Published in Cell on November 23, 2011
Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell (2014) 2.47
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature (2013) 2.34
Lin28: primal regulator of growth and metabolism in stem cells. Cell Stem Cell (2013) 2.27
How does Lin28 let-7 control development and disease? Trends Cell Biol (2012) 2.09
Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis. Science (2012) 2.03
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Nat Genet (2012) 1.96
Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). RNA (2012) 1.74
Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. Nat Genet (2012) 1.74
The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells. Nat Cell Biol (2013) 1.67
MicroRNAs shape the neuronal landscape. Neuron (2012) 1.64
ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell (2016) 1.50
The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs. PLoS Genet (2015) 1.46
MicroRNA biogenesis: regulating the regulators. Crit Rev Biochem Mol Biol (2012) 1.41
Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation. Genome Res (2017) 1.40
Regulation of microRNA function in somatic stem cell proliferation and differentiation. Nat Rev Mol Cell Biol (2014) 1.38
Identification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition. RNA (2013) 1.27
LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. Genes Dev (2013) 1.23
β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A (2014) 1.23
High expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancer. Br J Cancer (2012) 1.22
Dysregulation of microRNAs in cancer. J Biomed Sci (2012) 1.20
SET7/9 methylation of the pluripotency factor LIN28A is a nucleolar localization mechanism that blocks let-7 biogenesis in human ESCs. Cell Stem Cell (2014) 1.20
In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs. RNA (2012) 1.20
Tissue-specific control of brain-enriched miR-7 biogenesis. Genes Dev (2013) 1.18
Exposure to endocrine disruptor induces transgenerational epigenetic deregulation of microRNAs in primordial germ cells. PLoS One (2015) 1.16
Lower and upper stem-single-stranded RNA junctions together determine the Drosha cleavage site. Proc Natl Acad Sci U S A (2013) 1.12
Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells (2013) 1.09
MicroRNAs: potential mediators and biomarkers of diabetic complications. Free Radic Biol Med (2013) 1.08
Lin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer. J Biol Chem (2012) 1.08
Biogenesis of mammalian microRNAs: a global view. Genomics Proteomics Bioinformatics (2012) 1.04
PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth. Oncotarget (2015) 1.02
miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis. Oncogene (2013) 1.02
Changes in hypothalamic expression of the Lin28/let-7 system and related microRNAs during postnatal maturation and after experimental manipulations of puberty. Endocrinology (2013) 1.02
let-7 miRNAs can act through notch to regulate human gliogenesis. Stem Cell Reports (2014) 1.01
Genomic DNA copy-number alterations of the let-7 family in human cancers. PLoS One (2012) 1.01
Mechanisms of Lin28-mediated miRNA and mRNA regulation--a structural and functional perspective. Int J Mol Sci (2013) 1.00
Pivots of pluripotency: the roles of non-coding RNA in regulating embryonic and induced pluripotent stem cells. Biochim Biophys Acta (2012) 1.00
Increased expression of Lin28B associates with poor prognosis in patients with oral squamous cell carcinoma. PLoS One (2013) 0.99
Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function. Nat Immunol (2015) 0.99
Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival. PLoS Genet (2012) 0.99
Lin28 regulates BMP4 and functions with Oct4 to affect ovarian tumor microenvironment. Cell Cycle (2012) 0.99
The role of microRNAs in human neural stem cells, neuronal differentiation and subtype specification. Cell Tissue Res (2014) 0.98
miR-9 is a tumor suppressor in pediatric AML with t(8;21). Leukemia (2013) 0.98
Outside the coding genome, mammalian microRNAs confer structural and functional complexity. Sci Signal (2015) 0.97
A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis. Cancer Cell (2015) 0.97
Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer. Mol Cancer (2015) 0.97
Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase. Nat Struct Mol Biol (2012) 0.96
Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res (2014) 0.96
Regulation of microRNA biogenesis and turnover by animals and their viruses. Cell Mol Life Sci (2013) 0.95
miR-125b promotes early germ layer specification through Lin28/let-7d and preferential differentiation of mesoderm in human embryonic stem cells. PLoS One (2012) 0.93
MicroRNAs in diabetic nephropathy: functions, biomarkers, and therapeutic targets. Ann N Y Acad Sci (2015) 0.92
MicroRNAs and triple negative breast cancer. Int J Mol Sci (2013) 0.91
LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans. Genes Dev (2015) 0.91
Metabolic rescue of obese adipose-derived stem cells by Lin28/Let7 pathway. Diabetes (2013) 0.91
Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target. Oncotarget (2015) 0.90
Terminal loop-mediated regulation of miRNA biogenesis: selectivity and mechanisms. Biochem Soc Trans (2013) 0.90
