Published in Nature on June 26, 2013
TET enzymes, TDG and the dynamics of DNA demethylation. Nature (2013) 3.49
Reversing DNA methylation: mechanisms, genomics, and biological functions. Cell (2014) 3.17
Generation and characterization of induced pluripotent stem cells from Aid-deficient mice. PLoS One (2014) 1.43
Molecular control of induced pluripotency. Cell Stem Cell (2014) 1.22
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Small molecules facilitate rapid and synchronous iPSC generation. Nat Methods (2014) 1.04
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Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells. Proc Natl Acad Sci U S A (2013) 0.90
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Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID. PLoS Genet (2015) 0.84
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Processive DNA demethylation via DNA deaminase-induced lesion resolution. PLoS One (2014) 0.83
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Epigenetic function of activation-induced cytidine deaminase and its link to lymphomagenesis. Front Immunol (2014) 0.79
No evidence for AID/MBD4-coupled DNA demethylation in zebrafish embryos. PLoS One (2014) 0.79
The epigenetic basis of diffuse large B-cell lymphoma. Semin Hematol (2015) 0.78
An interplay of the base excision repair and mismatch repair pathways in active DNA demethylation. Nucleic Acids Res (2016) 0.78
Etoposide induces nuclear re-localisation of AID. PLoS One (2013) 0.77
Cancer-like epigenetic derangements of human pluripotent stem cells and their impact on applications in regeneration and repair. Curr Opin Genet Dev (2014) 0.77
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Grand challenges in the field of stem cell research. Front Cell Dev Biol (2014) 0.76
Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution. Nat Commun (2016) 0.76
Activation-induced cytidine deaminase selectively catalyzed active DNA demethylation in pluripotency gene and improved cell reprogramming in bovine SCNT embryo. Cytotechnology (2016) 0.75
Mechanisms underlying the formation of induced pluripotent stem cells. Wiley Interdiscip Rev Dev Biol (2015) 0.75
Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming. Cell Rep (2017) 0.75
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Cutting Edge: The Transcription Factor Sox2 Regulates AID Expression in Class-Switched B Cells. J Immunol (2017) 0.75
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Defining chromosomal translocation risks in cancer. Proc Natl Acad Sci U S A (2016) 0.75
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Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell (2012) 7.17
Identification and classification of chromosomal aberrations in human induced pluripotent stem cells. Cell Stem Cell (2010) 7.16
Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature (2010) 6.20
Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells (2009) 5.69
Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature (2003) 5.20
The promise of induced pluripotent stem cells in research and therapy. Nature (2012) 5.05
A molecular roadmap of reprogramming somatic cells into iPS cells. Cell (2012) 4.41
Dynamic single-cell imaging of direct reprogramming reveals an early specifying event. Nat Biotechnol (2010) 3.98
DNA demethylation dynamics. Cell (2011) 3.82
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Epigenetic modifications in pluripotent and differentiated cells. Nat Biotechnol (2010) 3.02
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet (2012) 2.94
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Embryonic stem cells induce pluripotency in somatic cell fusion through biphasic reprogramming. Mol Cell (2012) 1.14
A critical role for AID in the initiation of reprogramming to induced pluripotent stem cells. FASEB J (2012) 0.90
Critical role of activation induced cytidine deaminase in experimental autoimmune encephalomyelitis. Autoimmunity (2013) 0.82
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Punctuated evolution of prostate cancer genomes. Cell (2013) 7.23
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell (2012) 6.99
Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature (2010) 6.69
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells. PLoS Biol (2009) 4.60
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
Unmasking activation of the zygotic genome using chromosomal deletions in the Drosophila embryo. PLoS Biol (2007) 3.53
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell (2013) 3.13
