Published in PLoS One on September 25, 2009
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell (2010) 15.58
Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res (2010) 4.19
Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol (2012) 3.48
Injectable shear-thinning hydrogels used to deliver endothelial progenitor cells, enhance cell engraftment, and improve ischemic myocardium. J Thorac Cardiovasc Surg (2015) 2.43
Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction. Circ Res (2010) 2.33
Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cells. Circulation (2011) 2.29
Cardiac cell therapy: where we've been, where we are, and where we should be headed. Br Med Bull (2011) 2.26
Cardiospheres recapitulate a niche-like microenvironment rich in stemness and cell-matrix interactions, rationalizing their enhanced functional potency for myocardial repair. Stem Cells (2010) 2.10
Intracoronary delivery of self-assembling heart-derived microtissues (cardiospheres) for prevention of adverse remodeling in a pig model of convalescent myocardial infarction. Circ Cardiovasc Interv (2015) 2.04
Assessment and optimization of cell engraftment after transplantation into the heart. Circ Res (2010) 1.90
Dedifferentiation and proliferation of mammalian cardiomyocytes. PLoS One (2010) 1.89
Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies. J Mol Cell Cardiol (2010) 1.88
Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in myocardial repair. JACC Heart Fail (2014) 1.76
Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells. Stem Cells (2010) 1.63
Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair. Cardiovasc Res (2010) 1.41
Human cardiospheres are a source of stem cells with cardiomyogenic potential. Stem Cells (2010) 1.33
Role of stem cells in cardiovascular biology. J Thromb Haemost (2011) 1.31
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Developmental and regenerative biology of multipotent cardiovascular progenitor cells. Circ Res (2011) 1.16
Functional performance of human cardiosphere-derived cells delivered in an in situ polymerizable hyaluronan-gelatin hydrogel. Biomaterials (2012) 1.14
Human cardiac stem cells isolated from atrial appendages stably express c-kit. PLoS One (2011) 1.14
Early stem cell engraftment predicts late cardiac functional recovery: preclinical insights from molecular imaging. Circ Cardiovasc Imaging (2012) 1.13
Relative roles of CD90 and c-kit to the regenerative efficacy of cardiosphere-derived cells in humans and in a mouse model of myocardial infarction. J Am Heart Assoc (2014) 1.13
Increased potency of cardiac stem cells compared with bone marrow mesenchymal stem cells in cardiac repair. Stem Cells Transl Med (2012) 1.10
Strategies for cardiac regeneration and repair. Sci Transl Med (2014) 1.08
THY-1 receptor expression differentiates cardiosphere-derived cells with divergent cardiogenic differentiation potential. Stem Cell Reports (2014) 1.06
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Dose-dependent functional benefit of human cardiosphere transplantation in mice with acute myocardial infarction. J Cell Mol Med (2012) 0.96
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Secondary sphere formation enhances the functionality of cardiac progenitor cells. Mol Ther (2012) 0.94
The role of notch 1 activation in cardiosphere derived cell differentiation. Stem Cells Dev (2012) 0.92
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Stem cell therapy for cardiac dysfunction. Springerplus (2014) 0.90
Functional impairment of human resident cardiac stem cells by the cardiotoxic antineoplastic agent trastuzumab. Stem Cells Transl Med (2012) 0.89
The stimulation of the cardiac differentiation of mesenchymal stem cells in tissue constructs that mimic myocardium structure and biomechanics. Biomaterials (2011) 0.88
Cardiosphere-derived cell sheet primed with hypoxia improves left ventricular function of chronically infarcted heart. Am J Transl Res (2015) 0.86
Antifibrotic therapies to control cardiac fibrosis. Biomater Res (2016) 0.86
MicroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts. J Mol Cell Cardiol (2011) 0.86
Durable Benefits of Cellular Postconditioning: Long-Term Effects of Allogeneic Cardiosphere-Derived Cells Infused After Reperfusion in Pigs with Acute Myocardial Infarction. J Am Heart Assoc (2016) 0.85
Stem cell therapy for heart failure. Methodist Debakey Cardiovasc J (2013) 0.85
Epigenetic regulation of cardiac progenitor cells marker c-kit by stromal cell derived factor-1α. PLoS One (2013) 0.83
Cardiac progenitor/stem cells on myocardial infarction or ischemic heart disease: what we have known from current research. Heart Fail Rev (2014) 0.83
Characteristic of c-Kit+ progenitor cells in explanted human hearts. Clin Res Cardiol (2014) 0.83
Paracrine Engineering of Human Cardiac Stem Cells With Insulin-Like Growth Factor 1 Enhances Myocardial Repair. J Am Heart Assoc (2015) 0.82
Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts. J Cell Mol Med (2015) 0.81
Myocardial regeneration of the failing heart. Heart Fail Rev (2013) 0.81
Human cardiospheres as a source of multipotent stem and progenitor cells. Stem Cells Int (2013) 0.80
Cardiac explant-derived cells are regulated by Notch-modulated mesenchymal transition. PLoS One (2012) 0.80
Cardiomyocyte regeneration. Cells (2013) 0.80
