Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.

PubWeight™: 1.47‹?› | Rank: Top 5%

🔗 View Article (PMC 3461907)

Published in J Clin Invest on September 10, 2012

Authors

Kirby D Johnson1, Amy P Hsu, Myung-Jeom Ryu, Jinyong Wang, Xin Gao, Meghan E Boyer, Yangang Liu, Youngsook Lee, Katherine R Calvo, Sunduz Keles, Jing Zhang, Steven M Holland, Emery H Bresnick

Author Affiliations

1: Department of Cell and Regenerative Biology, Wisconsin Institutes for Medical Research, UW Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA.

Articles citing this

GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity. Blood (2013) 2.82

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis. Nature (2015) 2.15

Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset. Blood (2013) 1.93

GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome. Blood (2013) 1.44

The evolution of cellular deficiency in GATA2 mutation. Blood (2013) 1.36

A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression. Cancer Cell (2014) 1.27

Gata2 is required for HSC generation and survival. J Exp Med (2013) 1.26

Acquired ASXL1 mutations are common in patients with inherited GATA2 mutations and correlate with myeloid transformation. Haematologica (2013) 1.17

New developments in clinical aspects of lymphatic disease. J Clin Invest (2014) 1.04

Haematopoietic and immune defects associated with GATA2 mutation. Br J Haematol (2015) 1.04

The cup runneth over: lessons from the ever-expanding pool of primary immunodeficiency diseases. Nat Rev Immunol (2013) 1.02

Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo. J Exp Med (2013) 0.99

GATA2 deficiency-associated bone marrow disorder differs from idiopathic aplastic anemia. Blood (2014) 0.95

GATA2 is required for lymphatic vessel valve development and maintenance. J Clin Invest (2015) 0.93

Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA-2. EMBO Rep (2014) 0.93

Intermediate phenotypes in patients with autosomal dominant hyper-IgE syndrome caused by somatic mosaicism. J Allergy Clin Immunol (2013) 0.92

The GATA factor revolution in hematology. Blood (2017) 0.90

Transcriptional mechanisms underlying hemoglobin synthesis. Cold Spring Harb Perspect Med (2013) 0.90

Mechanism governing a stem cell-generating cis-regulatory element. Proc Natl Acad Sci U S A (2014) 0.90

Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development (2015) 0.87

Malat1 as an evolutionarily conserved lncRNA, plays a positive role in regulating proliferation and maintaining undifferentiated status of early-stage hematopoietic cells. BMC Genomics (2015) 0.86

Hematopoietic transcriptional mechanisms: from locus-specific to genome-wide vantage points. Exp Hematol (2014) 0.84

Mechanism governing heme synthesis reveals a GATA factor/heme circuit that controls differentiation. EMBO Rep (2015) 0.82

GATA2 deficiency. Curr Opin Allergy Clin Immunol (2015) 0.82

GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2. Angiogenesis (2013) 0.80

Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome. Mol Cell (2015) 0.80

Cis-regulatory mechanisms governing stem and progenitor cell transitions. Sci Adv (2015) 0.79

Heterogeneity of GATA2-related myeloid neoplasms. Int J Hematol (2017) 0.79

Epigenetic Determinants of Erythropoiesis: Role of the Histone Methyltransferase SetD8 in Promoting Erythroid Cell Maturation and Survival. Mol Cell Biol (2015) 0.79

Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes. Mol Cancer (2015) 0.79

Histone methyltransferase Setd8 represses Gata2 expression and regulates erythroid maturation. Mol Cell Biol (2015) 0.78

Functional and molecular characterization of mouse Gata2-independent hematopoietic progenitors. Blood (2016) 0.77

Gata2 Is a Rheostat for Mesenchymal Stem Cell Fate in Male Mice. Endocrinology (2016) 0.76

GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis. Stem Cell Reports (2016) 0.75

Lymphatic vessel development: fluid flow and valve-forming cells. J Clin Invest (2015) 0.75

GATA Factor-Dependent Positive-Feedback Circuit in Acute Myeloid Leukemia Cells. Cell Rep (2016) 0.75

