDK-like kinase Ime2 regulate the MAPK Smk1 and spore morphogenesis in Saccharomyces cerevisiae. Genetics (2008) 0.89
The N-terminal fragment of GRP94 is sufficient for peptide presentation via professional antigen-presenting cells. Int Immunol (2006) 0.88
Modification of ligand-independent B cell receptor tonic signals activates receptor editing in immature B lymphocytes. J Biol Chem (2003) 0.86
Cysteines in CH1 underlie retention of unassembled Ig heavy chains. J Biol Chem (2005) 0.84
Therapy failure resulting from superinfection by a drug-resistant HIV variant. Antivir Ther (2012) 0.81
The actin regulatory protein HS1 is required for antigen uptake and presentation by dendritic cells. J Immunol (2011) 0.78
Candidate genes that affect aging through protein homeostasis. Adv Exp Med Biol (2015) 0.78
Alternative pathways of disulfide bond formation yield secretion-competent, stable and functional immunoglobulins. Mol Immunol (2008) 0.76
Relief of acute migraine headache with intravenous oxytocin: report of two cases. J Pain Palliat Care Pharmacother (2006) 0.76
Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death. PLoS One (2012) 0.76
Establishment and characterization of new cellular lymphoma model expressing transgenic human MDR1. Leuk Res (2005) 0.76