Published in Mol Cell Biol on August 06, 2007
Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing. J Cell Biol (2009) 1.29
Angiopoietin-like 4 interacts with matrix proteins to modulate wound healing. J Biol Chem (2010) 1.19
Genetic ablation of the fatty acid-binding protein FABP5 suppresses HER2-induced mammary tumorigenesis. Cancer Res (2013) 1.12
Fatty acid-binding protein 5 and PPARbeta/delta are critical mediators of epidermal growth factor receptor-induced carcinoma cell growth. J Biol Chem (2010) 1.10
Peroxisome Proliferator-Activated Receptor beta/delta in the Brain: Facts and Hypothesis. PPAR Res (2008) 1.05
Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2. Nat Commun (2014) 0.98
PPARs Mediate Lipid Signaling in Inflammation and Cancer. PPAR Res (2008) 0.96
Nuclear control of the inflammatory response in mammals by peroxisome proliferator-activated receptors. PPAR Res (2013) 0.94
New insights into the role of peroxisome proliferator-activated receptors in regulating the inflammatory response after tissue injury. PPAR Res (2012) 0.94
Chronic expression of PPAR-delta by oligodendrocyte lineage cells in the injured rat spinal cord. J Comp Neurol (2010) 0.92
Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion. Oncogene (2012) 0.91
TNIP1 is a corepressor of agonist-bound PPARs. Arch Biochem Biophys (2011) 0.90
Regulation of cell proliferation and migration by TAK1 via transcriptional control of von Hippel-Lindau tumor suppressor. J Biol Chem (2009) 0.89
Src is activated by the nuclear receptor peroxisome proliferator-activated receptor β/δ in ultraviolet radiation-induced skin cancer. EMBO Mol Med (2014) 0.88
PPARdelta promotes wound healing by up-regulating TGF-beta1-dependent or -independent expression of extracellular matrix proteins. J Cell Mol Med (2009) 0.86
Angiopoietin-like 4 regulates epidermal differentiation. PLoS One (2011) 0.85
Integrative and systemic approaches for evaluating PPARβ/δ (PPARD) function. Nucl Recept Signal (2015) 0.84
PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice. J Clin Invest (2012) 0.82
Polymorphisms of peroxisome proliferator-activated receptors and survival of lung cancer and upper aero-digestive tract cancers. Lung Cancer (2014) 0.81
PPARβ interprets a chromatin signature of pluripotency to promote embryonic differentiation at gastrulation. PLoS One (2013) 0.78
PPAR-alpha and PPAR-beta expression changes in the hippocampus of rats undergoing global cerebral ischemia/reperfusion due to PPAR-gamma status. Behav Brain Funct (2014) 0.77
Suppression of PPARβ, and DHA treatment, inhibit NaV1.5 and NHE-1 pro-invasive activities. Pflugers Arch (2014) 0.77
Conceptus elongation in ruminants: roles of progesterone, prostaglandin, interferon tau and cortisol. J Anim Sci Biotechnol (2014) 0.77
PPARδ as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance. PPAR Res (2016) 0.75
Cellular motility driven by assembly and disassembly of actin filaments. Cell (2003) 26.05
Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol (2006) 23.04
Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol (2005) 16.77
Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol (2003) 11.12
Regulation of wound healing by growth factors and cytokines. Physiol Rev (2003) 9.82
Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol (1999) 8.66
Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology (1996) 7.92
Biology of the p21-activated kinases. Annu Rev Biochem (2003) 7.63
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science (2000) 6.93
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell (2002) 6.36
Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol (1999) 5.58
Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J Cell Biol (1998) 4.91
Function and interactions of integrins. Cell Tissue Res (2001) 4.13
Eukaryotic chemotaxis: distinctions between directional sensing and polarization. J Biol Chem (2003) 3.95
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell (2005) 3.78
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res (2003) 3.58
Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell (2005) 3.01
Cell migration at a glance. J Cell Sci (2005) 2.80
Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. EMBO J (2002) 2.70
Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J (2001) 2.55
Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol Cell (2002) 2.50
Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J Cell Sci (2003) 2.49
Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J Cell Biol (2001) 2.41
Critical roles of PPAR beta/delta in keratinocyte response to inflammation. Genes Dev (2001) 2.32
