MicroRNAs as novel regulators of angiogenesis.

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia. J Cell Mol Med (2011) 2.63

MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. Proc Natl Acad Sci U S A (2010) 2.58

MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arterioscler Thromb Vasc Biol (2011) 2.31

Global microRNA depletion suppresses tumor angiogenesis. Genes Dev (2014) 1.76

Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci U S A (2010) 1.73

MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1. Am J Physiol Endocrinol Metab (2010) 1.73

Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium. Arterioscler Thromb Vasc Biol (2012) 1.71

Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer. Oncogene (2013) 1.71

MicroRNA-196: critical roles and clinical applications in development and cancer. J Cell Mol Med (2011) 1.59

MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling. Circ Res (2010) 1.56

Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues. J Exp Clin Cancer Res (2012) 1.55

VEGF-Induced Expression of miR-17-92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis. Circ Res (2015) 1.52

Circulating microRNAs in cancer: origin, function and application. J Exp Clin Cancer Res (2012) 1.50

microRNAs and cholesterol metabolism. Trends Endocrinol Metab (2010) 1.49

Enhanced Cardiac Regenerative Ability of Stem Cells After Ischemia-Reperfusion Injury: Role of Human CD34(+) Cells Deficient in MicroRNA-377. J Am Coll Cardiol (2015) 1.45

Extracellular matrix, inflammation, and the angiogenic response. Cardiovasc Res (2010) 1.45

αV integrins in angiogenesis and cancer. Cold Spring Harb Perspect Med (2011) 1.33

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function. PLoS One (2011) 1.33

The role of microRNAs in cholesterol efflux and hepatic lipid metabolism. Annu Rev Nutr (2011) 1.30

In vivo delivery of miRNAs for cancer therapy: challenges and strategies. Adv Drug Deliv Rev (2014) 1.28

miR-221 is required for endothelial tip cell behaviors during vascular development. Dev Cell (2012) 1.28

miRNAs as modulators of angiogenesis. Cold Spring Harb Perspect Med (2013) 1.21

Vascular endothelial cell-specific microRNA-15a inhibits angiogenesis in hindlimb ischemia. J Biol Chem (2012) 1.19

Restoration of altered microRNA expression in the ischemic heart with resveratrol. PLoS One (2010) 1.17

Ets-1 and Ets-2 regulate the expression of microRNA-126 in endothelial cells. Arterioscler Thromb Vasc Biol (2010) 1.17

Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury? Physiol Genomics (2010) 1.16

Regulation of vascular endothelial growth factor signaling by miR-200b. Mol Cells (2011) 1.15

miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo. Mol Cell Biol (2010) 1.15

Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes. Environ Health Perspect (2010) 1.07

MicroRNA signatures in tumor tissue related to angiogenesis in non-small cell lung cancer. PLoS One (2012) 1.07

Down-regulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2. PLoS One (2011) 1.07

MicroRNAs in hepatocellular carcinoma: carcinogenesis, progression, and therapeutic target. Biomed Res Int (2014) 1.07

The roles of microRNAs in tumorigenesis and angiogenesis. Int J Physiol Pathophysiol Pharmacol (2010) 1.03

Regulation of cancer metastasis by cell-free miRNAs. Biochim Biophys Acta (2014) 1.02

Influence of sex differences on microRNA gene regulation in disease. Biol Sex Differ (2014) 1.00

Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221. Mol Cell Biol (2010) 1.00

Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules: the Normative Aging Study. Environ Health (2011) 1.00

MicroRNA-mediated regulation of the angiogenic switch. Curr Opin Hematol (2011) 1.00

Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression. J Biol Chem (2012) 0.99

miRNAs: roles and clinical applications in vascular disease. Expert Rev Mol Diagn (2011) 0.98

MicroRNAs, immune cells and pregnancy. Cell Mol Immunol (2014) 0.97

miRNAs in breast cancer tumorigenesis (Review). Oncol Rep (2011) 0.96

Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells. J Gerontol A Biol Sci Med Sci (2012) 0.95

MicroRNAs and Multiple Sclerosis. Autoimmune Dis (2010) 0.94

Sustained delivery of proangiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation. FASEB J (2013) 0.94

