Published in Proc Natl Acad Sci U S A on October 10, 2007
Amyloid beta-protein assembly and Alzheimer disease. J Biol Chem (2008) 2.90
Amyloid beta-protein monomer folding: free-energy surfaces reveal alloform-specific differences. J Mol Biol (2008) 1.62
Protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival. PLoS Biol (2008) 1.61
Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor? Biochemistry (2008) 1.54
Structure and dynamics of the Abeta(21-30) peptide from the interplay of NMR experiments and molecular simulations. J Am Chem Soc (2008) 1.47
Beta arcades: recurring motifs in naturally occurring and disease-related amyloid fibrils. FASEB J (2009) 1.37
Molecular mechanisms of disease-causing missense mutations. J Mol Biol (2013) 1.31
Effects of familial Alzheimer's disease mutations on the folding nucleation of the amyloid beta-protein. J Mol Biol (2008) 1.24
Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin. Neurobiol Dis (2008) 1.23
Beta-amyloid precursor protein mutants respond to gamma-secretase modulators. J Biol Chem (2010) 1.12
Aβ monomers transiently sample oligomer and fibril-like configurations: ensemble characterization using a combined MD/NMR approach. J Mol Biol (2013) 1.12
Amino acid position-specific contributions to amyloid beta-protein oligomerization. J Biol Chem (2009) 1.10
The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation? Alzheimers Res Ther (2010) 1.09
Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-beta variants in cells composing the cerebral vessel walls. FASEB J (2009) 1.08
Effects of the English (H6R) and Tottori (D7N) familial Alzheimer disease mutations on amyloid beta-protein assembly and toxicity. J Biol Chem (2010) 1.07
Contrasting disease and nondisease protein aggregation by molecular simulation. Acc Chem Res (2008) 1.01
The molecular basis of distinct aggregation pathways of islet amyloid polypeptide. J Biol Chem (2010) 1.01
C-terminal turn stability determines assembly differences between Aβ40 and Aβ42. J Mol Biol (2012) 1.00
Two distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analyses. J Biol Chem (2011) 1.00
Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity. Biochemistry (2010) 0.97
Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease. Curr Pharm Des (2008) 0.97
Tauroursodeoxycholic acid prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells. Cell Mol Life Sci (2009) 0.96
Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease. Alzheimers Res Ther (2012) 0.95
Zn(++) binding disrupts the Asp(23)-Lys(28) salt bridge without altering the hairpin-shaped cross-β Structure of Aβ(42) amyloid aggregates. Biophys J (2011) 0.91
Amyloid beta-protein: experiment and theory on the 21-30 fragment. J Phys Chem B (2009) 0.91
Recombinant amyloid beta-peptide production by coexpression with an affibody ligand. BMC Biotechnol (2008) 0.90
A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity. ACS Chem Neurosci (2012) 0.90
Effect of zinc binding on β-amyloid structure and dynamics: implications for Aβ aggregation. Biophys J (2011) 0.90
Structural dynamics of the ΔE22 (Osaka) familial Alzheimer's disease-linked amyloid β-protein. Amyloid (2011) 0.87
Dynamics of metastable β-hairpin structures in the folding nucleus of amyloid β-protein. J Phys Chem B (2012) 0.87
Influence of residue 22 on the folding, aggregation profile, and toxicity of the Alzheimer's amyloid beta peptide. Biophys J (2009) 0.84
Gly25-Ser26 amyloid β-protein structural isomorphs produce distinct Aβ42 conformational dynamics and assembly characteristics. J Mol Biol (2014) 0.83
Association thermodynamics and conformational stability of beta-sheet amyloid beta(17-42) oligomers: effects of E22Q (Dutch) mutation and charge neutralization. Biophys J (2010) 0.83
Solid-support electron paramagnetic resonance (EPR) studies of Aβ40 monomers reveal a structured state with three ordered segments. J Biol Chem (2012) 0.81
E22Q-mutant Abeta peptide (AbetaDutch) increases vascular but reduces parenchymal Abeta deposition. Am J Pathol (2009) 0.81
Dynamic properties of pH-dependent structural organization of the amyloidogenic beta-protein (1-40). Prion (2009) 0.81
Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn23 Iowa mutation. Biochem J (2013) 0.80
Distinguishing amyloid fibril structures in Alzheimer's disease (AD) by two-dimensional ultraviolet (2DUV) spectroscopy. Biochemistry (2011) 0.79