Control of actin assembly dynamics in cell motility. J Biol Chem (2007) 2.03
The p21Rac/Cdc42-activated kinases (PAKs). Int J Biochem Cell Biol (1998) 2.00
Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins. Mol Cell Biol (2004) 1.93
Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. J Cell Biol (2002) 1.87
Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion. Curr Opin Cell Biol (2000) 1.82
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol (2007) 1.63
p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J Biol Chem (2000) 1.61
Actin polymerization machinery: the finish line of signaling networks, the starting point of cellular movement. Cell Mol Life Sci (2005) 1.60
Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin. J Cell Sci (2003) 1.45
Akt/PKB signaling in cancer: a function in cell motility and invasion. Cell Cycle (2006) 1.42
Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1. J Cell Sci (2007) 1.39
Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway. Mol Endocrinol (2006) 1.35
Wound-healing defects in mice lacking fibrinogen. Blood (2001) 1.34
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases. Immunology (2002) 1.25
Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development. Mol Cell Biol (2005) 1.12
An ex vivo assay to assess the potential of skin keratinocytes for wound epithelialization. J Invest Dermatol (2002) 1.11
Peroxisome proliferator-activated receptor beta/delta exerts a strong protection from ischemic acute renal failure. J Am Soc Nephrol (2005) 1.08
Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis. J Cell Sci (2007) 1.06
Genetic- or transforming growth factor-beta 1-induced changes in epidermal peroxisome proliferator-activated receptor beta/delta expression dictate wound repair kinetics. J Biol Chem (2005) 0.94
Integrin-linked kinase and its partners: a modular platform regulating cell-matrix adhesion dynamics and cytoskeletal organization. Eur J Cell Biol (2005) 0.94
A knotty turnabout?: Akt1 as a metastasis suppressor. Cancer Cell (2005) 0.93
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
Transcriptional regulation of metabolism. Physiol Rev (2006) 3.68
The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J Biol Chem (2005) 3.51
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev (2006) 3.48
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog Lipid Res (2006) 3.01
Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science (2010) 2.93
Peroxisome-proliferator-activated receptors and cancers: complex stories. Nat Rev Cancer (2004) 2.93
Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription. Mol Cell Biol (2002) 2.58
Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol Cell (2002) 2.50
Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci U S A (2004) 2.46
The G0/G1 switch gene 2 is a novel PPAR target gene. Biochem J (2005) 2.29
PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes. Cell Metab (2006) 2.26
The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment. J Biol Chem (2004) 2.23
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma. J Exp Med (2005) 2.06
PPARbeta/delta regulates paneth cell differentiation via controlling the hedgehog signaling pathway. Gastroenterology (2006) 2.01
Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes. Cardiovasc Res (2005) 1.95
Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock. Mol Endocrinol (2006) 1.91
The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis. J Biol Chem (2007) 1.89
PPARs at the crossroads of lipid signaling and inflammation. Trends Endocrinol Metab (2012) 1.87
PixFRET, an ImageJ plug-in for FRET calculation that can accommodate variations in spectral bleed-throughs. Microsc Res Tech (2005) 1.85
Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Proc Natl Acad Sci U S A (2006) 1.84
The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway. Cell Signal (2007) 1.82
PPARalpha governs glycerol metabolism. J Clin Invest (2004) 1.79
Loss of egg yolk genes in mammals and the origin of lactation and placentation. PLoS Biol (2008) 1.77
Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice. Mol Cell Biol (2005) 1.75
Nutrigenomics and nutrigenetics: the emerging faces of nutrition. FASEB J (2005) 1.59
Involvement of PPAR nuclear receptors in tissue injury and wound repair. J Clin Invest (2006) 1.55
In vivo activation of PPAR target genes by RXR homodimers. EMBO J (2004) 1.53
Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta. Mol Cell Biol (2006) 1.49
Be fit or be sick: peroxisome proliferator-activated receptors are down the road. Mol Endocrinol (2004) 1.48
Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation. J Invest Dermatol (2004) 1.45
Peroxisome proliferator-activated receptors (PPARs) in skin health, repair and disease. Biochim Biophys Acta (2007) 1.41
Peroxisome proliferator-activated receptors mediate host cell proinflammatory responses to Pseudomonas aeruginosa autoinducer. J Bacteriol (2008) 1.41
A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activity. Mol Endocrinol (2002) 1.40
PPARs in diseases: control mechanisms of inflammation. Curr Med Chem (2005) 1.33
Multiple expression control mechanisms of peroxisome proliferator-activated receptors and their target genes. J Steroid Biochem Mol Biol (2005) 1.32
Fat poetry: a kingdom for PPAR gamma. Cell Res (2007) 1.31
Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1. FEBS Lett (2006) 1.30
Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing. J Cell Biol (2009) 1.29
Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats. PLoS One (2011) 1.24
Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism. PLoS One (2011) 1.22
Smad3 deficiency in mice protects against insulin resistance and obesity induced by a high-fat diet. Diabetes (2011) 1.21
PPAR expression and function during vertebrate development. Int J Dev Biol (2002) 1.21
The anti-apoptotic role of PPARbeta contributes to efficient skin wound healing. J Steroid Biochem Mol Biol (2003) 1.19
Fluorescence imaging reveals the nuclear behavior of peroxisome proliferator-activated receptor/retinoid X receptor heterodimers in the absence and presence of ligand. J Biol Chem (2005) 1.18
The adaptor protein Gab1 couples the stimulation of vascular endothelial growth factor receptor-2 to the activation of phosphoinositide 3-kinase. J Biol Chem (2006) 1.15
GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation. Cell Biosci (2012) 1.15
Differential regulation of vascular endothelial growth factor expression by peroxisome proliferator-activated receptors in bladder cancer cells. J Biol Chem (2002) 1.14
PPARs as drug targets to modulate inflammatory responses? Curr Drug Targets Inflamm Allergy (2004) 1.12
Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development. Mol Cell Biol (2005) 1.12
IL-13 induces expression of CD36 in human monocytes through PPARgamma activation. Eur J Immunol (2007) 1.11
PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation. J Lipid Res (2002) 1.10
Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation. Endocrinology (2004) 1.10
Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes. J Invest Dermatol (2007) 1.09
Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice. J Clin Invest (2009) 1.08
Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression. EMBO J (2004) 1.08
Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts. Am J Respir Cell Mol Biol (2005) 1.08
Peroxisome proliferator-activated receptor beta/delta exerts a strong protection from ischemic acute renal failure. J Am Soc Nephrol (2005) 1.08
Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain. Endocrinology (2006) 1.08
Smad3 signaling is required for satellite cell function and myogenic differentiation of myoblasts. Cell Res (2011) 1.06
Atherosclerotic mice exhibit systemic inflammation in periadventitial and visceral adipose tissue, liver, and pancreatic islets. Atherosclerosis (2009) 1.06
Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity. Proc Natl Acad Sci U S A (2011) 1.05
Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone action. Mol Endocrinol (2004) 1.05
Kinase signaling cascades that modulate peroxisome proliferator-activated receptors. Curr Opin Cell Biol (2005) 1.04
Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gamma. J Biol Chem (2007) 1.03
Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells. Gastroenterology (2003) 1.03
Sex difference in hepatic peroxisome proliferator-activated receptor alpha expression: influence of pituitary and gonadal hormones. Endocrinology (2003) 1.01
Functions of the peroxisome proliferator-activated receptor (PPAR) alpha and beta in skin homeostasis, epithelial repair, and morphogenesis. J Investig Dermatol Symp Proc (2006) 1.01
Nuclear factor I-C links platelet-derived growth factor and transforming growth factor beta1 signaling to skin wound healing progression. Mol Cell Biol (2009) 1.00
Peroxisome proliferator-activated receptor-beta as a target for wound healing drugs. Expert Opin Ther Targets (2004) 1.00
Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins. J Biol Chem (2005) 1.00
Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia. Cell Metab (2011) 0.98