Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver.

Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis. Genes Dev (2008) 4.93

Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing. Nucleic Acids Res (2008) 4.08

Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine. Hepatology (2010) 2.10

Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers. Genome Res (2009) 1.89

Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways. J Mol Endocrinol (2008) 1.89

A global view of transcriptional regulation by nuclear receptors: gene expression, factor localization, and DNA sequence analysis. Nucl Recept Signal (2008) 1.62

Unbiased, genome-wide in vivo mapping of transcriptional regulatory elements reveals sex differences in chromatin structure associated with sex-specific liver gene expression. Mol Cell Biol (2010) 1.45

The genome landscape of ERalpha- and ERbeta-binding DNA regions. Proc Natl Acad Sci U S A (2008) 1.27

PPARγ and the global map of adipogenesis and beyond. Trends Endocrinol Metab (2014) 1.26

3D shortcuts to gene regulation. Curr Opin Cell Biol (2010) 1.25

Research resource: whole-genome estrogen receptor α binding in mouse uterine tissue revealed by ChIP-seq. Mol Endocrinol (2012) 1.20

Glucocorticoid receptor activation of the Ciz1-Lcn2 locus by long range interactions. J Biol Chem (2009) 1.15

Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction. J Biol Chem (2010) 1.04

Farnesoid X receptor activation mediates head-to-tail chromatin looping in the Nr0b2 gene encoding small heterodimer partner. Mol Endocrinol (2010) 1.04

Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation. PPAR Res (2010) 0.98

Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. PLoS One (2012) 0.96

Expanded methyl-sensitive cut counting reveals hypomethylation as an epigenetic state that highlights functional sequences of the genome. Proc Natl Acad Sci U S A (2011) 0.96

Multiple sequence-specific DNA-binding proteins mediate estrogen receptor signaling through a tethering pathway. Mol Endocrinol (2011) 0.95

Estrogen receptor-mediated regulation of microRNA inhibits proliferation of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2012) 0.94

Early B cell factor 1 regulates adipocyte morphology and lipolysis in white adipose tissue. Cell Metab (2014) 0.90

Genome-wide binding and transcriptome analysis of human farnesoid X receptor in primary human hepatocytes. PLoS One (2014) 0.89

Signal transducer and activator of transcription 3-stimulated hypoxia inducible factor-1alpha mediates estrogen receptor-alpha-induced mesenchymal stem cell vascular endothelial growth factor production. J Thorac Cardiovasc Surg (2009) 0.88

Nuclear receptors reverse McGarry's vicious cycle to insulin resistance. Cell Metab (2012) 0.87

Tetradian oscillation of estrogen receptor α is necessary to prevent liver lipid deposition. Proc Natl Acad Sci U S A (2012) 0.86

An innovative method to classify SERMs based on the dynamics of estrogen receptor transcriptional activity in living animals. Mol Endocrinol (2010) 0.85

Genome-wide analysis of BP1 transcriptional targets in breast cancer cell line Hs578T. Int J Biol Sci (2008) 0.85

Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches. Front Physiol (2012) 0.84

Quantitative nanoproteomics for protein complexes (QNanoPX) related to estrogen transcriptional action. Mol Cell Proteomics (2009) 0.84

ORegAnno 3.0: a community-driven resource for curated regulatory annotation. Nucleic Acids Res (2015) 0.82

An Essential Role for Liver ERα in Coupling Hepatic Metabolism to the Reproductive Cycle. Cell Rep (2016) 0.79

Research resource: The estrogen receptor α cistrome defined by DamIP. Mol Endocrinol (2011) 0.79

Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis. Int J Endocrinol (2015) 0.79

Regulation of the F11, Klkb1, Cyp4v3 gene cluster in livers of metabolically challenged mice. PLoS One (2013) 0.77

The Estrogen Receptor α-Cistrome Beyond Breast Cancer. Mol Endocrinol (2016) 0.76

Metabolic outcome of female mice exposed to a mixture of low-dose pollutants in a diet-induced obesity model. PLoS One (2015) 0.76

Research resource: Aorta- and liver-specific ERα-binding patterns and gene regulation by estrogen. Mol Endocrinol (2014) 0.76