GATA factor mutations in hematologic disease. Blood (2017) 0.75

High-Throughput siRNA Screening to Reveal GATA-2 Upstream Transcriptional Mechanisms in Hematopoietic Cells. PLoS One (2015) 0.75

Establishment of a cell-type-specific genetic network by the mediator complex component Med1. Mol Cell Biol (2013) 0.75

A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function. Cell Rep (2016) 0.75

Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program. Cell Rep (2017) 0.75

GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia. Dev Cell (2017) 0.75

Integrating microRNA and messenger RNA expression profiles in a rat model of deep vein thrombosis. Int J Mol Med (2017) 0.75

Articles cited by this

Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol (2004) 101.91

An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature (1994) 8.60

The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J (1997) 6.36

Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest (1999) 5.65

Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med (2002) 5.07

A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J (1997) 4.61

Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med (2008) 4.55

Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome. Blood (2011) 4.21

Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell (2009) 3.96

Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood (1997) 3.95

Function of GATA transcription factors in preadipocyte-adipocyte transition. Science (2000) 3.60

A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature (2009) 3.44

Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia. Nat Genet (2011) 3.41

Transfection of a DNA locus that mediates the conversion of 10T1/2 fibroblasts to myoblasts. Cell (1986) 3.34

GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc Natl Acad Sci U S A (2003) 3.32

Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency. Blood (2011) 3.16

Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome). Nat Genet (2011) 3.05

Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia. Blood (2009) 3.00

GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. J Exp Med (2004) 2.94

Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Blood (2006) 2.67

Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood (2005) 2.47

Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells. J Biol Chem (1991) 2.37

GATA switches as developmental drivers. J Biol Chem (2010) 2.32

Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis. Blood (1999) 2.14

Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia. Proc Natl Acad Sci U S A (2008) 2.10

Distinct functions of dispersed GATA factor complexes at an endogenous gene locus. Mol Cell Biol (2006) 1.94

Myelodysplasia in autosomal dominant and sporadic monocytopenia immunodeficiency syndrome: diagnostic features and clinical implications. Haematologica (2011) 1.89

Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood (2011) 1.79

Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation. Blood (2008) 1.78

A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells. Mol Cell Biol (1990) 1.76

The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. Blood (2002) 1.76

Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. Dev Biol (1999) 1.64

CD150- cells are transiently reconstituting multipotent progenitors with little or no stem cell activity. Blood (2008) 1.57

Single-stranded DNA-binding proteins regulate the abundance of LIM domain and LIM domain-binding proteins. Genes Dev (2007) 1.57

Mechanisms of transcription factor deregulation in lymphoid cell transformation. Oncogene (2007) 1.56

A Gata2 intronic enhancer confers its pan-endothelia-specific regulation. Development (2007) 1.50

Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis. Proc Natl Acad Sci U S A (1998) 1.49

Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies. Nucleic Acids Res (2012) 1.38

The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell. J Biol Chem (2010) 1.37

The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis. Blood (1996) 1.37

High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle. Blood (2009) 1.36

Gata2 specifies serotonergic neurons downstream of sonic hedgehog. Development (2004) 1.34

GATA2 is associated with familial early-onset coronary artery disease. PLoS Genet (2006) 1.32

Targeted deletion of 5'HS1 and 5'HS4 of the beta-globin locus control region reveals additive activity of the DNaseI hypersensitive sites. Blood (2001) 1.30

Genetic framework for GATA factor function in vascular biology. Proc Natl Acad Sci U S A (2011) 1.29

GATA2 is required for the generation of V2 interneurons. Development (2000) 1.29

Molecular hallmarks of endogenous chromatin complexes containing master regulators of hematopoiesis. Mol Cell Biol (2008) 1.23

Context-dependent GATA factor function: combinatorial requirements for transcriptional control in hematopoietic and endothelial cells. J Biol Chem (2007) 1.22

A single cis element maintains repression of the key developmental regulator Gata2. PLoS Genet (2010) 1.14

Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression. EMBO J (2011) 1.13

Context-dependent function of "GATA switch" sites in vivo. Blood (2011) 1.08

Retinoid signaling regulates primitive (yolk sac) hematopoiesis. Blood (2002) 1.06

GATA-2 L359 V mutation is exclusively associated with CML progression but not other hematological malignancies and GATA-2 P250A is a novel single nucleotide polymorphism. Leuk Res (2009) 1.04

Overexpression of GATA2 predicts an adverse prognosis for patients with acute myeloid leukemia and it is associated with distinct molecular abnormalities. Leukemia (2011) 1.01

Cooperative interaction of Xvent-2 and GATA-2 in the activation of the ventral homeobox gene Xvent-1B. J Biol Chem (2002) 1.00

Defining the functional boundaries of the Gata2 locus by rescue with a linked bacterial artificial chromosome transgene. J Biol Chem (2008) 0.87

An antiangiogenic neurokinin-B/thromboxane A2 regulatory axis. J Cell Biol (2006) 0.86

The transcription factor GATA2 regulates differentiation of brown adipocytes. EMBO Rep (2005) 0.82

Articles by these authors

An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med (2007) 33.18

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

STAT3 mutations in the hyper-IgE syndrome. N Engl J Med (2007) 8.99

Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature (2008) 8.17

PlasmoDB: a functional genomic database for malaria parasites. Nucleic Acids Res (2008) 6.73

Astrocytic purinergic signaling coordinates synaptic networks. Science (2005) 6.55

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest (2003) 6.30

Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition. N Engl J Med (2006) 6.17

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature (2008) 6.04

Phanerozoic trends in the global diversity of marine invertebrates. Science (2008) 5.36

Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ Res (2003) 5.12

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature (2006) 4.80

Early-onset stroke and vasculopathy associated with mutations in ADA2. N Engl J Med (2014) 4.70

Combined immunodeficiency associated with DOCK8 mutations. N Engl J Med (2009) 4.52

Itraconazole to prevent fungal infections in chronic granulomatous disease. N Engl J Med (2003) 4.46

Pulmonary nontuberculous mycobacterial disease: prospective study of a distinct preexisting syndrome. Am J Respir Crit Care Med (2008) 4.33

Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome. Blood (2011) 4.21

Development and characterization of gemcitabine-resistant pancreatic tumor cells. Ann Surg Oncol (2007) 4.12

New world bats harbor diverse influenza A viruses. PLoS Pathog (2013) 4.10

Early repolarization pattern and risk for arrhythmia death: a meta-analysis. J Am Coll Cardiol (2013) 4.03

Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell (2009) 3.96

ToxoDB: an integrated Toxoplasma gondii database resource. Nucleic Acids Res (2007) 3.96

Eltrombopag and improved hematopoiesis in refractory aplastic anemia. N Engl J Med (2012) 3.93

An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China. Virol J (2010) 3.90

The research agenda of the National Institute of Allergy and Infectious Diseases for antimicrobial resistance. J Infect Dis (2008) 3.84

Antagonistic regulation of PIN phosphorylation by PP2A and PINOID directs auxin flux. Cell (2007) 3.84

Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems. Am J Respir Crit Care Med (2010) 3.83

Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc Natl Acad Sci U S A (2011) 3.80

TriTrypDB: a functional genomic resource for the Trypanosomatidae. Nucleic Acids Res (2009) 3.79

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell (2009) 3.75

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J (2005) 3.60

DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. Brain (2010) 3.57

Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag. Science (2013) 3.51

Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars. Nat Genet (2013) 3.41

GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc Natl Acad Sci U S A (2003) 3.32

Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension (2002) 3.23

Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J Allergy Clin Immunol (2009) 3.13

JAKs and STATs in immunity, immunodeficiency, and cancer. N Engl J Med (2013) 3.07

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling. J Cell Biol (2009) 3.04

Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia. Blood (2009) 3.00

Clinical features of dominant and recessive interferon gamma receptor 1 deficiencies. Lancet (2004) 2.90

