CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis.

PubWeight™: 5.22‹?› | Rank: Top 1%

🔗 View Article (PMC 2775564)

Published in Cell on July 23, 2009

Authors

Siddhartha Jaiswal1, Catriona H M Jamieson, Wendy W Pang, Christopher Y Park, Mark P Chao, Ravindra Majeti, David Traver, Nico van Rooijen, Irving L Weissman

Author Affiliations

1: Ludwig Center at Stanford, Stanford Cancer Center, Department of Pathology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. sjaiswal@stanford.edu

Articles citing this

(truncated to the top 100)

Macrophage diversity enhances tumor progression and metastasis. Cell (2010) 13.41

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol (2010) 9.59

Macrophage biology in development, homeostasis and disease. Nature (2013) 8.28

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A (2012) 4.20

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. J Exp Med (2011) 3.89

Quantitative assessment of single-cell RNA-sequencing methods. Nat Methods (2013) 3.52

Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. Cell (2010) 3.37

Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Science (2013) 3.25

Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47. Sci Transl Med (2010) 2.79

Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy. Blood (2011) 2.69

Apoptotic cell clearance: basic biology and therapeutic potential. Nat Rev Immunol (2014) 2.59

DNA damage checkpoints in stem cells, ageing and cancer. Nat Rev Mol Cell Biol (2012) 2.39

Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia. Cancer Res (2010) 2.25

Combination cancer immunotherapy and new immunomodulatory targets. Nat Rev Drug Discov (2015) 2.25

Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science (2015) 2.20

Rhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell (2013) 2.19

Functional heterogeneity of genetically defined subclones in acute myeloid leukemia. Cancer Cell (2014) 2.15

Clearing the dead: apoptotic cell sensing, recognition, engulfment, and digestion. Cold Spring Harb Perspect Biol (2013) 2.00

CD47 blockade triggers T cell-mediated destruction of immunogenic tumors. Nat Med (2015) 1.98

Cancer immunoediting by the innate immune system in the absence of adaptive immunity. J Exp Med (2012) 1.93

Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation. Cell Stem Cell (2011) 1.91

MYC regulates the antitumor immune response through CD47 and PD-L1. Science (2016) 1.87

Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma. Proc Natl Acad Sci U S A (2012) 1.86

The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications. Curr Opin Immunol (2012) 1.84

Programmed cell removal: a new obstacle in the road to developing cancer. Nat Rev Cancer (2011) 1.84

Macrophages as mediators of tumor immunosurveillance. Trends Immunol (2010) 1.80

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature (2017) 1.72

Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker. Proc Natl Acad Sci U S A (2011) 1.71

Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice. Proc Natl Acad Sci U S A (2011) 1.71

Alternative 3' UTRs act as scaffolds to regulate membrane protein localization. Nature (2015) 1.70

Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes. Proc Natl Acad Sci U S A (2013) 1.64

Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways. Cell Stem Cell (2012) 1.62

Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling. Sci Transl Med (2009) 1.47

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proc Natl Acad Sci U S A (2011) 1.44

Identification of tumorigenic cells and therapeutic targets in pancreatic neuroendocrine tumors. Proc Natl Acad Sci U S A (2016) 1.42

Nature Biotechnology's academic spinouts of 2016. Nat Biotechnol (2017) 1.38

Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer. Am J Transl Res (2012) 1.37

The spleen in local and systemic regulation of immunity. Immunity (2013) 1.33

Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels. Blood Cells Mol Dis (2010) 1.31

'Marker-of-self' functionalization of nanoscale particles through a top-down cellular membrane coating approach. Nanoscale (2013) 1.28

Modulating the stem cell niche for tissue regeneration. Nat Biotechnol (2014) 1.28

Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts. J Exp Med (2012) 1.24

Calreticulin in the immune system: ins and outs. Trends Immunol (2012) 1.23

Engineering humanized mice for improved hematopoietic reconstitution. Cell Mol Immunol (2012) 1.18

Calreticulin exposure on malignant blasts predicts a cellular anticancer immune response in patients with acute myeloid leukemia. Cell Death Dis (2010) 1.18

Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells. Am J Pathol (2011) 1.18

The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials (2011) 1.17

Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma. MAbs (2015) 1.16

Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications. J Hepatol (2010) 1.16

CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and Disease. ISRN Hematol (2013) 1.16

The immunosuppressive surface ligand CD200 augments the metastatic capacity of squamous cell carcinoma. Cancer Res (2010) 1.14

Antibody effector functions mediated by Fcγ-receptors are compromised during persistent viral infection. Immunity (2015) 1.13

Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors. Sci Rep (2013) 1.12

Intravenous delivery of siRNA targeting CD47 effectively inhibits melanoma tumor growth and lung metastasis. Mol Ther (2013) 1.12

Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential. PLoS One (2015) 1.09

Macrophages are critical effectors of antibody therapies for cancer. MAbs (2015) 1.09

Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk. Proc Natl Acad Sci U S A (2015) 1.08

Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression. Front Immunol (2014) 1.07

CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy. Cancer Res (2014) 1.07

Monocytes and macrophages in cancer: development and functions. Cancer Microenviron (2012) 1.06

CD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interest. Br J Pharmacol (2012) 1.06

Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. Blood (2012) 1.06

Chronic myeloid leukemia stem cell biology. Curr Hematol Malig Rep (2012) 1.05

Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice. J Exp Med (2012) 1.04

Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes? J Thorac Oncol (2016) 1.03

Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases. Cell Death Differ (2009) 1.03

The spatial and developmental relationships in the macrophage family. Arterioscler Thromb Vasc Biol (2011) 1.02

Primary phagocytosis of viable neurons by microglia activated with LPS or Aβ is dependent on calreticulin/LRP phagocytic signalling. J Neuroinflammation (2012) 1.02

Are cancer stem cells radioresistant? Future Oncol (2010) 1.01

CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression. J Clin Invest (2012) 0.99

Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche. Nature (2016) 0.99

Radiation-induced loss of cell surface CD47 enhances immune-mediated clearance of human papillomavirus-positive cancer. Int J Cancer (2013) 0.98

Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia. Blood Cancer J (2011) 0.97

Proteomic cornerstones of hematopoietic stem cell differentiation: distinct signatures of multipotent progenitors and myeloid committed cells. Mol Cell Proteomics (2012) 0.96

Single-cell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells. Cytometry A (2015) 0.95

Frequency of leukemic initiating cells does not depend on the xenotransplantation model used. Leukemia (2011) 0.94

HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells. Proc Natl Acad Sci U S A (2015) 0.94

Hypoxia and metabolic properties of hematopoietic stem cells. Antioxid Redox Signal (2013) 0.94

Harnessing the antitumor potential of macrophages for cancer immunotherapy. Oncoimmunology (2013) 0.93

Rab27a negatively regulates phagocytosis by prolongation of the actin-coating stage around phagosomes. J Biol Chem (2010) 0.93

Melanoma stem cells and metastasis: mimicking hematopoietic cell trafficking? Lab Invest (2013) 0.92

Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47 "Don't Eat Me" Signals. Clin Cancer Res (2015) 0.92

CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. J Clin Invest (2016) 0.92

Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies. Stem Cells Transl Med (2015) 0.92

Cancer stem cells and tumor-associated macrophages: a roadmap for multitargeting strategies. Oncogene (2015) 0.92

Concise review: Nanoparticles and cellular carriers-allies in cancer imaging and cellular gene therapy? Stem Cells (2010) 0.92

Leukemia cells induce changes in human bone marrow stromal cells. J Transl Med (2013) 0.92

The complex and central role of interferon-γ in graft-versus-host disease and graft-versus-tumor activity. Immunol Rev (2014) 0.91

Durable antitumor responses to CD47 blockade require adaptive immune stimulation. Proc Natl Acad Sci U S A (2016) 0.91

Co-expression of MET and CD47 is a novel prognosticator for survival of luminal breast cancer patients. Oncotarget (2014) 0.91

