Published in J Biol Chem on May 07, 2010
Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 2.01
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation. EMBO Mol Med (2011) 1.11
Amyloid β-protein oligomers and Alzheimer's disease. Alzheimers Res Ther (2013) 1.07
The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation. J Biol Chem (2014) 1.07
Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding. J Biol Chem (2012) 1.05
Familial Alzheimer's disease mutations differentially alter amyloid β-protein oligomerization. ACS Chem Neurosci (2012) 1.05
Effect of the Tottori familial disease mutation (D7N) on the monomers and dimers of Aβ40 and Aβ42. ACS Chem Neurosci (2013) 0.88
C-terminal tetrapeptides inhibit Aβ42-induced neurotoxicity primarily through specific interaction at the N-terminus of Aβ42. J Med Chem (2011) 0.84
Alzheimer's protective A2T mutation changes the conformational landscape of the Aβ₁₋₄₂ monomer differently than does the A2V mutation. Biophys J (2015) 0.84
Effect of the English familial disease mutation (H6R) on the monomers and dimers of Aβ40 and Aβ42. ACS Chem Neurosci (2014) 0.83
Phosphorylation modifies the molecular stability of β-amyloid deposits. Nat Commun (2016) 0.83
Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer's Aβ1-42 dimer in terms of aggregation and toxicity. ACS Chem Neurosci (2013) 0.81
Interplay of histidine residues of the Alzheimer's disease Aβ peptide governs its Zn-induced oligomerization. Sci Rep (2016) 0.80
Specific antibody binding to the APP672-699 region shifts APP processing from α- to β-cleavage. Cell Death Dis (2014) 0.80
Amyloid β-Protein Assembly: Differential Effects of the Protective A2T Mutation and Recessive A2V Familial Alzheimer's Disease Mutation. ACS Chem Neurosci (2015) 0.80
The domestic cat as a natural animal model of Alzheimer's disease. Acta Neuropathol Commun (2015) 0.77
High-speed atomic force microscopy reveals structural dynamics of amyloid β1-42 aggregates. Proc Natl Acad Sci U S A (2016) 0.76
Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer's Disease. J Amino Acids (2011) 0.76
Role of Species-Specific Primary Structure Differences in Aβ42 Assembly and Neurotoxicity. ACS Chem Neurosci (2015) 0.75
Kinetics of the Interactions between Copper and Amyloid-β with FAD Mutations and Phosphorylation at the N terminus. Chembiochem (2016) 0.75
Alzheimer's amyloid-β A2T variant and its N-terminal peptides inhibit amyloid-β fibrillization and rescue the induced cytotoxicity. PLoS One (2017) 0.75
Phosphorylation Interferes with Maturation of Amyloid-β Fibrillar Structure in the N Terminus. J Biol Chem (2016) 0.75
Allosteric stabilization of the amyloid-β peptide hairpin by the fluctuating N-terminal. Chem Commun (Camb) (2015) 0.75
Familial Alzheimer's disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid beta peptide. J Biol Chem (2017) 0.75
Protein folding, misfolding and aggregation: The importance of two-electron stabilizing interactions. PLoS One (2017) 0.75
Divalent copper ion bound amyloid-β(40) and amyloid-β(42) alloforms are less preferred than divalent zinc ion bound amyloid-β(40) and amyloid-β(42) alloforms. J Biol Inorg Chem (2016) 0.75
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods (1983) 114.35
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature (2002) 19.36
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol (2007) 17.69
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med (2008) 17.09
Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell (1993) 10.15
A beta oligomers - a decade of discovery. J Neurochem (2007) 8.88
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci (2007) 8.27
Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. Protein Sci (1993) 7.92
Quantification of beta-sheet amyloid fibril structures with thioflavin T. Methods Enzymol (1999) 5.89
Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways. Proc Natl Acad Sci U S A (2002) 5.46
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron (1996) 5.30
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat Neurosci (2001) 5.29
Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate. J Biol Chem (1997) 5.07
On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants. Proc Natl Acad Sci U S A (1996) 4.75
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science (1990) 4.71
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat Rev Neurosci (2008) 4.64
Structural insights into a yeast prion illuminate nucleation and strain diversity. Nature (2005) 3.86
Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies. J Neurosci Res (2002) 3.79
Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J Physiol (2006) 3.74
Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy. Ann Neurol (2001) 3.46
Kinetic theory of fibrillogenesis of amyloid beta-protein. Proc Natl Acad Sci U S A (1997) 3.40
Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med (2005) 3.28
Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis. J Mol Biol (2001) 3.26
Structure-neurotoxicity relationships of amyloid beta-protein oligomers. Proc Natl Acad Sci U S A (2009) 3.06
Amyloid beta-protein assembly and Alzheimer disease. J Biol Chem (2008) 2.90
Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus. Brain Res (2002) 2.88
