Caloric restriction, SIRT1 and longevity.

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Metabolic networks of longevity. Cell (2010) 1.79

From sirtuin biology to human diseases: an update. J Biol Chem (2012) 1.60

Mammalian circadian clock and metabolism - the epigenetic link. J Cell Sci (2010) 1.55

Signaling pathways in mitochondrial dysfunction and aging. Mech Ageing Dev (2010) 1.54

SIRT1 contributes to telomere maintenance and augments global homologous recombination. J Cell Biol (2010) 1.48

SIRT1 and p53, effect on cancer, senescence and beyond. Biochim Biophys Acta (2010) 1.46

Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan. Ageing Res Rev (2011) 1.42

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Protein deacetylation by SIRT1: an emerging key post-translational modification in metabolic regulation. Pharmacol Res (2009) 1.27

Calorie restriction: is AMPK a key sensor and effector? Physiology (Bethesda) (2011) 1.23

The journey of resveratrol from yeast to human. Aging (Albany NY) (2012) 1.22

NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease. Cell Metab (2014) 1.18

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Effect of feeding regimens on circadian rhythms: implications for aging and longevity. Aging (Albany NY) (2010) 1.14

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Ageing: longevity hits a roadblock. Nature (2011) 1.13

Controlling SIRT1 expression by microRNAs in health and metabolic disease. Aging (Albany NY) (2010) 1.12

NAD+ as a signaling molecule modulating metabolism. Cold Spring Harb Symp Quant Biol (2012) 1.12

The other lives of ribosomal proteins. Hum Genomics (2010) 1.10

Longevity in the red flour beetle Tribolium castaneum is enhanced by broccoli and depends on nrf-2, jnk-1 and foxo-1 homologous genes. Genes Nutr (2013) 1.08

Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging. Circ Res (2014) 1.06

Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation. Curr Neurovasc Res (2010) 1.06

SIRT6: a master epigenetic gatekeeper of glucose metabolism. Transcription (2012) 1.06

SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL. J Lipid Res (2011) 1.03

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS). Dose Response (2014) 1.00

Midlife gene expressions identify modulators of aging through dietary interventions. Proc Natl Acad Sci U S A (2012) 1.00

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Disruption of adaptive energy metabolism and elevated ribosomal p-S6K1 levels contribute to INCL pathogenesis: partial rescue by resveratrol. Hum Mol Genet (2010) 0.97

SirT1 in muscle physiology and disease: lessons from mouse models. Dis Model Mech (2010) 0.97

Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment. Biochim Biophys Acta (2014) 0.96

Interactions between light, mealtime and calorie restriction to control daily timing in mammals. J Comp Physiol B (2010) 0.95

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New Insights for Oxidative Stress and Diabetes Mellitus. Oxid Med Cell Longev (2015) 0.94

SIRT1 in the brain-connections with aging-associated disorders and lifespan. Front Cell Neurosci (2015) 0.93

Diabetes mellitus: channeling care through cellular discovery. Curr Neurovasc Res (2010) 0.93

Translating cell survival and cell longevity into treatment strategies with SIRT1. Rom J Morphol Embryol (2011) 0.93

Nutrition and healthy ageing: calorie restriction or polyphenol-rich "MediterrAsian" diet? Oxid Med Cell Longev (2013) 0.93

Targeting cardiovascular disease with novel SIRT1 pathways. Future Cardiol (2012) 0.92

Food scarcity, neuroadaptations, and the pathogenic potential of dieting in an unnatural ecology: binge eating and drug abuse. Physiol Behav (2011) 0.90

Sirtuins: from metabolic regulation to brain aging. Front Aging Neurosci (2013) 0.90

Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. Mol Aspects Med (2013) 0.89

Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism. Vitam Horm (2013) 0.88

dSir2 and longevity in Drosophila. Exp Gerontol (2010) 0.88

dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies. Aging (Albany NY) (2012) 0.87

Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity. PLoS One (2013) 0.87

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Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity. Aging Cell (2012) 0.86

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Maintaining ancient organelles: mitochondrial biogenesis and maturation. Circ Res (2015) 0.85

Interference between PARPs and SIRT1: a novel approach to healthy ageing? Aging (Albany NY) (2011) 0.85

Circadian clocks in fuel harvesting and energy homeostasis. Cold Spring Harb Symp Quant Biol (2011) 0.84

SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer. World J Stem Cells (2015) 0.84

A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human. PLoS One (2015) 0.84

SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway. Age (Dordr) (2013) 0.83

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Stem cell guidance through the mechanistic target of rapamycin. World J Stem Cells (2015) 0.81

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Sirt1 and the Mitochondria. Mol Cells (2016) 0.80

Calorie restriction inhibits ovarian follicle development and follicle loss through activating SIRT1 signaling in mice. Eur J Med Res (2015) 0.79

Targeting sirtuin-1 in Huntington's disease: rationale and current status. CNS Drugs (2013) 0.79

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Involvement of arterial baroreflex in the protective effect of dietary restriction against stroke. J Cereb Blood Flow Metab (2013) 0.78

Circadian redox oscillations and metabolism. Trends Endocrinol Metab (2015) 0.78

Transgenerational programming of longevity and reproduction by post-eclosion dietary manipulation in Drosophila. Aging (Albany NY) (2016) 0.78

The role of SIRT1 in cancer: the saga continues. Am J Pathol (2014) 0.78

SIRT1 Interacts with and Deacetylates ATP6V1B2 in Mature Adipocytes. PLoS One (2015) 0.78

Effects of resveratrol on daily rhythms of locomotor activity and body temperature in young and aged grey mouse lemurs. Oxid Med Cell Longev (2013) 0.77

Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders. Clin Transl Med (2016) 0.77

Differential responses of Trans-Resveratrol on proliferation of neural progenitor cells and aged rat hippocampal neurogenesis. Sci Rep (2016) 0.76

Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation in Drosophila. Aging (Albany NY) (2016) 0.75

Sirt1 is involved in decreased bone formation in aged apolipoprotein E-deficient mice. Acta Pharmacol Sin (2015) 0.75

Harnessing the Power of SIRT1 and Non-coding RNAs in Vascular Disease. Curr Neurovasc Res (2016) 0.75

Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue. EMBO Rep (2017) 0.75

Reduced AMPKα2 protein expression restores glucose-induced insulin secretion in islets from calorie-restricted rats. Int J Exp Pathol (2016) 0.75

Sirt1 negatively regulates FcεRI-mediated mast cell activation through AMPK- and PTP1B-dependent processes. Sci Rep (2017) 0.75

Positive effects of meal frequency and calorie restriction on antioxidant systems in rats. North Clin Istanb (2017) 0.75

Obesity-linked phosphorylation of SIRT1 by CK2 inhibits its nuclear localization and promotes fatty liver. Mol Cell Biol (2017) 0.75

Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell (2006) 19.16

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 14.44

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LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease. Proc Natl Acad Sci U S A (2007) 1.35

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Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection. Gastroenterology (2005) 1.33

Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a 'mitohormesis' mechanism involving reactive oxygen species and PGC-1. Eur Heart J (2011) 1.33

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Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A (2011) 1.29

Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem (2009) 1.29

Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. J Clin Invest (2013) 1.29

Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5. J Med Chem (2007) 1.28

Protein deacetylation by SIRT1: an emerging key post-translational modification in metabolic regulation. Pharmacol Res (2009) 1.27

Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models. J Invest Dermatol (2002) 1.25

Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J Med Chem (2010) 1.23

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TGR5 potentiates GLP-1 secretion in response to anionic exchange resins. Sci Rep (2012) 1.23