Macrophages: gatekeepers of tissue integrity. Cancer Immunol Res (2013) 0.91

Circulating and disseminated tumour cells - mechanisms of immune surveillance and escape. Nat Rev Clin Oncol (2016) 0.91

Dendritic cell-based immunotherapy for myeloid leukemias. Front Immunol (2013) 0.90

Regulation of cancer stem cell activities by tumor-associated macrophages. Am J Cancer Res (2012) 0.90

CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer. Cancer Med (2015) 0.89

Cancer immunoediting of the NK group 2D ligand H60a. J Immunol (2011) 0.89

MHC-matched induced pluripotent stem cells can attenuate cellular and humoral immune responses but are still susceptible to innate immunity in pigs. PLoS One (2014) 0.89

Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47. Expert Opin Ther Targets (2012) 0.89

Hemophagocytic syndrome in patients with acute myeloid leukemia undergoing intensive chemotherapy. Haematologica (2013) 0.88

NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One (2012) 0.87

Articles cited by this

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature (2000) 16.75

Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J Immunol Methods (1994) 13.53

Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science (1999) 8.43

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature (2005) 7.18

Physiological migration of hematopoietic stem and progenitor cells. Science (2001) 7.02

Role of CD47 as a marker of self on red blood cells. Science (2000) 7.00

Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell (2005) 5.90

Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell (2007) 5.17

Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Nat Immunol (2007) 4.22

The purification and characterization of fetal liver hematopoietic stem cells. Proc Natl Acad Sci U S A (1995) 4.21

Integrin-associated protein (CD47) and its ligands. Trends Cell Biol (2001) 3.79

Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilization. Proc Natl Acad Sci U S A (1997) 3.74

Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients. Blood (2004) 3.73

Prospective isolation of human clonogenic common myeloid progenitors. Proc Natl Acad Sci U S A (2002) 3.50

Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle. Blood (2001) 3.11

Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med (2002) 2.96

Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J Exp Med (1989) 2.72

Ontogeny of the hematopoietic system. Annu Rev Immunol (2007) 2.55

Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Science (1996) 2.55

Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J Biol Chem (1999) 2.44

Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin. J Biol Chem (1996) 2.37

Circulation and chemotaxis of fetal hematopoietic stem cells. PLoS Biol (2004) 2.18

LPS-binding proteins and receptors. J Leukoc Biol (1998) 2.14

CD47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells. J Exp Med (2001) 1.99

Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning. J Exp Med (2005) 1.77

CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia. Nat Med (1999) 1.73

Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Immunity (1998) 1.67

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias. Proc Natl Acad Sci U S A (2003) 1.64

Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells. Proc Natl Acad Sci U S A (2007) 1.58

The role of CD47 in neutrophil transmigration. Increased rate of migration correlates with increased cell surface expression of CD47. J Biol Chem (2001) 1.55

Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia. Blood (2005) 1.55

Costimulation of T cell activation by integrin-associated protein (CD47) is an adhesion-dependent, CD28-independent signaling pathway. J Exp Med (1997) 1.49

Expression of the self-marker CD47 on dendritic cells governs their trafficking to secondary lymphoid organs. EMBO J (2006) 1.44

Changes in integrin expression are associated with altered homing properties of Lin(-/lo)Thy1.1(lo)Sca-1(+)c-kit(+) hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte colony-stimulating factor. Exp Hematol (2002) 1.43

Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors. Mol Ther (2002) 1.41

An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains. Cancer Res (1992) 1.40

Antitumor activity of a monoclonal antibody against CD47 in xenograft models of human leukemia. Oncol Rep (2007) 1.26

Promotion of neurite and filopodium formation by CD47: roles of integrins, Rac, and Cdc42. Mol Biol Cell (2004) 1.16

Alpha-Pal/NRF-1 regulates the promoter of the human integrin-associated protein/CD47 gene. J Biol Chem (2004) 1.02

Dose-dependent inhibitory effect of CD47 in macrophage uptake of IgG-opsonized murine erythrocytes. Biochem Biophys Res Commun (2006) 0.98

