PubRank

Francis S Willard

Author PubWeight™ 53.90‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Int J Biol Sci 2005 2.76
2 Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos. Science 2003 2.46
3 A seven-transmembrane RGS protein that modulates plant cell proliferation. Science 2003 2.41
4 RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos. Cell 2004 2.09
5 GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling. Proc Natl Acad Sci U S A 2007 2.05
6 Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. Structure 2005 1.98
7 Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc Natl Acad Sci U S A 2008 1.72
8 Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique. Neuropsychopharmacology 2006 1.69
9 Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration. Exp Cell Res 2004 1.49
10 Crystal structure of the human PRMT5:MEP50 complex. Proc Natl Acad Sci U S A 2012 1.42
11 Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division. Development 2005 1.37
12 Comment on "A G protein coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid". Science 2007 1.37
13 Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism. EMBO J 2007 1.31
14 Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity. Proc Natl Acad Sci U S A 2010 1.30
15 The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face. Biochim Biophys Acta 2007 1.29
16 Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). J Biol Chem 2009 1.16
17 Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets. Diabetes 2010 1.14
18 Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif. Biochem J 2004 1.13
19 Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation. EMBO J 2007 1.08
20 D2 dopamine receptor activation of potassium channels is selectively decoupled by Galpha-specific GoLoco motif peptides. J Neurochem 2005 1.07
21 Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer. Biochemistry 2006 1.06
22 Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands. Mol Pharmacol 2013 1.02
23 G alpha selectivity and inhibitor function of the multiple GoLoco motif protein GPSM2/LGN. Biochim Biophys Acta 2005 1.00
24 RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Dev Cell 2004 0.99
25 Allosteric modulation of endogenous metabolites as an avenue for drug discovery. Mol Pharmacol 2012 0.98
26 A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction. Comb Chem High Throughput Screen 2008 0.96
27 A sweet cycle for Arabidopsis G-proteins: Recent discoveries and controversies in plant G-protein signal transduction. Plant Signal Behav 2008 0.93
28 The GoLoco motif: heralding a new tango between G protein signaling and cell division. Mol Interv 2002 0.92
29 A capture coupling method for the covalent immobilization of hexahistidine tagged proteins for surface plasmon resonance. Methods Mol Biol 2010 0.91
30 The effect of RGS12 on PDGFbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells. Cell Signal 2005 0.90
31 Open innovation for phenotypic drug discovery: The PD2 assay panel. J Biomol Screen 2011 0.90
32 Established and emerging fluorescence-based assays for G-protein function: heterotrimeric G-protein alpha subunits and regulator of G-protein signaling (RGS) proteins. Comb Chem High Throughput Screen 2003 0.88
33 Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants. J Biol Chem 2010 0.86
34 High-affinity immobilization of proteins using biotin- and GST-based coupling strategies. Methods Mol Biol 2010 0.85
35 A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis. PLoS Pathog 2012 0.85
36 RGS14 is a microtubule-associated protein. Cell Cycle 2005 0.85
37 Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans. J Biol Chem 2008 0.84
38 Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica. PLoS Pathog 2012 0.83
39 State-selective binding peptides for heterotrimeric G-protein subunits: novel tools for investigating G-protein signaling dynamics. Comb Chem High Throughput Screen 2008 0.81
40 Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. J Biol Chem 2012 0.80
41 Analysis of interactions between regulator of G-protein signaling-14 and microtubules. Methods Enzymol 2004 0.79
42 Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis. Structure 2012 0.79
43 Purification and in vitro functional analyses of RGS12 and RGS14 GoLoco motif peptides. Methods Enzymol 2004 0.76
44 Does WAVE1 contain a GoLoco/GPR motif? Int J Biol Sci 2006 0.75
45 RGS21, a regulator of taste and mucociliary clearance? Laryngoscope 2013 0.75
46 GPCR high throughput screening (part 1). Comb Chem High Throughput Screen 2008 0.75