Hepatic estrogen receptor α is critical for regulation of gluconeogenesis and lipid metabolism in males. Sci Rep (2017) 0.75

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09

Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19

Applied bioinformatics for the identification of regulatory elements. Nat Rev Genet (2004) 9.96

JASPAR 2010: the greatly expanded open-access database of transcription factor binding profiles. Nucleic Acids Res (2009) 9.42

JASPAR, the open access database of transcription factor-binding profiles: new content and tools in the 2008 update. Nucleic Acids Res (2007) 8.79

A promoter-level mammalian expression atlas. Nature (2014) 6.25

JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles. Nucleic Acids Res (2013) 6.12

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02

Estrogen receptors: how do they signal and what are their targets. Physiol Rev (2007) 5.27

A new generation of JASPAR, the open-access repository for transcription factor binding site profiles. Nucleic Acids Res (2006) 4.32

Principles for modulation of the nuclear receptor superfamily. Nat Rev Drug Discov (2004) 4.19

Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis. Genome Res (2011) 3.81

Hidden layers of human small RNAs. BMC Genomics (2008) 3.31

Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe. PLoS One (2008) 3.09

Metazoan promoters: emerging characteristics and insights into transcriptional regulation. Nat Rev Genet (2012) 2.92

Estrogen signaling: a subtle balance between ER alpha and ER beta. Mol Interv (2003) 2.88

Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells. Genome Biol (2004) 2.77

A code for transcription initiation in mammalian genomes. Genome Res (2007) 2.71

Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D. Proc Natl Acad Sci U S A (2004) 2.64

Genome-wide detection and analysis of hippocampus core promoters using DeepCAGE. Genome Res (2008) 2.60

Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science (2002) 2.45

Estrogen receptor (ER)-beta reduces ERalpha-regulated gene transcription, supporting a "ying yang" relationship between ERalpha and ERbeta in mice. Mol Endocrinol (2003) 2.38

International Union of Pharmacology. LXIV. Estrogen receptors. Pharmacol Rev (2006) 2.15

Polyadenylation site-induced decay of upstream transcripts enforces promoter directionality. Nat Struct Mol Biol (2013) 2.11

Estrogen receptor beta: an overview and update. Nucl Recept Signal (2008) 1.97

An estrogen-dependent four-gene micronet regulating social recognition: a study with oxytocin and estrogen receptor-alpha and -beta knockout mice. Proc Natl Acad Sci U S A (2003) 1.93

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science (2015) 1.91

Transcriptional and structural impact of TATA-initiation site spacing in mammalian core promoters. Genome Biol (2006) 1.87

Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells. Cell Stem Cell (2009) 1.84

An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci U S A (2002) 1.82

Reflections on the discovery and significance of estrogen receptor beta. Endocr Rev (2005) 1.75

Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol (2004) 1.74

Estrogen increases locomotor activity in mice through estrogen receptor alpha: specificity for the type of activity. Endocrinology (2003) 1.73

Transcriptional corepression by SHP: molecular mechanisms and physiological consequences. Trends Endocrinol Metab (2005) 1.71

ERBB2 amplification is superior to protein expression status in predicting patient outcome in serous ovarian carcinoma. Gynecol Oncol (2004) 1.70

The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis. Endocrinology (2005) 1.69

Estrogen receptors ER alpha and ER beta in proliferation in the rodent mammary gland. Proc Natl Acad Sci U S A (2004) 1.66

Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration. Proc Natl Acad Sci U S A (2002) 1.65

Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene (2005) 1.65

Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium. Proc Natl Acad Sci U S A (2002) 1.63

The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism. J Biol Chem (2003) 1.61

Liver X receptor in cholesterol metabolism. J Endocrinol (2009) 1.59

Gateways to the FANTOM5 promoter level mammalian expression atlas. Genome Biol (2015) 1.58

Increased estrogen receptor betacx expression during mammary carcinogenesis. Clin Cancer Res (2005) 1.56

PROMoter uPstream Transcripts share characteristics with mRNAs and are produced upstream of all three major types of mammalian promoters. Nucleic Acids Res (2011) 1.56

Gut flora, Toll-like receptors and nuclear receptors: a tripartite communication that tunes innate immunity in large intestine. Cell Microbiol (2007) 1.55

Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses. Nat Med (2009) 1.54

The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk. Carcinogenesis (2002) 1.53

Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha. Proc Natl Acad Sci U S A (2006) 1.53

The diversity of sex steroid action: regulation of metabolism by estrogen signaling. J Endocrinol (2011) 1.52

Isoflavone treatment for acute menopausal symptoms. Menopause (2007) 1.52

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response. Genes Dev (2010) 1.52

Cross species comparison of C/EBPα and PPARγ profiles in mouse and human adipocytes reveals interdependent retention of binding sites. BMC Genomics (2011) 1.52

False positives in MALDI-TOF detection of ERbeta in mitochondria. Biochem Biophys Res Commun (2006) 1.51

Evolutionary turnover of mammalian transcription start sites. Genome Res (2006) 1.51

Estrogen receptor beta regulates epithelial cellular differentiation in the mouse ventral prostate. Proc Natl Acad Sci U S A (2004) 1.51

Biogenic mechanisms and utilization of small RNAs derived from human protein-coding genes. Nat Struct Mol Biol (2011) 1.51

Role of estrogen receptor beta in colonic epithelium. Proc Natl Acad Sci U S A (2006) 1.49

Dragon ERE Finder version 2: A tool for accurate detection and analysis of estrogen response elements in vertebrate genomes. Nucleic Acids Res (2003) 1.49

Disruption of estrogen receptor beta gene impairs spatial learning in female mice. Proc Natl Acad Sci U S A (2002) 1.47

Lack of functional estrogen receptor beta influences anxiety behavior and serotonin content in female mice. Physiol Behav (2004) 1.45

Putative metabolic effects of the liver X receptor (LXR). Diabetes (2004) 1.44

Adipose tissue microRNAs as regulators of CCL2 production in human obesity. Diabetes (2012) 1.44

Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain. Proc Natl Acad Sci U S A (2003) 1.44

ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress. J Biol Chem (2002) 1.44

Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity (2012) 1.44

Regulation of postnatal lung development and homeostasis by estrogen receptor beta. Mol Cell Biol (2003) 1.44

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function. J Biol Chem (2005) 1.44

Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death. J Biol Chem (2002) 1.43

The complexity of the mammalian transcriptome. J Physiol (2006) 1.43

Estrogen receptor (ER) beta modulates ERalpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promoters. Mol Endocrinol (2005) 1.42

Dynamic usage of transcription start sites within core promoters. Genome Biol (2006) 1.41

Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors. J Clin Endocrinol Metab (2004) 1.41

Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters. Mol Cell Biol (2005) 1.40

Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice. Am J Physiol Endocrinol Metab (2008) 1.40

Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells. Cancer Res (2009) 1.40

Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice. Proc Natl Acad Sci U S A (2005) 1.40

Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation. Oncogene (2003) 1.39

Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis. J Biol Chem (2002) 1.39

Enterococcus faecalis from newborn babies regulate endogenous PPARgamma activity and IL-10 levels in colonic epithelial cells. Proc Natl Acad Sci U S A (2008) 1.38

Lung dysfunction causes systemic hypoxia in estrogen receptor beta knockout (ERbeta-/-) mice. Proc Natl Acad Sci U S A (2006) 1.37

Analysis of the DNA methylome and transcriptome in granulopoiesis reveals timed changes and dynamic enhancer methylation. Blood (2014) 1.36

Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3. Mol Endocrinol (2006) 1.36

Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis. Carcinogenesis (2004) 1.36

Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β. PLoS One (2012) 1.36

Estrogen receptor beta inhibits angiogenesis and growth of T47D breast cancer xenografts. Cancer Res (2006) 1.35

Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cells. Cancer Res (2007) 1.35

Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma. PLoS Genet (2008) 1.35

Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha. J Biol Chem (2002) 1.35

Estrogen receptor and aryl hydrocarbon receptor signaling pathways. Nucl Recept Signal (2006) 1.35

Accumulation of foam cells in liver X receptor-deficient mice. Circulation (2002) 1.34

A role for epithelial-mesenchymal transition in the etiology of benign prostatic hyperplasia. Proc Natl Acad Sci U S A (2009) 1.33

Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha. J Biol Chem (2003) 1.33