Published in Blood on August 29, 2007
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell (2011) 2.53
Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc Natl Acad Sci U S A (2010) 2.07
Hedgehog and Bmp polarize hematopoietic stem cell emergence in the zebrafish dorsal aorta. Dev Cell (2009) 1.20
sFRP2 suppression of bone morphogenic protein (BMP) and Wnt signaling mediates mesenchymal stem cell (MSC) self-renewal promoting engraftment and myocardial repair. J Biol Chem (2010) 1.18
Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs. Dev Cell (2013) 1.11
Hematopoietic stem cell emergence in the conceptus and the role of Runx1. Int J Dev Biol (2010) 1.11
BMP4/Smad5 dependent stress erythropoiesis is required for the expansion of erythroid progenitors during fetal development. Dev Biol (2008) 1.07
The biochemistry of hematopoietic stem cell development. Biochim Biophys Acta (2012) 1.01
Dynamic analysis of BMP-responsive smad activity in live zebrafish embryos. Dev Dyn (2011) 0.94
Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system. Neural Dev (2010) 0.88
MiR-24 is required for hematopoietic differentiation of mouse embryonic stem cells. PLoS Genet (2015) 0.86
Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment. Blood (2011) 0.84
BMP receptor-activated Smads confer diverse functions during the development of the dorsal spinal cord. Dev Biol (2012) 0.83
Regulation of hematopoiesis by the BMP signaling pathway in adult zebrafish. Exp Hematol (2008) 0.81
Transcriptional factors smad1 and smad9 act redundantly to mediate zebrafish ventral specification downstream of smad5. J Biol Chem (2014) 0.81
Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1. Blood (2014) 0.80
Zebrafish scube1 (signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor) domain-containing protein 1) is involved in primitive hematopoiesis. J Biol Chem (2012) 0.78
Alk3/Alk3b and Smad5 mediate BMP signaling during lymphatic development in zebrafish. Mol Cells (2014) 0.78
Structural basis for the Smad5 MH1 domain to recognize different DNA sequences. Nucleic Acids Res (2015) 0.76
BMP signaling balances murine myeloid potential through SMAD-independent p38MAPK and NOTCH pathways. Blood (2014) 0.76
The polycomb group protein L3MBTL1 represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells. Stem Cell Reports (2015) 0.75
Modeling murine yolk sac hematopoiesis with embryonic stem cell culture systems. Front Biol (Beijing) (2014) 0.75
Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice. Blood (2017) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
Stages of embryonic development of the zebrafish. Dev Dyn (1995) 42.72
Smad transcription factors. Genes Dev (2005) 13.43
Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol (2005) 11.18
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev (1995) 7.13
Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood (2003) 3.98
Tracing hematopoietic precursor migration to successive hematopoietic organs during zebrafish development. Immunity (2006) 3.62
Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development. Nucleic Acids Res (1993) 3.31
Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB J (1999) 3.28
Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafish. Blood (2001) 2.61
The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis. Oncogene (2004) 2.54
Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. Development (1999) 2.35
Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development (1999) 2.34
The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Development (1997) 2.14
Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. Development (1996) 2.13
Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. Development (2001) 2.04
Use of the zebrafish system to study primitive and definitive hematopoiesis. Annu Rev Genet (2005) 2.02
Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation. Development (2000) 1.74
Migratory path of definitive hematopoietic stem/progenitor cells during zebrafish development. Blood (2007) 1.74
Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation. Development (2001) 1.71
Targeted mutagenesis of Smad1 reveals an essential role in chorioallantoic fusion. Dev Biol (2001) 1.71
Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish. Development (1996) 1.65
Transcriptional regulation of BMP4 synexpression in transgenic Xenopus. EMBO J (2004) 1.60
The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo. Development (2001) 1.44
The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity. Proc Natl Acad Sci U S A (2007) 1.36
Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. Dev Biol (2006) 1.32
The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo. Development (1999) 1.24
Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo. Development (2000) 1.22
BMP4: its role in development of the hematopoietic system and potential as a hematopoietic growth factor. Stem Cells (2004) 1.18
BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis. Development (2006) 1.07
Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish. Curr Biol (2006) 1.06
Smad1 expands the hemangioblast population within a limited developmental window. Blood (2006) 1.05
Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling. Dev Biol (2002) 1.02