Stability of transmembrane amyloid β-peptide and membrane integrity tested by molecular modeling of site-specific Aβ42 mutations. PLoS One (2013) 0.79
Structural dynamics of the amyloid β-protein monomer folding nucleus. Biochemistry (2012) 0.78
Monomeric Aβ(1-40) and Aβ(1-42) Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil. Biochemistry (2016) 0.76
Effects of hydroxylated carbon nanotubes on the aggregation of Aβ16-22 peptides: a combined simulation and experimental study. Biophys J (2014) 0.76
Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity. Acta Neuropathol (2016) 0.76
Mutation-based structural modification and dynamics study of amyloid beta peptide (1-42): An in-silico-based analysis to cognize the mechanism of aggregation. Genom Data (2016) 0.75
Amino acid substitutions [K16A] and [K28A] distinctly affect amyloid β-protein oligomerization. J Biol Phys (2016) 0.75
Structure of ring-shaped Aβ42 oligomers determined by conformational selection. Sci Rep (2016) 0.75
Binding of protofibrillar Aβ trimers to lipid bilayer surface enhances Aβ structural stability and causes membrane thinning. Phys Chem Chem Phys (2017) 0.75
Continuous flow reactor for the production of stable amyloid protein oligomers. Biochemistry (2012) 0.75
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol (2007) 17.69
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A (1998) 16.04
3D structure of Alzheimer's amyloid-beta(1-42) fibrils. Proc Natl Acad Sci U S A (2005) 8.60
Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils. Biochemistry (2006) 6.54
Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways. Proc Natl Acad Sci U S A (2002) 5.46
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat Neurosci (2001) 5.29
Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron (2004) 4.88
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science (1990) 4.71
Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies. J Neurosci Res (2002) 3.79
Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy. Ann Neurol (2001) 3.46
Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease. Neurobiol Aging (2004) 3.13
beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc Natl Acad Sci U S A (1993) 2.80
On the nucleation of amyloid beta-protein monomer folding. Protein Sci (2005) 2.47
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene. Nat Genet (1992) 2.40
Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization. J Biol Chem (2003) 2.31
The Alzheimer's peptide a beta adopts a collapsed coil structure in water. J Struct Biol (2000) 2.26
Mass spectrometry of purified amyloid beta protein in Alzheimer's disease. J Biol Chem (1992) 2.26
In silico study of amyloid beta-protein folding and oligomerization. Proc Natl Acad Sci U S A (2004) 2.13
Thermodynamics of a beta-hairpin structure: evidence for cooperative formation of folding nucleus. J Mol Biol (2000) 2.00
Deciphering the genetic basis of Alzheimer's disease. Annu Rev Genomics Hum Genet (2002) 1.96
Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch). Science (1990) 1.92
Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy. Nat Med (1998) 1.89
Effect of alanine versus glycine in alpha-helices on protein stability. Nature (1992) 1.88
Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies. Acc Chem Res (2004) 1.75
The gamma-secretase complex: membrane-embedded proteolytic ensemble. Biochemistry (2006) 1.70
Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region. Am J Hum Genet (1992) 1.63
Amyloid-beta precursor protein processing in neurodegeneration. Curr Opin Neurobiol (2004) 1.59
An autonomous folding unit mediates the assembly of two-stranded coiled coils. Proc Natl Acad Sci U S A (1998) 1.54
Structure of the 21-30 fragment of amyloid beta-protein. Protein Sci (2006) 1.51
Folding events in the 21-30 region of amyloid beta-protein (Abeta) studied in silico. Proc Natl Acad Sci U S A (2005) 1.43
Solvent and mutation effects on the nucleation of amyloid beta-protein folding. Proc Natl Acad Sci U S A (2005) 1.37
Residual helical structure in the C-terminal fragment of cytochrome c. Biochemistry (1993) 1.31
Conformational dynamics of amyloid beta-protein assembly probed using intrinsic fluorescence. Biochemistry (2005) 1.17
Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages. J Biol Chem (2007) 1.13
The conformations of the amyloid-beta (21-30) fragment can be described by three families in solution. J Chem Phys (2006) 1.07
