Published in Nat Immunol on October 28, 2007
Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling. Genome Biol (2008) 3.93
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev (2008) 3.80
NK cell development, homeostasis and function: parallels with CD8⁺ T cells. Nat Rev Immunol (2011) 3.38
Controlling natural killer cell responses: integration of signals for activation and inhibition. Annu Rev Immunol (2013) 3.38
The alliance of sphingosine-1-phosphate and its receptors in immunity. Nat Rev Immunol (2008) 3.35
The outs and the ins of sphingosine-1-phosphate in immunity. Nat Rev Immunol (2011) 3.07
T-cell and natural killer-cell large granular lymphocyte leukemia neoplasias. Leuk Lymphoma (2011) 2.37
International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev (2010) 2.10
Cutting edge: Priming of NK cells by IL-18. J Immunol (2008) 2.08
Molecular definition of the identity and activation of natural killer cells. Nat Immunol (2012) 1.97
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med (2009) 1.86
Oncolytic virotherapy: molecular targets in tumor-selective replication and carrier cell-mediated delivery of oncolytic viruses. Biochim Biophys Acta (2008) 1.82
T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med (2014) 1.82
Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. J Exp Med (2010) 1.73
Extracellular and intracellular actions of sphingosine-1-phosphate. Adv Exp Med Biol (2010) 1.67
The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat Immunol (2014) 1.51
Organ-specific features of natural killer cells. Nat Rev Immunol (2011) 1.48
Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential. Mediators Inflamm (2016) 1.46
Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes. Blood (2008) 1.45
Biological roles of lysophospholipid receptors revealed by genetic null mice: an update. Biochim Biophys Acta (2008) 1.43
An update on the biology of sphingosine 1-phosphate receptors. J Lipid Res (2014) 1.37
Fingolimod is a potential novel therapy for multiple sclerosis. Nat Rev Neurol (2010) 1.36
Sphingosine 1-phosphate in coagulation and inflammation. Semin Immunopathol (2011) 1.34
Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. Chem Rev (2011) 1.29
Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. J Biol Chem (2010) 1.27
Sphingosine-1-phosphate and immune regulation: trafficking and beyond. Trends Pharmacol Sci (2010) 1.27
Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation. J Immunol (2009) 1.26
Lysophospholipids and their receptors in the central nervous system. Biochim Biophys Acta (2012) 1.21
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A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow. PLoS One (2010) 1.20
The role of sphingosine-1-phosphate transporter Spns2 in immune system function. J Immunol (2012) 1.20
Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation. Biochimie (2010) 1.19
Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection. J Exp Med (2015) 1.11
Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets. Blood (2012) 1.07
S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development. Eur J Immunol (2010) 1.04
Natural killer cell responses to viral infection. J Innate Immun (2011) 1.03
NK cells in immunotolerant organs. Cell Mol Immunol (2013) 1.01
p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease. Proc Natl Acad Sci U S A (2009) 1.00
An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease. Adv Exp Med Biol (2011) 0.99
Sphingosine-1-phosphate receptor 2. FEBS J (2013) 0.97
Natural killer cell distribution and trafficking in human tissues. Front Immunol (2012) 0.96
Fingolimod for the treatment of neurological diseases-state of play and future perspectives. Front Cell Neurosci (2014) 0.96
CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice. PLoS One (2012) 0.95
Detection of host-derived sphingosine by Pseudomonas aeruginosa is important for survival in the murine lung. PLoS Pathog (2014) 0.93
Sphingosine 1-phosphate chemical biology. Biochim Biophys Acta (2008) 0.93
Transcriptional control of natural killer cell differentiation and function. Cell Mol Life Sci (2011) 0.93
The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis. Lymphat Res Biol (2012) 0.92
Unraveling the complexities of sphingosine-1-phosphate function: the mast cell model. Prostaglandins Other Lipid Mediat (2008) 0.92
Emerging insights into natural killer cells in human peripheral tissues. Nat Rev Immunol (2016) 0.91
Transcription factors involved in the regulation of natural killer cell development and function: an update. Front Immunol (2012) 0.91
Human Circulating and Tissue-Resident CD56(bright) Natural Killer Cell Populations. Front Immunol (2016) 0.89
Kruppel-like factor 4 (KLF4) promotes the survival of natural killer cells and maintains the number of conventional dendritic cells in the spleen. J Leukoc Biol (2012) 0.87
Immunological function of sphingosine 1-phosphate in the intestine. Nutrients (2012) 0.86
Chronic alcohol consumption decreases the percentage and number of NK cells in the peripheral lymph nodes and exacerbates B16BL6 melanoma metastasis into the draining lymph nodes. Cell Immunol (2010) 0.86
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. J Exp Med (2014) 0.85
PTEN regulates natural killer cell trafficking in vivo. Proc Natl Acad Sci U S A (2015) 0.85
