Published in Science on August 17, 2007
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DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell (2009) 5.97
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science (2008) 5.36
Examining the link between chromosomal instability and aneuploidy in human cells. J Cell Biol (2008) 4.95
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Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast. Nature (2010) 3.72
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Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor. Cell (2008) 3.26
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The parasexual cycle in Candida albicans provides an alternative pathway to meiosis for the formation of recombinant strains. PLoS Biol (2008) 2.78
Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. Science (2017) 2.72
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Gene balance hypothesis: connecting issues of dosage sensitivity across biological disciplines. Proc Natl Acad Sci U S A (2012) 2.20
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Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes. PLoS Pathog (2010) 2.04
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Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells. Nat Cell Biol (2014) 1.86
Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy. Nature (2012) 1.82
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Transcriptional consequences of aneuploidy. Proc Natl Acad Sci U S A (2012) 1.70
Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata. Proc Natl Acad Sci U S A (2009) 1.69
A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole. PLoS Biol (2014) 1.69
Aneuploidy causes proteotoxic stress in yeast. Genes Dev (2012) 1.66
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The aneuploidy paradox: costs and benefits of an incorrect karyotype. Trends Genet (2011) 1.60
Initial quantitative proteomic map of 28 mouse tissues using the SILAC mouse. Mol Cell Proteomics (2013) 1.60
Dosage compensation can buffer copy-number variation in wild yeast. Elife (2015) 1.58
Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells. Mol Syst Biol (2012) 1.57
Aneuploidy-induced cellular stresses limit autophagic degradation. Genes Dev (2015) 1.54
Chromosomal instability and aneuploidy in cancer: from yeast to man. EMBO Rep (2012) 1.51
Evolution of eukaryotic microbial pathogens via covert sexual reproduction. Cell Host Microbe (2010) 1.50
Regulatory hotspots in the malaria parasite genome dictate transcriptional variation. PLoS Biol (2008) 1.47
Genomic plasticity of the human fungal pathogen Candida albicans. Eukaryot Cell (2010) 1.46
Sex in fungi. Annu Rev Genet (2011) 1.45
Developmental Dynamics of X-Chromosome Dosage Compensation by the DCC and H4K20me1 in C. elegans. PLoS Genet (2015) 1.44
When 2+2=5: the origins and fates of aneuploid and tetraploid cells. Biochim Biophys Acta (2008) 1.42
Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer. Curr Opin Cell Biol (2010) 1.38
Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer. Cancer Epidemiol Biomarkers Prev (2011) 1.38
New insights into the troubles of aneuploidy. Annu Rev Cell Dev Biol (2012) 1.36
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Diploids in the Cryptococcus neoformans serotype A population homozygous for the alpha mating type originate via unisexual mating. PLoS Pathog (2009) 1.35
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Triple X syndrome: a review of the literature. Eur J Hum Genet (2009) 1.34
Meiotic chromosome segregation in triploid strains of Saccharomyces cerevisiae. Genetics (2010) 1.33
Proteomic changes resulting from gene copy number variations in cancer cells. PLoS Genet (2010) 1.32
Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy. BMC Biol (2014) 1.29
Aging by epigenetics--a consequence of chromatin damage? Exp Cell Res (2008) 1.25
pRB, a tumor suppressor with a stabilizing presence. Trends Cell Biol (2011) 1.25
Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis. Cancer Res (2009) 1.23
A strategy for constructing aneuploid yeast strains by transient nondisjunction of a target chromosome. BMC Genet (2009) 1.19
Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast. Elife (2014) 1.19
2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells. Semin Cell Dev Biol (2013) 1.19
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Effects of aneuploidy on genome structure, expression, and interphase organization in Arabidopsis thaliana. PLoS Genet (2008) 1.19
Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast. Elife (2014) 1.19
Dynamic large-scale chromosomal rearrangements fuel rapid adaptation in yeast populations. PLoS Genet (2013) 1.18
Centromere replication timing determines different forms of genomic instability in Saccharomyces cerevisiae checkpoint mutants during replication stress. Genetics (2009) 1.17
Aneuploidy: cancer's fatal flaw? Cancer Res (2009) 1.16
Aneuploid yeast strains exhibit defects in cell growth and passage through START. Mol Biol Cell (2013) 1.16
Aneuploidy and tumorigenesis. Semin Cell Dev Biol (2011) 1.15
Aneuploid chromosomes are highly unstable during DNA transformation of Candida albicans. Eukaryot Cell (2009) 1.15
Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein. J Biol Chem (2014) 1.14
