Published in Oncogene on October 15, 2007
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature (2014) 2.33
Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell (2013) 2.32
Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science (2016) 2.11
Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages. EMBO J (2010) 1.82
WT1 mutations in T-ALL. Blood (2009) 1.75
Genetic and environmental pathways to complex diseases. BMC Syst Biol (2009) 1.67
DNA secondary structures and epigenetic determinants of cancer genome evolution. Nat Struct Mol Biol (2011) 1.56
Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity. J Clin Invest (2012) 1.47
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Nat Immunol (2010) 1.28
Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia. Proc Natl Acad Sci U S A (2010) 1.27
Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents. Proc Natl Acad Sci U S A (2010) 1.25
SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature. PLoS One (2013) 1.25
Regulation of immune responses and tolerance: the microRNA perspective. Immunol Rev (2013) 1.18
T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell. Proc Natl Acad Sci U S A (2010) 1.13
Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia. Blood (2009) 1.11
The two faces of FBW7 in cancer drug resistance. Bioessays (2011) 1.08
NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J Exp Med (2010) 1.06
Mediator subunit 12 is required for neutrophil development in zebrafish. PLoS One (2011) 0.96
Dominant-negative mechanism of leukemogenic PAX5 fusions. Oncogene (2011) 0.95
Erythro-megakaryocytic transcription factors associated with hereditary anemia. Blood (2014) 0.95
HTLV-1 HBZ protein deregulates interactions between cellular factors and the KIX domain of p300/CBP. J Mol Biol (2011) 0.94
Upregulation of DLX5 promotes ovarian cancer cell proliferation by enhancing IRS-2-AKT signaling. Cancer Res (2010) 0.94
Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia. Haematologica (2010) 0.91
The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis. J Exp Med (2010) 0.91
Fine-tuning of hematopoietic stem cell homeostasis: novel role for ubiquitin ligase. Genes Dev (2008) 0.91
A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets. Oncotarget (2014) 0.88
Inferring chromatin-bound protein complexes from genome-wide binding assays. Genome Res (2013) 0.87
Characterisation of genome-wide PLZF/RARA target genes. PLoS One (2011) 0.86
Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. PLoS One (2013) 0.85
Peroxisome proliferator-activated receptor gamma overexpression and knockdown: impact on human B cell lymphoma proliferation and survival. Cancer Immunol Immunother (2008) 0.82
NK-like homeodomain proteins activate NOTCH3-signaling in leukemic T-cells. BMC Cancer (2009) 0.82
Polymorphisms in microRNA target sites modulate risk of lymphoblastic and myeloid leukemias and affect microRNA binding. J Hematol Oncol (2014) 0.81
Epigenetic inactivation of TWIST2 in acute lymphoblastic leukemia modulates proliferation, cell survival and chemosensitivity. Haematologica (2011) 0.81
Myc proteins in brain tumor development and maintenance. Ups J Med Sci (2012) 0.80
Pediatric T- and NK-cell lymphomas: new biologic insights and treatment strategies. Blood Cancer J (2012) 0.80
Identification of highly methylated genes across various types of B-cell non-hodgkin lymphoma. PLoS One (2013) 0.77
Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic mice. PLoS One (2012) 0.77
Ampelopsin induces apoptosis by regulating multiple c-Myc/S-phase kinase-associated protein 2/F-box and WD repeat-containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma cells. Mol Med Rep (2014) 0.76
Validation and implementation of a method for microarray gene expression profiling of minor B-cell subpopulations in man. BMC Immunol (2014) 0.76
MYC rearrangement involving a novel non-immunoglobulin chromosomal locus in precursor B-cell acute lymphoblastic leukemia. Ann Lab Med (2012) 0.75
Targeting binding partners of the CBFβ-SMMHC fusion protein for the treatment of inversion 16 acute myeloid leukemia. Oncotarget (2016) 0.75
Prognostic Significance of the Lymphoblastic Leukemia-Derived Sequence 1 (LYL1) GeneExpression in Egyptian Patients with AcuteMyeloid Leukemia. Turk J Haematol (2014) 0.75
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science (1994) 10.45
Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes. Mol Cell Biol (1998) 10.34
The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. Cell (1985) 10.17