Mouse lung and spleen natural killer cells have phenotypic and functional differences, in part influenced by macrophages. PLoS One (2012) 0.84
Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype. PLoS One (2012) 0.83
Differential chemotactic receptor requirements for NK cell subset trafficking into bone marrow. Front Immunol (2013) 0.83
Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature (2017) 0.83
The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and cancer cells. Expert Opin Ther Targets (2013) 0.82
The toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism. Oncotarget (2016) 0.82
Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism. Acta Pharm Sin B (2015) 0.82
Shining a light on intestinal traffic. Clin Dev Immunol (2011) 0.82
Differential modulating effect of natural killer (NK) T cells on interferon-γ production and cytotoxic function of NK cells and its relationship with NK subsets in Chlamydia muridarum infection. Immunology (2011) 0.82
TOX2 regulates human natural killer cell development by controlling T-BET expression. Blood (2014) 0.81
The role of sphingosine-1-phosphate in endothelial barrier function. Biochim Biophys Acta (2014) 0.81
CCR2 inhibition sequesters multiple subsets of leukocytes in the bone marrow. Sci Rep (2015) 0.80
Natural Killer Cells in Afferent Lymph Express an Activated Phenotype and Readily Produce IFN-γ. Front Immunol (2013) 0.80
Exit Strategies: S1P Signaling and T Cell Migration. Trends Immunol (2015) 0.80
Critical Role of the Sphingolipid Pathway in Stroke: a Review of Current Utility and Potential Therapeutic Targets. Transl Stroke Res (2016) 0.80
Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1. Blood (2013) 0.79
Controlled infection with a therapeutic virus defines the activation kinetics of human natural killer cells in vivo. Clin Exp Immunol (2015) 0.78
The sphingosine-1-phosphate receptor: A novel therapeutic target for multiple sclerosis and other autoimmune diseases. Clin Immunol (2016) 0.78
Immune dysfunction in Niemann-Pick disease type C. J Neurochem (2015) 0.78
Chronic alcohol consumption impairs distribution and compromises circulation of B cells in B16BL6 melanoma-bearing mice. J Immunol (2012) 0.78
Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. Annu Rev Physiol (2016) 0.77
Analysis of sphingosine kinase activity in single natural killer cells from peripheral blood. Integr Biol (Camb) (2015) 0.76
Targeting sphingosine-1-phosphate receptors in cancer. Anticancer Agents Med Chem (2011) 0.76
ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. PLoS One (2014) 0.76
Visualizing S1P-directed cellular egress by intravital imaging. Biochim Biophys Acta (2013) 0.76
The role of sphingosine 1-phosphate in immunity and sepsis. Am J Clin Exp Immunol (2012) 0.75
Comparative Analysis of Conventional Natural Killer Cell Responses to Acute Infection with Toxoplasma gondii Strains of Different Virulence. Front Immunol (2016) 0.75
Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis. J Exp Med (2015) 0.75
Frequency and phenotype of NK cells and NK cell subsets in bovine lymphoid compartments and blood. Immunology (2017) 0.75
Regulatory Functions of Natural Killer Cells in Multiple Sclerosis. Front Immunol (2016) 0.75
"Dicing and Splicing" Sphingosine Kinase and Relevance to Cancer. Int J Mol Sci (2017) 0.75
Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response. Nat Immunol (2016) 0.75
The novel sphingosine-1-phosphate receptors antagonist AD2900 affects lymphocyte activation and inhibits T-cell entry into the lymph nodes. Oncotarget (2017) 0.75
FTY720 ameliorates renal fibrosis by simultaneously affecting leukocyte recruitment and TGF-β signaling in fibroblasts. Clin Exp Immunol (2017) 0.75
Functions of natural killer cells. Nat Immunol (2008) 9.88
Innate lymphoid cells--a proposal for uniform nomenclature. Nat Rev Immunol (2013) 7.94
Human NK cell education by inhibitory receptors for MHC class I. Immunity (2006) 6.73
TLR3 deficiency in patients with herpes simplex encephalitis. Science (2007) 5.86
Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol (2008) 4.78
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science (2013) 4.60
The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. Immunity (2012) 4.32
Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling. Genome Biol (2008) 3.93
Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46. Proc Natl Acad Sci U S A (2007) 3.60
Maturation of mouse NK cells is a 4-stage developmental program. Blood (2009) 3.31
A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med (2006) 3.21
The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. J Exp Med (2009) 3.17
Natural-killer cells and dendritic cells: "l'union fait la force". Blood (2005) 3.10
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo. J Exp Med (2008) 3.03
Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nat Med (2011) 3.03
CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. J Exp Med (2005) 2.93
Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat Immunol (2002) 2.87
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med (2007) 2.85
Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood (2009) 2.75
The trafficking of natural killer cells. Immunol Rev (2007) 2.62
Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors. Proc Natl Acad Sci U S A (2005) 2.55
Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. Neuron (2007) 2.38
NK cell responsiveness is tuned commensurate with the number of inhibitory receptors for self-MHC class I: the rheostat model. J Immunol (2009) 2.12
Germ-line and rearranged Tcrd transcription distinguish bona fide NK cells and NK-like gammadelta T cells. Eur J Immunol (2007) 2.11
Cutting edge: Priming of NK cells by IL-18. J Immunol (2008) 2.08
Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future. Immunol Rev (2008) 2.05
Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor. Proc Natl Acad Sci U S A (2011) 2.01
Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins. J Biol Chem (2005) 2.01
Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. Science (2012) 1.98
Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses. J Immunol (2011) 1.97
Natural killer cells promote early CD8 T cell responses against cytomegalovirus. PLoS Pathog (2007) 1.93
Identity, regulation and in vivo function of gut NKp46+RORγt+ and NKp46+RORγt- lymphoid cells. EMBO J (2011) 1.74
Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J Exp Med (2007) 1.73
The speed of change: towards a discontinuity theory of immunity? Nat Rev Immunol (2013) 1.72
Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses. Blood (2007) 1.66
Natural killer cells: from CD3(-)NKp46(+) to post-genomics meta-analyses. Curr Opin Immunol (2007) 1.65
Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways. Blood (2008) 1.56
Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies. Blood (2013) 1.55
NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors. Nat Med (2012) 1.52
Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum. Proc Natl Acad Sci U S A (2005) 1.50
Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells. Blood (2005) 1.50
Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors. Eur J Immunol (2004) 1.48
Interferon-γ production by natural killer cells and cytomegalovirus in critically ill patients. Crit Care Med (2012) 1.43
Multiplicity and plasticity of natural killer cell signaling pathways. Blood (2005) 1.40
Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis. J Exp Med (2012) 1.39
Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist. J Immunol (2004) 1.39
Membrane nanotubes facilitate long-distance interactions between natural killer cells and target cells. Proc Natl Acad Sci U S A (2010) 1.38
Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency. J Clin Invest (2012) 1.35
Pivotal role of KARAP/DAP12 adaptor molecule in the natural killer cell-mediated resistance to murine cytomegalovirus infection. J Exp Med (2002) 1.33
Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance. Sci Signal (2011) 1.30
Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nat Immunol (2002) 1.29
Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. J Neurosci (2004) 1.29
Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition? Curr Opin Immunol (2002) 1.28
Syk regulation of phosphoinositide 3-kinase-dependent NK cell function. J Immunol (2002) 1.28
Natural killer cells in human autoimmune diseases. Immunology (2010) 1.27
DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections. J Immunol (2006) 1.26
Coordinated expression of Ig-like inhibitory MHC class I receptors and acquisition of cytotoxic function in human CD8+ T cells. J Immunol (2004) 1.26
Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression. Hepatology (2012) 1.24
Interactions between human NK cells and macrophages in response to Salmonella infection. J Immunol (2009) 1.23
High antitumor activity of RLI, an interleukin-15 (IL-15)-IL-15 receptor alpha fusion protein, in metastatic melanoma and colorectal cancer. Mol Cancer Ther (2009) 1.23
Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j). J Exp Med (2003) 1.22
Essential role of DAP12 signaling in macrophage programming into a fusion-competent state. Sci Signal (2008) 1.22
Natural killer cell-dendritic cell crosstalk in the initiation of immune responses. Expert Opin Biol Ther (2005) 1.22
KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions. Eur J Immunol (2005) 1.21
Nfil3-independent lineage maintenance and antiviral response of natural killer cells. J Exp Med (2013) 1.21
Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions. Blood (2013) 1.19
Selective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4+ T cells. J Exp Med (2003) 1.18
NK cell MHC class I specific receptors (KIR): from biology to clinical intervention. Curr Opin Immunol (2012) 1.18
Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo. Proc Natl Acad Sci U S A (2009) 1.16
A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivo. Blood (2008) 1.16
Differential responses of immune cells to type I interferon contribute to host resistance to viral infection. Cell Host Microbe (2012) 1.12
NCR3/NKp30 contributes to pathogenesis in primary Sjogren's syndrome. Sci Transl Med (2013) 1.12
TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells. Nat Cell Biol (2013) 1.12
DAP12 signaling regulates plasmacytoid dendritic cell homeostasis and down-modulates their function during viral infection. J Immunol (2006) 1.11
B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors. Cell Mol Life Sci (2011) 1.11