Heart regeneration using reprogramming technology. Proc Jpn Acad Ser B Phys Biol Sci (2013) 0.80
GPCRs in stem cell function. Prog Mol Biol Transl Sci (2013) 0.80
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Influence of aging on the quantity and quality of human cardiac stem cells. Sci Rep (2016) 0.79
Local activation of cardiac stem cells for post-myocardial infarction cardiac repair. J Cell Mol Med (2012) 0.79
Human cardiosphere-derived cells from patients with chronic ischaemic heart disease can be routinely expanded from atrial but not epicardial ventricular biopsies. J Cardiovasc Transl Res (2012) 0.79
Diastolic ventricular support with cardiac support devices: an alternative approach to prevent adverse ventricular remodeling. Heart Fail Rev (2013) 0.78
The impact of patient co-morbidities on the regenerative capacity of cardiac explant-derived stem cells. Stem Cell Res Ther (2016) 0.78
Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors. Stem Cells Int (2015) 0.78
Endogenous cardiac stem cells for the treatment of heart failure. Stem Cells Cloning (2013) 0.78
Epigenomic Reprogramming of Adult Cardiomyocyte-Derived Cardiac Progenitor Cells. Sci Rep (2015) 0.78
Chronic heart failure is associated with transforming growth factor beta-dependent yield and functional decline in atrial explant-derived c-Kit+ cells. J Am Heart Assoc (2013) 0.78
Contemporary perspective on endogenous myocardial regeneration. World J Stem Cells (2015) 0.77
Effects of Matrix Metalloproteinases on the Performance of Platelet Fibrin Gel Spiked With Cardiac Stem Cells in Heart Repair. Stem Cells Transl Med (2016) 0.77
Developmental origin and lineage plasticity of endogenous cardiac stem cells. Development (2016) 0.77
Cell shape and cardiosphere differentiation: a revelation by proteomic profiling. Biochem Res Int (2013) 0.77
Radiation Exposure Decreases the Quantity and Quality of Cardiac Stem Cells in Mice. PLoS One (2016) 0.77
Redox signaling in cardiac renewal. Antioxid Redox Signal (2014) 0.77
Improving Cell Engraftment in Cardiac Stem Cell Therapy. Stem Cells Int (2015) 0.76
Characterization of myelomonocytoid progenitor cells with mesenchymal differentiation potential obtained by outgrowth from pancreas explants. Biotechnol Res Int (2012) 0.76
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Electrical effects of stem cell transplantation for ischaemic cardiomyopathy: friend or foe? J Physiol (2016) 0.76
Selectins for cardiosphere culture: the "E's" have it! Mol Ther (2012) 0.75
Single-cell transcriptome and epigenomic reprogramming of cardiomyocyte-derived cardiac progenitor cells. Sci Data (2016) 0.75
Thermosensitive and Highly Flexible Hydrogels Capable of Stimulating Cardiac Differentiation of Cardiosphere-Derived Cells under Static and Dynamic Mechanical Training Conditions. ACS Appl Mater Interfaces (2016) 0.75
Are we closer to cardiac regeneration? Stem Cell Investig (2016) 0.75
Cardiac stem cells: translation to human studies. Biophys Rev (2014) 0.75
Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis. Stem Cell Reports (2017) 0.75
Administration of cells with thermosensitive hydrogel enhances the functional recovery in ischemic rat heart. J Tissue Eng (2016) 0.75
Cardiosphere-derived cells do not improve cardiac function in rats with cardiac failure. Stem Cell Res Ther (2017) 0.75
Cardiac Stem Cells for Myocardial Regeneration: They Are Not Alone. Front Cardiovasc Med (2017) 0.75
Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell (2003) 18.09
Evidence for cardiomyocyte renewal in humans. Science (2009) 14.17
Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis (2001) 12.85
Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med (2001) 10.03
Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation (2007) 8.62
Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res (2004) 8.41
Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med (2007) 8.06
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Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circ Res (2001) 6.15
Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A (2007) 3.19
Imaging survival and function of transplanted cardiac resident stem cells. J Am Coll Cardiol (2009) 2.58
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The adult human heart as a source for stem cells: repair strategies with embryonic-like progenitor cells. Nat Clin Pract Cardiovasc Med (2007) 1.70
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A novel two-step procedure to expand cardiac Sca-1+ cells clonally. Biochem Biophys Res Commun (2007) 1.54
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Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet (2012) 9.86
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Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension (2008) 6.96
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet (2006) 6.39
Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Circulation (2008) 5.26
Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation (2007) 5.09
Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res (2010) 4.19
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A causal modelling approach to the development of theory-based behaviour change programmes for trial evaluation. Health Educ Res (2005) 4.06
Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes. J Biol Chem (2003) 3.93
Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol (2012) 3.48
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest (2010) 3.47
Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy. Circulation (2009) 3.45
Late gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy. J Am Coll Cardiol (2008) 2.99
Biological pacemaker created by gene transfer. Nature (2002) 2.83
Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice. J Clin Invest (2002) 2.74
Combined cardiac magnetic resonance imaging and C-reactive protein levels identify a cohort at low risk for defibrillator firings and death. Circ Cardiovasc Imaging (2012) 2.62
Acupuncture for peripheral joint osteoarthritis. Cochrane Database Syst Rev (2010) 2.57
Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations. Circulation (2009) 2.55
An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J (2003) 2.52
Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circ Res (2005) 2.44
Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after transplantation in the heart. Circulation (2008) 2.37
Ectopic expression of the sodium-iodide symporter enables imaging of transplanted cardiac stem cells in vivo by single-photon emission computed tomography or positron emission tomography. J Am Coll Cardiol (2008) 2.33
Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction. Circ Res (2010) 2.33
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Proteomic analysis of pharmacological preconditioning: novel protein targets converge to mitochondrial metabolism pathways. Circ Res (2006) 2.20
Noninvasive quantification and optimization of acute cell retention by in vivo positron emission tomography after intramyocardial cardiac-derived stem cell delivery. J Am Coll Cardiol (2009) 2.20
Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells. J Physiol (2002) 2.18
A killer-protector system regulates both hybrid sterility and segregation distortion in rice. Science (2012) 2.16
Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction. J Am Coll Cardiol (2011) 2.15
Retracted MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts. J Biol Chem (2007) 2.14
Cardioprotection by N-acetylglucosamine linkage to cellular proteins. Circulation (2008) 2.11
Cardiospheres recapitulate a niche-like microenvironment rich in stemness and cell-matrix interactions, rationalizing their enhanced functional potency for myocardial repair. Stem Cells (2010) 2.10
Peripheral muscle microcirculatory alterations in patients with pulmonary arterial hypertension: a pilot study. Respir Care (2013) 2.09
Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel. Mol Cell (2004) 2.05
Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart. EMBO Mol Med (2013) 2.04
Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury. Am J Physiol Heart Circ Physiol (2006) 2.01
Assessment and optimization of cell engraftment after transplantation into the heart. Circ Res (2010) 1.90
Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ Res (2003) 1.89
Dedifferentiation and proliferation of mammalian cardiomyocytes. PLoS One (2010) 1.89
Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies. J Mol Cell Cardiol (2010) 1.88
Creation of a genetic calcium channel blocker by targeted gem gene transfer in the heart. Circ Res (2004) 1.87
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Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. Nat Biotechnol (2012) 1.74
A triallelic system of S5 is a major regulator of the reproductive barrier and compatibility of indica-japonica hybrids in rice. Proc Natl Acad Sci U S A (2008) 1.71
Disproportionate enhancement of myocardial contractility by the xanthine oxidase inhibitor oxypurinol in failing rat myocardium. Cardiovasc Res (2003) 1.70
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A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyte. Biophys J (2006) 1.69
Mesenchymal stem cell injection induces cardiac nerve sprouting and increased tenascin expression in a Swine model of myocardial infarction. J Cardiovasc Electrophysiol (2003) 1.68
CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart. Proc Natl Acad Sci U S A (2008) 1.66
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Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells. Stem Cells (2010) 1.63
Isoform-specific modulation of voltage-gated Na(+) channels by calmodulin. Circ Res (2002) 1.62
Cardiac resynchronization by cardiosphere-derived stem cell transplantation in an experimental model of myocardial infarction. J Am Soc Echocardiogr (2011) 1.61
Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K+ channel activity. Proc Natl Acad Sci U S A (2004) 1.60
Magnetic resonance-based anatomical analysis of scar-related ventricular tachycardia: implications for catheter ablation. Circ Res (2007) 1.58
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Biological pacemaker created by percutaneous gene delivery via venous catheters in a porcine model of complete heart block. Heart Rhythm (2012) 1.54
Mixed results for bone marrow–derived cell therapy for ischemic heart disease. JAMA (2012) 1.53
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Lack of Survival Benefit Found With Use of Intraaortic Balloon Pump in Extracorporeal Membrane Oxygenation: A Pooled Experience of 1517 Patients. J Invasive Cardiol (2015) 1.52