TRAP-1, the mitochondrial Hsp90.

Signaling the mitochondrial unfolded protein response. Biochim Biophys Acta (2012) 1.61

The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase. Cell Metab (2013) 1.36

Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism. Mol Cell (2014) 1.17

Selective targeting of the stress chaperome as a therapeutic strategy. Trends Pharmacol Sci (2014) 1.12

TRAP1 regulates proliferation, mitochondrial function, and has prognostic significance in NSCLC. Mol Cancer Res (2014) 0.99

Heat shock proteins in multiple myeloma. Oncotarget (2014) 0.95

Correlation between mitochondrial TRAP-1 expression and lymph node metastasis in colorectal cancer. World J Gastroenterol (2012) 0.94

New insights into TRAP1 pathway. Am J Cancer Res (2012) 0.92

Molecular cochaperones: tumor growth and cancer treatment. Scientifica (Cairo) (2013) 0.92

Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1. Cell Death Dis (2013) 0.92

An essential role for chloroplast heat shock protein 90 (Hsp90C) in protein import into chloroplasts. Proc Natl Acad Sci U S A (2013) 0.92

Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer. World J Gastroenterol (2014) 0.91

Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks. Cell Rep (2014) 0.87

Maximizing the Therapeutic Potential of HSP90 Inhibitors. Mol Cancer Res (2015) 0.86

Review: The HSP90 molecular chaperone-an enigmatic ATPase. Biopolymers (2016) 0.84

Targeting malignant mitochondria with therapeutic peptides. Ther Deliv (2012) 0.84

Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria. Mol Biol Cell (2012) 0.84

Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model. Oncotarget (2017) 0.83

Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. J Med Chem (2015) 0.83

Resistance to HSP90 inhibition involving loss of MCL1 addiction. Oncogene (2015) 0.83

Daily heat stress treatment rescues denervation-activated mitochondrial clearance and atrophy in skeletal muscle. J Physiol (2015) 0.82

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis. PLoS Biol (2016) 0.82

Parkinson's disease: dopaminergic nerve cell model is consistent with experimental finding of increased extracellular transport of α-synuclein. BMC Neurosci (2013) 0.78

N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting. J Biomed Sci (2015) 0.78

Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development. J Biol Chem (2016) 0.78

Mitochondrial Hsp90s suppress calcium-mediated stress signals propagating from mitochondria to the ER in cancer cells. Mol Cancer (2014) 0.76

The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells. Front Oncol (2017) 0.75

Mitochondrial chaperone TRAP1 activates the mitochondrial UPR and extends healthspan in Drosophila. Mech Ageing Dev (2014) 0.75

The diverse lives of TRAP1. Oncoscience (2014) 0.75

Cloning and differential expression of five heat shock protein genes associated with thermal stress and development in the polyphagous predatory mite Neoseiulus cucumeris (Acari: Phytoseiidae). Exp Appl Acarol (2015) 0.75

Autophagy in the pathogenesis of disease. Cell (2008) 34.68

Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol (2007) 33.06

Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science (2004) 15.91

The pathophysiology of mitochondrial cell death. Science (2004) 13.87

HSP90 and the chaperoning of cancer. Nat Rev Cancer (2005) 11.98

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature (2005) 11.22

Role of autophagy in cancer. Nat Rev Cancer (2007) 10.88

Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol (2006) 8.89

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature (2005) 8.51

HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol (2010) 7.16

Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer (2010) 6.81

Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov (2009) 6.36

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci U S A (2000) 6.30

Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. Cell (2007) 6.13

Parkinson's disease. First of two parts. N Engl J Med (1998) 5.90

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature (2004) 5.85

Mitochondrial complex I deficiency in Parkinson's disease. Lancet (1989) 5.72

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol (2007) 5.60

GHKL, an emergent ATPase/kinase superfamily. Trends Biochem Sci (2000) 4.20

Targeting mitochondria for cancer therapy. Nat Rev Drug Discov (2010) 4.07

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol (2007) 3.86

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med (2008) 3.69

Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability. Nat Cell Biol (2001) 3.60

