Published in Ann Med on January 01, 2007
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science (2009) 4.80
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev (2009) 3.23
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci (2010) 3.05
Disruption of the Ang II type 1 receptor promotes longevity in mice. J Clin Invest (2009) 2.49
Circadian rhythms and metabolic syndrome: from experimental genetics to human disease. Circ Res (2010) 2.49
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Syst Biol (2009) 1.94
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Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal (2010) 1.77
Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS One (2011) 1.65
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SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts. Am J Physiol Heart Circ Physiol (2014) 1.60
Mitochondrial approaches for neuroprotection. Ann N Y Acad Sci (2008) 1.48
Epigenetic mechanisms regulate Mallory Denk body formation in the livers of drug-primed mice. Exp Mol Pathol (2008) 1.41
Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. J Neuropathol Exp Neurol (2009) 1.39
Resveratrol, sirtuins, and the promise of a DR mimetic. Mech Ageing Dev (2010) 1.39
"Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging. Biochim Biophys Acta (2009) 1.29
Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation. Mol Cells (2009) 1.27
Protein deacetylation by SIRT1: an emerging key post-translational modification in metabolic regulation. Pharmacol Res (2009) 1.27
SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer. Cancer Res (2011) 1.21
The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis. J Physiol (2009) 1.17
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Epigenetic regulatory mechanisms in vertebrate eye development and disease. Heredity (Edinb) (2010) 1.16
Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases. J Biol Chem (2010) 1.15
SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans. J Physiol (2011) 1.15
Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on? Arthritis Res Ther (2008) 1.15
Protective effects and mechanisms of sirtuins in the nervous system. Prog Neurobiol (2011) 1.14
Effect of feeding regimens on circadian rhythms: implications for aging and longevity. Aging (Albany NY) (2010) 1.14
Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage. Mol Cancer Res (2010) 1.14
NAD+ as a signaling molecule modulating metabolism. Cold Spring Harb Symp Quant Biol (2012) 1.12
Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes. Front Biosci (Landmark Ed) (2009) 1.12
AMPK regulates circadian rhythms in a tissue- and isoform-specific manner. PLoS One (2011) 1.11
Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice. Aging Cell (2013) 1.11
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Human sirt-1: molecular modeling and structure-function relationships of an unordered protein. PLoS One (2008) 1.01
A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease. Hum Mol Genet (2014) 1.01
Oxidative stress and NAD+ in ischemic brain injury: current advances and future perspectives. Curr Med Chem (2010) 1.00
Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque. PLoS One (2011) 1.00
Dietary activators of Sirt1. Mol Cell Endocrinol (2008) 0.98
Sirt1 increases skeletal muscle precursor cell proliferation. Eur J Cell Biol (2008) 0.98
A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis. Pharmacol Res (2010) 0.98
Mitochondrial metabolic reprogramming induced by calorie restriction. Antioxid Redox Signal (2012) 0.98
Angiotensin receptors as determinants of life span. Pflugers Arch (2009) 0.97
Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway. Am J Pathol (2010) 0.96
Distinct effects of calorie restriction and resveratrol on diet-induced obesity and Fatty liver formation. J Nutr Metab (2011) 0.95
p30 DBC is a potential regulator of tumorigenesis. Cell Cycle (2009) 0.95
AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death. J Biol Chem (2009) 0.94
Age-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model. PLoS One (2014) 0.93
Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells. Int J Physiol Pathophysiol Pharmacol (2011) 0.93
SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty. Curr Opin Clin Nutr Metab Care (2009) 0.93
Epigenetics and the control of epithelial sodium channel expression in collecting duct. Kidney Int (2008) 0.93
From heterochromatin islands to the NAD World: a hierarchical view of aging through the functions of mammalian Sirt1 and systemic NAD biosynthesis. Biochim Biophys Acta (2009) 0.92
Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma. BMC Cancer (2014) 0.92
Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer. J Endocrinol (2011) 0.91
Stress proteins in aging and life span. Int J Hyperthermia (2013) 0.90
Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation. Genes Dis (2014) 0.90
Sirtuins: from metabolic regulation to brain aging. Front Aging Neurosci (2013) 0.90
AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle. J Physiol (2013) 0.89