Prognostic value of miR-21 in various cancers: an updating meta-analysis. PLoS One (2014) 0.93

The distribution of circulating microRNA and their relation to coronary disease. F1000Res (2012) 0.93

MicroRNAs as pharmacological targets in endothelial cell function and dysfunction. Pharmacol Res (2013) 0.92

Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXRα expression and cholesterol homeostasis. Cell Death Dis (2013) 0.92

Downregulation of microRNA-130a contributes to endothelial progenitor cell dysfunction in diabetic patients via its target Runx3. PLoS One (2013) 0.92

Non-coding RNAs in cerebral endothelial pathophysiology: emerging roles in stroke. Neurochem Int (2014) 0.92

MicroRNAs: promising new antiangiogenic targets in cancer. Biomed Res Int (2014) 0.91

Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer. PLoS One (2014) 0.90

Vascular remodeling process in pulmonary arterial hypertension, with focus on miR-204 and miR-126 (2013 Grover Conference series). Pulm Circ (2014) 0.90

An ER-associated miRNA signature predicts prognosis in ER-positive breast cancer. J Exp Clin Cancer Res (2014) 0.89

Epigenetic impact of curcumin on stroke prevention. Metab Brain Dis (2014) 0.89

Angiogenesis-regulating microRNAs and Ischemic Stroke. Curr Vasc Pharmacol (2015) 0.89

Novel tissue-specific mechanism of regulation of angiogenesis and cancer growth in response to hyperglycemia. J Am Heart Assoc (2012) 0.88

Autoregulation of glypican-1 by intronic microRNA-149 fine tunes the angiogenic response to FGF2 in human endothelial cells. J Cell Sci (2014) 0.87

MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome. BMC Med Genomics (2014) 0.86

A Comprehensive Review of Dysregulated miRNAs Involved in Cervical Cancer. Curr Genomics (2014) 0.86

Effect of maternal undernutrition on vascular expression of micro and messenger RNA in newborn and aging offspring. Am J Physiol Regul Integr Comp Physiol (2010) 0.86

Mechanistic, technical, and clinical perspectives in therapeutic stimulation of coronary collateral development by angiogenic growth factors. Mol Ther (2013) 0.86

Dual Anti-Inflammatory and Anti-Angiogenic Action of miR-15a in Diabetic Retinopathy. EBioMedicine (2016) 0.85

Myocardial therapeutic angiogenesis: a review of the state of development and future obstacles. Expert Rev Cardiovasc Ther (2011) 0.83

Lack of association between hsa-miR-149 rs2292832 polymorphism and cancer risk: a meta-analysis of 12 studies. PLoS One (2013) 0.83

MicroRNA-152 represses VEGF and TGFβ1 expressions through post-transcriptional inhibition of (Pro)renin receptor in human retinal endothelial cells. Mol Vis (2015) 0.83

MicroRNA in exosomes isolated directly from the liver circulation in patients with metastatic uveal melanoma. BMC Cancer (2014) 0.83

Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia. Exp Neurol (2015) 0.82

The role of the blood transcriptome in innate inflammation and stroke. Ann N Y Acad Sci (2010) 0.81

MicroRNAs: new insights into chronic childhood diseases. Biomed Res Int (2013) 0.81

MiR-34a regulates blood-tumor barrier function by targeting protein kinase Cε. Mol Biol Cell (2015) 0.81

Diagnostic value of microRNAs in asbestos exposure and malignant mesothelioma: systematic review and qualitative meta-analysis. Oncotarget (2016) 0.80

Peritoneal fluid reduces angiogenesis-related microRNA expression in cell cultures of endometrial and endometriotic tissues from women with endometriosis. PLoS One (2013) 0.80

Plasma levels of microRNA in chronic kidney disease: patterns in acute and chronic exercise. Am J Physiol Heart Circ Physiol (2015) 0.80

A panel of 13-miRNA signature as a potential biomarker for predicting survival in pancreatic cancer. Oncotarget (2016) 0.80

