Published in J Cell Sci on September 01, 2003
The genome of the social amoeba Dictyostelium discoideum. Nature (2005) 9.18
Lysosomal positioning coordinates cellular nutrient responses. Nat Cell Biol (2011) 4.96
Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity. Annu Rev Biophys (2010) 3.76
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol (2004) 3.44
A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling. Nat Cell Biol (2005) 2.99
Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Annu Rev Immunol (2008) 2.86
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell (2005) 2.76
Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling. J Cell Biol (2004) 2.56
Compartmentalization of redox signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal (2009) 2.17
Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors. Neuron (2007) 2.13
Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. J Cell Biol (2005) 2.05
Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism. Proc Natl Acad Sci U S A (2006) 1.89
Activation of Galphai3 triggers cell migration via regulation of GIV. J Cell Biol (2008) 1.88
CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase-independent manner. J Exp Med (2007) 1.85
Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster. J Cell Biol (2006) 1.73
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr Biol (2007) 1.62
Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell. Biophys J (2006) 1.58
Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts. J Cell Biol (2005) 1.58
Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J (2004) 1.56
Cells move when ions and water flow. Pflugers Arch (2006) 1.52
Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol Biol Cell (2005) 1.48
Exploring the control circuit of cell migration by mathematical modeling. Biophys J (2008) 1.44
Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway. Mol Cell Biol (2005) 1.42
Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia. J Neurosci (2010) 1.39
The role of phosphoinositide 3-kinases in neutrophil migration in 3D collagen gels. PLoS One (2015) 1.38
Essential role of PDK1 in regulating endothelial cell migration. J Cell Biol (2007) 1.35
beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1. Mol Biol Cell (2006) 1.32
Neurotrophin-dependent dendritic filopodial motility: a convergence on PI3K signaling. J Neurosci (2008) 1.32
GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression. Cell Adh Migr (2011) 1.31
Spatial analysis of 3' phosphoinositide signaling in living fibroblasts, III: influence of cell morphology and morphological Polarity. Biophys J (2005) 1.28
An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. J Cell Biol (2007) 1.25
Dynamic partitioning into lipid rafts controls the endo-exocytic cycle of the alphaL/beta2 integrin, LFA-1, during leukocyte chemotaxis. Mol Biol Cell (2005) 1.25
A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis. Mol Biol Cell (2005) 1.24
MicroRNA-205 promotes keratinocyte migration via the lipid phosphatase SHIP2. FASEB J (2010) 1.22
Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation. J Biol Chem (2013) 1.22
Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism. J Cell Biol (2012) 1.20
Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells. Mol Pharmacol (2008) 1.18
Imaging protein activity in live embryos using fluorescence resonance energy transfer biosensors. Nat Protoc (2011) 1.16
Multiscale modeling for biologists. Wiley Interdiscip Rev Syst Biol Med (2010) 1.16
The role of chemokines and their receptors in angiogenesis. Cell Mol Life Sci (2011) 1.15
TNF-like weak inducer of apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta-activated kinase 1. J Immunol (2009) 1.14
Conditional deletion of Pten causes bronchiolar hyperplasia. Am J Respir Cell Mol Biol (2007) 1.11
ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A. Oncogene (2010) 1.10
Dictyostelium PAKc is required for proper chemotaxis. Mol Biol Cell (2004) 1.09
A G alpha-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement. Genes Dev (2004) 1.08
The nuclear hormone receptor peroxisome proliferator-activated receptor beta/delta potentiates cell chemotactism, polarization, and migration. Mol Cell Biol (2007) 1.06
Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filaments. Histochem Cell Biol (2005) 1.02
