Published in Yale J Biol Med on December 01, 2006
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev (2003) 9.58
Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol (2002) 8.04
Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell (2005) 7.29
A genetic screen in Drosophila for metastatic behavior. Science (2003) 4.09
SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron (2009) 3.10
SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. Dev Cell (2007) 3.09
Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion. Nature (2010) 2.79
Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol (2006) 2.63
Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. Development (2007) 2.27
SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A (2009) 2.07
Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila. Dev Cell (2011) 2.07
Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion. Proc Natl Acad Sci U S A (2007) 1.97
Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev Cell (2009) 1.95
LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. Nat Cell Biol (2004) 1.86
An innate immune response of blood cells to tumors and tissue damage in Drosophila. Dis Model Mech (2008) 1.84
Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. Science (2009) 1.83
Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila. Dev Cell (2007) 1.68
KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. Hum Mol Genet (2010) 1.59
Role of trehalose phosphate synthase in anoxia tolerance and development in Drosophila melanogaster. J Biol Chem (2001) 1.46
Diagnostic accuracy of quantitative angiographic and intravascular ultrasound parameters predicting the functional significance of single de novo lesions. Int J Cardiol (2012) 1.42
A large-scale functional approach to uncover human genes and pathways in Drosophila. Cell Res (2008) 1.42
Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan. Dev Cell (2011) 1.41
LATS1 tumor suppressor regulates G2/M transition and apoptosis. Oncogene (2002) 1.38
ADAM10 is essential for proteolytic activation of Notch during thymocyte development. Int Immunol (2008) 1.38
A cell-intrinsic role for Mst1 in regulating thymocyte egress. J Immunol (2009) 1.35
Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes. Cell (2002) 1.29
Histone methyltransferase Ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20. Immunity (2013) 1.15
The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. Dev Biol (2005) 1.10
PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice. Nucleic Acids Res (2007) 1.07
The expanding role of mouse genetics for understanding human biology and disease. Dis Model Mech (2008) 1.05
Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. Curr Biol (2012) 1.05
Modeling Sjögren's syndrome with Id3 conditional knockout mice. Immunol Lett (2011) 1.05
Low-copy piggyBac transposon mutagenesis in mice identifies genes driving melanoma. Proc Natl Acad Sci U S A (2013) 1.04
Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis. Oncogene (2004) 1.03
Coiled versus straight peritoneal dialysis catheters: a randomized controlled trial and meta-analysis. Am J Kidney Dis (2011) 1.02
Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA. J Biol Chem (2005) 1.01
Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1. Hum Mol Genet (2004) 0.95
LATS1 tumor suppressor is a novel actin-binding protein and negative regulator of actin polymerization. Cell Res (2011) 0.95
piggyBac transposon somatic mutagenesis with an activated reporter and tracker (PB-SMART) for genetic screens in mice. PLoS One (2011) 0.95
A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila. Oncogene (2003) 0.95
Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease. J Immunol (2014) 0.94
A mitotic recombination system for mouse chromosome 17. Proc Natl Acad Sci U S A (2008) 0.93
Dissecting social cell biology and tumors using Drosophila genetics. Annu Rev Genet (2013) 0.92
Adam10 is essential for early embryonic cardiovascular development. Dev Dyn (2010) 0.89
Molecular mechanism of size control in development and human diseases. Cell Res (2011) 0.88
Ubiquitous expression of mRFP1 in transgenic mice. Genesis (2005) 0.88
Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem (2012) 0.88
Disruption of lysosome function promotes tumor growth and metastasis in Drosophila. J Biol Chem (2010) 0.87
Expression of Drosophila trehalose-phosphate synthase in HEK-293 cells increases hypoxia tolerance. J Biol Chem (2003) 0.87
Nickel-catalyzed Suzuki-Miyaura reaction of aryl fluorides. J Am Chem Soc (2011) 0.87
Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development. Dev Dyn (2010) 0.87
Karyotype-phenotype insights from 11q14.1-q23.2 interstitial deletions: FZD4 haploinsufficiency and exudative vitreoretinopathy in a patient with a complex chromosome rearrangement. Am J Med Genet A (2006) 0.87
Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye. BMC Dev Biol (2009) 0.86
Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors. Pigment Cell Melanoma Res (2014) 0.84
Dlic1 deficiency impairs ciliogenesis of photoreceptors by destabilizing dynein. Cell Res (2013) 0.84
Characterization of fluorescent eye markers for mammalian transgenic studies. PLoS One (2011) 0.84
Hypertension, alcohol drinking and stroke incidence: a population-based prospective cohort study among inner Mongolians in China. J Hypertens (2014) 0.84
Analyzing the function of tumor suppressor genes using a Drosophila model. Methods Mol Biol (2003) 0.84