R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res (2010) 2.87

Adult-onset immunodeficiency in Thailand and Taiwan. N Engl J Med (2012) 2.87

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med (2007) 2.85

Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression. Ann Neurol (2011) 2.84

GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity. Blood (2013) 2.82

Plant ABC proteins--a unified nomenclature and updated inventory. Trends Plant Sci (2008) 2.81

Gastrointestinal involvement in chronic granulomatous disease. Pediatrics (2004) 2.80

Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8. Nat Methods (2006) 2.71

CryptoDB: a Cryptosporidium bioinformatics resource update. Nucleic Acids Res (2006) 2.68

Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells. Glia (2005) 2.68

Residual NADPH oxidase and survival in chronic granulomatous disease. N Engl J Med (2010) 2.61

Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model. Cancer Res (2008) 2.59

Cohort study of molecular identification and typing of Mycobacterium abscessus, Mycobacterium massiliense, and Mycobacterium bolletii. J Clin Microbiol (2009) 2.58

Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria. Clin Infect Dis (2008) 2.55

HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene (2005) 2.53

MicroRNA identification based on sequence and structure alignment. Bioinformatics (2005) 2.52

ABP1 mediates auxin inhibition of clathrin-dependent endocytosis in Arabidopsis. Cell (2010) 2.51

Prevalence of nontuberculous mycobacterial lung disease in U.S. Medicare beneficiaries. Am J Respir Crit Care Med (2012) 2.44

Approaches for high internal quantum efficiency green InGaN light-emitting diodes with large overlap quantum wells. Opt Express (2011) 2.44

RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings. Cell Res (2012) 2.41

Reference values for continuous glucose monitoring in Chinese subjects. Diabetes Care (2009) 2.41

Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter. Nature (2009) 2.40

GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis. Nucleic Acids Res (2008) 2.35

Predictors of severe right ventricular failure after implantable left ventricular assist device insertion: analysis of 245 patients. Circulation (2002) 2.33

Revisiting human IL-12Rβ1 deficiency: a survey of 141 patients from 30 countries. Medicine (Baltimore) (2010) 2.33

GATA switches as developmental drivers. J Biol Chem (2010) 2.32

In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res (2007) 2.28

Both variant and IGHV4-34-expressing hairy cell leukemia lack the BRAF V600E mutation. Blood (2011) 2.28

The bone morphogenetic protein 1/Tolloid-like metalloproteinases. Matrix Biol (2007) 2.27

Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore) (2010) 2.26

Mass spectrometry based targeted protein quantification: methods and applications. J Proteome Res (2009) 2.20

Automatic detection and recognition of signs from natural scenes. IEEE Trans Image Process (2004) 2.19

The hyper-IgE syndromes. Immunol Allergy Clin North Am (2008) 2.19

X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production. J Exp Med (2006) 2.18

GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein. Proc Natl Acad Sci U S A (2008) 2.17

Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood (2005) 2.17

Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell (2013) 2.16

Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circ Res (2009) 2.16

Using OrthoMCL to assign proteins to OrthoMCL-DB groups or to cluster proteomes into new ortholog groups. Curr Protoc Bioinformatics (2011) 2.15

A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory. Immunity (2011) 2.15

Hand, foot, and mouth disease in China: patterns of spread and transmissibility. Epidemiology (2011) 2.13

In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers. Nat Med (2012) 2.13

EuPathDB: a portal to eukaryotic pathogen databases. Nucleic Acids Res (2009) 2.11

Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion. J Biol Chem (2003) 2.09

Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature. Blood (2011) 2.08

Understanding bereavement: what every oncology practitioner should know. J Support Oncol (2011) 2.08

Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N Engl J Med (2012) 2.08

Defects in the interferon-gamma and interleukin-12 pathways. Immunol Rev (2005) 2.07

A novel 3D mammalian cell perfusion-culture system in microfluidic channels. Lab Chip (2007) 2.03

Anti-IFN-gamma autoantibodies in disseminated nontuberculous mycobacterial infections. J Immunol (2005) 2.03