Functional analysis of the protein phosphatase activity of PTEN. Biochem J (2012) 1.01
Cellular distribution and functions of wild-type and constitutively activated Dictyostelium PakB. Mol Biol Cell (2004) 0.99
Protein kinase A regulates 3-phosphatidylinositide dynamics during platelet-derived growth factor-induced membrane ruffling and chemotaxis. J Biol Chem (2008) 0.98
Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration. Mol Biol Cell (2009) 0.97
CCR5 ligands modulate CXCL12-induced chemotaxis, adhesion, and Akt phosphorylation of human cord blood CD34+ cells. J Immunol (2009) 0.95
Open access microfluidic device for the study of cell migration during chemotaxis. Integr Biol (Camb) (2010) 0.93
Phosphatidylinositol 3-kinase plays a vital role in regulation of rice seed vigor via altering NADPH oxidase activity. PLoS One (2012) 0.93
Eukaryotic chemotaxis. Wiley Interdiscip Rev Syst Biol Med (2010) 0.92
Shear-induced resistance to neutrophil activation via the formyl peptide receptor. Biophys J (2012) 0.91
Nox2 is required for macrophage chemotaxis towards CSF-1. PLoS One (2013) 0.89
Gq-coupled purinergic receptors inhibit insulin-like growth factor-I/phosphoinositide 3-kinase pathway-dependent keratinocyte migration. Mol Biol Cell (2010) 0.88
A cell number counting factor regulates Akt/protein kinase B to regulate Dictyostelium discoideum group size. Eukaryot Cell (2004) 0.86
Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse. Sci Signal (2014) 0.85
Migration of Th1 lymphocytes is regulated by CD152 (CTLA-4)-mediated signaling via PI3 kinase-dependent Akt activation. PLoS One (2012) 0.84
Oxidation of Akt2 kinase promotes cell migration and regulates G1-S transition in the cell cycle. Cell Cycle (2011) 0.83
Evidence from bioinformatics, expression and inhibition studies of phosphoinositide-3 kinase signalling in Giardia intestinalis. BMC Microbiol (2006) 0.82
The chemotactic defect in wiskott-Aldrich syndrome macrophages is due to the reduced persistence of directional protrusions. PLoS One (2012) 0.81
Low-intensity pulsed ultrasound promotes chondrogenic progenitor cell migration via focal adhesion kinase pathway. Ultrasound Med Biol (2014) 0.79
Mechanisms of T cell organotropism. Cell Mol Life Sci (2016) 0.79
α-Syntrophin is required for the hepatocyte growth factor-induced migration of cultured myoblasts. Exp Cell Res (2011) 0.78
PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction. J Cell Biol (2014) 0.78
Docosahexaenoic Acid Promotes Axon Outgrowth by Translational Regulation of Tau and Collapsin Response Mediator Protein 2 Expression. J Biol Chem (2016) 0.77
Active JNK-dependent secretion of Drosophila Tyrosyl-tRNA synthetase by loser cells recruits haemocytes during cell competition. Nat Commun (2015) 0.77
Telomerase inhibition decreases alpha-fetoprotein expression and secretion by hepatocellular carcinoma cell lines: in vitro and in vivo study. PLoS One (2015) 0.77
G-protein signaling: a new branch in an old pathway. Curr Biol (2006) 0.76
Contact-mediated control of radial migration of corneal epithelial cells. Mol Vis (2016) 0.76
Advances in the biology of cerebral cavernous malformations. Surg Neurol Int (2010) 0.75
K+ Channel Inhibition Differentially Regulates Migration of Intestinal Epithelial Cells in Inflamed vs. Non-Inflamed Conditions in a PI3K/Akt-Mediated Manner. PLoS One (2016) 0.75
Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns. BMC Evol Biol (2015) 0.75
Regulation of human airway smooth muscle cell migration and relevance to asthma. Respir Res (2017) 0.75
PDGF controls contact inhibition of locomotion by regulating N-cadherin during neural crest migration. Development (2017) 0.75
Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2. Nat Immunol (2017) 0.75
Cell migration: integrating signals from front to back. Science (2003) 29.13
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell (2002) 6.36
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol (2004) 3.44
The regulation of cell motility and chemotaxis by phospholipid signaling. J Cell Sci (2008) 3.04
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell (2005) 2.76
Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Mol Biol Cell (2003) 2.56
G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J Cell Biol (2007) 2.34
Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry. Proc Natl Acad Sci U S A (2007) 2.11