Conformational analysis of peptides corresponding to all the secondary structure elements of protein L B1 domain: secondary structure propensities are not conserved in proteins with the same fold. Protein Sci (1997) 1.07
Probing the origins of increased activity of the E22Q "Dutch" mutant Alzheimer's beta-amyloid peptide. Biophys J (2001) 1.06
Unique physicochemical profile of beta-amyloid peptide variant Abeta1-40E22G protofibrils: conceivable neuropathogen in arctic mutant carriers. J Mol Biol (2004) 1.06
Long time dynamic simulations: exploring the folding pathways of an Alzheimer's amyloid Abeta-peptide. Acc Chem Res (2002) 1.03
Impact of the mutation A21G (Flemish variant) on Alzheimer's beta-amyloid dimers by molecular dynamics simulations. Biophys J (2006) 0.96
An NMR study on the beta-hairpin region of barnase. Fold Des (1996) 0.93
Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides. J Biol Chem (2002) 0.92
THE EQUILIBRIUM BETWEEN ACTIVE NATIVE TRYPSIN AND INACTIVE DENATURED TRYPSIN. J Gen Physiol (1934) 0.83
The kinetics of trypsin digestion. J Biol Chem (1950) 0.82
Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways. Proc Natl Acad Sci U S A (2002) 5.46
Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies. J Neurosci Res (2002) 3.79
Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nat Chem (2009) 3.66
Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia. Circulation (2011) 3.33
Structure-neurotoxicity relationships of amyloid beta-protein oligomers. Proc Natl Acad Sci U S A (2009) 3.06
A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancer. Cancer Prev Res (Phila) (2011) 3.03
Amyloid beta-protein assembly and Alzheimer disease. J Biol Chem (2008) 2.90
Development of a multimarker assay for early detection of ovarian cancer. J Clin Oncol (2010) 2.71
On the nucleation of amyloid beta-protein monomer folding. Protein Sci (2005) 2.47
Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization. J Biol Chem (2003) 2.31
Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. (MSU-2110) endophytic on Monstera sp. Microbiology (2004) 2.22
Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform. J Am Chem Soc (2005) 2.19
Amyloid beta-protein monomer structure: a computational and experimental study. Protein Sci (2006) 1.99
Neurotoxic protein oligomers--what you see is not always what you get. Amyloid (2005) 1.84
Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach. Acc Chem Res (2006) 1.80
Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease. J Neurosci (2008) 1.75
Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies. Acc Chem Res (2004) 1.75
A facile method for expression and purification of the Alzheimer's disease-associated amyloid beta-peptide. FEBS J (2009) 1.71
Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. Nat Struct Biol (2003) 1.68
Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans. Microbiology (2002) 1.65
Amyloid beta-protein monomer folding: free-energy surfaces reveal alloform-specific differences. J Mol Biol (2008) 1.62
Kinetic studies of amyloid beta-protein fibril assembly. Differential effects of alpha-helix stabilization. J Biol Chem (2002) 1.61
A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization. J Am Chem Soc (2003) 1.55
Serum biomarker panels for the discrimination of benign from malignant cases in patients with an adnexal mass. Gynecol Oncol (2010) 1.54
Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains. J Biol Chem (2009) 1.52
Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response. J Neurosci (2006) 1.51
Structure of the 21-30 fragment of amyloid beta-protein. Protein Sci (2006) 1.51
Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling. Genes Dev (2004) 1.46
Folding events in the 21-30 region of amyloid beta-protein (Abeta) studied in silico. Proc Natl Acad Sci U S A (2005) 1.43
Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays. J Biol Chem (2003) 1.42
Structure determination of micelle-like intermediates in amyloid beta -protein fibril assembly by using small angle neutron scattering. Proc Natl Acad Sci U S A (2001) 1.41
Solvent and mutation effects on the nucleation of amyloid beta-protein folding. Proc Natl Acad Sci U S A (2005) 1.37
A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Nat Cell Biol (2006) 1.36
Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity. J Biol Chem (2008) 1.33
Altered phase diagram due to a single point mutation in human gammaD-crystallin. Proc Natl Acad Sci U S A (2007) 1.32