microRNAs as novel regulators of stem cell pluripotency and somatic cell reprogramming. Bioessays (2012) 0.89
Processing of microRNA primary transcripts requires heme in mammalian cells. Proc Natl Acad Sci U S A (2014) 0.89
Role of miRNA let-7 and its major targets in prostate cancer. Biomed Res Int (2014) 0.89
Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS Genet (2012) 0.89
Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation. RNA Biol (2013) 0.88
Dark matter RNA: an intelligent scaffold for the dynamic regulation of the nuclear information landscape. Front Genet (2012) 0.88
Focal DNA copy number changes in neuroblastoma target MYCN regulated genes. PLoS One (2013) 0.88
MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC. Mol Cancer Res (2014) 0.87
MicroRNAs in biliary diseases. World J Gastroenterol (2012) 0.87
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Mol Nutr Food Res (2012) 0.87
Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2. PLoS Genet (2015) 0.86
The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis. Pediatr Surg Int (2012) 0.86
Lin28 and HER2: two stem cell regulators conspire to drive aggressive breast cancer. Cell Cycle (2012) 0.86
Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty. Horm Res Paediatr (2012) 0.84
Translational compensation of genomic instability in neuroblastoma. Sci Rep (2015) 0.84
MiR-208a stimulates the cocktail of SOX2 and β-catenin to inhibit the let-7 induction of self-renewal repression of breast cancer stem cells and formed miR208a/let-7 feedback loop via LIN28 and DICER1. Oncotarget (2015) 0.84
Identification of small molecule inhibitors of Zcchc11 TUTase activity. RNA Biol (2015) 0.84
let-7b/g silencing activates AKT signaling to promote gastric carcinogenesis. J Transl Med (2014) 0.83
A novel mechanism of LIN-28 regulation of let-7 microRNA expression revealed by in vivo HITS-CLIP in C. elegans. RNA (2015) 0.83
Stepwise assembly of multiple Lin28 proteins on the terminal loop of let-7 miRNA precursors. Nucleic Acids Res (2014) 0.83
Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans. PLoS Genet (2013) 0.83
The role of non-coding RNAs in the regulation of stem cells and progenitors in the normal mammary gland and in breast tumors. Front Genet (2015) 0.83
N6-adenosine methylation in MiRNAs. PLoS One (2015) 0.83
The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA. Nucleic Acids Res (2015) 0.82
Biogenesis and regulation of the let-7 miRNAs and their functional implications. Protein Cell (2015) 0.82
A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression. Cell Rep (2015) 0.82
A LIN28B polymorphism predicts for colon cancer survival. Cancer Biol Ther (2012) 0.82
Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity. Nucleic Acids Res (2015) 0.81
Overexpression of NF90-NF45 Represses Myogenic MicroRNA Biogenesis, Resulting in Development of Skeletal Muscle Atrophy and Centronuclear Muscle Fibers. Mol Cell Biol (2015) 0.81
Genetic variants in let-7/Lin28 modulate the risk of oral cavity cancer in a Chinese Han population. Sci Rep (2014) 0.81
A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B. Cancer Sci (2015) 0.81
MicroRNAs associated with HBV infection and HBV-related HCC. Theranostics (2014) 0.81
Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases. World J Gastroenterol (2015) 0.81
MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies. ISRN Hematol (2013) 0.80
Lin28B is a novel prognostic marker in gastric adenocarcinoma. Int J Clin Exp Pathol (2014) 0.80
Fibroblast growth factor (FGF) signaling during gastrulation negatively modulates the abundance of microRNAs that regulate proteins required for cell migration and embryo patterning. J Biol Chem (2012) 0.80
Lin28B expression correlates with aggressive clinicopathological characteristics in breast invasive ductal carcinoma. Cancer Biother Radiopharm (2014) 0.80
Proteomic characterization of the nucleolar linker histone H1 interaction network. J Mol Biol (2015) 0.80
The network of pluripotency, epithelial-mesenchymal transition, and prognosis of breast cancer. Breast Cancer (Dove Med Press) (2015) 0.80
Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types. Nat Commun (2016) 0.80
The LIN28/let-7 Pathway in Cancer. Front Genet (2017) 0.79
Polyuridylation in Eukaryotes: A 3'-End Modification Regulating RNA Life. Biomed Res Int (2015) 0.79
The pluripotency factor LIN28B is involved in oral carcinogenesis and associates with tumor aggressiveness and unfavorable prognosis. Cancer Cell Int (2015) 0.79
Genome-wide analysis of YB-1-RNA interactions reveals a novel role of YB-1 in miRNA processing in glioblastoma multiforme. Nucleic Acids Res (2015) 0.79
The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family. Nucleic Acids Res (2016) 0.79
Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science (2001) 31.33
Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86
Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res (2004) 18.86
The Microprocessor complex mediates the genesis of microRNAs. Nature (2004) 17.70
The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet (2010) 15.87
Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59
Selective blockade of microRNA processing by Lin28. Science (2008) 14.39
let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell (2007) 13.69