Mobilization of hematopoietic stem cells (CFU-C) into the peripheral blood of man by endotoxin. Exp Hematol (1977) 0.90

Articles by these authors

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res (2006) 17.42

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature (2003) 14.35

A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature (2003) 12.81

Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (2003) 12.54

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med (2004) 11.29

Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature (2005) 11.23

Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature (2009) 10.31

Little evidence for developmental plasticity of adult hematopoietic stem cells. Science (2002) 9.63

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest (2007) 9.09

Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science (2011) 8.53

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48

Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature (2004) 8.36

Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J Exp Med (2007) 7.87

Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol (2002) 7.78

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature (2007) 7.72

Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol (2002) 7.03

Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A (2005) 6.32

Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature (2010) 6.06

Stems cells and the pathways to aging and cancer. Cell (2008) 5.99

Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med (2005) 5.68

Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity (2013) 5.47

CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell (2009) 5.30

Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell (2007) 5.28

Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR. Proc Natl Acad Sci U S A (2006) 5.21

Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle. Cell (2004) 5.20

Plasticity of adult stem cells. Cell (2004) 5.13

Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell (2007) 5.09

Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature (2010) 5.05

Adenovirus serotype 5 hexon mediates liver gene transfer. Cell (2008) 5.00

Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature (2007) 4.88

Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev (2003) 4.71

In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation (2006) 4.48

Haematopoietic stem cells derive directly from aortic endothelium during development. Nature (2010) 4.42

Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc Natl Acad Sci U S A (2003) 4.41

Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev Cell (2002) 4.37

Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol (2006) 4.32

MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol (2009) 4.28

JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell (2004) 4.28

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A (2012) 4.20

Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med (2013) 4.14

Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci U S A (2003) 4.09

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med (2009) 4.07

Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med (2012) 4.05

Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat Genet (2008) 4.02

Dendritic cell-induced memory T cell activation in nonlymphoid tissues. Science (2008) 3.97

Coronary arteries form by developmental reprogramming of venous cells. Nature (2010) 3.95

Cancer stem cells in solid tumors. Curr Opin Biotechnol (2007) 3.91

Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med (2011) 3.88

Endochondral ossification is required for haematopoietic stem-cell niche formation. Nature (2008) 3.87

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci U S A (2009) 3.87

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nat Med (2009) 3.82

Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding. Nat Biotechnol (2011) 3.81

Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J Exp Med (2003) 3.74

BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol (2005) 3.68

Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood (2002) 3.59

Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell (2007) 3.59

Prospective isolation of human clonogenic common myeloid progenitors. Proc Natl Acad Sci U S A (2002) 3.50

Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery. J Exp Med (2006) 3.43

Microglia promote the death of developing Purkinje cells. Neuron (2004) 3.42

IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J Immunol (2009) 3.41

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci U S A (2010) 3.41

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc Natl Acad Sci U S A (2014) 3.39

Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. Cell (2010) 3.37

Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev (2005) 3.27

Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia. Am J Respir Crit Care Med (2002) 3.27

Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci U S A (2008) 3.27

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood (2010) 3.26

Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Science (2013) 3.25

Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia. JAMA (2010) 3.25

Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat Med (2004) 3.17

Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity (2003) 3.17

Macrophage depletion inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci (2003) 3.17

Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab (2005) 3.15

Myc-induced T cell leukemia in transgenic zebrafish. Science (2003) 3.15

The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab (2010) 3.11

Differential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet (2005) 3.11

The use of zebrafish to understand immunity. Immunity (2004) 3.09

Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Immunity (2004) 3.09

Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J Hepatol (2007) 3.06

An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Nat Biotechnol (2011) 3.05

Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations. J Immunol (2008) 3.04

Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip. Nature (2011) 3.03

Mitoferrin is essential for erythroid iron assimilation. Nature (2006) 2.99

Isolation and characterization of a protochordate histocompatibility locus. Nature (2005) 2.96

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci U S A (2011) 2.96

Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med (2002) 2.96

The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. Proc Natl Acad Sci U S A (2006) 2.94