Systematic Review of Micro-RNA Expression in Pre-Eclampsia Identifies a Number of Common Pathways Associated with the Disease. PLoS One (2016) 0.79

MicroRNA signature of inflamed lymphatic endothelium and role of miR-9 in lymphangiogenesis and inflammation. Am J Physiol Cell Physiol (2015) 0.79

Prognostic Role of MicroRNA-126 for Survival in Malignant Tumors: A Systematic Review and Meta-Analysis. Dis Markers (2015) 0.79

Expression of pro- and anti-angiogenic factors during the formation of the periocular vasculature and development of the avian cornea. Dev Dyn (2013) 0.79

Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer. PLoS Comput Biol (2015) 0.79

Dual targeting of ANGPT1 and TGFBR2 genes by miR-204 controls angiogenesis in breast cancer. Sci Rep (2016) 0.78

E2F and microRNA regulation of angiogenesis. Am J Cardiovasc Dis (2011) 0.78

A syntenic locus on buffalo chromosome 20: novel genomic hotspot for miRNAs involved in follicular-luteal transition. Funct Integr Genomics (2016) 0.77

MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2. Cancer Cell Int (2017) 0.77

Uterine microRNA signature and consequence of their dysregulation in uterine disorders. Anim Reprod (2010) 0.77

Altered miRNA expression in pulmonary sarcoidosis. BMC Med Genet (2016) 0.77

WISP-1 promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-300 in human oral squamous cell carcinoma cells. Oncotarget (2016) 0.77

Long-term exposure to black carbon, cognition and single nucleotide polymorphisms in microRNA processing genes in older men. Environ Int (2015) 0.77

Molecular Characterization of Macrophage-Biomaterial Interactions. Adv Exp Med Biol (2015) 0.77

CCL3 promotes angiogenesis by dysregulation of miR-374b/ VEGF-A axis in human osteosarcoma cells. Oncotarget (2016) 0.76

Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function. J Biol Chem (2014) 0.76

Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31. Stem Cells Transl Med (2016) 0.76

Myeloperoxidase oxidized LDL interferes with endothelial cell motility through miR-22 and heme oxygenase 1 induction: possible involvement in reendothelialization of vascular injuries. Mediators Inflamm (2014) 0.75

miR-92a Corrects CD34+ Cell Dysfunction in Diabetes by Modulating Core Circadian Genes Involved in Progenitor Differentiation. Diabetes (2015) 0.75

Acute Response of Circulating Vascular Regulating MicroRNAs during and after High-Intensity and High-Volume Cycling in Children. Front Physiol (2016) 0.75

Challenge and promise: the role of miRNA for pathogenesis and progression of malignant melanoma. Clin Epigenetics (2010) 0.75

MicroRNAs in congenital heart disease. Ann Transl Med (2015) 0.75

Dissecting the mechanism of carotid atherosclerosis from the perspective of regulation. Int J Mol Med (2014) 0.75

miR-17-3p Exacerbates Oxidative Damage in Human Retinal Pigment Epithelial Cells. PLoS One (2016) 0.75

MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59

The functions of animal microRNAs. Nature (2004) 64.85

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell (1993) 64.62

Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer (2006) 46.47

A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21

A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A (2006) 40.09

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature (2000) 39.31

miRBase: tools for microRNA genomics. Nucleic Acids Res (2007) 38.61

The nuclear RNase III Drosha initiates microRNA processing. Nature (2003) 35.49

Identification of tissue-specific microRNAs from mouse. Curr Biol (2002) 34.55

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell (1993) 33.79

Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56

The impact of microRNAs on protein output. Nature (2008) 32.39

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2002) 32.26

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet (2008) 32.08

c-Myc-regulated microRNAs modulate E2F1 expression. Nature (2005) 31.81

Widespread changes in protein synthesis induced by microRNAs. Nature (2008) 31.44