Smad1 and Smad5 have distinct roles during dorsoventral patterning of the zebrafish embryo. Dev Dyn (1999) 1.01
Smad5 is dispensable for adult murine hematopoiesis. Blood (2006) 1.00
Primitive erythropoiesis is regulated by Smad-dependent signaling in postgastrulation mesoderm. Blood (2003) 0.97
Characterization of zebrafish smad1, smad2 and smad5: the amino-terminus of smad1 and smad5 is required for specific function in the embryo. Mech Dev (1999) 0.93
Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis. Blood (2002) 0.88
A change in response to Bmp signalling precedes ectodermal fate choice. Int J Dev Biol (2007) 0.85
Structure, mRNA expression and linkage mapping of the brain-type fatty acid-binding protein gene (FABP7) from zebrafish (Danio rerio). Eur J Biochem (2003) 0.80
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med (2012) 10.20
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol (2010) 9.24
IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature (2012) 7.95
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell (2011) 7.37
Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature (2010) 6.69
Comparative isoschizomer profiling of cytosine methylation: the HELP assay. Genome Res (2006) 5.99
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature (2012) 4.04
methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles. Genome Biol (2012) 3.44
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet (2012) 3.33
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet (2012) 2.94
Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. Blood (2012) 2.55
Hop is an unusual homeobox gene that modulates cardiac development. Cell (2002) 2.52
CG dinucleotide clustering is a species-specific property of the genome. Nucleic Acids Res (2007) 2.48
The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization. J Clin Invest (2009) 2.18
Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1. Blood (2010) 2.15
Gata4 regulates the formation of multiple organs. Development (2005) 2.02
Evolutionarily conserved gene family important for fat storage. Proc Natl Acad Sci U S A (2007) 1.91
Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting. Blood (2010) 1.87
High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers. Nucleic Acids Res (2009) 1.80
The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis. Dev Cell (2008) 1.77
An injury-responsive gata4 program shapes the zebrafish cardiac ventricle. Curr Biol (2013) 1.73
Bmp and Fgf signaling are essential for liver specification in zebrafish. Development (2007) 1.66
Maternal control of vertebrate development before the midblastula transition: mutants from the zebrafish I. Dev Cell (2004) 1.63
Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. Dev Cell (2012) 1.62
Regulation of Msx genes by a Bmp gradient is essential for neural crest specification. Development (2003) 1.54
Notch activation inhibits AML growth and survival: a potential therapeutic approach. J Exp Med (2013) 1.54
Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat Cell Biol (2009) 1.50
Extracellular modulation of BMP activity in patterning the dorsoventral axis. Birth Defects Res C Embryo Today (2006) 1.50
DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis. Cancer Res (2010) 1.49
Anthracycline-induced suppression of GATA-4 transcription factor: implication in the regulation of cardiac myocyte apoptosis. Mol Pharmacol (2003) 1.45
DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation. Blood (2011) 1.40
Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines. Cancer Res (2008) 1.36
Maternal control of development at the midblastula transition and beyond: mutants from the zebrafish II. Dev Cell (2004) 1.36
Hepatocyte growth factor induces GATA-4 phosphorylation and cell survival in cardiac muscle cells. J Biol Chem (2002) 1.33
Maternal and zygotic control of zebrafish dorsoventral axial patterning. Annu Rev Genet (2011) 1.30
Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment. Nat Immunol (2013) 1.28
The pro-BMP activity of Twisted gastrulation is independent of BMP binding. Development (2003) 1.25
T-box binding sites are required for activity of a cardiac GATA-4 enhancer. Dev Biol (2004) 1.25
Dissection of organs from the adult zebrafish. J Vis Exp (2010) 1.23
Gata4 directs development of cardiac-inducing endoderm from ES cells. Dev Biol (2009) 1.23
Prolonged administration of azacitidine with or without entinostat for myelodysplastic syndrome and acute myeloid leukemia with myelodysplasia-related changes: results of the US Leukemia Intergroup trial E1905. J Clin Oncol (2014) 1.23
Bucky ball organizes germ plasm assembly in zebrafish. Curr Biol (2009) 1.22
Epigenetic roles of MLL oncoproteins are dependent on NF-κB. Cancer Cell (2013) 1.20
Dorsoventral patterning in the zebrafish: bone morphogenetic proteins and beyond. Results Probl Cell Differ (2002) 1.20
Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes. Dev Biol (2007) 1.19
H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia. Cancer Cell (2012) 1.19
AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes. Nature (2013) 1.18
Early zebrafish development: it's in the maternal genes. Curr Opin Genet Dev (2009) 1.15
C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia. J Clin Invest (2012) 1.14
Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning. Development (2004) 1.14
Tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development. Proc Natl Acad Sci U S A (2009) 1.14
Sphingosine 1-phosphate signalling. Development (2014) 1.14
Bucky ball functions in Balbiani body assembly and animal-vegetal polarity in the oocyte and follicle cell layer in zebrafish. Dev Biol (2008) 1.13
Neuromuscular synaptogenesis in wild-type and mutant zebrafish. Dev Biol (2005) 1.12
Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma. PLoS Genet (2011) 1.11
Using the zebrafish model to study GATA transcription factors. Semin Cell Dev Biol (2004) 1.10
Microtubule actin crosslinking factor 1 regulates the Balbiani body and animal-vegetal polarity of the zebrafish oocyte. PLoS Genet (2010) 1.08
BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis. Development (2006) 1.07
KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development. Cell Stem Cell (2013) 1.06
Retinoid signaling regulates primitive (yolk sac) hematopoiesis. Blood (2002) 1.06
Smad1 expands the hemangioblast population within a limited developmental window. Blood (2006) 1.05
HELP (HpaII tiny fragment enrichment by ligation-mediated PCR) assay for DNA methylation profiling of primary normal and malignant B lymphocytes. Methods Mol Biol (2010) 1.03
Regulation of cardiac myocyte apoptosis by the GATA-4 transcription factor. Life Sci (2004) 1.03
Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program. J Clin Invest (2015) 1.03
Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling. Dev Biol (2002) 1.02
Zebrafish as a "biosensor"? Effects of ionizing radiation and amifostine on embryonic viability and development. Cancer Res (2006) 1.01
Synthesis of 2-substituted 2H-chromenes using potassium vinyltrifluoroborates. Tetrahedron Lett (2008) 1.00
Genetic screens for genes controlling motor nerve-muscle development and interactions. Dev Biol (2005) 0.99
Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway. Dev Cell (2012) 0.98
Design and synthesis of (E)-1-((3-ethyl-2,4,4-trimethylcyclohex-2-enylidene)methyl-4-substituted benzenes from 1-(2,6,6-trimethylcyclohex-1-enyl)ethanol. Chem Commun (Camb) (2009) 0.98
Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis. Circ Res (2009) 0.98
Primitive erythropoiesis is regulated by Smad-dependent signaling in postgastrulation mesoderm. Blood (2003) 0.97
Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning. J Biol Chem (2012) 0.96
Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia. J Clin Invest (2015) 0.96
CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900. Blood (2012) 0.96
Novel retinoic acid receptor alpha agonists for treatment of kidney disease. PLoS One (2011) 0.95
A forward chemical screen using zebrafish embryos with novel 2-substituted 2H-chromene derivatives. Chem Biol Drug Des (2009) 0.95
A novel role for MAPKAPK2 in morphogenesis during zebrafish development. PLoS Genet (2009) 0.95
The maternal-effect gene cellular island encodes aurora B kinase and is essential for furrow formation in the early zebrafish embryo. PLoS Genet (2009) 0.95
A forward chemical screen in zebrafish identifies a retinoic acid derivative with receptor specificity. PLoS One (2010) 0.95
Dynamic assembly of brambleberry mediates nuclear envelope fusion during early development. Cell (2012) 0.94
Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis. J Biol Chem (2012) 0.94
Modulation of BMP activity in dorsal-ventral pattern formation by the chordin and ogon antagonists. Dev Biol (2002) 0.93
An Oct-1 binding site mediates activation of the gata2 promoter by BMP signaling. Nucleic Acids Res (2005) 0.93
The chromosomal passenger protein birc5b organizes microfilaments and germ plasm in the zebrafish embryo. PLoS Genet (2013) 0.91
Molecular cloning and developmental expression of the caveolin gene family in the amphibian Xenopus laevis. Biochemistry (2002) 0.89
Yaf2 inhibits caspase 8-mediated apoptosis and regulates cell survival during zebrafish embryogenesis. J Biol Chem (2006) 0.89
The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development. Proc Natl Acad Sci U S A (2006) 0.89
Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis. Proc Natl Acad Sci U S A (2013) 0.89
Temporal and spatial action of tolloid (mini fin) and chordin to pattern tail tissues. Dev Biol (2006) 0.88
Mutations in vacuolar H+ -ATPase subunits lead to biliary developmental defects in zebrafish. Dev Biol (2012) 0.88
Design and synthesis of novel pinacolylboronate containing combretastatin 'antimitotic agent' analogues. Tetrahedron Lett (2009) 0.88
Zebrafish homologs of genes within 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes. Dis Model Mech (2012) 0.86
SnapShot: BMP signaling in development. Cell (2011) 0.86
GATA factors efficiently direct cardiac fate from embryonic stem cells. Development (2013) 0.86
Tmem88a mediates GATA-dependent specification of cardiomyocyte progenitors by restricting WNT signaling. Development (2013) 0.85
Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock. Development (2013) 0.85
Small heat shock proteins Hspb7 and Hspb12 regulate early steps of cardiac morphogenesis. Dev Biol (2013) 0.85
Design and Synthesis of Potential New Apoptosis Agents: Hybrid Compounds Containing Perillyl Alcohol and New Constrained Retinoids. Tetrahedron Lett (2010) 0.84