The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell (1997) 12.87
An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell (2009) 10.09
Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell (2005) 9.27
Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell (2008) 8.32
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol (2008) 7.35
The multifunctional nucleolus. Nat Rev Mol Cell Biol (2007) 7.08
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA (2008) 6.86
Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet (2009) 6.35
Pervasive roles of microRNAs in cardiovascular biology. Nature (2011) 6.08
TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell (2009) 5.99
Opposing microRNA families regulate self-renewal in mouse embryonic stem cells. Nature (2010) 5.10
The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle (2008) 4.95
Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs. Nat Rev Mol Cell Biol (2007) 4.91
Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol (2009) 4.41
Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem (2008) 4.40
let-7 microRNAs in development, stem cells and cancer. Trends Mol Med (2008) 4.29
Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. Gene (2006) 4.13
The role of let-7 in cell differentiation and cancer. Endocr Relat Cancer (2010) 3.95
Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proc Natl Acad Sci U S A (2009) 3.76
Let-7 expression defines two differentiation stages of cancer. Proc Natl Acad Sci U S A (2007) 3.59
Lin28: A microRNA regulator with a macro role. Cell (2010) 3.39
Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7. EMBO J (2009) 3.11
A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature (2009) 2.88
Regression of murine lung tumors by the let-7 microRNA. Oncogene (2009) 2.83
LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Nat Struct Mol Biol (2009) 2.79
Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nat Genet (2010) 2.72
Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer. Oncogene (2010) 2.42
LIN28B promotes colon cancer progression and metastasis. Cancer Res (2011) 2.05
MicroRNA let-7: an emerging next-generation cancer therapeutic. Curr Oncol (2010) 1.90
Roles of small RNAs in tumor formation. Trends Mol Med (2010) 1.89
MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2. Hepatology (2010) 1.88
Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras. Int J Radiat Oncol Biol Phys (2010) 1.85
Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells. Cancer Res (2010) 1.78
Quantitative analysis of protein-RNA interactions by gel mobility shift. Methods Mol Biol (2008) 1.60
MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity. Cell Stem Cell (2010) 1.53
LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans. Nat Struct Mol Biol (2011) 1.51
Lin-28B expression promotes transformation and invasion in human hepatocellular carcinoma. Carcinogenesis (2010) 1.49
Pluripotent factor lin-28 and its homologue lin-28b in epithelial ovarian cancer and their associations with disease outcomes and expression of let-7a and IGF-II. Eur J Cancer (2009) 1.41
Characterization and prediction of protein nucleolar localization sequences. Nucleic Acids Res (2010) 1.40
A Yin-Yang balancing act of the lin28/let-7 link in tumorigenesis. J Hepatol (2010) 1.03
let-7 microRNA reduces tumor growth. Cell Cycle (2009) 0.89
Selective blockade of microRNA processing by Lin28. Science (2008) 14.39
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature (2005) 13.44
Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol (2009) 11.50
MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA (2007) 9.97
E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell (2008) 7.56
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res (2009) 6.74
Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Res (2006) 5.72
MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior. J Clin Oncol (2006) 5.40
The Lin28/let-7 axis regulates glucose metabolism. Cell (2011) 4.65
Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol (2009) 4.41
Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem (2008) 4.40
MicroRNA silencing through RISC recruitment of eIF6. Nature (2007) 4.37
An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell (2011) 4.29
The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform. Gynecol Oncol (2008) 4.10
A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell (2010) 4.02
MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci U S A (2008) 3.77
EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science (2012) 3.74
The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity (2009) 3.58
Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell (2010) 3.53
The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell (2013) 3.27
Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell (2013) 3.08
The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors. Cancer Res (2009) 3.03
Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. Am J Physiol Endocrinol Metab (2006) 3.03
Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione. Gastroenterology (2007) 2.72
Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol (2008) 2.51
MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci Signal (2009) 2.38
Targeted deletion of Wwox reveals a tumor suppressor function. Proc Natl Acad Sci U S A (2007) 2.37