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science (2001) 31.33

MicroRNAs modulate hematopoietic lineage differentiation. Science (2003) 30.05

NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A (2006) 21.58

miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A (2005) 21.51

MicroRNA genes are transcribed by RNA polymerase II. EMBO J (2004) 20.65

MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res (2005) 18.58

Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature (2005) 17.17

Nuclear export of microRNA precursors. Science (2003) 16.59

Requirement of bic/microRNA-155 for normal immune function. Science (2007) 16.24

Dicer is essential for mouse development. Nat Genet (2003) 15.87

microRNA functions. Annu Rev Cell Dev Biol (2007) 15.74

MicroRNA expression in zebrafish embryonic development. Science (2005) 15.52

Angiogenesis in life, disease and medicine. Nature (2005) 15.36

A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02

Vascular-specific growth factors and blood vessel formation. Nature (2000) 14.42

MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell (2003) 14.07

Angiogenesis in health and disease. Nat Med (2003) 14.02

Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci U S A (2005) 12.96

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature (2004) 12.75

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab (2006) 12.41

Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29

Regulation of the germinal center response by microRNA-155. Science (2007) 12.25

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol (2005) 12.12

Control of stress-dependent cardiac growth and gene expression by a microRNA. Science (2007) 12.08

The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev (2004) 11.58

Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA (2004) 11.52

LNA-mediated microRNA silencing in non-human primates. Nature (2008) 11.45

MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci U S A (2007) 11.42

MicroRNAs regulate brain morphogenesis in zebrafish. Science (2005) 11.16

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol (2008) 10.42

Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res (2005) 9.80

SMAD proteins control DROSHA-mediated microRNA maturation. Nature (2008) 9.67

Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol (2007) 9.65

Intronic microRNA precursors that bypass Drosha processing. Nature (2007) 9.65

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev (2004) 9.32

Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell (2005) 9.27

A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell (2005) 9.22

Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med (2003) 8.54

A MicroRNA feedback circuit in midbrain dopamine neurons. Science (2007) 8.33

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A (2005) 8.33

Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol (2007) 7.75

Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet (2006) 7.53

The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell (2008) 7.26

A microRNA signature of hypoxia. Mol Cell Biol (2006) 7.24

Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature (2007) 7.04

Angiogenesis. Annu Rev Med (2006) 6.94

miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell (2008) 6.59

Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression. Mol Cell Biol (2007) 6.43

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol (2005) 6.40

Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet (2006) 6.30

Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J (2007) 6.26

Illuminating the silence: understanding the structure and function of small RNAs. Nat Rev Mol Cell Biol (2007) 6.11

Dicer is essential for formation of the heterochromatin structure in vertebrate cells. Nat Cell Biol (2004) 5.92

A role for Dicer in immune regulation. J Exp Med (2006) 5.81

MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc Natl Acad Sci U S A (2005) 5.54

Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell (2008) 5.53

T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med (2005) 5.26

Argonaute proteins: mediators of RNA silencing. Mol Cell (2007) 5.16

MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci U S A (2008) 5.15

Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis. Circ Res (2007) 5.09

The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nat Genet (2003) 4.97

Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res (2008) 4.95

Evolving functions of endothelial cells in inflammation. Nat Rev Immunol (2007) 4.94

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest (1997) 4.92

Endothelial cells and VEGF in vascular development. Nature (2005) 4.92

The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution. Nat Struct Mol Biol (2008) 4.88

Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A (2006) 4.87

MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets. J Clin Invest (2007) 4.76

Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells. Circ Res (2007) 4.72

MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. J Biol Chem (2008) 4.69

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med (2008) 4.68

Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J Biol Chem (2006) 4.57

A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev (2005) 4.55

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis. RNA (2004) 4.50

Cerebellar neurodegeneration in the absence of microRNAs. J Exp Med (2007) 4.48

Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem (2004) 4.40

The E2F1-3 transcription factors are essential for cellular proliferation. Nature (2001) 4.37

T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell (2008) 4.32

Approaches to microRNA discovery. Nat Genet (2006) 4.32

MicroRNAs modulate the angiogenic properties of HUVECs. Blood (2006) 4.31

MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS One (2006) 4.29

Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A (2008) 4.00

MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression. Proc Natl Acad Sci U S A (2007) 3.92

Evolving functions of endothelial cells in inflammation. Nat Rev Immunol (2007) 4.94

Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells. Circ Res (2007) 4.72

Nitric oxide synthases: regulation and function. Eur Heart J (2011) 4.71

Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell (2006) 4.55

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J (2008) 4.49

Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. J Clin Invest (2005) 3.95

Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A (2008) 3.03

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circ Res (2002) 3.01

Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. Proc Natl Acad Sci U S A (2005) 2.81

A new role for Nogo as a regulator of vascular remodeling. Nat Med (2004) 2.63

Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab (2007) 2.53

Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels. J Clin Invest (2006) 2.47

Caveolae and caveolins in the cardiovascular system. Circ Res (2004) 2.24

Caveolin regulation of endothelial function. Am J Physiol Lung Cell Mol Physiol (2003) 2.22

Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice. Cancer Cell (2003) 2.16

Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice. J Exp Med (2007) 2.04

MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function. Arterioscler Thromb Vasc Biol (2010) 2.00

Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase. J Biol Chem (2003) 1.98

Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking. Proc Natl Acad Sci U S A (2006) 1.97

The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Sci Transl Med (2011) 1.95

Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen. J Biol Chem (2002) 1.91

Regulation of survivin function by Hsp90. Proc Natl Acad Sci U S A (2003) 1.86

Dominant-negative Hsp90 reduces VEGF-stimulated nitric oxide release and migration in endothelial cells. Arterioscler Thromb Vasc Biol (2007) 1.80

Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production. J Biol Chem (2003) 1.80

Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. J Cell Biol (2006) 1.79

Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking. Cell Metab (2009) 1.76

Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis. Proc Natl Acad Sci U S A (2004) 1.75

Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation. Cardiovasc Res (2010) 1.69

Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol (2008) 1.68

The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. J Clin Invest (2007) 1.67

Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides. Proc Natl Acad Sci U S A (2005) 1.64

Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo. Proc Natl Acad Sci U S A (2005) 1.62

Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Cancer Res (2007) 1.62

Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. J Cell Biol (2008) 1.56

Perivascular nitric oxide gradients normalize tumor vasculature. Nat Med (2008) 1.56

Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo. Nat Med (2003) 1.52

Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions. Am J Pathol (2007) 1.52

Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme. J Biol Chem (2001) 1.51

Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. J Biol Chem (2007) 1.51

Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis. Am J Pathol (2006) 1.50

Caveolin-1 can regulate vascular smooth muscle cell fate by switching platelet-derived growth factor signaling from a proliferative to an apoptotic pathway. Arterioscler Thromb Vasc Biol (2003) 1.50

AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J Clin Invest (2008) 1.49

Expression and function of recombinant S1179D endothelial NO synthase in human pial arteries. Stroke (2004) 1.47

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage. Proc Natl Acad Sci U S A (2009) 1.46

Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion. Circ Res (2002) 1.46

Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin Invest (2006) 1.46

Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis. Oncogene (2005) 1.45

Venous identity is lost but arterial identity is not gained during vein graft adaptation. Arterioscler Thromb Vasc Biol (2007) 1.45

Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis. Cell Metab (2009) 1.44

Endothelial nitric oxide synthase: the Cinderella of inflammation? Trends Pharmacol Sci (2003) 1.43

Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells. Am J Physiol Cell Physiol (2004) 1.43

Inhibitor of apoptosis protein survivin regulates vascular injury. Nat Med (2002) 1.42

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. J Clin Invest (2010) 1.42

Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. Proc Natl Acad Sci U S A (2006) 1.39

Endothelial nitric oxide synthase regulates microvascular hyperpermeability in vivo. J Physiol (2006) 1.36

Functional relevance of Golgi- and plasma membrane-localized endothelial NO synthase in reconstituted endothelial cells. Arterioscler Thromb Vasc Biol (2006) 1.34

Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release. J Biol Chem (2004) 1.34

Interferon-gamma plays a nonredundant role in mediating T cell-dependent outward vascular remodeling of allogeneic human coronary arteries. FASEB J (2004) 1.33

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function. PLoS One (2011) 1.33

Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis. Arterioscler Thromb Vasc Biol (2009) 1.32

Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proc Natl Acad Sci U S A (2006) 1.32