Aneuploidy in health, disease, and aging. J Cell Biol (2013) 1.13
Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells. Nat Commun (2015) 1.11
A genome-wide analysis reveals no nuclear dobzhansky-muller pairs of determinants of speciation between S. cerevisiae and S. paradoxus, but suggests more complex incompatibilities. PLoS Genet (2010) 1.09
Mutational landscape of yeast mutator strains. Proc Natl Acad Sci U S A (2014) 1.08
Aneuploidy and chromosomal instability in cancer: a jackpot to chaos. Cell Div (2015) 1.07
Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy. Genome Biol (2011) 1.07
Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients. BMC Genomics (2011) 1.06
The genomic landscape of compensatory evolution. PLoS Biol (2014) 1.06
Unique features of the transcriptional response to model aneuploidy in human cells. BMC Genomics (2014) 1.06
Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms. Proc Natl Acad Sci U S A (2010) 1.05
The genomically mosaic brain: aneuploidy and more in neural diversity and disease. Semin Cell Dev Biol (2013) 1.05
Comparative hybridization reveals extensive genome variation in the AIDS-associated pathogen Cryptococcus neoformans. Genome Biol (2008) 1.05
Dancing genomes: fungal nuclear positioning. Nat Rev Microbiol (2009) 1.04
Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects. Cell Death Differ (2008) 1.04
Design and use of multiplexed chemostat arrays. J Vis Exp (2013) 1.04
Cell cycle-dependent phosphorylation and ubiquitination of a G protein alpha subunit. J Biol Chem (2011) 1.03
Amplification of the 20q chromosomal arm occurs early in tumorigenic transformation and may initiate cancer. PLoS One (2011) 1.03
An integrated semiconductor device enabling non-optical genome sequencing. Nature (2011) 20.85
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science (2008) 5.36
Identification of aneuploidy-selective antiproliferation compounds. Cell (2011) 4.45
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation. Annu Rev Genet (2004) 4.18
Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell (2002) 4.16
Identification of aneuploidy-tolerating mutations. Cell (2010) 3.73
The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast. PLoS Genet (2008) 3.58
Aneuploidy: cells losing their balance. Genetics (2008) 3.48
Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray. Science (2006) 3.32
Aneuploidy drives genomic instability in yeast. Science (2011) 3.22
Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science (2013) 2.79
A genome-wide screen identifies genes required for centromeric cohesion. Science (2004) 2.60
Meiosis: cell-cycle controls shuffle and deal. Nat Rev Mol Cell Biol (2004) 2.53
Role of Polo-like kinase CDC5 in programming meiosis I chromosome segregation. Science (2003) 2.49
Cdc14 and condensin control the dissolution of cohesin-independent chromosome linkages at repeated DNA. Cell (2004) 2.44
Comparing whole genomes using DNA microarrays. Nat Rev Genet (2008) 2.27
Meiosis I is established through division-specific translational control of a cyclin. Cell (2008) 2.06
Measurement of mass, density, and volume during the cell cycle of yeast. Proc Natl Acad Sci U S A (2009) 2.04
Kinetochore orientation during meiosis is controlled by Aurora B and the monopolin complex. Cell (2007) 2.00
Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer. Genes Dev (2006) 1.98
At the interface between signaling and executing anaphase--Cdc14 and the FEAR network. Genes Dev (2004) 1.96
Functional analysis of gene duplications in Saccharomyces cerevisiae. Genetics (2006) 1.96
Checking your breaks: surveillance mechanisms of meiotic recombination. Curr Biol (2006) 1.94
Accurate detection of aneuploidies in array CGH and gene expression microarray data. Bioinformatics (2004) 1.89
The Awesome Power of Yeast Evolutionary Genetics: New Genome Sequences and Strain Resources for the Saccharomyces sensu stricto Genus. G3 (Bethesda) (2011) 1.86
The rate of cell growth is governed by cell cycle stage. Genes Dev (2009) 1.82
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Gene copy-number alterations: a cost-benefit analysis. Cell (2013) 1.79
Genome-wide consequences of deleting any single gene. Mol Cell (2013) 1.76
Transcriptional consequences of aneuploidy. Proc Natl Acad Sci U S A (2012) 1.70
The FK506 binding protein Fpr3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity. Cell (2005) 1.68
Gametogenesis eliminates age-induced cellular damage and resets life span in yeast. Science (2011) 1.67
The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol Cell (2005) 1.67
Rec8 phosphorylation and recombination promote the step-wise loss of cohesins in meiosis. Nature (2006) 1.66
Aneuploidy causes proteotoxic stress in yeast. Genes Dev (2012) 1.66
Transcription of two long noncoding RNAs mediates mating-type control of gametogenesis in budding yeast. Cell (2012) 1.61
The aneuploidy paradox: costs and benefits of an incorrect karyotype. Trends Genet (2011) 1.60
The Cdc14 phosphatase and the FEAR network control meiotic spindle disassembly and chromosome segregation. Dev Cell (2003) 1.58
Chromosomal instability and aneuploidy in cancer: from yeast to man. EMBO Rep (2012) 1.51
Predicting cellular growth from gene expression signatures. PLoS Comput Biol (2009) 1.50
