Published in Proc Natl Acad Sci U S A on July 25, 2005
Nitric oxide and peroxynitrite in health and disease. Physiol Rev (2007) 15.49
Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev (2011) 5.64
Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat Med (2005) 3.60
Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A (2008) 3.03
Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential. Circ Res (2008) 2.12
Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J Clin Invest (2007) 1.89
Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis. Proc Natl Acad Sci U S A (2008) 1.87
Loss of methyl-CpG-binding domain protein 2 enhances endothelial angiogenesis and protects mice against hind-limb ischemic injury. Circulation (2011) 1.74
Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med (2012) 1.68
Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease. Cold Spring Harb Perspect Med (2012) 1.66
Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation. Blood (2006) 1.56
Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis. Am J Pathol (2006) 1.50
AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J Clin Invest (2008) 1.49
The vascular endothelium and human diseases. Int J Biol Sci (2013) 1.49
Endothelial nitric oxide synthase deficiency causes collateral vessel rarefaction and impairs activation of a cell cycle gene network during arteriogenesis. Circ Res (2010) 1.48
Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy. Proc Natl Acad Sci U S A (2006) 1.48
Akt1 is critical for acute inflammation and histamine-mediated vascular leakage. Proc Natl Acad Sci U S A (2009) 1.46
Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin Invest (2006) 1.46
Hypoxic vasodilation by red blood cells: evidence for an s-nitrosothiol-based signal. Circ Res (2008) 1.42
Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake. J Biol Chem (2007) 1.41
Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest (2013) 1.32
A connecting hinge represses the activity of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (2007) 1.32
Exercise rehabilitation in peripheral artery disease: functional impact and mechanisms of benefits. Circulation (2011) 1.27
Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proc Natl Acad Sci U S A (2009) 1.27
An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production. Circ Res (2008) 1.26
Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis. Am J Pathol (2008) 1.25
The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Sci Signal (2009) 1.19
Angiogenic potential of 3-nitro-4-hydroxy benzene arsonic acid (roxarsone). Environ Health Perspect (2008) 1.18
Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of endothelial nitric-oxide synthase. J Biol Chem (2008) 1.18
Role of reactive oxygen and nitrogen species in the vascular responses to inflammation. Free Radic Biol Med (2011) 1.17
Update on therapeutic vascularization strategies. Regen Med (2009) 1.17
Cerebral blood flow alteration in neuroprotection following cerebral ischaemia. J Physiol (2011) 1.11
Attenuation of retinal vascular development and neovascularization in PECAM-1-deficient mice. Dev Biol (2008) 1.11
Engineering of multifunctional gels integrating highly efficient growth factor delivery with endothelial cell transplantation. FASEB J (2008) 1.11
Implanted microvessels progress through distinct neovascularization phenotypes. Microvasc Res (2009) 1.09
Dipyridamole enhances ischaemia-induced arteriogenesis through an endocrine nitrite/nitric oxide-dependent pathway. Cardiovasc Res (2010) 1.07
Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogen-activated protein kinase in mouse lung. Acta Pharmacol Sin (2010) 1.06
Endothelial-specific expression of mitochondrial thioredoxin promotes ischemia-mediated arteriogenesis and angiogenesis. Arterioscler Thromb Vasc Biol (2009) 1.04
Limb ischemia after iliac ligation in aged mice stimulates angiogenesis without arteriogenesis. J Vasc Surg (2008) 1.03
eNOS mediates TO90317 treatment-induced angiogenesis and functional outcome after stroke in mice. Stroke (2009) 1.03
Serial noninvasive targeted imaging of peripheral angiogenesis: validation and application of a semiautomated quantitative approach. J Nucl Med (2009) 1.02
Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: a double-blind placebo-controlled clinical trial. PLoS One (2012) 1.01
Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke. Stroke (2008) 1.00
Role of endothelial nitric oxide synthetase in arteriogenesis after stroke in mice. Neuroscience (2009) 0.97
Toward a mouse model of hind limb ischemia to test therapeutic angiogenesis. J Vasc Surg (2012) 0.97
Emerging role of PKA/eNOS pathway in therapeutic angiogenesis for ischaemic tissue diseases. Cardiovasc Res (2012) 0.96