Chaperone-dependent regulation of endothelial nitric-oxide synthase intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP. J Biol Chem (2003) 1.31

Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics. Circ Res (2004) 1.30

Intracellular location regulates calcium-calmodulin-dependent activation of organelle-restricted eNOS. Am J Physiol Cell Physiol (2005) 1.28

Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proc Natl Acad Sci U S A (2009) 1.27

Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis. Am J Pathol (2008) 1.25

PKCalpha activates eNOS and increases arterial blood flow in vivo. Circ Res (2005) 1.22

miRNAs as modulators of angiogenesis. Cold Spring Harb Perspect Med (2013) 1.21

The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Sci Signal (2009) 1.19

Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function. J Biol Chem (2007) 1.19

Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells. Mol Cell (2010) 1.18

T cell-mediated vascular dysfunction of human allografts results from IFN-gamma dysregulation of NO synthase. J Clin Invest (2004) 1.17

Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation. Proc Natl Acad Sci U S A (2007) 1.16

Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase. Free Radic Biol Med (2003) 1.16

Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury? Physiol Genomics (2010) 1.16

Mild increases in portal pressure upregulate vascular endothelial growth factor and endothelial nitric oxide synthase in the intestinal microcirculatory bed, leading to a hyperdynamic state. Am J Physiol Gastrointest Liver Physiol (2006) 1.15

Angiopoietin-1 negatively regulates expression and activity of tissue factor in endothelial cells. FASEB J (2001) 1.15

Myoferlin is critical for endocytosis in endothelial cells. Am J Physiol Cell Physiol (2009) 1.13

A noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice. J Clin Invest (2011) 1.13

Low levels of Nogo-B in human carotid atherosclerotic plaques are associated with an atheromatous phenotype, restenosis, and stenosis severity. Arterioscler Thromb Vasc Biol (2007) 1.12

Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report. Arterioscler Thromb Vasc Biol (2011) 1.11

Antiangiogenic therapy: creating a unique "window" of opportunity. Cancer Cell (2004) 1.10

ATP-binding cassette transporter G1 and high-density lipoprotein promote endothelial NO synthesis through a decrease in the interaction of caveolin-1 and endothelial NO synthase. Arterioscler Thromb Vasc Biol (2010) 1.10

Role of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo. Proc Natl Acad Sci U S A (2008) 1.09

MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries. J Exp Med (2008) 1.09

Eph-B4 prevents venous adaptive remodeling in the adult arterial environment. J Exp Med (2011) 1.08

Histamine inhibits conducted vasodilation through endothelium-derived NO production in arterioles of mouse skeletal muscle. FASEB J (2004) 1.07

Endothelial-specific overexpression of caveolin-1 accelerates atherosclerosis in apolipoprotein E-deficient mice. Am J Pathol (2010) 1.05

eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases. J Cell Sci (2013) 1.04

Interaction between the 90-kDa heat shock protein and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding. Mol Pharmacol (2005) 1.04

Endothelial caveolin-1 regulates pathologic angiogenesis in a mouse model of colitis. Gastroenterology (2008) 1.04

Chronic treatment with nitric oxide-releasing aspirin reduces plasma low-density lipoprotein oxidation and oxidative stress, arterial oxidation-specific epitopes, and atherogenesis in hypercholesterolemic mice. Proc Natl Acad Sci U S A (2002) 1.04

The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation. Proc Natl Acad Sci U S A (2003) 1.04

Diabetic mouse angiopathy is linked to progressive sympathetic receptor deletion coupled to an enhanced caveolin-1 expression. Arterioscler Thromb Vasc Biol (2004) 1.03

Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation. Blood (2010) 1.03

Serial noninvasive targeted imaging of peripheral angiogenesis: validation and application of a semiautomated quantitative approach. J Nucl Med (2009) 1.02

Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension. Am J Physiol Gastrointest Liver Physiol (2002) 1.02

In vivo modulation of Nogo-B attenuates neointima formation. Mol Ther (2008) 1.02

An engineered VEGF-activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced-age mice. FASEB J (2006) 1.01

Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. J Exp Med (2010) 1.01