Published in Arthritis Res Ther on January 01, 2007
Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders. Am J Pathol (2011) 2.15
A one-year, phase I/IIa, open-label pilot trial of imatinib mesylate in the treatment of systemic sclerosis-associated active interstitial lung disease. Arthritis Rheum (2011) 1.70
Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma? Arthritis Rheum (2011) 1.51
Cell-extracellular matrix interactions in normal and diseased skin. Cold Spring Harb Perspect Biol (2011) 1.37
Yin and Yang: CCN3 inhibits the pro-fibrotic effects of CCN2. J Cell Commun Signal (2009) 1.09
Cellular and molecular mechanisms of intestinal fibrosis. World J Gastroenterol (2012) 1.07
Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro. J Cell Sci (2013) 1.03
Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGFβ-dependent mechanism. PLoS One (2011) 0.97
Role of endothelial to mesenchymal transition in the pathogenesis of the vascular alterations in systemic sclerosis. ISRN Rheumatol (2013) 0.95
Activation of TGF-β pathway by areca nut constituents: a possible cause of oral submucous fibrosis. PLoS One (2012) 0.94
Targeting the jagged/notch pathway: a new treatment for fibrosis? J Cell Commun Signal (2010) 0.91
The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases. Clin Transl Med (2015) 0.90
Inhibition of α-SMA by the ectodomain of FGFR2c attenuates lung fibrosis. Mol Med (2012) 0.88
Gingival fibroblasts display reduced adhesion and spreading on extracellular matrix: a possible basis for scarless tissue repair? PLoS One (2011) 0.88
Endothelin inhibits cholangiocarcinoma growth by a decrease in the vascular endothelial growth factor expression. Liver Int (2009) 0.87
Clinical trials in systemic sclerosis: lessons learned and outcomes. Arthritis Res Ther (2007) 0.84
Systemic Sclerosis-Associated Interstitial Lung Disease: Lessons from Clinical Trials, Outcome Measures, and Future Study Design. Curr Rheumatol Rev (2010) 0.82
Evaluation of myofibroblasts by expression of alpha smooth muscle actin: a marker in fibrosis, dysplasia and carcinoma. J Clin Diagn Res (2014) 0.81
Computational Modeling Predicts Simultaneous Targeting of Fibroblasts and Epithelial Cells Is Necessary for Treatment of Pulmonary Fibrosis. Front Pharmacol (2016) 0.80
Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality? Matrix Biol (2016) 0.80
The IL-33 gene is related to increased susceptibility to systemic sclerosis. Rheumatol Int (2016) 0.79
Keloids: The paradigm of skin fibrosis - Pathomechanisms and treatment. Matrix Biol (2016) 0.79
Impaired Cav-1 expression in SSc mesenchymal cells upregulates VEGF signaling: a link between vascular involvement and fibrosis. Fibrogenesis Tissue Repair (2014) 0.79
FIZZ1-Induced Myofibroblast Transdifferentiation from Adipocytes and Its Potential Role in Dermal Fibrosis and Lipoatrophy. Am J Pathol (2015) 0.79
The LIM-only protein FHL2 attenuates lung inflammation during bleomycin-induced fibrosis. PLoS One (2013) 0.79
CCN2: a bona fide target for anti-fibrotic drug intervention. J Cell Commun Signal (2011) 0.78
Treatment of Rapidly Progressive Systemic Sclerosis: Current and Futures Perspectives. Expert Opin Orphan Drugs (2015) 0.77
Role of endothelial-to-mesenchymal transition induced by TGF-β1 in transplant kidney interstitial fibrosis. J Cell Mol Med (2017) 0.77
Involvement of collagen-binding heat shock protein 47 in scleroderma-associated fibrosis. Protein Cell (2015) 0.75
ROCK/actin/MRTF signaling promotes the fibrogenic phenotype of fibroblast-like synoviocytes derived from the temporomandibular joint. Int J Mol Med (2017) 0.75
5Z-7-Oxozeanol Inhibits the Effects of TGFβ1 on Human Gingival Fibroblasts. PLoS One (2015) 0.75
Embryonic Stem Cell-like Population in Dupuytren's Disease. Plast Reconstr Surg Glob Open (2016) 0.75
Transition from inflammation to proliferation: a critical step during wound healing. Cell Mol Life Sci (2016) 0.75
Succinate/NLRP3 Inflammasome Induces Synovial Fibroblast Activation: Therapeutical Effects of Clematichinenoside AR on Arthritis. Front Immunol (2016) 0.75
Serum prolidase activity in systemic sclerosis. Clin Rheumatol (2017) 0.75
Invasive Intraneural Interfaces: Foreign Body Reaction Issues. Front Neurosci (2017) 0.75
Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol (2002) 14.80
Regulation of wound healing by growth factors and cytokines. Physiol Rev (2003) 9.82
Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis. Arthritis Rheum (2007) 3.02
Connective tissue growth factor: what's in a name? Mol Genet Metab (2000) 2.82
Pulmonary fibrosis and chronic lung inflammation in ET-1 transgenic mice. Am J Respir Cell Mol Biol (2000) 2.35
The endothelin system in pulmonary arterial hypertension. Cardiovasc Res (2004) 2.09
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors. Mol Cell Biol (2006) 1.87
