Published in Cell Metab on November 01, 2008
mTOR signaling in growth control and disease. Cell (2012) 29.21
mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16
Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell (2010) 7.61
mTOR is a key modulator of ageing and age-related disease. Nature (2013) 5.40
Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov (2011) 4.05
Autophagy regulates adipose mass and differentiation in mice. J Clin Invest (2009) 3.95
Primary cilia regulate mTORC1 activity and cell size through Lkb1. Nat Cell Biol (2010) 3.55
An emerging role of mTOR in lipid biosynthesis. Curr Biol (2009) 3.50
Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest (2011) 2.90
Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony. J Biol Chem (2010) 2.90
The TOR pathway comes of age. Biochim Biophys Acta (2009) 2.83
Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metab (2011) 2.73
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. J Clin Invest (2011) 2.72
Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes (2010) 2.65
Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS One (2009) 2.54
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes (2010) 2.30
mTOR couples cellular nutrient sensing to organismal metabolic homeostasis. Trends Endocrinol Metab (2011) 2.28
Regulation of mTORC1 and its impact on gene expression at a glance. J Cell Sci (2013) 2.22
Mitochondrial complex III ROS regulate adipocyte differentiation. Cell Metab (2011) 2.21
Regulation of glucose transport by insulin: traffic control of GLUT4. Nat Rev Mol Cell Biol (2012) 2.18
Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biol (2009) 2.15
Growth and aging: a common molecular mechanism. Aging (Albany NY) (2009) 2.13
mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature (2014) 2.13
The critical role of metabolic pathways in aging. Diabetes (2012) 2.12
mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proc Natl Acad Sci U S A (2009) 2.05
Metabolic reprogramming, caloric restriction and aging. Trends Endocrinol Metab (2009) 1.95
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response. Oncotarget (2012) 1.85
S6K1 plays a critical role in early adipocyte differentiation. Dev Cell (2010) 1.74
Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov (2013) 1.66
Duration of rapamycin treatment has differential effects on metabolism in mice. Cell Metab (2013) 1.61
A Central role for mTOR in lipid homeostasis. Cell Metab (2013) 1.57
Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity. Cell (2014) 1.53
Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes. Mol Med (2010) 1.48
Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage. Diabetes (2010) 1.44
NCI's provocative questions on cancer: some answers to ignite discussion. Oncotarget (2011) 1.42
Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment. Hum Mol Genet (2009) 1.40
Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology. J Cell Biol (2013) 1.35
Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats. Br J Pharmacol (2012) 1.32
Feedback on fat: p62-mTORC1-autophagy connections. Cell (2011) 1.31
An emerging role for TOR signaling in mammalian tissue and stem cell physiology. Development (2011) 1.27
mTORC1 is essential for leukemia propagation but not stem cell self-renewal. J Clin Invest (2012) 1.27
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The skinny on fat: lipolysis and fatty acid utilization in adipocytes. Trends Endocrinol Metab (2009) 1.22
Hot topics in aging research: protein translation and TOR signaling, 2010. Aging Cell (2011) 1.22
Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction. Proc Natl Acad Sci U S A (2009) 1.22
PTEN in cancer, metabolism, and aging. Trends Endocrinol Metab (2012) 1.18
Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion. Am J Physiol Endocrinol Metab (2009) 1.17
WNT7B promotes bone formation in part through mTORC1. PLoS Genet (2014) 1.16
The multifaceted role of mTORC1 in the control of lipid metabolism. EMBO Rep (2012) 1.16
DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity. Cell Metab (2012) 1.15
Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skelet Muscle (2013) 1.14
A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods. Mol Endocrinol (2012) 1.13
Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure. J Biol Chem (2012) 1.13
Rapamycin-induced metabolic defects are reversible in both lean and obese mice. Aging (Albany NY) (2014) 1.12
Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes. J Biol Chem (2013) 1.11
mTOR coordinates protein synthesis, mitochondrial activity and proliferation. Cell Cycle (2015) 1.11
Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype. Circ Res (2012) 1.11
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging. Cell Metab (2016) 1.10
mTOR Signaling in Growth, Metabolism, and Disease. Cell (2017) 1.10
The integral role of mTOR in lipid metabolism. Cell Cycle (2011) 1.10
Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination. J Neurosci (2014) 1.09
Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila. EMBO J (2012) 1.08
mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis. Development (2014) 1.08
Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. Cell Metab (2014) 1.07
mTOR signaling in tumorigenesis. Biochim Biophys Acta (2014) 1.06
Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging. Aging (Albany NY) (2012) 1.05
Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS). Dose Response (2014) 1.00
Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR. J Biol Chem (2009) 1.00
ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling. Am J Physiol Cell Physiol (2011) 0.99
Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. PLoS One (2013) 0.99
BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. Sci Signal (2013) 0.97
An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivation. Mol Cell (2015) 0.97
Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning. J Clin Invest (2016) 0.97
Mammalian TOR signaling to the AGC kinases. Crit Rev Biochem Mol Biol (2011) 0.97
Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species. Proc Natl Acad Sci U S A (2014) 0.95
mTORC1 signaling and regulation of pancreatic β-cell mass. Cell Cycle (2012) 0.94
Leucine supplementation improves adiponectin and total cholesterol concentrations despite the lack of changes in adiposity or glucose homeostasis in rats previously exposed to a high-fat diet. Nutr Metab (Lond) (2011) 0.94
Obesity and nutrient sensing TOR pathway in flies and vertebrates: Functional conservation of genetic mechanisms. Trends Endocrinol Metab (2011) 0.94
mTOR Inhibition: From Aging to Autism and Beyond. Scientifica (Cairo) (2013) 0.94
Akt isoforms and glucose homeostasis - the leptin connection. Trends Endocrinol Metab (2010) 0.93
Mitochondria and organismal longevity. Curr Genomics (2012) 0.93
Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance. PLoS One (2013) 0.93
Major involvement of mTOR in the PPARγ-induced stimulation of adipose tissue lipid uptake and fat accretion. J Lipid Res (2012) 0.92
Mechanistic target of rapamycin controls homeostasis of adipogenesis. J Lipid Res (2013) 0.92
Rheb and mammalian target of rapamycin in mitochondrial homoeostasis. Open Biol (2013) 0.92
Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Mol Metab (2015) 0.92
Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue. Diabetes (2016) 0.91
P62/SQSTM1 at the interface of aging, autophagy, and disease. Age (Dordr) (2014) 0.91
Contributions of adipocyte lipid metabolism to body fat content and implications for the treatment of obesity. Curr Opin Pharmacol (2010) 0.90
Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis. PLoS One (2014) 0.90
Tamoxifen reduces fat mass by boosting reactive oxygen species. Cell Death Dis (2015) 0.89
Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging. Genome Biol (2015) 0.89
Primary respiratory chain disease causes tissue-specific dysregulation of the global transcriptome and nutrient-sensing signaling network. PLoS One (2013) 0.88
Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity. J Clin Invest (2015) 0.88
Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice. PLoS One (2014) 0.88
Inhibition of S6K by resveratrol: in search of the purpose. Aging (Albany NY) (2009) 0.88
Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling. Proc Natl Acad Sci U S A (2014) 0.88
Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity. Protein Cell (2014) 0.88
Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation. J Cell Biol (2014) 0.87
Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo. Mol Metab (2014) 0.87
TOR signaling in growth and metabolism. Cell (2006) 35.29
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell (2006) 19.16
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature (2004) 12.36
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol (2004) 12.12
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell (2002) 11.59
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature (2009) 10.59
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature (2006) 9.36
TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab (2009) 6.91
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell (2007) 5.67
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab (2008) 5.44
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab (2008) 4.91
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest (2004) 4.65
Targeting bile-acid signalling for metabolic diseases. Nat Rev Drug Discov (2008) 4.43
SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell (2002) 4.31
TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1. Cell (2004) 4.21
Mitonuclear protein imbalance as a conserved longevity mechanism. Nature (2013) 4.18
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature (2012) 4.15
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol (2009) 4.09
Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov (2011) 4.05
Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci U S A (2003) 4.03
Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol (2003) 3.97
A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell (2013) 3.50
