Published in J Biol Chem on August 10, 2007
Alpha4 is an essential regulator of PP2A phosphatase activity. Mol Cell (2009) 1.55
Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development. Oncogene (2010) 1.21
Structural basis of protein phosphatase 2A stable latency. Nat Commun (2013) 1.03
The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation. J Biol Chem (2011) 1.02
Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A. PLoS One (2008) 0.99
Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae. PLoS One (2009) 0.92
The MID1 E3 ligase catalyzes the polyubiquitination of Alpha4 (α4), a regulatory subunit of protein phosphatase 2A (PP2A): novel insights into MID1-mediated regulation of PP2A. J Biol Chem (2013) 0.84
mTOR signaling in lymphangioleiomyomatosis. Lymphat Res Biol (2010) 0.81
MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac. PLoS One (2014) 0.81
Visualization of subunit interactions and ternary complexes of protein phosphatase 2A in mammalian cells. PLoS One (2014) 0.80
Microcystin-LR (MCLR) induces a compensation of PP2A activity mediated by α4 protein in HEK293 cells. Int J Biol Sci (2011) 0.79
Essential roles of the Tap42-regulated protein phosphatase 2A (PP2A) family in wing imaginal disc development of Drosophila melanogaster. PLoS One (2012) 0.78
XLOS-observed mutations of MID1 Bbox1 domain cause domain unfolding. PLoS One (2014) 0.77
Phosphorylation of Serine 402 Regulates RacGAP Protein Activity of FilGAP Protein. J Biol Chem (2015) 0.76
Molecular dynamics simulation reveals insights into the mechanism of unfolding by the A130T/V mutations within the MID1 zinc-binding Bbox1 domain. PLoS One (2015) 0.75
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature (2005) 22.40
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature (2009) 19.65
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87
Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell (2005) 17.81
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A (2007) 15.88
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell (2010) 15.20
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell (2010) 13.13
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A (2008) 11.71
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell (2005) 11.19
Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell (2012) 9.88
Akt stimulates aerobic glycolysis in cancer cells. Cancer Res (2004) 9.35
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell (2005) 9.33
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest (2007) 9.33
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85
ATP-citrate lyase links cellular metabolism to histone acetylation. Science (2009) 8.82
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature (2012) 8.66
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol (2005) 8.27
IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature (2012) 7.95
Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev (2008) 7.87
Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science (2003) 7.75
ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell (2005) 7.65
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res (2007) 7.42
Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol (2005) 7.11
The CD28 signaling pathway regulates glucose metabolism. Immunity (2002) 6.65
Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev (2009) 6.46
Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci (2010) 6.30
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol (2005) 6.18
Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev (2004) 6.08
Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood (2008) 5.43
Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol (2004) 5.31
Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol (2005) 5.29
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A (2011) 5.24
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol Biol Cell (2002) 5.06
Necrotic death as a cell fate. Genes Dev (2006) 4.93
The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis. Immunity (2007) 4.74
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science (2009) 4.72
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature (2013) 4.71
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell (2010) 4.62
The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. Immunity (2012) 4.32
The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. Oncogene (2005) 4.28
Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20
Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J Biol Chem (2002) 4.19
The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev (2007) 4.13
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell (2007) 4.10
Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science (2008) 4.04
Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood (2010) 3.98
Akt-dependent transformation: there is more to growth than just surviving. Oncogene (2005) 3.91
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol (2003) 3.84
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor. Genes Dev (2003) 3.79
PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol Cell (2006) 3.66
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell (2004) 3.62
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol (2002) 3.58
Revving the engine: signal transduction fuels T cell activation. Immunity (2007) 3.57
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol (2003) 3.52
Autophagy: basic principles and relevance to disease. Annu Rev Pathol (2008) 3.52
ATP citrate lyase is an important component of cell growth and transformation. Oncogene (2005) 3.48
Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth. J Biol Chem (2006) 3.45
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. Genes Dev (2010) 3.40
The roles of therapy-induced autophagy and necrosis in cancer treatment. Clin Cancer Res (2007) 3.35
Metabolic enzymes as oncogenes or tumor suppressors. N Engl J Med (2009) 3.24
Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem (2002) 3.18
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science (2010) 3.05
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev (2011) 2.97
The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R. Nat Cell Biol (2005) 2.94
Ammonia-induced autophagy is independent of ULK1/ULK2 kinases. Proc Natl Acad Sci U S A (2011) 2.91
Cellular metabolism and disease: what do metabolic outliers teach us? Cell (2012) 2.90
Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. J Biol Chem (2003) 2.80
BAX and BAK mediate p53-independent suppression of tumorigenesis. Cancer Cell (2002) 2.64
The survival kinases Akt and Pim as potential pharmacological targets. J Clin Invest (2005) 2.62
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A (2013) 2.57
Regulation of T lymphocyte metabolism. J Immunol (2004) 2.55
Metabolic regulation of epigenetics. Cell Metab (2012) 2.55
The molecular determinants of de novo nucleotide biosynthesis in cancer cells. Curr Opin Genet Dev (2009) 2.54
Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol (2004) 2.54
Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell (2010) 2.50
Pathways of apoptosis in lymphocyte development, homeostasis, and disease. Cell (2002) 2.48
Ars2 regulates both miRNA- and siRNA- dependent silencing and suppresses RNA virus infection in Drosophila. Cell (2009) 2.38
A two-way street: reciprocal regulation of metabolism and signalling. Nat Rev Mol Cell Biol (2012) 2.35
Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. Eur J Immunol (2003) 2.31
Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Cell (2009) 2.28
Therapeutic targets in cancer cell metabolism and autophagy. Nat Biotechnol (2012) 2.27
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature (2010) 2.21
Airway smooth muscle cells enhance C3a-induced mast cell degranulation following cell-cell contact. FASEB J (2005) 2.13
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci U S A (2012) 2.10
Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival. Blood (2005) 2.09
Defective autophagy leads to cancer. Cancer Cell (2003) 2.08