Changes in cell morphology are coordinated with cell growth through the TORC1 pathway. Curr Biol (2013) 1.50
The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Cell (2010) 1.48
Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast. Genome Res (2013) 1.47
New insights into the troubles of aneuploidy. Annu Rev Cell Dev Biol (2012) 1.36
Whole-genome sequencing of a laboratory-evolved yeast strain. BMC Genomics (2010) 1.34
The core centromere and Sgo1 establish a 50-kb cohesin-protected domain around centromeres during meiosis I. Genes Dev (2005) 1.30
The role of the polo kinase Cdc5 in controlling Cdc14 localization. Mol Biol Cell (2003) 1.30
APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus. Genes Dev (2008) 1.26
Control of meiosis by respiration. Curr Biol (2008) 1.25
The multiple roles of cohesin in meiotic chromosome morphogenesis and pairing. Mol Biol Cell (2008) 1.24
Control of Lte1 localization by cell polarity determinants and Cdc14. Curr Biol (2002) 1.23
The protein phosphatase 2A functions in the spindle position checkpoint by regulating the checkpoint kinase Kin4. Genes Dev (2009) 1.20
Cell polarity determinants establish asymmetry in MEN signaling. Dev Cell (2009) 1.20
The replication fork block protein Fob1 functions as a negative regulator of the FEAR network. Curr Biol (2004) 1.19
Novel response to microtubule perturbation in meiosis. Mol Cell Biol (2005) 1.17
Aneuploidy: cancer's fatal flaw? Cancer Res (2009) 1.16
Aneuploid yeast strains exhibit defects in cell growth and passage through START. Mol Biol Cell (2013) 1.16
Mitotic CDKs control the metaphase-anaphase transition and trigger spindle elongation. Genes Dev (2008) 1.16
Spo13 maintains centromeric cohesion and kinetochore coorientation during meiosis I. Curr Biol (2004) 1.16
Global mapping of transposon location. PLoS Genet (2006) 1.16
Emerging roles for centromeres in meiosis I chromosome segregation. Nat Rev Genet (2008) 1.14
The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients. Cancer Cell (2002) 1.13
The stress-activated mitogen-activated protein kinase signaling cascade promotes exit from mitosis. Mol Biol Cell (2006) 1.12
Regulation of Spo12 phosphorylation and its essential role in the FEAR network. Curr Biol (2009) 1.12
The FEAR network. Curr Biol (2009) 1.11
Regulation of entry into gametogenesis. Philos Trans R Soc Lond B Biol Sci (2011) 1.10
Meiosis I chromosome segregation is established through regulation of microtubule-kinetochore interactions. Elife (2012) 1.08
Competitive repair by naturally dispersed repetitive DNA during non-allelic homologous recombination. PLoS Genet (2010) 1.07
Shugoshin promotes sister kinetochore biorientation in Saccharomyces cerevisiae. Mol Biol Cell (2007) 1.06
The yeast Alix homolog Bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes. Dev Cell (2013) 1.05
Origin-dependent inverted-repeat amplification: a replication-based model for generating palindromic amplicons. PLoS Genet (2011) 1.04
Design and use of multiplexed chemostat arrays. J Vis Exp (2013) 1.04
Mitotic exit regulation through distinct domains within the protein kinase Cdc15. Mol Cell Biol (2003) 1.03
Ribosomal DNA transcription-dependent processes interfere with chromosome segregation. Mol Cell Biol (2006) 1.02
Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes. Science (2013) 1.02
A low cost, customizable turbidostat for use in synthetic circuit characterization. ACS Synth Biol (2014) 1.02
Condensins promote coorientation of sister chromatids during meiosis I in budding yeast. Genetics (2010) 1.01
Aneuploidy: implications for protein homeostasis and disease. Dis Model Mech (2014) 1.00
The dynamics of diverse segmental amplifications in populations of Saccharomyces cerevisiae adapting to strong selection. G3 (Bethesda) (2014) 1.00
Cdc15 integrates Tem1 GTPase-mediated spatial signals with Polo kinase-mediated temporal cues to activate mitotic exit. Genes Dev (2011) 0.98
Polo kinase--meiotic cell cycle coordinator. Cell Cycle (2003) 0.98
Linked for life: temporal and spatial coordination of late mitotic events. Curr Opin Cell Biol (2004) 0.97
Ras and the Rho effector Cla4 collaborate to target and anchor Lte1 at the bud cortex. Cell Cycle (2005) 0.96
The Polo-like kinase Cdc5 interacts with FEAR network components and Cdc14. Cell Cycle (2008) 0.95
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A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern. Genes Dev (2013) 0.94
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Spo13 regulates cohesin cleavage. Genes Dev (2002) 0.91
Spindle position is coordinated with cell-cycle progression through establishment of mitotic exit-activating and -inhibitory zones. Mol Cell (2010) 0.91
High-resolution mapping, characterization, and optimization of autonomously replicating sequences in yeast. Genome Res (2012) 0.90
The Ras/cAMP pathway and the CDK-like kinase Ime2 regulate the MAPK Smk1 and spore morphogenesis in Saccharomyces cerevisiae. Genetics (2008) 0.89
Effects of age on meiosis in budding yeast. Dev Cell (2009) 0.86
Lte1 promotes mitotic exit by controlling the localization of the spindle position checkpoint kinase Kin4. Proc Natl Acad Sci U S A (2011) 0.86
Translocation and assembly of mitochondrially coded Saccharomyces cerevisiae cytochrome c oxidase subunit Cox2 by Oxa1 and Yme1 in the absence of Cox18. Genetics (2009) 0.85