Redox regulation of SERCA2 is required for vascular endothelial growth factor-induced signaling and endothelial cell migration. Antioxid Redox Signal (2012) 0.95
Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. J Clin Invest (2013) 0.95
Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions. J Gerontol A Biol Sci Med Sci (2011) 0.95
Ischemia is not required for arteriogenesis in zebrafish embryos. Arterioscler Thromb Vasc Biol (2007) 0.94
Arteriolar genesis and angiogenesis induced by endothelial nitric oxide synthase overexpression results in a mature vasculature. Arterioscler Thromb Vasc Biol (2008) 0.94
Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2. Proc Natl Acad Sci U S A (2011) 0.94
Endothelial nitric oxide synthase affects both early and late collateral arterial adaptation and blood flow recovery after induction of hind limb ischemia in mice. J Vasc Surg (2009) 0.94
Macrophage β2 integrin-mediated, HuR-dependent stabilization of angiogenic factor-encoding mRNAs in inflammatory angiogenesis. Am J Pathol (2012) 0.93
PHD2 regulates arteriogenic macrophages through TIE2 signalling. EMBO Mol Med (2013) 0.92
Molecular controls of arterial morphogenesis. Circ Res (2015) 0.91
Obesity induced-insulin resistance causes endothelial dysfunction without reducing the vascular response to hindlimb ischemia. Basic Res Cardiol (2009) 0.91
Exercise training and peripheral arterial disease. Compr Physiol (2012) 0.90
CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress. Am J Physiol Cell Physiol (2009) 0.89
Therapeutic Potential of the Nitrite-Generated NO Pathway in Vascular Dysfunction. Front Immunol (2013) 0.88
S100A1 deficiency impairs postischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation. Circ Res (2012) 0.87
Endothelium-driven myocardial growth or nitric oxide at the crossroads. Trends Cardiovasc Med (2008) 0.86
Inorganic nitrite and chronic tissue ischaemia: a novel therapeutic modality for peripheral vascular diseases. Cardiovasc Res (2010) 0.86
Mechanistic, technical, and clinical perspectives in therapeutic stimulation of coronary collateral development by angiogenic growth factors. Mol Ther (2013) 0.86
Nitric oxide synthase gene transfer restores activity of circulating angiogenic cells from patients with coronary artery disease. Mol Ther (2011) 0.86
Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well as promote ischemic blood flow recovery. J Biol Chem (2014) 0.86
Homing of stem cells to ischemic myocardium. Am J Transl Res (2013) 0.86
Redox balance dynamically regulates vascular growth and remodeling. Semin Cell Dev Biol (2012) 0.85
Antioxidants reverse age-related collateral growth impairment. J Vasc Res (2009) 0.85
Vascular biology and pathobiology of the liver: Report of a single-topic symposium. Hepatology (2008) 0.85
Impaired collateral recruitment and outward remodeling in experimental diabetes. Diabetes (2008) 0.85
Expansion of microvascular networks in vivo by phthalimide neovascular factor 1 (PNF1). Biomaterials (2008) 0.84
AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosatetraenoic acid-induced angiogenesis. J Biol Chem (2010) 0.83
Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice. J Gerontol A Biol Sci Med Sci (2012) 0.83
Molecular and cellular basis of viable dysfunctional myocardium. Circ Heart Fail (2014) 0.83
RGS5 promotes arterial growth during arteriogenesis. EMBO Mol Med (2014) 0.82
A modified fluorescent microsphere-based approach for determining resting and hyperemic blood flows in individual murine skeletal muscles. Vascul Pharmacol (2007) 0.82
Endothelial glycocalyx dimensions are reduced in growing collateral arteries and modulate leucocyte adhesion in arteriogenesis. J Cell Mol Med (2009) 0.82
Alpha(1)-adrenergic-mediated eNOS phosphorylation in intact arteries. Vascul Pharmacol (2012) 0.81
Inhibition of VEGF- and NO-dependent angiogenesis does not impair liver regeneration. Am J Physiol Regul Integr Comp Physiol (2010) 0.81
Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells. Diabetes (2016) 0.81
Mechanotransduction drives post ischemic revascularization through K(ATP) channel closure and production of reactive oxygen species. Antioxid Redox Signal (2013) 0.81
The endothelial saga: the past, the present, the future. Pflugers Arch (2010) 0.81
Advances and challenges in skeletal muscle angiogenesis. Am J Physiol Heart Circ Physiol (2015) 0.81
Minicircle DNA-mediated endothelial nitric oxide synthase gene transfer enhances angiogenic responses of bone marrow-derived mesenchymal stem cells. Stem Cell Res Ther (2016) 0.80
Development of a cerebral microvascular dysplasia model in rodents. Acta Neurochir Suppl (2008) 0.80
Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome. Am J Physiol Heart Circ Physiol (2015) 0.80
Nitric oxide and TNFα are critical regulators of reversible lymph node vascular remodeling and adaptive immune response. PLoS One (2013) 0.80
Endothelial miR-17∼92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling. Proc Natl Acad Sci U S A (2015) 0.79
Treatment of stroke with (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl) amino] diazen-1-ium-1, 2-diolate and bone marrow stromal cells upregulates angiopoietin-1/Tie2 and enhances neovascularization. Neuroscience (2008) 0.78
Challenging the surgical rodent hindlimb ischemia model with the miniinterventional technique. J Vasc Interv Radiol (2011) 0.78
Vasostatin inhibits VEGF-induced endothelial cell proliferation, tube formation and induces cell apoptosis under oxygen deprivation. Int J Mol Sci (2014) 0.78
Endothelium derived nitric oxide synthase negatively regulates the PDGF-survivin pathway during flow-dependent vascular remodeling. PLoS One (2012) 0.77
Relative quantitative expression of hypoxia-inducible factor-1α, -2α and -3α, and vascular endothelial growth factor A in laryngeal carcinoma. Oncol Lett (2015) 0.77
EZH2 modulates angiogenesis in vitro and in a mouse model of limb ischemia. Mol Ther (2014) 0.77
Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function. J Biol Chem (2014) 0.76
Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol (2016) 0.76
Mechanisms of Amplified Arteriogenesis in Collateral Artery Segments Exposed to Reversed Flow Direction. Arterioscler Thromb Vasc Biol (2015) 0.76
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med (2004) 49.02
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature (1999) 13.73
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature (1999) 11.37
Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature (1995) 9.86
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med (2001) 6.73
Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med (2003) 6.09
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J Clin Invest (1998) 5.95
Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (1996) 5.94
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest (1997) 4.92
Mouse model of angiogenesis. Am J Pathol (1998) 4.28
Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci U S A (2001) 3.88
Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest (1994) 3.51
Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J Clin Invest (1997) 3.39
Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling. J Biol Chem (2004) 3.01
Reciprocal relation between VEGF and NO in the regulation of endothelial integrity. Nat Med (1997) 2.73
Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res (1994) 2.64
Matrix metalloproteinase-9 is required for adequate angiogenic revascularization of ischemic tissues: potential role in capillary branching. Circ Res (2003) 2.51
Flow regulates arterial-venous differentiation in the chick embryo yolk sac. Development (2003) 2.43
Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways. Biochem J (2003) 2.27
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice. Cancer Cell (2003) 2.16
Enhanced electron flux and reduced calmodulin dissociation may explain "calcium-independent" eNOS activation by phosphorylation. J Biol Chem (2000) 2.10
Influence of mechanical, cellular, and molecular factors on collateral artery growth (arteriogenesis). Circ Res (2004) 2.08
Collateral artery growth (arteriogenesis) after experimental arterial occlusion is impaired in mice lacking CC-chemokine receptor-2. Circ Res (2004) 1.87
Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide. J Biol Chem (2000) 1.86
Caveolin-1 expression is critical for vascular endothelial growth factor-induced ischemic hindlimb collateralization and nitric oxide-mediated angiogenesis. Circ Res (2004) 1.71
Antiangiogenic effect of interleukin-10 in ischemia-induced angiogenesis in mice hindlimb. Circ Res (2000) 1.55
Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo. Nat Med (2003) 1.52
Neuropeptide Y induces ischemic angiogenesis and restores function of ischemic skeletal muscles. J Clin Invest (2003) 1.52
Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion. Circ Res (2002) 1.46
Control of arterial branching morphogenesis in embryogenesis: go with the flow. Cardiovasc Res (2005) 1.39
Evidence for the importance of angiotensin II type 1 receptor in ischemia-induced angiogenesis. J Clin Invest (2002) 1.25
Postnatal growth of the heart and its blood vessels. J Vasc Res (1996) 1.16
Endothelial nitric oxide synthase lies downstream from angiotensin II-induced angiogenesis in ischemic hindlimb. Hypertension (2002) 1.11