Targeting Histone Deacetylases in Diseases: Where Are We? Antioxid Redox Signal (2014) 0.88
Differential expression of sirtuins in the aging rat brain. Front Cell Neurosci (2015) 0.87
Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila. Aging (Albany NY) (2013) 0.87
Metabolic reprograming of mononuclear phagocytes in progressive multiple sclerosis. Front Immunol (2015) 0.87
Sirtuins, bioageing, and cancer. J Aging Res (2011) 0.86
Transition state of ADP-ribosylation of acetyllysine catalyzed by Archaeoglobus fulgidus Sir2 determined by kinetic isotope effects and computational approaches. J Am Chem Soc (2010) 0.86
Arabidopsis putative deacetylase AtSRT2 regulates basal defense by suppressing PAD4, EDS5 and SID2 expression. Plant Cell Physiol (2010) 0.86
2, 3, 5, 4'-Tetrahydroxystilbene-2-O-beta-D-glucoside improves gastrointestinal motility disorders in STZ-induced diabetic mice. PLoS One (2012) 0.86
Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation. Curr Opin Chem Biol (2016) 0.85
Cellular stress response, sirtuins and UCP proteins in Alzheimer disease: role of vitagenes. Immun Ageing (2013) 0.85
Cellular stress response, redox status, and vitagenes in glaucoma: a systemic oxidant disorder linked to Alzheimer's disease. Front Pharmacol (2014) 0.85
Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice. Histochem Cell Biol (2011) 0.85
Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6. Sci Rep (2013) 0.85
Circadian clocks in fuel harvesting and energy homeostasis. Cold Spring Harb Symp Quant Biol (2011) 0.84
Computational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicals. PLoS Negl Trop Dis (2014) 0.84
Quality control systems in cardiac aging. Ageing Res Rev (2015) 0.83
Association of the sirtuin and mitochondrial uncoupling protein genes with carotid intima-media thickness. Transl Res (2012) 0.83
Sirtuins in neurodegenerative diseases: a biological-chemical perspective. Neurodegener Dis (2011) 0.83
Sirtuins of parasitic protozoa: in search of function(s). Mol Biochem Parasitol (2012) 0.82
Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis. Arthritis Res Ther (2011) 0.82
Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humans. PLoS One (2012) 0.82
Genetic association of sirtuin genes and Parkinson's disease. J Neurol (2013) 0.81
An RGS-containing sorting nexin controls Drosophila lifespan. PLoS One (2008) 0.81
Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc. Endocrinology (2012) 0.80
Cellular conditioning with trichostatin A enhances the anti-stress response through up-regulation of HDAC4 and down-regulation of the IGF/Akt pathway. Aging Cell (2008) 0.80
The role of MutY homolog (Myh1) in controlling the histone deacetylase Hst4 in the fission yeast Schizosaccharomyces pombe. J Mol Biol (2010) 0.80
Respected Sir(2): magic target for diabetes. Cellscience (2008) 0.80
Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. PLoS One (2012) 0.80
Sirtuins and Cancer: Role in the Epithelial-Mesenchymal Transition. Oxid Med Cell Longev (2016) 0.79
New Therapeutic Concept of NAD Redox Balance for Cisplatin Nephrotoxicity. Biomed Res Int (2016) 0.79
Vitamin B3 boosts neutrophil counts. Nat Med (2009) 0.79
Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise. Appl Clin Genet (2012) 0.79
Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells. Clin Epigenetics (2010) 0.79
Gene expression mapping of histone deacetylases and co-factors, and correlation with survival time and 1H-HRMAS metabolomic profile in human gliomas. Sci Rep (2015) 0.79
NAD(+) Metabolism in Age-Related Hearing Loss. Aging Dis (2014) 0.79
Gene expression in the spinal cord in female lewis rats with experimental autoimmune encephalomyelitis induced with myelin basic protein. PLoS One (2012) 0.79
Effect of Resveratrol, a SIRT1 Activator, on the Interactions of the CLOCK/BMAL1 Complex. Endocrinol Metab (Seoul) (2014) 0.78
Sirtuins and proteolytic systems: implications for pathogenesis of synucleinopathies. Biomolecules (2015) 0.78
Roles of NAD (+) , PARP-1, and Sirtuins in Cell Death, Ischemic Brain Injury, and Synchrotron Radiation X-Ray-Induced Tissue Injury. Scientifica (Cairo) (2013) 0.77
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell (2006) 19.16
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature (2004) 12.36
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature (2009) 10.59
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature (2006) 9.36
TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab (2009) 6.91
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab (2008) 5.44
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest (2004) 4.65
Targeting bile-acid signalling for metabolic diseases. Nat Rev Drug Discov (2008) 4.43
Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab (2008) 4.36
SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell (2002) 4.31
Mitonuclear protein imbalance as a conserved longevity mechanism. Nature (2013) 4.18
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature (2012) 4.15