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature (2013) 2.34
Molecular basis for interaction of let-7 microRNAs with Lin28. Cell (2011) 2.28
Principles and clinical implications of the brain-gut-enteric microbiota axis. Nat Rev Gastroenterol Hepatol (2009) 2.24
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature (2009) 2.22
Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc Natl Acad Sci U S A (2012) 2.11
How does Lin28 let-7 control development and disease? Trends Cell Biol (2012) 2.09
Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci U S A (2005) 2.08
Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia. Am J Physiol Gastrointest Liver Physiol (2005) 1.99
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell (2011) 1.95
Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression. Proc Natl Acad Sci U S A (2010) 1.94
Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine. Gastroenterology (2003) 1.91
NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc Natl Acad Sci U S A (2010) 1.90
Serum and colonic mucosal immune markers in irritable bowel syndrome. Am J Gastroenterol (2011) 1.89
Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. Mol Cell (2010) 1.86
Concern WWOX gene restoration prevents lung cancer growth in vitro and in vivo. Proc Natl Acad Sci U S A (2005) 1.84
A comparison of normalization techniques for microRNA microarray data. Stat Appl Genet Mol Biol (2008) 1.82
Translation inhibitor Pdcd4 is targeted for degradation during tumor promotion. Cancer Res (2008) 1.78
Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). RNA (2012) 1.74
Alterations of the tumor suppressor gene ARLTS1 in ovarian cancer. Cancer Res (2006) 1.71
Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents. Gastroenterology (2011) 1.71
Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer. Gastroenterology (2008) 1.70
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism. J Biol Chem (2008) 1.67
Post-transcriptional control of DGCR8 expression by the Microprocessor. RNA (2009) 1.67
Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. Gut (2012) 1.65
Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea. Gastroenterology (2005) 1.62
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology (2007) 1.60
MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity. Cell Stem Cell (2010) 1.53
FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway. Mol Cell (2011) 1.49
Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression. Ann Rheum Dis (2011) 1.49
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma. Cancer (2004) 1.49
Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation. Cancer Res (2011) 1.48
A role for the WWOX gene in prostate cancer. Cancer Res (2006) 1.45
MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells. J Biol Chem (2004) 1.42
MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis. Gastroenterology (2013) 1.41
Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. Physiol Rev (2014) 1.40
Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes. J Biol Chem (2004) 1.38
Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun (2012) 1.35
Epigenetic aberrations during oncogenesis. Cell Mol Life Sci (2011) 1.32
TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells. J Biol Chem (2010) 1.31
gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A. Infect Immun (2008) 1.30
Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells. J Biol Chem (2006) 1.27
MicroRNA Gene Networks in Oncogenesis. Curr Genomics (2009) 1.26
Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression. Biochem Biophys Res Commun (2006) 1.26
Substance P mediates antiapoptotic responses in human colonocytes by Akt activation. Proc Natl Acad Sci U S A (2007) 1.25
Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders. Therap Adv Gastroenterol (2012) 1.25
Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase. Gastroenterology (2005) 1.25
Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis. J Biol Chem (2006) 1.25
Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors. Gastroenterology (2011) 1.24
Wwox and Ap2gamma expression levels predict tamoxifen response. Clin Cancer Res (2007) 1.22
An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state. Proc Natl Acad Sci U S A (2012) 1.22
Role of neuropeptides in inflammatory bowel disease. Inflamm Bowel Dis (2007) 1.22
Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats. Am J Physiol Gastrointest Liver Physiol (2011) 1.22
Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci U S A (2006) 1.22
Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins. Nat Med (2011) 1.19
Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation. Proc Natl Acad Sci U S A (2004) 1.19
Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis. Endocrinology (2008) 1.19
Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo. Cancer Res (2007) 1.19
Corticotropin-releasing hormone antagonists possess anti-inflammatory effects in the mouse ileum. Gastroenterology (2002) 1.18
Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation. Gastroenterology (2002) 1.17
Lsh controls silencing of the imprinted Cdkn1c gene. Development (2005) 1.16
Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. J Biol Chem (2005) 1.16