Published in BMC Syst Biol on May 05, 2009
The Comparative Toxicogenomics Database: update 2011. Nucleic Acids Res (2010) 3.15
Improving the human hazard characterization of chemicals: a Tox21 update. Environ Health Perspect (2013) 2.95
MEDIC: a practical disease vocabulary used at the Comparative Toxicogenomics Database. Database (Oxford) (2012) 2.35
The curation paradigm and application tool used for manual curation of the scientific literature at the Comparative Toxicogenomics Database. Database (Oxford) (2011) 1.73
Predicting environmental chemical factors associated with disease-related gene expression data. BMC Med Genomics (2010) 1.55
Toxicogenomic profiling of chemically exposed humans in risk assessment. Mutat Res (2010) 1.30
Perspectives on validation of high-throughput assays supporting 21st century toxicity testing. ALTEX (2013) 1.19
Exposome informatics: considerations for the design of future biomedical research information systems. J Am Med Inform Assoc (2013) 1.07
DiseaseComps: a metric that discovers similar diseases based upon common toxicogenomic profiles at CTD. Bioinformation (2011) 1.03
A genome-wide association scan on estrogen receptor-negative breast cancer. Breast Cancer Res (2010) 1.02
The implications of relationships between human diseases and metabolic subpathways. PLoS One (2011) 0.94
Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water. Crit Rev Toxicol (2015) 0.94
Protocol of the baseline assessment for the Environments for Healthy Living (EHL) Wales cohort study. BMC Public Health (2010) 0.91
Application of computational systems biology to explore environmental toxicity hazards. Environ Health Perspect (2011) 0.91
Preferential regulation of miRNA targets by environmental chemicals in the human genome. BMC Genomics (2011) 0.91
Targeted journal curation as a method to improve data currency at the Comparative Toxicogenomics Database. Database (Oxford) (2012) 0.90
Considerations for Using Genetic and Epigenetic Information in Occupational Health Risk Assessment and Standard Setting. J Occup Environ Hyg (2015) 0.86
Using bioinformatic approaches to identify pathways targeted by human leukemogens. Int J Environ Res Public Health (2012) 0.81
Modeling autism: a systems biology approach. J Clin Bioinforma (2012) 0.79
Analysis of the transcriptome in molecular epidemiology studies. Environ Mol Mutagen (2013) 0.79
Genomics era and complex disorders: Implications of GWAS with special reference to coronary artery disease, type 2 diabetes mellitus, and cancers. J Postgrad Med (2016) 0.79
Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research. Environ Health Perspect (2015) 0.78
Aquatic models, genomics and chemical risk management. Comp Biochem Physiol C Toxicol Pharmacol (2011) 0.78
Application of biclustering of gene expression data and gene set enrichment analysis methods to identify potentially disease causing nanomaterials. Beilstein J Nanotechnol (2015) 0.76
In vitro Toxicity Testing in the Twenty-First Century. Front Pharmacol (2011) 0.75
The Use of Signal-Transduction and Metabolic Pathways to Predict Human Disease Targets from Electric and Magnetic Fields Using in vitro Data in Human Cell Lines. Front Public Health (2016) 0.75
Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A (1998) 192.97
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46
Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res (2003) 103.76
Collective dynamics of 'small-world' networks. Nature (1998) 98.45
Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med (2006) 49.95
From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res (2006) 44.35
TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes. Nucleic Acids Res (2006) 22.20
The human disease network. Proc Natl Acad Sci U S A (2007) 19.58
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet (2007) 12.13
The genetic association database. Nat Genet (2004) 11.29
A human phenome-interactome network of protein complexes implicated in genetic disorders. Nat Biotechnol (2007) 9.90
Mendelian Inheritance in Man and its online version, OMIM. Am J Hum Genet (2007) 9.61
Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw (2006) 7.19
Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication study. JAMA (2007) 7.12
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet (2008) 6.71
The many faces of PPARgamma. Cell (2005) 6.24
Creation and implications of a phenome-genome network. Nat Biotechnol (2006) 5.79
Transcription factors in myeloid development: balancing differentiation with transformation. Nat Rev Immunol (2007) 4.27
Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks. Nucleic Acids Res (2008) 3.19
Retinaldehyde represses adipogenesis and diet-induced obesity. Nat Med (2007) 3.18
Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 2001-02. Vital Health Stat 13 (2006) 3.07