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev (2006) 3.48
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab (2010) 3.46
Activation of mTORC2 by association with the ribosome. Cell (2011) 3.38
The expanding TOR signaling network. Curr Opin Cell Biol (2005) 3.30
Target of rapamycin (TOR) in nutrient signaling and growth control. Genetics (2011) 3.28
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev (2009) 3.23
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab (2006) 3.22
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab (2012) 3.18
Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring) (2009) 3.15
Endocrine functions of bile acids. EMBO J (2006) 3.03
Nuclear receptors and the control of metabolism. Annu Rev Physiol (2002) 3.00
Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr (2011) 2.98
Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest (2011) 2.90
The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc Natl Acad Sci U S A (2002) 2.87
Glutaminolysis activates Rag-mTORC1 signaling. Mol Cell (2012) 2.82
NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell (2011) 2.75
mTOR signaling in disease. Curr Opin Cell Biol (2011) 2.73
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. J Clin Invest (2011) 2.72
E2Fs regulate adipocyte differentiation. Dev Cell (2002) 2.71
Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae. Microbiol Mol Biol Rev (2002) 2.69
Sirtuins: the 'magnificent seven', function, metabolism and longevity. Ann Med (2007) 2.64
The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev Cell (2002) 2.61
Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis. Gastroenterology (2003) 2.59
mTOR in aging, metabolism, and cancer. Curr Opin Genet Dev (2013) 2.53
mTOR and the control of whole body metabolism. Curr Opin Cell Biol (2009) 2.52
Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science (2013) 2.44
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Mol Cell Biol (2005) 2.44
Transcriptional coregulators in the control of energy homeostasis. Trends Cell Biol (2007) 2.40
Sirtuin functions in health and disease. Mol Endocrinol (2007) 2.38
Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation. Mol Cell (2004) 2.31
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy. J Cell Biol (2009) 2.30
Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeast. Mol Cell Biol (2004) 2.26
Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity. Cell (2011) 2.26
LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis. Trends Cell Biol (2004) 2.24
TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab (2011) 2.17
Molecular organization of target of rapamycin complex 2. J Biol Chem (2005) 2.15
Growth and aging: a common molecular mechanism. Aging (Albany NY) (2009) 2.13
Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD). Nephrol Dial Transplant (2005) 2.09
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS One (2007) 2.07
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma. J Exp Med (2005) 2.06
TOR complex 2: a signaling pathway of its own. Trends Biochem Sci (2009) 2.05
mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proc Natl Acad Sci U S A (2009) 2.05
Histone methyl transferases and demethylases; can they link metabolism and transcription? Cell Metab (2010) 2.04
Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology. Endocr Rev (2004) 2.04
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c. Cell Metab (2012) 2.03
The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms. Environ Health Perspect (2010) 1.98
AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci (2010) 1.95
The metabolic footprint of aging in mice. Sci Rep (2011) 1.93
Where is mTOR and what is it doing there? J Cell Biol (2013) 1.91
Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab (2009) 1.89
Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. Proc Natl Acad Sci U S A (2003) 1.89
Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1. Mol Cell Biol (2007) 1.89
PPAR(gamma) and glucose homeostasis. Annu Rev Nutr (2002) 1.86
Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem (2008) 1.85
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol Rev (2011) 1.85
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}. Proc Natl Acad Sci U S A (2008) 1.80
Metabolic networks of longevity. Cell (2010) 1.79
Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study. Physiol Genomics (2008) 1.76
The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. J Hepatol (2010) 1.69
Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol (2004) 1.69
Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov (2013) 1.66
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proc Natl Acad Sci U S A (2008) 1.65
Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells. Genes Dev (2012) 1.64
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling. Trends Cell Biol (2012) 1.63
Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J Biol Chem (2011) 1.62
The role of sirtuins in the control of metabolic homeostasis. Ann N Y Acad Sci (2009) 1.62