Published in Neurobiol Aging on June 23, 2006
Phospholipase D: enzymology, functionality, and chemical modulation. Chem Rev (2011) 1.66
Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. J Neurosci (2010) 1.49
Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biol Psychiatry (2014) 1.42
Lipid signaling on the mitochondrial surface. Biochim Biophys Acta (2009) 0.98
Functional regulation of phospholipase D expression in cancer and inflammation. J Biol Chem (2014) 0.86
Altered expression of claudin family proteins in Alzheimer's disease and vascular dementia brains. J Cell Mol Med (2010) 0.82
A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction. Sci Rep (2016) 0.77
Targeting phospholipase D in cancer, infection and neurodegenerative disorders. Nat Rev Drug Discov (2017) 0.75
C-terminal loop of Streptomyces phospholipase D has multiple functional roles. Protein Sci (2006) 0.75
Role of phospholipase d in g-protein coupled receptor function. Membranes (Basel) (2014) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/β-catenin signaling. J Natl Cancer Inst (2014) 2.96
SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci (2008) 2.12
Formal protocol for emergency treatment of ruptured intracranial aneurysms to reduce in-hospital rebleeding and improve clinical outcomes. J Neurosurg (2014) 2.04
High prevalence of leukoaraiosis in cerebral magnetic resonance images of patients on peritoneal dialysis. Am J Kidney Dis (2007) 1.88
Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis (2003) 1.64
Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. J Biol Chem (2003) 1.55
Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress. FASEB J (2002) 1.52
The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism. J Biol Chem (2006) 1.46
Function and regulation of Dyrk1A: towards understanding Down syndrome. Cell Mol Life Sci (2009) 1.44
Acute serious rebleeding after angiographically successful coil embolization of ruptured cerebral aneurysms. Acta Neurochir (Wien) (2010) 1.42
p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance. Proc Natl Acad Sci U S A (2002) 1.42
Molecular interaction between parkin and PINK1 in mammalian neuronal cells. Mol Cell Neurosci (2009) 1.36
A two-photon fluorescent probe for lipid raft imaging: C-laurdan. Chembiochem (2007) 1.36
Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1. Mol Cell Biol (2002) 1.35
Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1. Oncogene (2005) 1.34
Early detection of abnormal prion protein in genetic human prion diseases now possible using real-time QUIC assay. PLoS One (2013) 1.30
Changes in IP3 receptor are associated with altered calcium response to cholecystokinin in diabetic rat pancreatic acini. Pancreas (2004) 1.29
Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange. J Biol Chem (2009) 1.27
Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases. J Biol Chem (2005) 1.25
Lipid raft proteome reveals ATP synthase complex in the cell surface. Proteomics (2004) 1.25
A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation. Genes Dev (2009) 1.25
Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction. Oncogene (2004) 1.22
Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kappaB/Sp1-mediated signaling pathways. Carcinogenesis (2009) 1.20
Parkin ubiquitinates and promotes the degradation of RanBP2. J Biol Chem (2005) 1.19
Quantitative evaluation of liver function with MRI Using Gd-EOB-DTPA. Korean J Radiol (2005) 1.17
MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling. Nat Commun (2013) 1.16
Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways. Eur J Biochem (2003) 1.15
Transmodulation between phospholipase D and c-Src enhances cell proliferation. Mol Cell Biol (2003) 1.15
Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43, in angiogenesis. J Biol Chem (2002) 1.14
Generation of monoclonal antibody recognized by the GXXXG motif (glycine zipper) of prion protein. Hybridoma (Larchmt) (2006) 1.13
Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. Free Radic Biol Med (2009) 1.13
Phorbol ester up-regulates phospholipase D1 but not phospholipase D2 expression through a PKC/Ras/ERK/NFkappaB-dependent pathway and enhances matrix metalloproteinase-9 secretion in colon cancer cells. J Biol Chem (2007) 1.13
Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence. Cancer Res (2009) 1.11
Rotational vertebral artery occlusion: mechanisms and long-term outcome. Stroke (2013) 1.10
Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1. BMB Rep (2009) 1.09
On the mechanism of internalization of alpha-synuclein into microglia: roles of ganglioside GM1 and lipid raft. J Neurochem (2009) 1.08
Amyloid beta oligomerization is induced by brain lipid rafts. J Cell Biochem (2006) 1.07
Monocyte cell adhesion induced by a human aminoacyl-tRNA synthetase-associated factor, p43: identification of the related adhesion molecules and signal pathways. J Leukoc Biol (2002) 1.07
Involvement of mitophagy in oncogenic K-Ras-induced transformation: overcoming a cellular energy deficit from glucose deficiency. Autophagy (2011) 1.06
alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells. J Biol Chem (2002) 1.06
Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria. J Biol Chem (2006) 1.06
Oxidation-reduction respiratory chains and ATP synthase complex are localized in detergent-resistant lipid rafts. Proteomics (2006) 1.06
