Published in Cell on May 31, 2002
Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol (2013) 7.10
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol (2003) 4.02
Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity. Annu Rev Biophys (2010) 3.76
Chemotaxis in cancer. Nat Rev Cancer (2011) 3.68
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacol Rev (2009) 3.65
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol (2004) 3.44
PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr Biol (2008) 3.06
The regulation of cell motility and chemotaxis by phospholipid signaling. J Cell Sci (2008) 3.04
A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling. Nat Cell Biol (2005) 2.99
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J Cell Biol (2005) 2.97
Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J Cell Biol (2004) 2.93
The neutrophil in vascular inflammation. Nat Med (2011) 2.84
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell (2005) 2.76
Advances in early kidney specification, development and patterning. Development (2009) 2.62
Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Mol Biol Cell (2003) 2.56
Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. J Cell Biol (2004) 2.55
Cells navigate with a local-excitation, global-inhibition-biased excitable network. Proc Natl Acad Sci U S A (2010) 2.54
Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci U S A (2004) 2.52
UNC-6/Netrin induces neuronal asymmetry and defines the site of axon formation. Nat Neurosci (2006) 2.42
G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J Cell Biol (2007) 2.34
Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis. Mol Biol Cell (2003) 2.19
Shear stress-induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases. J Cell Biol (2003) 2.14
Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method. PLoS Comput Biol (2006) 2.13
Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors. Neuron (2007) 2.13
Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. J Cell Biol (2005) 2.05
Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity. Cold Spring Harb Perspect Biol (2009) 2.01
Directional sensing in eukaryotic chemotaxis: a balanced inactivation model. Proc Natl Acad Sci U S A (2006) 1.98
Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells. Biophys J (2004) 1.91
Big roles for small GTPases in the control of directed cell movement. Biochem J (2007) 1.89
Directional sensing during chemotaxis. FEBS Lett (2008) 1.84
Ca2+ influx is an essential component of the positive-feedback loop that maintains leading-edge structure and activity in macrophages. Proc Natl Acad Sci U S A (2007) 1.81
Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis. J Cell Biol (2007) 1.80
Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J Neurosci (2009) 1.80
Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium. Mol Biol Cell (2004) 1.76
Biased random walk by stochastic fluctuations of chemoattractant-receptor interactions at the lower limit of detection. Biophys J (2007) 1.74
A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration. Dev Cell (2010) 1.74
Calpain regulates neutrophil chemotaxis. Proc Natl Acad Sci U S A (2003) 1.73
Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster. J Cell Biol (2006) 1.73
Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis. J Cell Biol (2004) 1.72
Uniform cAMP stimulation of Dictyostelium cells induces localized patches of signal transduction and pseudopodia. Mol Biol Cell (2003) 1.70
Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum. J Cell Biol (2008) 1.69
Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Mol Biol Cell (2006) 1.67
PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A (2005) 1.67
Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions. Blood (2007) 1.65
Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth. Mol Cell Biol (2007) 1.65
Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis. J Cell Biol (2010) 1.64
Chemoattractant-induced Ras activation during Dictyostelium aggregation. EMBO Rep (2004) 1.63
Chemotaxis, chemokine receptors and human disease. Cytokine (2008) 1.63
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr Biol (2007) 1.62
Chemotaxis: signalling modules join hands at front and tail. EMBO Rep (2004) 1.61
Spatiotemporal regulation of Ras activity provides directional sensing. Curr Biol (2008) 1.60
RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Cell (2013) 1.60
Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell. Biophys J (2006) 1.58
Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J (2004) 1.56
Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A (2010) 1.53
Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway. Sci Signal (2012) 1.53
The signaling mechanisms underlying cell polarity and chemotaxis. Cold Spring Harb Perspect Biol (2009) 1.53
Phosphoinositide signaling plays a key role in cytokinesis. J Cell Biol (2006) 1.51
A mass conserved reaction-diffusion system captures properties of cell polarity. PLoS Comput Biol (2007) 1.51
Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity. Am J Respir Cell Mol Biol (2004) 1.47
A tumor suppressor homolog, AtPTEN1, is essential for pollen development in Arabidopsis. Plant Cell (2002) 1.47
PI 3-kinases and PTEN: how opposites chemoattract. Cell (2002) 1.46
Self-organization of the phosphatidylinositol lipids signaling system for random cell migration. Proc Natl Acad Sci U S A (2010) 1.45
Regulation of cell migration and survival by focal adhesion targeting of Lasp-1. J Cell Biol (2004) 1.38
Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs. Mol Biol Cell (2006) 1.38
Ordered patterns of cell shape and orientational correlation during spontaneous cell migration. PLoS One (2008) 1.38
Delineation of the roles played by RasG and RasC in cAMP-dependent signal transduction during the early development of Dictyostelium discoideum. Mol Biol Cell (2006) 1.36
Essential role of PDK1 in regulating endothelial cell migration. J Cell Biol (2007) 1.35
The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration. J Cell Sci (2007) 1.34
Ion channels in microbes. Physiol Rev (2008) 1.33
A mathematical model for neutrophil gradient sensing and polarization. PLoS Comput Biol (2007) 1.32
Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell (2008) 1.32
Spatial analysis of 3' phosphoinositide signaling in living fibroblasts, III: influence of cell morphology and morphological Polarity. Biophys J (2005) 1.28
Cellular responses to extracellular guidance cues. EMBO J (2010) 1.25
Locally controlled inhibitory mechanisms are involved in eukaryotic GPCR-mediated chemosensing. J Cell Biol (2007) 1.25
Dynamic partitioning into lipid rafts controls the endo-exocytic cycle of the alphaL/beta2 integrin, LFA-1, during leukocyte chemotaxis. Mol Biol Cell (2005) 1.25
A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis. Mol Biol Cell (2005) 1.24
How cells integrate complex stimuli: the effect of feedback from phosphoinositides and cell shape on cell polarization and motility. PLoS Comput Biol (2012) 1.22
Distinguishing modes of eukaryotic gradient sensing. Biophys J (2005) 1.22
Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation. J Biol Chem (2013) 1.22
Reverse leukocyte migration can be attractive or repulsive. Trends Cell Biol (2008) 1.21
Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity. J Cell Biol (2006) 1.20
ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Blood (2009) 1.19
Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner. Cell Death Differ (2013) 1.19
Self-organizing actin waves as planar phagocytic cup structures. Cell Adh Migr (2009) 1.18
Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2. Mol Cell Biol (2004) 1.17
Golgi polarization in a strong electric field. J Cell Sci (2005) 1.16
Moving in the right direction: how eukaryotic cells migrate along chemical gradients. Semin Cell Dev Biol (2011) 1.15
Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes. Cell Mol Life Sci (2014) 1.15
Membrane organization and dynamics in cell polarity. Cold Spring Harb Perspect Biol (2009) 1.15
Cell polarity as a regulator of cancer cell behavior plasticity. Annu Rev Cell Dev Biol (2012) 1.15
Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis. J Biol Chem (2010) 1.14
Asymmetric localization of calpain 2 during neutrophil chemotaxis. Mol Biol Cell (2006) 1.14
Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experiments. Biophys J (2004) 1.13
A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning. Dev Cell (2008) 1.13
A developmentally regulated Na-H exchanger in Dictyostelium discoideum is necessary for cell polarity during chemotaxis. J Cell Biol (2005) 1.13
Involvement of the cytoskeleton in controlling leading-edge function during chemotaxis. Mol Biol Cell (2010) 1.13