Endothelial nitric oxide synthase is essential for the HMG-CoA reductase inhibitor cerivastatin to promote collateral growth in response to ischemia. FASEB J (2001) 1.07
CCR2-/- knockout mice revascularize normally in response to severe hindlimb ischemia. J Vasc Surg (2004) 1.06
Endothelial NOS is main mediator for shear stress-dependent angiogenesis in skeletal muscle after prazosin administration. Am J Physiol Heart Circ Physiol (2004) 1.04
Nitric oxide in endothelial dysfunction and vascular remodeling: clinical correlates and experimental links. Am J Hum Genet (1999) 1.00
What makes blood vessels grow? J Physiol (1991) 0.99
Expression and function of recombinant S1179D endothelial nitric oxide synthase in canine cerebral arteries. Stroke (2002) 0.86
Evolving functions of endothelial cells in inflammation. Nat Rev Immunol (2007) 4.94
Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells. Circ Res (2007) 4.72
Nitric oxide synthases: regulation and function. Eur Heart J (2011) 4.71
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell (2006) 4.55
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J (2008) 4.49
Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. J Clin Invest (2005) 3.95
Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A (2008) 3.03
Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circ Res (2002) 3.01
Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem (2006) 3.00
A new role for Nogo as a regulator of vascular remodeling. Nat Med (2004) 2.63
Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab (2007) 2.53
Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels. J Clin Invest (2006) 2.47
Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle. J Gene Med (2004) 2.35
MicroRNAs as novel regulators of angiogenesis. Circ Res (2009) 2.33
Caveolae and caveolins in the cardiovascular system. Circ Res (2004) 2.24
Caveolin regulation of endothelial function. Am J Physiol Lung Cell Mol Physiol (2003) 2.22
Impact of mouse strain differences in innate hindlimb collateral vasculature. Arterioscler Thromb Vasc Biol (2006) 2.17
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice. Cancer Cell (2003) 2.16
Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice. J Exp Med (2007) 2.04
MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function. Arterioscler Thromb Vasc Biol (2010) 2.00
Gene expression profiling of human aortic endothelial cells exposed to disturbed flow and steady laminar flow. Physiol Genomics (2002) 1.99
Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase. J Biol Chem (2003) 1.98
Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking. Proc Natl Acad Sci U S A (2006) 1.97
The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Sci Transl Med (2011) 1.95
Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen. J Biol Chem (2002) 1.91
Regulation of survivin function by Hsp90. Proc Natl Acad Sci U S A (2003) 1.86
Dominant-negative Hsp90 reduces VEGF-stimulated nitric oxide release and migration in endothelial cells. Arterioscler Thromb Vasc Biol (2007) 1.80
Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production. J Biol Chem (2003) 1.80
Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. J Cell Biol (2006) 1.79
Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking. Cell Metab (2009) 1.76
Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis. Proc Natl Acad Sci U S A (2004) 1.75
Angiogenesis-dependent and independent phases of intimal hyperplasia. Circulation (2004) 1.71
Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation. Cardiovasc Res (2010) 1.69
Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol (2008) 1.68
The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. J Clin Invest (2007) 1.67
Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides. Proc Natl Acad Sci U S A (2005) 1.64
Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo. Proc Natl Acad Sci U S A (2005) 1.62
Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Cancer Res (2007) 1.62
Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. J Cell Biol (2008) 1.56
Perivascular nitric oxide gradients normalize tumor vasculature. Nat Med (2008) 1.56
Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo. Nat Med (2003) 1.52
Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions. Am J Pathol (2007) 1.52
Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme. J Biol Chem (2001) 1.51
Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. J Biol Chem (2007) 1.51
Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis. Am J Pathol (2006) 1.50
Caveolin-1 can regulate vascular smooth muscle cell fate by switching platelet-derived growth factor signaling from a proliferative to an apoptotic pathway. Arterioscler Thromb Vasc Biol (2003) 1.50
AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J Clin Invest (2008) 1.49
Expression and function of recombinant S1179D endothelial NO synthase in human pial arteries. Stroke (2004) 1.47
Akt1 is critical for acute inflammation and histamine-mediated vascular leakage. Proc Natl Acad Sci U S A (2009) 1.46
Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion. Circ Res (2002) 1.46
Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin Invest (2006) 1.46
Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis. Oncogene (2005) 1.45
Venous identity is lost but arterial identity is not gained during vein graft adaptation. Arterioscler Thromb Vasc Biol (2007) 1.45
Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis. Cell Metab (2009) 1.44
Endothelial nitric oxide synthase: the Cinderella of inflammation? Trends Pharmacol Sci (2003) 1.43
Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells. Am J Physiol Cell Physiol (2004) 1.43
Inhibitor of apoptosis protein survivin regulates vascular injury. Nat Med (2002) 1.42
CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. J Clin Invest (2010) 1.42
Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. Proc Natl Acad Sci U S A (2006) 1.39
Endothelial nitric oxide synthase regulates microvascular hyperpermeability in vivo. J Physiol (2006) 1.36
Functional relevance of Golgi- and plasma membrane-localized endothelial NO synthase in reconstituted endothelial cells. Arterioscler Thromb Vasc Biol (2006) 1.34
Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release. J Biol Chem (2004) 1.34
Interferon-gamma plays a nonredundant role in mediating T cell-dependent outward vascular remodeling of allogeneic human coronary arteries. FASEB J (2004) 1.33
Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function. PLoS One (2011) 1.33
Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis. Arterioscler Thromb Vasc Biol (2009) 1.32
Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proc Natl Acad Sci U S A (2006) 1.32
Chaperone-dependent regulation of endothelial nitric-oxide synthase intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP. J Biol Chem (2003) 1.31
Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors. BMC Cancer (2004) 1.31
Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics. Circ Res (2004) 1.30
Directed evolution generates a novel oncolytic virus for the treatment of colon cancer. PLoS One (2008) 1.30
Lipopolysaccharide induces macrophage migration via prostaglandin D(2) and prostaglandin E(2). J Pharmacol Exp Ther (2008) 1.29
Intracellular location regulates calcium-calmodulin-dependent activation of organelle-restricted eNOS. Am J Physiol Cell Physiol (2005) 1.28
Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proc Natl Acad Sci U S A (2009) 1.27
Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis. Am J Pathol (2008) 1.25
Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis. Circulation (2005) 1.24
PKCalpha activates eNOS and increases arterial blood flow in vivo. Circ Res (2005) 1.22
miRNAs as modulators of angiogenesis. Cold Spring Harb Perspect Med (2013) 1.21
The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Sci Signal (2009) 1.19
Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function. J Biol Chem (2007) 1.19
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells. Mol Cell (2010) 1.18
Effect of estrogen on endothelial function and angiogenesis. Vascul Pharmacol (2002) 1.18
T cell-mediated vascular dysfunction of human allografts results from IFN-gamma dysregulation of NO synthase. J Clin Invest (2004) 1.17
Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation. Proc Natl Acad Sci U S A (2007) 1.16
Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase. Free Radic Biol Med (2003) 1.16
Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury? Physiol Genomics (2010) 1.16
Mild increases in portal pressure upregulate vascular endothelial growth factor and endothelial nitric oxide synthase in the intestinal microcirculatory bed, leading to a hyperdynamic state. Am J Physiol Gastrointest Liver Physiol (2006) 1.15
Angiopoietin-1 negatively regulates expression and activity of tissue factor in endothelial cells. FASEB J (2001) 1.15
A noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice. J Clin Invest (2011) 1.13
Myoferlin is critical for endocytosis in endothelial cells. Am J Physiol Cell Physiol (2009) 1.13
Low levels of Nogo-B in human carotid atherosclerotic plaques are associated with an atheromatous phenotype, restenosis, and stenosis severity. Arterioscler Thromb Vasc Biol (2007) 1.12
Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report. Arterioscler Thromb Vasc Biol (2011) 1.11