Feedback signaling controls leading-edge formation during chemotaxis. Curr Opin Genet Dev (2006) 1.95
Big roles for small GTPases in the control of directed cell movement. Biochem J (2007) 1.89
Mechanosensing through cooperative interactions between myosin II and the actin crosslinker cortexillin I. Curr Biol (2009) 1.86
Directional sensing during chemotaxis. FEBS Lett (2008) 1.84
A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration. Dev Cell (2010) 1.74
Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J (2004) 1.56
Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway. Sci Signal (2012) 1.53
Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR. Eur J Cell Biol (2006) 1.51
Insights into morphogenesis from a simple developmental system. Nat Rev Mol Cell Biol (2004) 1.48
Rap1 controls cell adhesion and cell motility through the regulation of myosin II. J Cell Biol (2007) 1.45
Myosin II is essential for the spatiotemporal organization of traction forces during cell motility. Mol Biol Cell (2009) 1.37
Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium. J Biol Chem (2002) 1.36
Activated membrane patches guide chemotactic cell motility. PLoS Comput Biol (2011) 1.32
Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium. J Biol Chem (2007) 1.30
Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis. Dev Cell (2002) 1.26
A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis. Mol Biol Cell (2005) 1.24
Breaking symmetries: regulation of Dictyostelium development through chemoattractant and morphogen signal-response. Curr Opin Genet Dev (2004) 1.15
Involvement of the cytoskeleton in controlling leading-edge function during chemotaxis. Mol Biol Cell (2010) 1.13
Two poles and a compass. Cell (2003) 1.10
Dictyostelium PAKc is required for proper chemotaxis. Mol Biol Cell (2004) 1.09
Evidence that DIF-1 and hyper-osmotic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase. Development (2008) 1.04
Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells. J Cell Biol (2007) 1.04
Rho Rocks PTEN. Nat Cell Biol (2005) 1.01
Both contractile axial and lateral traction force dynamics drive amoeboid cell motility. J Cell Biol (2014) 0.99
Signaling pathways at the leading edge of chemotaxing cells. J Muscle Res Cell Motil (2002) 0.95
A regulator of G protein signaling-containing kinase is important for chemotaxis and multicellular development in dictyostelium. Mol Biol Cell (2003) 0.93
A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi. J Biol Chem (2003) 0.92
Regulation of Dictyostelium morphogenesis by RapGAP3. Dev Biol (2009) 0.92
Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects. Mol Cell Biol (2005) 0.91
Dictyostelium Dock180-related RacGEFs regulate the actin cytoskeleton during cell motility. Mol Biol Cell (2008) 0.90
Regulation of contractile vacuole formation and activity in Dictyostelium. EMBO J (2008) 0.90
Dictyostelium stress-activated protein kinase alpha, a novel stress-activated mitogen-activated protein kinase kinase kinase-like kinase, is important for the proper regulation of the cytoskeleton. Mol Biol Cell (2003) 0.90
MEK1 and protein phosphatase 4 coordinate Dictyostelium development and chemotaxis. Mol Cell Biol (2007) 0.90
Spatiotemporal regulation of Ras-GTPases during chemotaxis. Methods Mol Biol (2009) 0.89
The SCAR/WAVE complex is necessary for proper regulation of traction stresses during amoeboid motility. Mol Biol Cell (2011) 0.89
Follow the leader. Dev Cell (2003) 0.86
Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility. Mol Biol Cell (2012) 0.85
The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton. Mol Biol Cell (2011) 0.83
An Oscillatory Contractile Pole-Force Component Dominates the Traction Forces Exerted by Migrating Amoeboid Cells. Cell Mol Bioeng (2011) 0.79
Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis. J Biol Chem (2013) 0.78
Assaying chemotaxis of Dictyostelium cells. Methods Mol Biol (2006) 0.78
Finding the way: directional sensing and cell polarization through Ras signalling. Novartis Found Symp (2005) 0.78
"TORCing" neutrophil chemotaxis. Dev Cell (2010) 0.76
Leading the way. Nat Cell Biol (2002) 0.76
Adaptation in a eukaryotic pathway: combining experiments with modeling. Cell Cycle (2012) 0.75
The novel ankyrin-repeat containing kinase ARCK-1 acts as a suppressor of the Spalten signaling pathway during Dictyostelium development. Dev Biol (2003) 0.75