Amyloid beta-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins. J Biol Chem (2001) 2.77
On the nucleation of amyloid beta-protein monomer folding. Protein Sci (2005) 2.47
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene. Nat Genet (1992) 2.40
The Alzheimer's peptides Abeta40 and 42 adopt distinct conformations in water: a combined MD / NMR study. J Mol Biol (2007) 2.35
A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia. Ann Neurol (2008) 2.32
Chemistry for the analysis of protein-protein interactions: rapid and efficient cross-linking triggered by long wavelength light. Proc Natl Acad Sci U S A (1999) 2.19
Alzheimer disease: mechanistic understanding predicts novel therapies. Ann Intern Med (2004) 2.06
A general model for amyloid fibril assembly based on morphological studies using atomic force microscopy. Biophys J (2003) 1.93
Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach. Acc Chem Res (2006) 1.80
Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies. Acc Chem Res (2004) 1.75
Early onset familial Alzheimer's disease: Mutation frequency in 31 families. Neurology (2003) 1.71
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue. Proc Natl Acad Sci U S A (1997) 1.69
Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region. Am J Hum Genet (1992) 1.63
Amyloid beta-protein monomer folding: free-energy surfaces reveal alloform-specific differences. J Mol Biol (2008) 1.62
Preparation of amyloid beta-protein for structural and functional studies. Methods Enzymol (2006) 1.61
Familial Alzheimer's disease mutations alter the stability of the amyloid beta-protein monomer folding nucleus. Proc Natl Acad Sci U S A (2007) 1.55
Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils-current status. J Chem Biol (2009) 1.55
Structural and kinetic features of amyloid beta-protein fibrillogenesis. Amyloid (1998) 1.50
First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro. Lab Invest (1996) 1.47
Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin. Neurobiol Dis (2008) 1.23
The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation. J Biol Chem (2006) 1.21
Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo. Eur J Neurosci (2004) 1.19
Conformational dynamics of amyloid beta-protein assembly probed using intrinsic fluorescence. Biochemistry (2005) 1.17
Amino acid position-specific contributions to amyloid beta-protein oligomerization. J Biol Chem (2009) 1.10
Amyloid beta protein inhibits cellular MTT reduction not by suppression of mitochondrial succinate dehydrogenase but by acceleration of MTT formazan exocytosis in cultured rat cortical astrocytes. Neurosci Res (1998) 1.06
Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease. J Neurol Neurosurg Psychiatry (2004) 1.06
Scope, limitations and mechanistic aspects of the photo-induced cross-linking of proteins by water-soluble metal complexes. Chem Biol (2000) 1.04
Abeta mediated diminution of MTT reduction--an artefact of single cell culture? PLoS One (2008) 0.88
Structures of Abeta-related peptide--monoclonal antibody complexes. Biochemistry (2009) 0.82
Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways. Proc Natl Acad Sci U S A (2002) 5.46
Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies. J Neurosci Res (2002) 3.79
Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nat Chem (2009) 3.66
Structure-neurotoxicity relationships of amyloid beta-protein oligomers. Proc Natl Acad Sci U S A (2009) 3.06
Amyloid beta-protein assembly and Alzheimer disease. J Biol Chem (2008) 2.90
On the nucleation of amyloid beta-protein monomer folding. Protein Sci (2005) 2.47
Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization. J Biol Chem (2003) 2.31
Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. (MSU-2110) endophytic on Monstera sp. Microbiology (2004) 2.22
Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform. J Am Chem Soc (2005) 2.19
Amyloid beta-protein monomer structure: a computational and experimental study. Protein Sci (2006) 1.99
Neurotoxic protein oligomers--what you see is not always what you get. Amyloid (2005) 1.84
Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease. J Neurosci (2008) 1.75
Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies. Acc Chem Res (2004) 1.75
A facile method for expression and purification of the Alzheimer's disease-associated amyloid beta-peptide. FEBS J (2009) 1.71
Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans. Microbiology (2002) 1.65
Amyloid beta-protein monomer folding: free-energy surfaces reveal alloform-specific differences. J Mol Biol (2008) 1.62
Kinetic studies of amyloid beta-protein fibril assembly. Differential effects of alpha-helix stabilization. J Biol Chem (2002) 1.61
Familial Alzheimer's disease mutations alter the stability of the amyloid beta-protein monomer folding nucleus. Proc Natl Acad Sci U S A (2007) 1.55
A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization. J Am Chem Soc (2003) 1.55
Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains. J Biol Chem (2009) 1.52
Structure of the 21-30 fragment of amyloid beta-protein. Protein Sci (2006) 1.51
Folding events in the 21-30 region of amyloid beta-protein (Abeta) studied in silico. Proc Natl Acad Sci U S A (2005) 1.43
Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays. J Biol Chem (2003) 1.42