Phospholipase C regulation of phosphatidylinositol 3,4,5-trisphosphate-mediated chemotaxis. Mol Biol Cell (2007) 1.12
Stimulus-dependent phosphorylation of profilin-1 in angiogenesis. Nat Cell Biol (2012) 1.12
PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney. Dev Biol (2007) 1.12
Cell migration: integrating signals from front to back. Science (2003) 29.13
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci U S A (2006) 7.00
2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken) (2012) 5.22
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol (2004) 3.44
The regulation of cell motility and chemotaxis by phospholipid signaling. J Cell Sci (2008) 3.04
2012 American College of Rheumatology guidelines for management of gout. Part 2: therapy and antiinflammatory prophylaxis of acute gouty arthritis. Arthritis Care Res (Hoboken) (2012) 2.83
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell (2005) 2.76
Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Mol Biol Cell (2003) 2.56
Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J Cell Sci (2003) 2.49
G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J Cell Biol (2007) 2.34
Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry. Proc Natl Acad Sci U S A (2007) 2.11
Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells. Arthritis Rheum (2012) 2.03
Feedback signaling controls leading-edge formation during chemotaxis. Curr Opin Genet Dev (2006) 1.95
Big roles for small GTPases in the control of directed cell movement. Biochem J (2007) 1.89
Mechanosensing through cooperative interactions between myosin II and the actin crosslinker cortexillin I. Curr Biol (2009) 1.86
Directional sensing during chemotaxis. FEBS Lett (2008) 1.84
Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75. Nat Struct Mol Biol (2008) 1.78
A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration. Dev Cell (2010) 1.74
Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J (2004) 1.56
Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway. Sci Signal (2012) 1.53
Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR. Eur J Cell Biol (2006) 1.51
Insights into morphogenesis from a simple developmental system. Nat Rev Mol Cell Biol (2004) 1.48
Rap1 controls cell adhesion and cell motility through the regulation of myosin II. J Cell Biol (2007) 1.45
Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome. J Pediatr (2003) 1.42
Myosin II is essential for the spatiotemporal organization of traction forces during cell motility. Mol Biol Cell (2009) 1.37
Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium. J Biol Chem (2002) 1.36
Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome. Arthritis Res Ther (2004) 1.33
Activated membrane patches guide chemotactic cell motility. PLoS Comput Biol (2011) 1.32
Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation. J Immunol (2003) 1.31
Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium. J Biol Chem (2007) 1.30
Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis. Dev Cell (2002) 1.26
A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis. Mol Biol Cell (2005) 1.24
Phase Ib dose-escalation study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma. Clin Cancer Res (2013) 1.19
Three-dimensional quantification of cellular traction forces and mechanosensing of thin substrata by fourier traction force microscopy. PLoS One (2013) 1.16
Breaking symmetries: regulation of Dictyostelium development through chemoattractant and morphogen signal-response. Curr Opin Genet Dev (2004) 1.15
Hydrolase regulates NAD+ metabolites and modulates cellular redox. J Biol Chem (2009) 1.13
Involvement of the cytoskeleton in controlling leading-edge function during chemotaxis. Mol Biol Cell (2010) 1.13
Two poles and a compass. Cell (2003) 1.10
Dictyostelium PAKc is required for proper chemotaxis. Mol Biol Cell (2004) 1.09
Autoacetylation of the histone acetyltransferase Rtt109. J Biol Chem (2011) 1.08
End of life care--the importance of advance care planning. Aust Fam Physician (2010) 1.06
Acetylation-dependent ADP-ribosylation by Trypanosoma brucei Sir2. J Biol Chem (2007) 1.06
Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells. J Cell Biol (2007) 1.04
Evidence that DIF-1 and hyper-osmotic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase. Development (2008) 1.04
Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3). J Biol Chem (2011) 1.04
Rho Rocks PTEN. Nat Cell Biol (2005) 1.01