C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity. Proc Natl Acad Sci U S A (2008) 1.32
Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc Natl Acad Sci U S A (2012) 1.32
Amyloid beta protein: Abeta40 inhibits Abeta42 oligomerization. J Am Chem Soc (2009) 1.30
Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. J Am Chem Soc (2011) 1.25
Effects of familial Alzheimer's disease mutations on the folding nucleation of the amyloid beta-protein. J Mol Biol (2008) 1.24
Characterization of oligomeric intermediates in alpha-synuclein fibrillation: FRET studies of Y125W/Y133F/Y136F alpha-synuclein. J Mol Biol (2005) 1.24
The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation. J Biol Chem (2006) 1.21
Development of multimarker panel for early detection of endometrial cancer. High diagnostic power of prolactin. Gynecol Oncol (2007) 1.20
The structure of Abeta42 C-terminal fragments probed by a combined experimental and theoretical study. J Mol Biol (2009) 1.19
Methionine oxidation, alpha-synuclein and Parkinson's disease. Biochim Biophys Acta (2004) 1.19
Conformational dynamics of amyloid beta-protein assembly probed using intrinsic fluorescence. Biochemistry (2005) 1.17
Alzheimer's disease and the amyloid β-protein. Prog Mol Biol Transl Sci (2012) 1.16
Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays. Methods Mol Biol (2005) 1.15
Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy. Acta Neuropathol (2009) 1.10
Apical sorting of beta-secretase limits amyloid beta-peptide production. J Biol Chem (2001) 1.10
Amino acid position-specific contributions to amyloid beta-protein oligomerization. J Biol Chem (2009) 1.10
Effects of nitration on the structure and aggregation of alpha-synuclein. Brain Res Mol Brain Res (2005) 1.09
Effects of the English (H6R) and Tottori (D7N) familial Alzheimer disease mutations on amyloid beta-protein assembly and toxicity. J Biol Chem (2010) 1.07
1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients. J Alzheimers Dis (2013) 1.05
Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding. J Biol Chem (2012) 1.05
A non-amyloidogenic function of BACE-2 in the secretory pathway. J Neurochem (2002) 1.05
Methionine oxidation inhibits fibrillation of human alpha-synuclein in vitro. FEBS Lett (2002) 1.05
Familial Alzheimer's disease mutations differentially alter amyloid β-protein oligomerization. ACS Chem Neurosci (2012) 1.05
Computer simulations of Alzheimer's amyloid beta-protein folding and assembly. Curr Alzheimer Res (2006) 1.04
Successful applications of computer aided drug discovery: moving drugs from concept to the clinic. Curr Top Med Chem (2010) 1.03
C-terminal turn stability determines assembly differences between Aβ40 and Aβ42. J Mol Biol (2012) 1.00
Polyglutamine repeat length-dependent proteolysis of huntingtin. Neurobiol Dis (2002) 1.00
STAS domain structure and function. Cell Physiol Biochem (2011) 1.00
Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 N-terminal domain. J Biol Chem (2007) 1.00
Two distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analyses. J Biol Chem (2011) 1.00
Determination of Peptide oligomerization state using rapid photochemical crosslinking. Methods Mol Biol (2005) 0.99
Probing the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase. J Biol Chem (2008) 0.97
Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease. Curr Pharm Des (2008) 0.97
Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment. J Neurosci (2012) 0.97
Critical role for the Ets transcription factor ELF-1 in the development of tumor angiogenesis. Blood (2005) 0.97
A peptide hairpin inhibitor of amyloid beta-protein oligomerization and fibrillogenesis. Biochemistry (2009) 0.97
Solution structure of the guanine nucleotide-binding STAS domain of SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. J Biol Chem (2010) 0.97
Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments. Biochemistry (2010) 0.96
Three children with plastic bronchitis associated with 2009 H1N1 influenza virus infection. Pediatr Infect Dis J (2011) 0.96
Modulation of protein aggregation by polyethylene glycol conjugation: GCSF as a case study. Protein Sci (2006) 0.95
Munumbicins E-4 and E-5: novel broad-spectrum antibiotics from Streptomyces NRRL 3052. FEMS Microbiol Lett (2006) 0.94
Effect of polyethylene glycol on the liquid-liquid phase transition in aqueous protein solutions. Proc Natl Acad Sci U S A (2002) 0.94