Caspases in apoptosis and beyond. Oncogene (2008) 3.47

What is the mitochondrial permeability transition pore? J Mol Cell Cardiol (2009) 3.29

The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol Cell (2010) 3.26

The mitochondrial UPR - protecting organelle protein homeostasis. J Cell Sci (2010) 3.06

Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Cell (2007) 3.00

Directing cancer cells to self-destruct with pro-apoptotic receptor agonists. Nat Rev Drug Discov (2008) 2.95

More than folding: localized functions of cytosolic chaperones. Trends Biochem Sci (2003) 2.95

Death receptors in chemotherapy and cancer. Oncogene (2004) 2.64

Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome. Mol Cell (2009) 2.47

Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion. EMBO J (2001) 2.30

Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. J Biol Chem (2005) 2.26

The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. J Biol Chem (2000) 2.24

Structural and functional link between the mitochondrial network and the endoplasmic reticulum. Int J Biochem Cell Biol (2009) 2.20

The HSP90 family of genes in the human genome: insights into their divergence and evolution. Genomics (2005) 2.17

Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function? FEBS Lett (2002) 2.08

Regulation of survivin function by Hsp90. Proc Natl Acad Sci U S A (2003) 1.86

Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor. J Biol Chem (1995) 1.82

Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Proc Natl Acad Sci U S A (2007) 1.76

Rational design of shepherdin, a novel anticancer agent. Cancer Cell (2005) 1.74

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90. J Clin Invest (2009) 1.72

Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme M-mediated apoptosis. J Biol Chem (2007) 1.64

GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Mol Biol Cell (2007) 1.46

Tumor necrosis factor-associated protein 1 (TRAP-1) protects cells from oxidative stress and apoptosis. Stress (2007) 1.46

A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease. Hum Mol Genet (2010) 1.41

Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J Clin Invest (2011) 1.41

A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock. Mol Cell Biol (1996) 1.40

TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells. Cancer Lett (2009) 1.38

The ATPase cycle of the mitochondrial Hsp90 analog Trap1. J Biol Chem (2008) 1.32

GRP94 in ER quality control and stress responses. Semin Cell Dev Biol (2010) 1.29

Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer. Am J Pathol (2009) 1.26

Mitochondrial chaperone Trap1 and the calcium binding protein Sorcin interact and protect cells against apoptosis induced by antiblastic agents. Cancer Res (2010) 1.20

Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells. Cancer Res (2010) 1.19

Immunoelectron microscopy provides evidence that tumor necrosis factor receptor-associated protein 1 (TRAP-1) is a mitochondrial protein which also localizes at specific extramitochondrial sites. Exp Cell Res (2000) 1.15

Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. J Biol Chem (2004) 1.14

The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche. PLoS One (2011) 1.07

A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. PLoS One (2011) 1.03

The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery? Br J Pharmacol (2011) 1.02

Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species. J Cell Biochem (2007) 1.02

Tumor necrosis factor receptor-associated protein 1(TRAP1) regulates genes involved in cell cycle and metastases. Cancer Lett (2010) 1.01

Preclinical characterization of mitochondria-targeted small molecule hsp90 inhibitors, gamitrinibs, in advanced prostate cancer. Clin Cancer Res (2010) 1.01

ISO: a critical evaluation of the role of peptides in heat shock/chaperone protein-mediated tumor rejection. Curr Opin Immunol (2003) 0.99

Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease. Br J Cancer (2011) 0.97

Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones. Oncogene (2009) 0.92

Hypoxia conditions differentially modulate human normal and osteoarthritic chondrocyte proteomes. J Proteome Res (2010) 0.90

Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation. J Immunol (2006) 0.87

Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J Biol Chem (2005) 3.97

Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation. J Biol Chem (2009) 3.62

Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase. J Cell Physiol (2006) 3.32

A microRNA signature for a BMP2-induced osteoblast lineage commitment program. Proc Natl Acad Sci U S A (2008) 3.29

Networks and hubs for the transcriptional control of osteoblastogenesis. Rev Endocr Metab Disord (2006) 3.25

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol Endocrinol (2004) 3.09

MicroRNAs 221 and 222 bypass quiescence and compromise cell survival. Cancer Res (2008) 2.97

Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors. Crit Rev Eukaryot Gene Expr (2004) 2.81

Primary mouse embryonic fibroblasts: a model of mesenchymal cartilage formation. J Cell Physiol (2004) 2.59

miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res (2012) 2.52

IAP regulation of metastasis. Cancer Cell (2010) 2.47

Targeted deletion of Wwox reveals a tumor suppressor function. Proc Natl Acad Sci U S A (2007) 2.37

Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. Mol Cell Biol (2002) 2.35

A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program. Proc Natl Acad Sci U S A (2010) 2.29

Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2. Nature (2007) 2.28

Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol (2006) 2.27

CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression. J Biol Chem (2001) 2.27

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene (2004) 2.25

Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts. Cancer Res (2003) 2.20

The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion. Mol Cell Biol (2005) 2.18

BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network. J Biol Chem (2006) 2.15

Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription. EMBO J (2004) 2.12

A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2. Proc Natl Acad Sci U S A (2011) 2.05

MicroRNA control of bone formation and homeostasis. Nat Rev Endocrinol (2012) 2.05

Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene. Mol Cell Biol (2004) 1.99

Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha. J Biol Chem (2001) 1.99

Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration. J Cell Biol (2003) 1.97

The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts. J Biol Chem (2005) 1.93

Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2. Proc Natl Acad Sci U S A (2007) 1.91

Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal. J Biol Chem (2008) 1.84

Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo. Proc Natl Acad Sci U S A (2005) 1.83

Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. J Clin Invest (2008) 1.81

Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. J Biol Chem (2003) 1.80

Mitotic bookmarking of genes: a novel dimension to epigenetic control. Nat Rev Genet (2010) 1.76

The integrin-growth factor receptor duet. J Cell Physiol (2007) 1.75

Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. J Cell Physiol (2005) 1.70

Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity. Mol Cell Biol (2003) 1.69

The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism. J Biol Chem (2008) 1.67

HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes. Mol Cell Biol (2007) 1.67

Nuclear microenvironments in biological control and cancer. Nat Rev Cancer (2007) 1.65

Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells. Cancer Res (2008) 1.63

Fibronectin protects prostate cancer cells from tumor necrosis factor-alpha-induced apoptosis via the AKT/survivin pathway. J Biol Chem (2003) 1.59

Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. Cancer Res (2003) 1.57

Phenotype discovery by gene expression profiling: mapping of biological processes linked to BMP-2-mediated osteoblast differentiation. J Cell Biochem (2003) 1.56

Integrins in prostate cancer progression. Endocr Relat Cancer (2008) 1.56

Establishment of histone gene regulation and cell cycle checkpoint control in human embryonic stem cells. J Cell Physiol (2007) 1.55

The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis. J Cell Biochem (2005) 1.54

Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse. Dev Biol (2010) 1.52

Survival responses of human embryonic stem cells to DNA damage. J Cell Physiol (2009) 1.51

Cbfbeta interacts with Runx2 and has a critical role in bone development. Nat Genet (2002) 1.50

Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites. Proc Natl Acad Sci U S A (2002) 1.47

Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential. Proc Natl Acad Sci U S A (2007) 1.46

A Runx2 threshold for the cleidocranial dysplasia phenotype. Hum Mol Genet (2008) 1.45

Pluripotency: toward a gold standard for human ES and iPS cells. J Cell Physiol (2009) 1.44

Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease. Cancer Res (2004) 1.43

Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells. Proc Natl Acad Sci U S A (2008) 1.41