A phase I/II study of carfilzomib 2-10-min infusion in patients with advanced solid tumors. Cancer Chemother Pharmacol (2013) 1.00
Both contractile axial and lateral traction force dynamics drive amoeboid cell motility. J Cell Biol (2014) 0.99
Feasibility of interactive text message response (ITR) as a novel, real-time measure of adherence to antiretroviral therapy for HIV+ youth. AIDS Behav (2013) 0.96
Signaling pathways at the leading edge of chemotaxing cells. J Muscle Res Cell Motil (2002) 0.95
A regulator of G protein signaling-containing kinase is important for chemotaxis and multicellular development in dictyostelium. Mol Biol Cell (2003) 0.93
Regulation of Dictyostelium morphogenesis by RapGAP3. Dev Biol (2009) 0.92
A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi. J Biol Chem (2003) 0.92
Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects. Mol Cell Biol (2005) 0.91
Dictyostelium Dock180-related RacGEFs regulate the actin cytoskeleton during cell motility. Mol Biol Cell (2008) 0.90
Regulation of contractile vacuole formation and activity in Dictyostelium. EMBO J (2008) 0.90
Dictyostelium stress-activated protein kinase alpha, a novel stress-activated mitogen-activated protein kinase kinase kinase-like kinase, is important for the proper regulation of the cytoskeleton. Mol Biol Cell (2003) 0.90
MEK1 and protein phosphatase 4 coordinate Dictyostelium development and chemotaxis. Mol Cell Biol (2007) 0.90
Understandings of death and dying for people of Chinese origin. Death Stud (2009) 0.89
The SCAR/WAVE complex is necessary for proper regulation of traction stresses during amoeboid motility. Mol Biol Cell (2011) 0.89
Spatiotemporal regulation of Ras-GTPases during chemotaxis. Methods Mol Biol (2009) 0.89
Safety of early mobilization of patients with blunt solid organ injuries. Arch Surg (2008) 0.88
Is work stress in palliative care nurses a cause for concern? A literature review. Int J Palliat Nurs (2012) 0.87
Follow the leader. Dev Cell (2003) 0.86
Community-acquired pneumonia in immunocompromised patients. Opportunistic infections to consider in differential diagnosis. Postgrad Med (2003) 0.86
A detailed immunohistochemical analysis of 2 cases of papillary cystadenoma of the broad ligament: an extremely rare neoplasm characteristic of patients with von hippel-lindau disease. Int J Gynecol Pathol (2012) 0.86
Processing mechanism and substrate selectivity of the core NuA4 histone acetyltransferase complex. Biochemistry (2011) 0.86
Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility. Mol Biol Cell (2012) 0.85
Adipose segmentation in small animals at 7T: a preliminary study. BMC Genomics (2010) 0.83
The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton. Mol Biol Cell (2011) 0.83
Ure(k)a! Sirtuins Regulate Mitochondria. Cell (2009) 0.83
School-aged and adolescent children's experience when a parent has non-terminal cancer: a systematic review and meta-synthesis of qualitative studies. Psychooncology (2013) 0.82
IknowUshould2: Feasibility of a Youth-Driven Social Media Campaign to Promote STI and HIV Testing Among Adolescents in Philadelphia. AIDS Behav (2015) 0.81
MammoSite multilumen catheter: dosimetry considerations. J Cancer Res Ther (2011) 0.80
Vulnerable populations and multicentred research. Int J Ment Health Nurs (2009) 0.79
An Oscillatory Contractile Pole-Force Component Dominates the Traction Forces Exerted by Migrating Amoeboid Cells. Cell Mol Bioeng (2011) 0.79
Nursing care of the family before and after a death in the ICU--an exploratory pilot study. Aust Crit Care (2012) 0.79
Quantitative effect of refrigerated storage time on the enumeration of Campylobacter, Listeria, and Salmonella on artificially inoculated raw chicken meat. J Food Prot (2007) 0.78
Pediatric primary care provider practices, knowledge, and attitudes of human immunodeficiency virus screening among adolescents. J Pediatr (2013) 0.78
Assaying chemotaxis of Dictyostelium cells. Methods Mol Biol (2006) 0.78
Lymphangioma in an elderly patient: an unusual cause of axillary mass. Breast J (2011) 0.78
Finding the way: directional sensing and cell polarization through Ras signalling. Novartis Found Symp (2005) 0.78
Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis. J Biol Chem (2013) 0.78
Understanding moral habitability: a framework to enhance the quality of the clinical environment as a workplace. Contemp Nurse (2013) 0.77