Structure determination of micelle-like intermediates in amyloid beta -protein fibril assembly by using small angle neutron scattering. Proc Natl Acad Sci U S A (2001) 1.41
Solvent and mutation effects on the nucleation of amyloid beta-protein folding. Proc Natl Acad Sci U S A (2005) 1.37
A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Nat Cell Biol (2006) 1.36
Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity. J Biol Chem (2008) 1.33
C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity. Proc Natl Acad Sci U S A (2008) 1.32
Amyloid beta protein: Abeta40 inhibits Abeta42 oligomerization. J Am Chem Soc (2009) 1.30
Effects of familial Alzheimer's disease mutations on the folding nucleation of the amyloid beta-protein. J Mol Biol (2008) 1.24
The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation. J Biol Chem (2006) 1.21
The structure of Abeta42 C-terminal fragments probed by a combined experimental and theoretical study. J Mol Biol (2009) 1.19
Conformational dynamics of amyloid beta-protein assembly probed using intrinsic fluorescence. Biochemistry (2005) 1.17
Alzheimer's disease and the amyloid β-protein. Prog Mol Biol Transl Sci (2012) 1.16
Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays. Methods Mol Biol (2005) 1.15
Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy. Acta Neuropathol (2009) 1.10
Apical sorting of beta-secretase limits amyloid beta-peptide production. J Biol Chem (2001) 1.10
Amino acid position-specific contributions to amyloid beta-protein oligomerization. J Biol Chem (2009) 1.10
1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients. J Alzheimers Dis (2013) 1.05
Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding. J Biol Chem (2012) 1.05
A non-amyloidogenic function of BACE-2 in the secretory pathway. J Neurochem (2002) 1.05
Familial Alzheimer's disease mutations differentially alter amyloid β-protein oligomerization. ACS Chem Neurosci (2012) 1.05
Computer simulations of Alzheimer's amyloid beta-protein folding and assembly. Curr Alzheimer Res (2006) 1.04
C-terminal turn stability determines assembly differences between Aβ40 and Aβ42. J Mol Biol (2012) 1.00
Polyglutamine repeat length-dependent proteolysis of huntingtin. Neurobiol Dis (2002) 1.00
Two distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analyses. J Biol Chem (2011) 1.00
Determination of Peptide oligomerization state using rapid photochemical crosslinking. Methods Mol Biol (2005) 0.99
Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease. Curr Pharm Des (2008) 0.97
A peptide hairpin inhibitor of amyloid beta-protein oligomerization and fibrillogenesis. Biochemistry (2009) 0.97
Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment. J Neurosci (2012) 0.97
Munumbicins E-4 and E-5: novel broad-spectrum antibiotics from Streptomyces NRRL 3052. FEMS Microbiol Lett (2006) 0.94
Mechanism of amyloid β-protein dimerization determined using single-molecule AFM force spectroscopy. Sci Rep (2013) 0.92
Amyloid beta-protein: experiment and theory on the 21-30 fragment. J Phys Chem B (2009) 0.91
Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease. J Alzheimers Dis (2010) 0.90
Nanoprobing of the effect of Cu(2+) cations on misfolding, interaction and aggregation of amyloid β peptide. J Neuroimmune Pharmacol (2012) 0.89
Carvedilol as a potential novel agent for the treatment of Alzheimer's disease. Neurobiol Aging (2010) 0.88
Effect of melatonin on α-synuclein self-assembly and cytotoxicity. Neurobiol Aging (2011) 0.88
Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. J Biol Chem (2008) 0.88
Structural dynamics of the ΔE22 (Osaka) familial Alzheimer's disease-linked amyloid β-protein. Amyloid (2011) 0.87
Quasielastic light scattering for protein assembly studies. Methods Mol Biol (2005) 0.87
Quasielastic light scattering study of amyloid beta-protein fibril formation. Protein Pept Lett (2006) 0.82
Identification of antihypertensive drugs which inhibit amyloid-beta protein oligomerization. J Alzheimers Dis (2009) 0.82
Factors that drive peptide assembly and fibril formation: experimental and theoretical analysis of Sup35 NNQQNY mutants. J Phys Chem B (2013) 0.81
Cerebrospinal Fluid from Alzheimer's disease patients promotes amyloid beta-protein oligomerization. J Alzheimers Dis (2010) 0.81
Factors that drive peptide assembly from native to amyloid structures: experimental and theoretical analysis of [leu-5]-enkephalin mutants. J Phys Chem B (2014) 0.80
A direct interaction between transforming growth factor (TGF)-betas and amyloid-beta protein affects fibrillogenesis in a TGF-beta receptor-independent manner. J Biol Chem (2003) 0.80
Preparation of stable amyloid β-protein oligomers of defined assembly order. Methods Mol Biol (2012) 0.79
The exception makes the rule: not all Aβ plaques are created equal. Neurology (2012) 0.79
Structural dynamics of the amyloid β-protein monomer folding nucleus. Biochemistry (2012) 0.78
Quasielastic light scattering study of amyloid β-protein fibrillogenesis. Methods Mol Biol (2012) 0.77
Common threads in neurodegenerative disorders of aging. Alzheimers Dement (2006) 0.76
Continuous flow reactor for the production of stable amyloid protein oligomers. Biochemistry (2012) 0.75
Molecular biology of neurodegenerative diseases. Preface. Prog Mol Biol Transl Sci (2012) 0.75