Mechanisms and consequences of fibrosis in systemic sclerosis. Nat Clin Pract Rheumatol (2006) 1.73
A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation. Genome Res (1996) 1.57
Paracrine regulation of keratinocyte proliferation and differentiation. Trends Cell Biol (2001) 1.43
Endothelin and endothelin receptor antagonists in systemic rheumatic disease. Arthritis Rheum (2003) 1.42
Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1. Am J Pathol (2004) 1.39
TGF-beta and CTGF have overlapping and distinct fibrogenic effects on human renal cells. Am J Physiol Renal Physiol (2002) 1.38
Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension. J Clin Invest (1997) 1.37
Interstitial fibrosis and growth factors. Environ Health Perspect (2000) 1.32
Scleroderma--clinical and pathological advances. Best Pract Res Clin Rheumatol (2004) 1.31
Connective tissue growth factor causes persistent proalpha2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model. J Cell Physiol (2005) 1.28
Functional cooperation between Smad proteins and activator protein-1 regulates transforming growth factor-beta-mediated induction of endothelin-1 expression. Circ Res (2003) 1.27
Role of endothelin in fibrosis and anti-fibrotic potential of bosentan. Ann Med (2005) 1.23
Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis. J Invest Dermatol (2005) 1.18
Interactions of primary fibroblasts and keratinocytes with extracellular matrix proteins: contribution of alpha2beta1 integrin. J Cell Sci (2006) 1.17
Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytes. Thromb Haemost (2004) 1.15
Endothelin-1, via ETA receptor and independently of transforming growth factor-beta, increases the connective tissue growth factor in vascular smooth muscle cells. Circ Res (2005) 1.15
Cell and molecular regulation of endothelin-1 production during hepatic wound healing. Mol Biol Cell (2003) 1.05
Myocardial fibrosis in DOCA-salt hypertensive rats: effect of endothelin ET(A) receptor antagonism. Circulation (2001) 1.02
Interaction of keratinocytes and fibroblasts modulates the expression of matrix metalloproteinases-2 and -9 and their inhibitors. Mol Cell Biochem (2005) 1.01
Effects of the protein kinase inhibitor, imatinib mesylate, on epithelial/mesenchymal phenotypes: implications for treatment of fibrotic diseases. J Pharmacol Exp Ther (2007) 1.00
Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen. Arthritis Rheum (2004) 0.98
Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering. J Invest Dermatol (2004) 0.96
Bleomycin increases steady-state levels of type I collagen, fibronectin and decorin mRNAs in human skin fibroblasts. Arch Dermatol Res (2000) 0.88
Angiopoietin-related growth factor (AGF) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with RGD-binding integrins. Biochem Biophys Res Commun (2006) 0.82
Hammerhead ribozyme-mediated silencing of the mutant fibrillin-1 of tight skin mouse: insight into the functional role of mutant fibrillin-1. Exp Cell Res (2006) 0.82
Transforming growth factor-beta receptor requirements for the induction of the endothelin-1 gene. Exp Biol Med (Maywood) (2006) 0.81
SKL-2841, a dual antagonist of MCP-1 and MIP-1 beta, prevents bleomycin-induced skin sclerosis in mice. Biomed Pharmacother (2006) 0.81
PATRIC, the bacterial bioinformatics database and analysis resource. Nucleic Acids Res (2013) 7.63
Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest (2007) 5.19
Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med (2013) 3.81
Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells (2010) 3.24
reCAPTCHA: human-based character recognition via Web security measures. Science (2008) 2.99
Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev (2008) 2.40
Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med (2007) 2.17
A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists. Arthritis Rheum (2007) 2.11
Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies. J Invest Dermatol (2012) 1.91
Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins. Genes Dev (2002) 1.89
Improved diagnosis of Strongyloides stercoralis using recombinant antigen-based serologies in a community-wide study in northern Argentina. Clin Vaccine Immunol (2010) 1.70
Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum (2010) 1.64
Myofibroblasts and hyalinized collagen as markers of skin disease in systemic sclerosis. Arthritis Rheum (2006) 1.60
Association of Interferon- and transforming growth factor β-regulated genes and macrophage activation with systemic sclerosis-related progressive lung fibrosis. Arthritis Rheumatol (2014) 1.58
High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1. Mol Biol Cell (2011) 1.55
Eosinophils can function as antigen-presenting cells to induce primary and secondary immune responses to Strongyloides stercoralis. Infect Immun (2006) 1.53
Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma? Arthritis Rheum (2011) 1.51
Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors. Ann Rheum Dis (2013) 1.51
Capillary regeneration in scleroderma: stem cell therapy reverses phenotype? PLoS One (2008) 1.42
Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13. Proc Natl Acad Sci U S A (2007) 1.39
Connective tissue growth factor: structure-function relationships of a mosaic, multifunctional protein. Growth Factors (2008) 1.36
Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis. J Invest Dermatol (2007) 1.35
Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets. Am J Pathol (2012) 1.32
Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension. Arthritis Rheum (2011) 1.31
Role of eosinophils and neutrophils in innate and adaptive protective immunity to larval strongyloides stercoralis in mice. Infect Immun (2006) 1.29
A public health response against Strongyloides stercoralis: time to look at soil-transmitted helminthiasis in full. PLoS Negl Trop Dis (2013) 1.27
Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury. PLoS One (2010) 1.25
Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice. J Infect Dis (2007) 1.25
Steroids in Duchenne muscular dystrophy: from clinical trials to genomic research. Neuromuscul Disord (2002) 1.21
Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression. PLoS One (2009) 1.20
Molecular signatures in skin associated with clinical improvement during mycophenolate treatment in systemic sclerosis. J Invest Dermatol (2013) 1.19
Clinical and pathological significance of interleukin 6 overexpression in systemic sclerosis. Ann Rheum Dis (2012) 1.19
Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. J Neurochem (2004) 1.17
Poly(I:C) drives type I IFN- and TGFβ-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis. J Invest Dermatol (2010) 1.17
Dominant-negative inhibition of M-like potassium conductances in hair cells of the mouse inner ear. J Neurosci (2007) 1.16
The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes. PLoS One (2009) 1.16
The role of B cells in immunity against larval Strongyloides stercoralis in mice. Parasite Immunol (2002) 1.16
Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1. J Biol Chem (2005) 1.15
Antimalarial agents: closing the gate on Toll-like receptors? Arthritis Rheum (2006) 1.15
Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice. Infect Immun (2011) 1.14
Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma. Am J Pathol (2012) 1.11
Microfibril-associated MAGP-2 stimulates elastic fiber assembly. J Biol Chem (2006) 1.10
Extra-cellular matrix in vascular networks. Cell Prolif (2004) 1.07
Transforming growth factor beta induces fibroblast fibrillin-1 matrix formation. Arthritis Rheum (2002) 1.06
Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation. Arthritis Rheum (2012) 1.06
Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients. J Clin Invest (2015) 1.06
Platelet-derived growth factor signaling in mesenchymal cells. Front Biosci (Landmark Ed) (2013) 1.03
TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming. J Immunol (2009) 1.03
Immunoaffinity-isolated antigens induce protective immunity against larval Strongyloides stercoralis in mice. Exp Parasitol (2002) 1.03
Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro. J Cell Sci (2013) 1.03
Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice. J Immunol (2006) 1.02
Specificity and mechanism of immunoglobulin M (IgM)- and IgG-dependent protective immunity to larval Strongyloides stercoralis in mice. Infect Immun (2003) 1.01
Prednisolone-induced changes in dystrophic skeletal muscle. FASEB J (2005) 1.00
Innate and adaptive immunity to the nematode Strongyloides stercoralis in a mouse model. Immunol Res (2011) 1.00
Col1a2 enhancer regulates collagen activity during development and in adult tissue repair. Matrix Biol (2004) 1.00
Human and mouse macrophages collaborate with neutrophils to kill larval Strongyloides stercoralis. Infect Immun (2013) 0.99
Human immunoglobulin G mediates protective immunity and identifies protective antigens against larval Strongyloides stercoralis in mice. J Infect Dis (2004) 0.99
Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril-associated glycoprotein 2 and type I collagen. Arthritis Rheum (2004) 0.98
Onchocerca volvulus glycolytic enzyme fructose-1,6-bisphosphate aldolase as a target for a protective immune response in humans. Infect Immun (2002) 0.98
Towards a recombinant antigen vaccine against Onchocerca volvulus. Trends Parasitol (2002) 0.98
Antagonistic effect of the matricellular signaling protein CCN3 on TGF-beta- and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome. J Invest Dermatol (2010) 0.97
Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering. J Invest Dermatol (2004) 0.96