Functional interaction of neuronal Cav1.3 L-type calcium channel with ryanodine receptor type 2 in the rat hippocampus. J Biol Chem (2007) 1.05
Switching strategy for mechanical thrombectomy of acute large vessel occlusion in the anterior circulation. Stroke (2013) 1.04
The cellular prion protein (PrPC) prevents apoptotic neuronal cell death and mitochondrial dysfunction induced by serum deprivation. Brain Res Mol Brain Res (2004) 1.03
Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. J Biol Chem (2006) 1.03
Molecular mechanisms for lipopolysaccharide-induced biphasic activation of nuclear factor-kappa B (NF-kappa B). J Biol Chem (2002) 1.03
Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein. J Neurochem (2006) 1.03
Involvement of c-Src kinase in the regulation of TGF-beta1-induced apoptosis. Oncogene (2004) 1.03
The prevalence of human endogenous retroviruses in cerebrospinal fluids from patients with sporadic Creutzfeldt-Jakob disease. J Clin Virol (2009) 1.02
Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J Biol Chem (2010) 1.02
Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin β1 signaling. Biochem Biophys Res Commun (2012) 1.01
Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells. Biochem Pharmacol (2012) 1.01
Phospholipase D meets Wnt signaling: a new target for cancer therapy. Cancer Res (2011) 1.01
Phospholipase D1 drives a positive feedback loop to reinforce the Wnt/beta-catenin/TCF signaling axis. Cancer Res (2010) 1.00
Pyrrolidine dithiocarbamate and zinc inhibit proteasome-dependent proteolysis. Exp Cell Res (2004) 0.99
Association of sporadic Creutzfeldt-Jakob disease with homozygous genotypes at PRNP codons 129 and 219 in the Korean population. Neurogenetics (2005) 0.98
Parkin directly modulates 26S proteasome activity. J Neurosci (2010) 0.98
Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome. Mol Cell Neurosci (2007) 0.98
Redox metals and oxidative abnormalities in human prion diseases. Acta Neuropathol (2005) 0.98
NecroX as a novel class of mitochondrial reactive oxygen species and ONOO⁻ scavenger. Arch Pharm Res (2010) 0.97
Programmed death-1 receptor negatively regulates LPS-mediated IL-12 production and differentiation of murine macrophage RAW264.7 cells. Immunol Lett (2009) 0.97
Cell-surface receptor for complement component C1q (gC1qR) is a key regulator for lamellipodia formation and cancer metastasis. J Biol Chem (2011) 0.97
Accumulation of citrullinated proteins by up-regulated peptidylarginine deiminase 2 in brains of scrapie-infected mice: a possible role in pathogenesis. Am J Pathol (2008) 0.97
Functional modulation of parkin through physical interaction with SUMO-1. J Neurosci Res (2006) 0.97
Autoregulation of phospholipase D activity is coupled to selective induction of phospholipase D1 expression to promote invasion of breast cancer cells. Int J Cancer (2011) 0.97
Ginsenoside Rh2 induces ligand-independent Fas activation via lipid raft disruption. Biochem Biophys Res Commun (2009) 0.96
Crystal structure of PRY-SPRY domain of human TRIM72. Proteins (2010) 0.96
Signaling pathways for TNF production induced by human aminoacyl-tRNA synthetase-associating factor, p43. Cytokine (2002) 0.96
Identification of variants in cyclin D1 ( CCND1) and B-Cell CLL/lymphoma 2 ( BCL2). J Hum Genet (2004) 0.95
Extracellular ATP is generated by ATP synthase complex in adipocyte lipid rafts. Exp Mol Med (2004) 0.95
Activation of mitogen-activated protein kinases in hamster brains infected with 263K scrapie agent. J Neurochem (2005) 0.95
Proteome analysis of adipocyte lipid rafts reveals that gC1qR plays essential roles in adipogenesis and insulin signal transduction. Proteomics (2009) 0.95
Lipid rafts are required for efficient signal transduction by CD1d. Biochem Biophys Res Commun (2005) 0.94
NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1. J Biol Chem (2007) 0.94
Expression of angiogenic factor Cyr61 during neuronal cell death via the activation of c-Jun N-terminal kinase and serum response factor. J Biol Chem (2003) 0.94
Lipid raft proteome reveals that oxidative phosphorylation system is associated with the plasma membrane. Expert Rev Proteomics (2010) 0.94
The pathogenic mechanisms of prion diseases. Mech Ageing Dev (2002) 0.94
Pleckstrin homology domains of phospholipase C-gamma1 directly interact with beta-tubulin for activation of phospholipase C-gamma1 and reciprocal modulation of beta-tubulin function in microtubule assembly. J Biol Chem (2004) 0.94
Effect of transition metals (Mn, Cu, Fe) and deoxycholic acid (DA) on the conversion of PrPC to PrPres. FASEB J (2005) 0.94
The involvement of cellular prion protein in the autophagy pathway in neuronal cells. Mol Cell Neurosci (2008) 0.93
Epigallocatechin-3-gallate increases intracellular [Ca2+] in U87 cells mainly by influx of extracellular Ca2+ and partly by release of intracellular stores. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.93
Positive feedback regulation between phospholipase D and Wnt signaling promotes Wnt-driven anchorage-independent growth of colorectal cancer cells. PLoS One (2010) 0.93
Polymorphisms of the prion protein gene (PRNP) in a Korean population. J Hum Genet (2004) 0.93
α-synuclein in the inner retina in parkinson disease. Ann Neurol (2014) 0.93