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med (2000) 5.04
Human aminopeptidase N is a receptor for human coronavirus 229E. Nature (1992) 3.91
Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the Children's Oncology Group. J Clin Oncol (2005) 2.97
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia. Nat Genet (2004) 2.96
Myelopoiesis in the zebrafish, Danio rerio. Blood (2001) 2.67
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms. N Engl J Med (1992) 2.64
SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol Cell (1999) 2.52
Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci U S A (1998) 2.46
The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials. Genes Dev (1991) 2.34
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. Cancer Res (1993) 2.24
Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science (1992) 2.19
Cell surface expression of v-fms-coded glycoproteins is required for transformation. Mol Cell Biol (1984) 2.09
Cellular DNA content as a predictor of response to chemotherapy in infants with unresectable neuroblastoma. N Engl J Med (1984) 2.09
Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors. Mol Cell Biol (2001) 2.03
New chromosomal translocations correlate with specific immunophenotypes of childhood acute lymphoblastic leukemia. Cell (1984) 1.99
Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. Genomics (1992) 1.99
Amplification of the gli gene in childhood sarcomas. Cancer Res (1989) 1.84
Retrovirus-mediated gene transfer of NPM-ALK causes lymphoid malignancy in mice. Blood (1997) 1.83
A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3. Proc Natl Acad Sci U S A (1995) 1.82
Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes. Proc Natl Acad Sci U S A (1997) 1.82
Characterization of human homologs of the Drosophila seven in absentia (sina) gene. Genomics (1997) 1.79
Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1). Mol Cell Biol (1994) 1.77
Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key! Blood (1993) 1.77
Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia (2012) 1.77
Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect. N Engl J Med (1986) 1.67
The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. Oncogene (1996) 1.65
Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics. Leukemia (2009) 1.63
The v-fms oncogene induces factor independence and tumorigenicity in CSF-1 dependent macrophage cell line. Nature (1987) 1.61
Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes. Cell (1988) 1.59
Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras. Proc Natl Acad Sci U S A (1993) 1.55
Detection of N-myc gene amplification by fluorescence in situ hybridization. Diagnostic utility for neuroblastoma. Am J Pathol (1993) 1.50
Residential pesticide exposure and neuroblastoma. Epidemiology (2001) 1.47
Detection of MYCN gene amplification in neuroblastoma by fluorescence in situ hybridization: a pediatric oncology group study. Neoplasia (2001) 1.44
Risk of adverse events in children completing treatment for acute lymphoblastic leukemia: St. Jude Total Therapy studies VIII, IX, and X. J Clin Oncol (1991) 1.42
Transmembrane orientation of glycoproteins encoded by the v-fms oncogene. Cell (1985) 1.41
Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia. Semin Hematol (2000) 1.40
Two-color flow cytometric measurement of DNA distributions of rat megakaryocytes in unfixed, unfractionated marrow cell suspensions. Blood (1984) 1.38
Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish. Oncogene (2008) 1.36
Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. Nat Genet (1994) 1.33
Bone-marrow transplantation in a patient with sickle-cell anemia. N Engl J Med (1984) 1.32
Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas. Cancer Res (1992) 1.31
Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization. Cancer Res (1997) 1.31
Significance of chromosome 1p loss of heterozygosity in neuroblastoma. Cancer Res (1995) 1.30
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science (1995) 1.27
Metalloprotease activity of CD13/aminopeptidase N on the surface of human myeloid cells. Blood (1990) 1.26
Identification and characterization of neogenin, a DCC-related gene. Oncogene (1997) 1.25
Splice-site mutation of the p53 gene in a family with hereditary breast-ovarian cancer. Oncogene (1994) 1.25
Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. Nature (1996) 1.24
Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study. Blood (1990) 1.20
Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias. Leukemia (2006) 1.19
DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein. Mol Cell Biol (1994) 1.19
Transcription of the human colony-stimulating factor-1 receptor gene is regulated by separate tissue-specific promoters. Blood (1992) 1.19
Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes. Mol Cell Biol (1999) 1.18
Natural history and biology of stage A neuroblastoma: a Pediatric Oncology Group Study. J Pediatr Hematol Oncol (2000) 1.17
NOTCH1-induced T-cell leukemia in transgenic zebrafish. Leukemia (2007) 1.15
Improved outcome in childhood acute lymphoblastic leukaemia with reinforced early treatment and rotational combination chemotherapy. Lancet (1991) 1.15
Clinical significance of CD34 expression in childhood acute lymphoblastic leukemia. Blood (1993) 1.14
Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia. Blood (1990) 1.14
Aneuploidy and percentage of S-phase cells determined by flow cytometry correlate with cell phenotype in childhood acute leukemia. Blood (1982) 1.13
Aminopeptidase N is directly sorted to the apical domain in MDCK cells. J Cell Biol (1990) 1.09
Genetic staging of unresectable or metastatic neuroblastoma in infants: a Pediatric Oncology Group study. J Natl Cancer Inst (1997) 1.05
Lack of correlation of N-myc gene amplification with prognosis in localized neuroblastoma: a Pediatric Oncology Group study. Cancer Res (1995) 1.05
Prognostic importance of structural chromosomal abnormalities in children with hyperdiploid (greater than 50 chromosomes) acute lymphoblastic leukemia. Blood (1989) 1.04
Biological variables in thoracic neuroblastoma: a Pediatric Oncology Group study. J Pediatr Surg (1995) 1.04
Effects of the epipodophyllotoxin VP-16-213 on cell cycle traverse, DNA synthesis, and DNA strand size in cultures of human leukemic lymphoblasts. Cancer Res (1983) 1.04
Prognostic importance of blast cell DNA content in childhood acute lymphoblastic leukemia. Blood (1985) 1.03
Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1). Gene (1999) 1.03
Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency. Leukemia (2012) 1.03
Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells. J Biol Chem (1991) 1.02
Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. Cell Growth Differ (1999) 1.01
A novel treatment of childhood lymphoblastic non-Hodgkin's lymphoma: early and intermittent use of teniposide plus cytarabine. Blood (1985) 1.01
Prognostic significance of age, MYCN oncogene amplification, tumor cell ploidy, and histology in 110 infants with stage D(S) neuroblastoma: the pediatric oncology group experience--a pediatric oncology group study. J Clin Oncol (1998) 1.01
Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb. Leukemia (2010) 1.00
Molecular cloning, expression, and chromosomal localization of a human gene encoding the CD33 myeloid differentiation antigen. Blood (1988) 1.00
The chimeric E2A-HLF transcription factor abrogates p53-induced apoptosis in myeloid leukemia cells. Blood (1998) 1.00
Chromosomal localization and cDNA cloning of the human DBP and TEF genes. Genomics (1994) 1.00
Hypodiploidy is associated with a poor prognosis in childhood acute lymphoblastic leukemia. Blood (1987) 1.00
Oncogene amplification in pediatric brain tumors. Cancer Res (1990) 0.99
New recurring chromosomal translocations in childhood acute lymphoblastic leukemia. Blood (1991) 0.99
E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF. Mol Cell Biol (1995) 0.99
Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. Genomics (1996) 0.98
p27KIP1 deletions in childhood acute lymphoblastic leukemia. Neoplasia (1999) 0.97
Deletion of the zinc-binding motif of CD13/aminopeptidase N molecules results in loss of epitopes that mediate binding of inhibitory antibodies. Blood (1992) 0.97
Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family. Dev Biol (1997) 0.96
Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line. Genomics (1995) 0.96
Arsenic and apoptosis in the treatment of acute promyelocytic leukemia. J Natl Cancer Inst (1998) 0.96
A new recurrent 9q34 duplication in pediatric T-cell acute lymphoblastic leukemia. Leukemia (2006) 0.95
Hyperdiploidy and chromosomal rearrangements define the anaplastic variant of Wilms' tumor. J Clin Oncol (1986) 0.95
Molecular cloning, expression, and chromosomal localization of the gene encoding a human myeloid membrane antigen (gp150). J Clin Invest (1986) 0.95
BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals. Cell Death Differ (2008) 0.95