Muscle atrophy in transgenic mice expressing a human TSC1 transgene. FEBS Lett (2006) 0.83
piggyBac as a high-capacity transgenesis and gene-therapy vector in human cells and mice. Dis Model Mech (2013) 0.83
Magnesium intake and cardiovascular disease mortality: a meta-analysis of prospective cohort studies. Int J Cardiol (2012) 0.82
Effects of moxibustion or acupoint therapy for the treatment of primary dysmenorrhea: a meta-analysis. Altern Ther Health Med (2014) 0.82
A study of ovarian cancer biomarker amplification using ultrasound for early stage detection. Ultrasonics (2013) 0.82
Antifungal activity of alkaloids from the seeds of Chimonanthus praecox. Chem Biodivers (2009) 0.82
Early Blood Pressure Reduction in Acute Ischemic Stroke with Various Severities: A Subgroup Analysis of the CATIS Trial. Cerebrovasc Dis (2016) 0.79
Eiger and wengen: the Drosophila orthologs of TNF/TNFR. Adv Exp Med Biol (2011) 0.79
Somatic genetics empowers the mouse for modeling and interrogating developmental and disease processes. PLoS Genet (2011) 0.79
Acute effects of nicardipine and esmolol on the cardiac cycle, intracardiac hemodynamic and endothelial shear stress in patients with unstable angina pectoris and moderate coronary stenosis: results from single center, randomized study. Cardiovasc Ther (2011) 0.79
C-terminal deletion of the atrophin-1 protein results in growth retardation but not neurodegeneration in mice. Dev Dyn (2009) 0.79
Serial intravascular ultrasound analysis comparing double kissing and classical crush stenting for coronary bifurcation lesions. Catheter Cardiovasc Interv (2011) 0.78
[Effect of occupational stress on oxidation/antioxidant capacity in nurses]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi (2014) 0.78
Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation. Proc Natl Acad Sci U S A (2013) 0.78
Generation of genetically engineered mice by the piggyBac transposon system. Methods Mol Biol (2014) 0.77
Generation of Dhx9-deficient clones in T-cell development with a mitotic recombination technique. Genesis (2012) 0.77
Optimization of fermentation conditions for maximal recombinant hepatitis B surface antigen particle production in Pichia pastoris. Sheng Wu Gong Cheng Xue Bao (2008) 0.77
Real polymer-free sirolimus- and probucol-eluting versus biodegradable polymer sirolimus-eluting stents for obstructive coronary artery disease: DKPLUS-Wave 1, a multicenter, randomized, prospective trial. Cardiovasc Ther (2013) 0.77
Lipid Accumulation Product and Hypertension Related to Stroke: a 9.2-Year Prospective Study Among Mongolians in China. J Atheroscler Thromb (2016) 0.76
Optimized quantitative angiographic and intravascular ultrasound parameters predicting the functional significance of single de novo lesions in the left anterior descending artery. Chin Med J (Engl) (2012) 0.76
Optical coherence tomography assessment of a complex bifurcation lesion treated with double kissing Crush technique: A case report. Medicine (Baltimore) (2017) 0.75
Two-year clinical outcomes after coronary drug-eluting stent placement in Chinese men and women: a multicenter, prospective registry study. Patient Prefer Adherence (2013) 0.75
Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity. J Clin Invest (2016) 0.75
Correction: Identification of a Male-Produced Pheromone Component of the Citrus Longhorned Beetle, Anoplophora chinensis. PLoS One (2015) 0.75
Wide color gamut white light-emitting diodes based on two-dimensional semiconductor nanoplatelets. Opt Express (2022) 0.75
Drying-mediated optical assembly of silica spheres in a symmetrical metallic waveguide structure. Opt Lett (2017) 0.75
Resting energy expenditure: a valuable predictor for KT/Vurea in peritoneal dialysis patients . Clin Nephrol (2017) 0.75
Intravenous injection of nicardipine changed the distribution of coronary artery endothelial shear stress and fluid dynamics in patients with unstable angina. Chin Med J (Engl) (2012) 0.75
Corrigendum: Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion. Nature (2017) 0.75
Blood pressure reduction in acute ischemic stroke according to time to treatment: a subgroup analysis of the China Antihypertensive Trial in Acute Ischemic Stroke trial. J Hypertens (2017) 0.75
[Analysis of correlation between occupational stress and serum monoamine neurotransmitters in nurses]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi (2014) 0.75
Vps18 deficiency inhibits dendritogenesis in Purkinje cells by blocking the lysosomal degradation of Lysyl Oxidase. Biochem Biophys Res Commun (2012) 0.75
Interleukin-6, but not C-reactive protein, predicts the occurrence of cardiovascular events after drug-eluting stent for unstable angina. J Interv Cardiol (2014) 0.75
Multifunctional Nanocomposite with Magnetism, Thermosensitivity and Surface Enhanced Raman Scattering Effect. J Nanosci Nanotechnol (2015) 0.75
Hemodynamic change in wall shear stress in patients with coronary bifurcation lesions treated by double kissing crush or single-stent technique. Chin Med J (Engl) (2012) 0.75
Angioscopy study from a large patient population comparing sirolimus-eluting stent with biodegradable versus durable polymer. Catheter Cardiovasc Interv (2012) 0.75
Refractive index modulating Raman spectroscopy based on perovskite PMN-PT ceramics. Appl Opt (2016) 0.75
Effects of storage condition factors on fungal invasion of Radix Ophiopogonis. J Agric Food Chem (2010) 0.75