Chronic Toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis. Arthritis Res Ther (2014) 0.94
Rituximab: a potential therapeutic advance in scleroderma: what is the evidence? Rheumatology (Oxford) (2009) 0.93
Anti-CD95-induced lethality requires radioresistant Fcgamma RII+ cells. A novel mechanism for fulminant hepatic failure. J Biol Chem (2002) 0.93
The c-Abl tyrosine kinase controls protein kinase Cδ-induced Fli-1 phosphorylation in human dermal fibroblasts. Arthritis Rheum (2011) 0.93
JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction. Nucleic Acids Res (2009) 0.93
Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode Strongyloides stercoralis. J Innate Immun (2009) 0.92
dsRNA activation of endothelin-1 and markers of vascular activation in endothelial cells and fibroblasts. Ann Rheum Dis (2010) 0.92
Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor β. Arthritis Rheum (2013) 0.91
Endothelin in pulmonary fibrosis. Am J Respir Cell Mol Biol (2010) 0.91
p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-β: epigenetic feed-forward amplification of fibrosis. J Invest Dermatol (2013) 0.91
Platelet-derived growth factor alpha and beta receptors have overlapping functional activities towards fibroblasts. Fibrogenesis Tissue Repair (2013) 0.89
Toll-like receptors in ischaemia and its potential role in the pathophysiology of muscle damage in critical limb ischaemia. Cardiol Res Pract (2012) 0.89
Role of aggrecanase 1 in Lyme arthritis. Arthritis Rheum (2006) 0.88
Type I interferons inhibition of inflammatory T helper cell responses in systemic lupus erythematosus. Ann N Y Acad Sci (2007) 0.88
Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma. Arthritis Res Ther (2010) 0.88
Toll-like receptor 4 (TLR4) is required for protective immunity to larval Strongyloides stercoralis in mice. Microbes Infect (2006) 0.88
Soluble extract from the nematode Strongyloides stercoralis induces CXCR2 dependent/IL-17 independent neutrophil recruitment. Microbes Infect (2011) 0.87
Activity of azithromycin against Leishmania major in vitro and in vivo. Am J Trop Med Hyg (2002) 0.87
Sustained β-catenin activity in dermal fibroblasts promotes fibrosis by up-regulating expression of extracellular matrix protein-coding genes. J Pathol (2015) 0.87
Increased expression of type I collagen induced by microfibril-associated glycoprotein 2: novel mechanistic insights into the molecular basis of dermal fibrosis in scleroderma. Arthritis Rheum (2005) 0.86
A randomized clinical trial comparing oral azithromycin and meglumine antimoniate for the treatment of American cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis. Am J Trop Med Hyg (2007) 0.86
Fibrillin in Marfan syndrome and tight skin mice provides new insights into transforming growth factor-beta regulation and systemic sclerosis. Curr Opin Rheumatol (2006) 0.85
Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension. Arthritis Rheum (2013) 0.85
CD4+-dependent immunity to Onchocerca volvulus third-stage larvae in humans and the mouse vaccination model: common ground and distinctions. Int J Parasitol (2003) 0.85
Role for Toll-like receptor 3 in muscle regeneration after cardiotoxin injury. Muscle Nerve (2011) 0.84
DNA immunization with Na+-K+ ATPase (Sseat-6) induces protective immunity to larval Strongyloides stercoralis in mice. Infect Immun (2005) 0.83
Signaling through Galphai2 protein is required for recruitment of neutrophils for antibody-mediated elimination of larval Strongyloides stercoralis in mice. J Leukoc Biol (2007) 0.83
Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis. J Clin Invest (2016) 0.83
Identification of the key regions within the mouse pro-alpha 2(I) collagen gene far-upstream enhancer. J Biol Chem (2001) 0.83
Identification of cadherin 11 as a mediator of dermal fibrosis and possible role in systemic sclerosis. Arthritis Rheumatol (2014) 0.83
Neuronal regulators and vascular dysfunction in Raynaud's phenomenon and systemic sclerosis. Curr Vasc Pharmacol (2009) 0.83
Vaccination with recombinant Brugia malayi cystatin proteins alters worm migration, homing and final niche selection following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae. Parasit Vectors (2014) 0.82
Protective immunity to the larval stages of onchocerca volvulus is dependent on Toll-like receptor 4. Infect Immun (2005) 0.82
Care of patients with scleroderma in the intensive care setting. J Intensive Care Med (2010) 0.82
Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension. Arthritis Rheum (2013) 0.81
HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells. PLoS One (2013) 0.80
Microarray-based analysis of differential gene expression between infective and noninfective larvae of Strongyloides stercoralis. PLoS Negl Trop Dis (2011) 0.80
Comparison of reactivity to allergens using the TRUE Test and IQ chamber system. Contact Dermatitis (2007) 0.80