Published in Arterioscler Thromb Vasc Biol on November 01, 2007
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J (2008) 4.49
Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis. Mol Cancer Res (2009) 1.10
Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived reactive oxygen species. Arterioscler Thromb Vasc Biol (2010) 1.04
Regulation of heat shock protein 60 and 72 expression in the failing heart. J Mol Cell Cardiol (2009) 1.01
Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process. FASEB J (2011) 0.98
High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction. Am J Physiol Cell Physiol (2008) 0.97
Nogo-B receptor is essential for angiogenesis in zebrafish via Akt pathway. Blood (2010) 0.96
Histone deacetylase inhibitors increase glucocerebrosidase activity in Gaucher disease by modulation of molecular chaperones. Proc Natl Acad Sci U S A (2012) 0.95
HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-κB pathways. Inflamm Res (2012) 0.95
HSF1 protects neurons through a novel trimerization- and HSP-independent mechanism. J Neurosci (2014) 0.93
Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis. Mol Cell Biol (2010) 0.90
A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair. PLoS One (2012) 0.90
ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein. J Biol Chem (2010) 0.89
Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme. Proc Natl Acad Sci U S A (2012) 0.88
Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. Free Radic Biol Med (2012) 0.87
Role of nitric oxide in placental vascular development and function. Placenta (2011) 0.86
Heat shock protein 90 inhibitors prevent LPS-induced endothelial barrier dysfunction by disrupting RhoA signaling. Am J Respir Cell Mol Biol (2014) 0.85
Hantavirus interferon regulation and virulence determinants. Virus Res (2014) 0.81
Hypoxia induces permeability and giant cell responses of Andes virus-infected pulmonary endothelial cells by activating the mTOR-S6K signaling pathway. J Virol (2013) 0.79
Amyloid β peptide-induced inhibition of endothelial nitric oxide production involves oxidative stress-mediated constitutive eNOS/HSP90 interaction and disruption of agonist-mediated Akt activation. J Neuroinflammation (2015) 0.77
Inhibitor-κB kinase attenuates Hsp90-dependent endothelial nitric oxide synthase function in vascular endothelial cells. Am J Physiol Cell Physiol (2015) 0.77
TRIM32-Cytoplasmic-Body Formation Is an ATP-Consuming Process Stimulated by HSP70 in Cells. PLoS One (2017) 0.75
Expression of endothelial nitric oxide synthase protein is not necessary for mechanical strain-induced nitric oxide production by cultured osteoblasts. Osteoporos Int (2012) 0.75
Hsp90 regulation of fibroblast activation in pulmonary fibrosis. JCI Insight (2017) 0.75
Bipartite Role of Heat Shock Protein 90 (Hsp90) Keeps CRAF Kinase Poised for Activation. J Biol Chem (2016) 0.75
Twin layers of lightning: a new role for the chaperone Hsp90 in angiogenesis. Arterioscler Thromb Vasc Biol (2007) 0.75
Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha. Oncotarget (2017) 0.75
Differential effects of heat shock protein 90 and serine 1179 phosphorylation on endothelial nitric oxide synthase activity and on its cofactors. PLoS One (2017) 0.75
Evolving functions of endothelial cells in inflammation. Nat Rev Immunol (2007) 4.94
Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells. Circ Res (2007) 4.72
Nitric oxide synthases: regulation and function. Eur Heart J (2011) 4.71
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell (2006) 4.55
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J (2008) 4.49
Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. J Clin Invest (2005) 3.95
Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A (2008) 3.03
Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circ Res (2002) 3.01
Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. Proc Natl Acad Sci U S A (2005) 2.81
A new role for Nogo as a regulator of vascular remodeling. Nat Med (2004) 2.63
Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab (2007) 2.53
Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels. J Clin Invest (2006) 2.47
MicroRNAs as novel regulators of angiogenesis. Circ Res (2009) 2.33
Caveolae and caveolins in the cardiovascular system. Circ Res (2004) 2.24
Caveolin regulation of endothelial function. Am J Physiol Lung Cell Mol Physiol (2003) 2.22
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice. Cancer Cell (2003) 2.16
Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice. J Exp Med (2007) 2.04
MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function. Arterioscler Thromb Vasc Biol (2010) 2.00
Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase. J Biol Chem (2003) 1.98
Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking. Proc Natl Acad Sci U S A (2006) 1.97
The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Sci Transl Med (2011) 1.95
Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen. J Biol Chem (2002) 1.91
Regulation of survivin function by Hsp90. Proc Natl Acad Sci U S A (2003) 1.86
Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production. J Biol Chem (2003) 1.80
Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. J Cell Biol (2006) 1.79
Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking. Cell Metab (2009) 1.76
Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis. Proc Natl Acad Sci U S A (2004) 1.75
Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation. Cardiovasc Res (2010) 1.69
Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol (2008) 1.68
The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. J Clin Invest (2007) 1.67
Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides. Proc Natl Acad Sci U S A (2005) 1.64
Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo. Proc Natl Acad Sci U S A (2005) 1.62
Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Cancer Res (2007) 1.62
eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity. J Endocrinol (2011) 1.60
Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. J Cell Biol (2008) 1.56
Perivascular nitric oxide gradients normalize tumor vasculature. Nat Med (2008) 1.56
Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration. J Cell Sci (2005) 1.54
Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo. Nat Med (2003) 1.52
Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions. Am J Pathol (2007) 1.52
Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme. J Biol Chem (2001) 1.51
Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. J Biol Chem (2007) 1.51
Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis. Am J Pathol (2006) 1.50
Caveolin-1 can regulate vascular smooth muscle cell fate by switching platelet-derived growth factor signaling from a proliferative to an apoptotic pathway. Arterioscler Thromb Vasc Biol (2003) 1.50
AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J Clin Invest (2008) 1.49
Expression and function of recombinant S1179D endothelial NO synthase in human pial arteries. Stroke (2004) 1.47
Akt1 is critical for acute inflammation and histamine-mediated vascular leakage. Proc Natl Acad Sci U S A (2009) 1.46
Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion. Circ Res (2002) 1.46
Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin Invest (2006) 1.46
Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis. Oncogene (2005) 1.45
Venous identity is lost but arterial identity is not gained during vein graft adaptation. Arterioscler Thromb Vasc Biol (2007) 1.45
Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis. Cell Metab (2009) 1.44
Endothelial nitric oxide synthase: the Cinderella of inflammation? Trends Pharmacol Sci (2003) 1.43
Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells. Am J Physiol Cell Physiol (2004) 1.43
Inhibitor of apoptosis protein survivin regulates vascular injury. Nat Med (2002) 1.42
CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. J Clin Invest (2010) 1.42
Following footsteps. Q&A with David Fulton Jr. 2013 CDS President. Interview by Walter Lamacki. CDS Rev (2013) 1.39
Traverse the cliffs as a unified profession. CDS Rev (2013) 1.39
Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. Proc Natl Acad Sci U S A (2006) 1.39
Retracted Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration. J Cell Sci (2016) 1.38
Subcellular targeting and trafficking of nitric oxide synthases. Biochem J (2006) 1.37
Endothelial nitric oxide synthase regulates microvascular hyperpermeability in vivo. J Physiol (2006) 1.36
Differences in eNOS activity because of subcellular localization are dictated by phosphorylation state rather than the local calcium environment. J Biol Chem (2005) 1.35
Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release. J Biol Chem (2004) 1.34
Functional relevance of Golgi- and plasma membrane-localized endothelial NO synthase in reconstituted endothelial cells. Arterioscler Thromb Vasc Biol (2006) 1.34
Interferon-gamma plays a nonredundant role in mediating T cell-dependent outward vascular remodeling of allogeneic human coronary arteries. FASEB J (2004) 1.33
Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function. PLoS One (2011) 1.33
Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis. Arterioscler Thromb Vasc Biol (2009) 1.32
Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proc Natl Acad Sci U S A (2006) 1.32
Chaperone-dependent regulation of endothelial nitric-oxide synthase intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP. J Biol Chem (2003) 1.31
Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics. Circ Res (2004) 1.30
Intracellular location regulates calcium-calmodulin-dependent activation of organelle-restricted eNOS. Am J Physiol Cell Physiol (2005) 1.28
Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proc Natl Acad Sci U S A (2009) 1.27
Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis. Am J Pathol (2008) 1.25
PKCalpha activates eNOS and increases arterial blood flow in vivo. Circ Res (2005) 1.22
miRNAs as modulators of angiogenesis. Cold Spring Harb Perspect Med (2013) 1.21
The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Sci Signal (2009) 1.19
Coordinated regulation of endothelial nitric oxide synthase activity by phosphorylation and subcellular localization. Free Radic Biol Med (2006) 1.19
Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function. J Biol Chem (2007) 1.19