Risk of childhood leukemia associated with exposure to pesticides and with gene polymorphisms. Epidemiology (1999) 2.85
Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. PLoS Genet (2006) 2.80
Predicting tissue-specific enhancers in the human genome. Genome Res (2007) 2.72
The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. Lancet (2004) 2.59
Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways. Hum Mol Genet (2007) 2.55
Network-based analysis of affected biological processes in type 2 diabetes models. PLoS Genet (2007) 2.54
The link between abdominal obesity, metabolic syndrome and cardiovascular disease. Nutr Metab Cardiovasc Dis (2006) 2.47
Uncertainties for endocrine disrupters: our view on progress. Toxicol Sci (2003) 2.36
Mendelian disorders deserve more attention. Nat Rev Genet (2006) 2.36
Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature (2005) 2.29
Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes. Diabetologia (2005) 2.03
The comparative toxicogenomics database: a cross-species resource for building chemical-gene interaction networks. Toxicol Sci (2006) 2.00
Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. Mol Psychiatry (2004) 1.95
Design and analysis issues in genome-wide somatic mutation studies of cancer. Genomics (2008) 1.95
Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc Natl Acad Sci U S A (2008) 1.87
Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG (2006) 1.78
Dopamine activation of an orphan of the steroid receptor superfamily. Science (1991) 1.78
A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation. Proc Natl Acad Sci U S A (1999) 1.73
Variance-modeled posterior inference of microarray data: detecting gene-expression changes in 3T3-L1 adipocytes. Bioinformatics (2004) 1.65
Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice. Diabetes (2006) 1.64
Characterization of the proneural gene regulatory network during mouse telencephalon development. BMC Biol (2008) 1.59
Mechanisms of transcription factor deregulation in lymphoid cell transformation. Oncogene (2007) 1.56
Gene expression changes in children with autism. Genomics (2007) 1.55
Emerging roles for zic genes in early development. Dev Dyn (2007) 1.49
Inflammation-related genes up-regulated in schizophrenia brains. BMC Psychiatry (2007) 1.43
A gene expression biomarker provides early prediction and mechanistic assessment of hepatic tumor induction by nongenotoxic chemicals. Toxicol Sci (2007) 1.41
Efficacy and safety of a new HMG-CoA reductase inhibitor, atorvastatin, in patients with hypertriglyceridemia. JAMA (1996) 1.29
A screen for downstream effectors of Neurogenin2 in the embryonic neocortex. Dev Biol (2004) 1.24
Gene-environment interactions in asthma and other respiratory diseases. Annu Rev Med (2005) 1.15
Risk of childhood leukemia associated with diagnostic irradiation and polymorphisms in DNA repair genes. Environ Health Perspect (2000) 1.13
Choosing the right path: enhancement of biologically relevant sets of genes or proteins using pathway structure. Genome Biol (2009) 1.13
Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats. Toxicology (2008) 1.11
Peroxisome proliferator-activated receptors: how their effects on macrophages can lead to the development of a new drug therapy against atherosclerosis. Annu Rev Pharmacol Toxicol (2006) 1.05
Global effects of vitamin A deficiency on gene expression in rat liver: evidence for hypoandrogenism. J Nutr Biochem (2005) 1.04
Obesity and related metabolic abnormalities during antipsychotic drug administration: mechanisms, management and research perspectives. Pharmacopsychiatry (2002) 1.01
The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes. Toxicol Sci (2006) 0.97
A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity. Mol Pharmacol (2007) 0.95
Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs. Dev Biol (2003) 0.92
Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide. Mol Cancer Ther (2006) 0.90
N-3 PUFAs modulate global gene expression profile in cultured rat cardiomyocytes. Implications in cardiac hypertrophy and heart failure. FEBS Lett (2007) 0.90
Subtoxic chlorpyrifos treatment resulted in differential expression of genes implicated in neurological functions and development. Arch Toxicol (2008) 0.88
Myocyte enhancer factor 2C upregulates MASH-1 expression and induces neurogenesis in P19 cells. FEBS Lett (2000) 0.85
Foxl1 null mice have abnormal intestinal epithelia, postnatal growth retardation, and defective intestinal glucose uptake. Am J Physiol Gastrointest Liver Physiol (2004) 0.84
Monocyte gene-expression profile in men with familial combined hyperlipidemia and its modification by atorvastatin treatment. Pharmacogenomics (2008) 0.83
Update on fenofibrate. Cardiovasc Drug Rev (2002) 0.83
NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-Hexyl Phthalate (DnHP). NTP CERHR MON (2003) 0.78
Genomics and public health in the United States: signposts on the translation highway. Community Genet (2006) 0.77
A new polymorphic site located in the human UCP1 gene controls the in vitro binding of CREB-like factor. Int J Obes Relat Metab Disord (2002) 0.77
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
The genetic association database. Nat Genet (2004) 11.29
Analysis of microarray data using Z score transformation. J Mol Diagn (2003) 6.82
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22
LincRNA-p21 suppresses target mRNA translation. Mol Cell (2012) 3.87
Global analysis of stress-regulated mRNA turnover by using cDNA arrays. Proc Natl Acad Sci U S A (2002) 3.71
RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron (2003) 3.58
Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet (2006) 3.34
AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22
Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks. Nucleic Acids Res (2008) 3.19
The Comparative Toxicogenomics Database: update 2011. Nucleic Acids Res (2010) 3.15
Compound cytotoxicity profiling using quantitative high-throughput screening. Environ Health Perspect (2008) 3.11
White spot syndromes of the retina: a hypothesis based on the common genetic hypothesis of autoimmune/inflammatory disease. Am J Ophthalmol (2003) 2.97
Text mining and manual curation of chemical-gene-disease networks for the comparative toxicogenomics database (CTD). BMC Bioinformatics (2009) 2.72
The Comparative Toxicogenomics Database: update 2013. Nucleic Acids Res (2012) 2.72
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
MicroRNA expression and identification of putative miRNA targets in ovarian cancer. PLoS One (2008) 2.60
Application of z-score transformation to Affymetrix data. Appl Bioinformatics (2003) 2.56
MEDIC: a practical disease vocabulary used at the Comparative Toxicogenomics Database. Database (Oxford) (2012) 2.35
Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability. BMC Genomics (2005) 2.18
Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells. Immunity (2009) 2.11
The comparative toxicogenomics database: a cross-species resource for building chemical-gene interaction networks. Toxicol Sci (2006) 2.00
Temperature, air pollution, and hospitalization for cardiovascular diseases among elderly people in Denver. Environ Health Perspect (2003) 1.99
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci U S A (2009) 1.91
Weight loss through living well: translating an effective lifestyle intervention into clinical practice. Diabetes Educ (2009) 1.90
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res (2012) 1.85
The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study. BMC Med Genomics (2008) 1.82
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study. Schizophr Res (2002) 1.76
The curation paradigm and application tool used for manual curation of the scientific literature at the Comparative Toxicogenomics Database. Database (Oxford) (2011) 1.73
VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats. J Clin Invest (2008) 1.68
Collaborative biocuration--text-mining development task for document prioritization for curation. Database (Oxford) (2012) 1.67
Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess. Endocrinology (2007) 1.59
A CTD-Pfizer collaboration: manual curation of 88,000 scientific articles text mined for drug-disease and drug-phenotype interactions. Database (Oxford) (2013) 1.59
The association between biomarker-based exposure estimates for phthalates and demographic factors in a human reference population. Environ Health Perspect (2002) 1.59
Characterization of the proneural gene regulatory network during mouse telencephalon development. BMC Biol (2008) 1.59
A signal-to-noise crossover dose as the point of departure for health risk assessment. Environ Health Perspect (2011) 1.58
Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information. BMC Med Genomics (2010) 1.57
Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J (2009) 1.52
Rule-based human gene normalization in biomedical text with confidence estimation. Comput Syst Bioinformatics Conf (2007) 1.51
Stability regulation of mRNA and the control of gene expression. Ann N Y Acad Sci (2005) 1.46
Estimating the global public health implications of electricity and coal consumption. Environ Health Perspect (2011) 1.42
Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes. Glia (2013) 1.37
VENNTURE--a novel Venn diagram investigational tool for multiple pharmacological dataset analysis. PLoS One (2012) 1.36
Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender. Genome Biol (2007) 1.35
Age-related changes in microRNA levels in serum. Aging (Albany NY) (2013) 1.35
Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation. J Exp Med (2010) 1.33
The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells. Oncogene (2003) 1.30
Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates. J Neurochem (2008) 1.30
Evaluation of toxic equivalency factors for induction of cytochromes P450 CYP1A1 and CYP1A2 enzyme activity by dioxin-like compounds. Toxicol Appl Pharmacol (2004) 1.29
Dose-additive carcinogenicity of a defined mixture of "dioxin-like compounds". Environ Health Perspect (2005) 1.29
Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging. Immunol Rev (2005) 1.28
Text mining effectively scores and ranks the literature for improving chemical-gene-disease curation at the comparative toxicogenomics database. PLoS One (2013) 1.28
GeneComps and ChemComps: a new CTD metric to identify genes and chemicals with shared toxicogenomic profiles. Bioinformation (2009) 1.27
Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice. Neurobiol Aging (2008) 1.22
Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation. EMBO J (2011) 1.21
Enhanced translation by Nucleolin via G-rich elements in coding and non-coding regions of target mRNAs. Nucleic Acids Res (2011) 1.21
Increased fibronectin expression in sturge-weber syndrome fibroblasts and brain tissue. Pediatr Res (2003) 1.21
Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway. Proc Natl Acad Sci U S A (2009) 1.18
Dynamic BRG1 recruitment during T helper differentiation and activation reveals distal regulatory elements. Mol Cell Biol (2011) 1.17
A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development. J Pathol (2014) 1.17
iTRAQ analysis of complex proteome alterations in 3xTgAD Alzheimer's mice: understanding the interface between physiology and disease. PLoS One (2008) 1.16
FACS purification of immunolabeled cell types from adult rat brain. J Neurosci Methods (2011) 1.15
Nontelomeric TRF2-REST interaction modulates neuronal gene silencing and fate of tumor and stem cells. Curr Biol (2008) 1.14
Application of a mathematical model to describe the effects of chlorpyrifos on Caenorhabditis elegans development. PLoS One (2009) 1.14
Gene expression profiling of oxidative stress on atrial fibrillation in humans. Exp Mol Med (2003) 1.14
Transcriptome analysis of age-, gender- and diet-associated changes in murine thymus. Cell Immunol (2007) 1.14
Choosing the right path: enhancement of biologically relevant sets of genes or proteins using pathway structure. Genome Biol (2009) 1.13
Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues. Exp Cell Res (2006) 1.13
Protein kinase A isozyme switching: eliciting differential cAMP signaling and tumor reversion. Oncogene (2004) 1.12
Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity. Gene Expr (2004) 1.12
A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells. PLoS One (2009) 1.11
CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes. PLoS One (2011) 1.11
Identification of transformation-related pathways in a breast epithelial cell model using a ribonomics approach. Cancer Res (2008) 1.11
Global gene expression profiling of a population exposed to a range of benzene levels. Environ Health Perspect (2010) 1.10
CREB phosphorylation regulates striatal transcriptional responses in the self-administration model of methamphetamine addiction in the rat. Neurobiol Dis (2013) 1.10
Identification and analysis of plasticity-induced late-response genes. Proc Natl Acad Sci U S A (2004) 1.10
A rapid method for microarray cross platform comparisons using gene expression signatures. Mol Cell Probes (2006) 1.09
Senescence-associated lncRNAs: senescence-associated long noncoding RNAs. Aging Cell (2013) 1.09
MyD88 expression by CNS-resident cells is pivotal for eliciting protective immunity in brain abscesses. ASN Neuro (2009) 1.09
Time-dependent c-Myc transactomes mapped by Array-based nuclear run-on reveal transcriptional modules in human B cells. PLoS One (2010) 1.08
Ignoring and adding errors do not improve the science. Carcinogenesis (2013) 1.07
A mechanism for the inhibition of neural progenitor cell proliferation by cocaine. PLoS Med (2008) 1.07
Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males. PLoS One (2008) 1.07
Development of a highly specialized cDNA array for the study and diagnosis of epithelial ovarian cancer. Cancer Res (2002) 1.07
Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation. Toxicol Sci (2007) 1.07
Microarray analysis reveals interleukin-6 as a novel secretory product of the hypothalamo-neurohypophyseal system. J Biol Chem (2003) 1.07
Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One (2010) 1.06
Methamphetamine causes differential alterations in gene expression and patterns of histone acetylation/hypoacetylation in the rat nucleus accumbens. PLoS One (2012) 1.06