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol (2009) 4.09
Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci U S A (2003) 4.03
A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell (2013) 3.50
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev (2006) 3.48
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab (2010) 3.46
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev (2009) 3.23
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab (2006) 3.22
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab (2012) 3.18
Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring) (2009) 3.15
Endocrine functions of bile acids. EMBO J (2006) 3.03
Nuclear receptors and the control of metabolism. Annu Rev Physiol (2002) 3.00
Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr (2011) 2.98
Germline mitochondrial DNA mutations aggravate ageing and can impair brain development. Nature (2013) 2.90
NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell (2011) 2.75
E2Fs regulate adipocyte differentiation. Dev Cell (2002) 2.71
The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev Cell (2002) 2.61
Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis. Gastroenterology (2003) 2.59
Transcriptional coregulators in the control of energy homeostasis. Trends Cell Biol (2007) 2.40
Sirtuin functions in health and disease. Mol Endocrinol (2007) 2.38
Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation. Mol Cell (2004) 2.31
Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity. Cell (2011) 2.26
LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis. Trends Cell Biol (2004) 2.24
TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab (2011) 2.17
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma. J Exp Med (2005) 2.06
mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proc Natl Acad Sci U S A (2009) 2.05
Histone methyl transferases and demethylases; can they link metabolism and transcription? Cell Metab (2010) 2.04
Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology. Endocr Rev (2004) 2.04
The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms. Environ Health Perspect (2010) 1.98
AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci (2010) 1.95
The metabolic footprint of aging in mice. Sci Rep (2011) 1.93
Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab (2009) 1.89
Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. Proc Natl Acad Sci U S A (2003) 1.89
Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1. Mol Cell Biol (2007) 1.89
PPAR(gamma) and glucose homeostasis. Annu Rev Nutr (2002) 1.86
Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem (2008) 1.85
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol Rev (2011) 1.85
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}. Proc Natl Acad Sci U S A (2008) 1.80
Metabolic networks of longevity. Cell (2010) 1.79
Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study. Physiol Genomics (2008) 1.76
The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. J Hepatol (2010) 1.69
Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol (2004) 1.69
Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov (2013) 1.66
Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells. Genes Dev (2012) 1.64
Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J Biol Chem (2011) 1.62
The role of sirtuins in the control of metabolic homeostasis. Ann N Y Acad Sci (2009) 1.62
Retrospective comparison of chemoradiotherapy followed by adjuvant chemotherapy, with or without prior gliadel implantation (carmustine) after initial surgery in patients with newly diagnosed high-grade gliomas. Int J Radiat Oncol Biol Phys (2011) 1.60
PPARgamma in human and mouse physiology. Biochim Biophys Acta (2007) 1.58
LRH-1-dependent glucose sensing determines intermediary metabolism in liver. J Clin Invest (2012) 1.58
Systematic gene expression mapping clusters nuclear receptors according to their function in the brain. Cell (2007) 1.58
Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS One (2012) 1.58
Transcriptional targets of sirtuins in the coordination of mammalian physiology. Curr Opin Cell Biol (2008) 1.57
Mouse functional genomics requires standardization of mouse handling and housing conditions. Mamm Genome (2004) 1.56
Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice. J Clin Invest (2004) 1.55
The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity. Mol Endocrinol (2002) 1.54
Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation. J Exp Med (2003) 1.53
Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit. J Biol Chem (2003) 1.52
Genetic background determines metabolic phenotypes in the mouse. Mamm Genome (2008) 1.51
Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases. Lancet (2002) 1.50
Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea. Biochem Biophys Res Commun (2007) 1.49
Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program. Proc Natl Acad Sci U S A (2006) 1.49
Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development. Mol Cell Biol (2003) 1.48