The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages. Dev Cell (2008) 3.08
Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst. Development (2008) 2.88
Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex. Neuron (2008) 2.86
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature (2005) 2.63
Revealing global regulatory perturbations across human cancers. Mol Cell (2009) 2.62
Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol Cell (2002) 2.49
The role of the non-homologous end-joining pathway in lymphocyte development. Immunol Rev (2004) 2.44
Mechanisms promoting translocations in editing and switching peripheral B cells. Nature (2009) 2.27
The first cleavage of the mouse zygote predicts the blastocyst axis. Nature (2005) 2.25
Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Adv Immunol (2005) 2.19
Androgen receptor signaling regulates DNA repair in prostate cancers. Cancer Discov (2013) 2.15
EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis. Blood (2010) 2.11
Revealing posttranscriptional regulatory elements through network-level conservation. PLoS Comput Biol (2005) 2.04
The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL. Blood (2009) 2.04
Gata4 regulates the formation of multiple organs. Development (2005) 2.02
Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite. PLoS Pathog (2010) 2.00
An evolutionarily conserved target motif for immunoglobulin class-switch recombination. Nat Immunol (2004) 1.98
An integrated ChIP-seq analysis platform with customizable workflows. BMC Bioinformatics (2011) 1.92
A sensitive and bright single-cell resolution live imaging reporter of Wnt/ß-catenin signaling in the mouse. BMC Dev Biol (2010) 1.92
Evolutionarily conserved gene family important for fat storage. Proc Natl Acad Sci U S A (2007) 1.91
Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration. Dev Cell (2013) 1.89
Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition. Blood (2012) 1.87
Downregulation of Par3 and aPKC function directs cells towards the ICM in the preimplantation mouse embryo. J Cell Sci (2005) 1.85
In vivo imaging and differential localization of lipid-modified GFP-variant fusions in embryonic stem cells and mice. Genesis (2006) 1.85
Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair. Nature (2011) 1.80
Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood (2011) 1.79
Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol (2004) 1.79
Luminal mitosis drives epithelial cell dispersal within the branching ureteric bud. Dev Cell (2013) 1.79
DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma. Blood (2010) 1.77
Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Nat Cell Biol (2008) 1.76
Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression. Cell (2012) 1.74
An injury-responsive gata4 program shapes the zebrafish cardiac ventricle. Curr Biol (2013) 1.73
Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa. Am J Hum Genet (2010) 1.72
Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination. Nat Immunol (2009) 1.69
A hybrid blob-slice model for accurate and efficient detection of fluorescence labeled nuclei in 3D. BMC Bioinformatics (2010) 1.69
Using a histone yellow fluorescent protein fusion for tagging and tracking endothelial cells in ES cells and mice. Genesis (2005) 1.69
Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nat Immunol (2007) 1.68
let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts. J Biol Chem (2009) 1.65
Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. Dev Cell (2012) 1.62
CtIP promotes microhomology-mediated alternative end joining during class-switch recombination. Nat Struct Mol Biol (2010) 1.59
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci (2013) 1.57
Developmental potential and behavior of tetraploid cells in the mouse embryo. Dev Biol (2005) 1.56
Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling. Immunity (2013) 1.55
Production of green fluorescent protein transgenic embryonic stem cells using the GENSAT bacterial artificial chromosome library. Stem Cells (2006) 1.55
Using transcriptome sequencing to identify mechanisms of drug action and resistance. Nat Chem Biol (2012) 1.53
Genetic and spectrally distinct in vivo imaging: embryonic stem cells and mice with widespread expression of a monomeric red fluorescent protein. BMC Biotechnol (2005) 1.52
LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1. Proc Natl Acad Sci U S A (2013) 1.51
Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity. PLoS Genet (2013) 1.50
Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A (2009) 1.50
Ab initio genotype-phenotype association reveals intrinsic modularity in genetic networks. Mol Syst Biol (2006) 1.49
FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse. Development (2012) 1.47
Anthracycline-induced suppression of GATA-4 transcription factor: implication in the regulation of cardiac myocyte apoptosis. Mol Pharmacol (2003) 1.45
Internal IgH class switch region deletions are position-independent and enhanced by AID expression. Proc Natl Acad Sci U S A (2002) 1.44
Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell (2013) 1.41
DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation. Blood (2011) 1.40
Oncogene-mediated alterations in chromatin conformation. Proc Natl Acad Sci U S A (2012) 1.40
Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression. Cancer Res (2012) 1.40
Use of KikGR a photoconvertible green-to-red fluorescent protein for cell labeling and lineage analysis in ES cells and mouse embryos. BMC Dev Biol (2009) 1.40
Production of chimeras by aggregation of embryonic stem cells with diploid or tetraploid mouse embryos. Nat Protoc (2006) 1.39
Coupling of zygotic transcription to mitotic control at the Drosophila mid-blastula transition. Development (2009) 1.34
The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev Biol (2010) 1.34
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia. Cancer Discov (2012) 1.33
Differential plasticity of epiblast and primitive endoderm precursors within the ICM of the early mouse embryo. Development (2011) 1.33
A membrane associated mCherry fluorescent reporter line for studying vascular remodeling and cardiac function during murine embryonic development. Anat Rec (Hoboken) (2009) 1.33
Hepatocyte growth factor induces GATA-4 phosphorylation and cell survival in cardiac muscle cells. J Biol Chem (2002) 1.33
Eomes::GFP-a tool for live imaging cells of the trophoblast, primitive streak, and telencephalon in the mouse embryo. Genesis (2007) 1.31
Cellular dynamics in the early mouse embryo: from axis formation to gastrulation. Curr Opin Genet Dev (2010) 1.30
Tg(Afp-GFP) expression marks primitive and definitive endoderm lineages during mouse development. Dev Dyn (2006) 1.30
NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche. Nature (2013) 1.29
Faster sequencers, larger datasets, new challenges. Genome Biol (2012) 1.29
Dynamic imaging of mammalian neural tube closure. Dev Biol (2010) 1.29
A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters. Cell Rep (2013) 1.28
Transthyretin mouse transgenes direct RFP expression or Cre-mediated recombination throughout the visceral endoderm. Genesis (2009) 1.28
A panel of four miRNAs accurately differentiates malignant from benign indeterminate thyroid lesions on fine needle aspiration. Clin Cancer Res (2012) 1.28
A membrane-associated β-catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells. Development (2013) 1.26
A transgenic mouse that reveals cell shape and arrangement during ureteric bud branching. Genesis (2009) 1.26
Live-imaging fluorescent proteins in mouse embryos: multi-dimensional, multi-spectral perspectives. Trends Biotechnol (2009) 1.25
T-box binding sites are required for activity of a cardiac GATA-4 enhancer. Dev Biol (2004) 1.25
A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea. Development (2012) 1.25
Gata4 directs development of cardiac-inducing endoderm from ES cells. Dev Biol (2009) 1.23
Oriented cell motility and division underlie early limb bud morphogenesis. Development (2010) 1.23
Anatomy of a blastocyst: cell behaviors driving cell fate choice and morphogenesis in the early mouse embryo. Genesis (2013) 1.21
Dual transgene strategy for live visualization of chromatin and plasma membrane dynamics in murine embryonic stem cells and embryonic tissues. Genesis (2009) 1.21
The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA. Nat Immunol (2010) 1.20
Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes. Dev Biol (2007) 1.19
A role for PDGF signaling in expansion of the extra-embryonic endoderm lineage of the mouse blastocyst. Development (2010) 1.18
Nap1-mediated actin remodeling is essential for mammalian myoblast fusion. J Cell Sci (2009) 1.18
EZH2 mutations are frequent and represent an early event in follicular lymphoma. Blood (2013) 1.17
Smad1 and Smad5 differentially regulate embryonic hematopoiesis. Blood (2007) 1.16
IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proc Natl Acad Sci U S A (2014) 1.15
Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse. Development (2007) 1.15