Published in Cell on October 15, 2004
Spindle orientation during asymmetric cell division. Nat Cell Biol (2009) 4.08
Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer. Genes Dev (2009) 2.76
G-protein signaling: back to the future. Cell Mol Life Sci (2005) 2.38
GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling. Proc Natl Acad Sci U S A (2007) 2.05
Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. Structure (2005) 1.98
GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling. Proc Natl Acad Sci U S A (2009) 1.81
Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle. Mol Cell Biol (2010) 1.81
Cortical dynein is critical for proper spindle positioning in human cells. J Cell Biol (2012) 1.69
Differential roles of Arabidopsis heterotrimeric G-protein subunits in modulating cell division in roots. Plant Physiol (2006) 1.62
NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. Nat Cell Biol (2009) 1.60
Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans. J Cell Biol (2007) 1.50
Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor. Curr Biol (2008) 1.41
Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling. Pharmacol Ther (2006) 1.38
Resistance to inhibitors of cholinesterase 8A catalyzes release of Galphai-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Galphai-GDP complexes. Proc Natl Acad Sci U S A (2005) 1.35
A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem (2010) 1.32
Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association. Sci Signal (2011) 1.32
GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression. Cell Adh Migr (2011) 1.31
A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics. J Biol Chem (2008) 1.29
The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face. Biochim Biophys Acta (2007) 1.29
Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3. J Biol Chem (2008) 1.19
Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions. Genes Dev (2005) 1.15
Retracted Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity. Proc Natl Acad Sci U S A (2007) 1.14
The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1. PLoS One (2011) 1.14
Local cortical pulling-force repression switches centrosomal centration and posterior displacement in C. elegans. J Cell Biol (2007) 1.07
Non-canonical signaling and localizations of heterotrimeric G proteins. Cell Signal (2011) 1.07
Epithelial polarity and spindle orientation: intersecting pathways. Philos Trans R Soc Lond B Biol Sci (2013) 1.03
Two Galpha(i1) rate-modifying mutations act in concert to allow receptor-independent, steady-state measurements of RGS protein activity. J Biomol Screen (2009) 1.03
Visualization of dynein-dependent microtubule gliding at the cell cortex: implications for spindle positioning. J Cell Biol (2011) 1.02
Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila. Dev Cell (2008) 1.00
Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos. Development (2010) 0.98
Ric-8B stabilizes the alpha subunit of stimulatory G protein by inhibiting its ubiquitination. J Biol Chem (2010) 0.97
A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction. Comb Chem High Throughput Screen (2008) 0.96
On the inscrutable role of Inscuteable: structural basis and functional implications for the competitive binding of NuMA and Inscuteable to LGN. Open Biol (2012) 0.94
Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad. Mol Pharmacol (2013) 0.93
A sweet cycle for Arabidopsis G-proteins: Recent discoveries and controversies in plant G-protein signal transduction. Plant Signal Behav (2008) 0.93
Asymmetric spindle positioning. Curr Opin Cell Biol (2005) 0.90
PAR-3 and PAR-1 inhibit LET-99 localization to generate a cortical band important for spindle positioning in Caenorhabditis elegans embryos. Mol Biol Cell (2007) 0.89
Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization. J Biol Chem (2011) 0.89
Purkinje cell protein-2 (Pcp2) stimulates differentiation in PC12 cells by Gbetagamma-mediated activation of Ras and p38 MAPK. Biochem J (2005) 0.89
Polarity mediates asymmetric trafficking of the Gbeta heterotrimeric G-protein subunit GPB-1 in C. elegans embryos. Development (2011) 0.88
Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors. J Biol Chem (2012) 0.88
Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants. J Biol Chem (2010) 0.86
RIC8 is a guanine-nucleotide exchange factor for Galpha subunits that regulates growth and development in Neurospora crassa. Genetics (2011) 0.86
Biophysical studies support a predicted superhelical structure with armadillo repeats for Ric-8. Protein Sci (2009) 0.86
A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis. PLoS Pathog (2012) 0.85
Ric-8 regulation of heterotrimeric G proteins. J Recept Signal Transduct Res (2013) 0.85
A bifunctional Galphai/Galphas modulatory peptide that attenuates adenylyl cyclase activity. FEBS Lett (2005) 0.85
Regulation of mitotic spindle orientation: an integrated view. EMBO Rep (2016) 0.84
Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans. J Biol Chem (2008) 0.84
The guanine nucleotide exchange factor Ric-8A induces domain separation and Ras domain plasticity in Gαi1. Proc Natl Acad Sci U S A (2015) 0.83
Implications of non-canonical G-protein signaling for the immune system. Cell Signal (2014) 0.82
Oriented Cell Division in the C. elegans Embryo Is Coordinated by G-Protein Signaling Dependent on the Adhesion GPCR LAT-1. PLoS Genet (2015) 0.82
Data integration from two microarray platforms identifies bi-allelic genetic inactivation of RIC8A in a breast cancer cell line. BMC Med Genomics (2009) 0.82
The putative guanine nucleotide exchange factor RicA mediates upstream signaling for growth and development in Aspergillus. Eukaryot Cell (2012) 0.82
Left-right patterning in the C. elegans embryo: Unique mechanisms and common principles. Commun Integr Biol (2011) 0.81
Drosophila Ric-8 interacts with the Gα12/13 subunit, Concertina, during activation of the Folded gastrulation pathway. Mol Biol Cell (2013) 0.80
The G protein α chaperone Ric-8 as a potential therapeutic target. Mol Pharmacol (2014) 0.80
Resistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity. PLoS One (2014) 0.79
Regulation, Signaling, and Physiological Functions of G-Proteins. J Mol Biol (2016) 0.79
GDP-bound Galphai2 regulates spinal motor neuron differentiation through interaction with GDE2. Dev Biol (2010) 0.79
Atypical protein kinase Cλ is critical for growth factor receptor-induced dorsal ruffle turnover and cell migration. J Biol Chem (2013) 0.78
Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein Activation. Mol Biol Evol (2015) 0.78
Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death. PLoS One (2013) 0.77
E2F8 is a nonreceptor activator of heterotrimeric G proteins. J Mol Signal (2007) 0.77
Cell Fate Decision Making through Oriented Cell Division. J Dev Biol (2015) 0.76
Polarity-dependent asymmetric distribution and MEX-5/6-mediated translational activation of the Era-1 mRNA in C. elegans embryos. PLoS One (2015) 0.76
B Lymphocyte-Specific Loss of Ric-8A Results in a Gα Protein Deficit and Severe Humoral Immunodeficiency. J Immunol (2015) 0.76
Gα13 Stimulates the Tyrosine Phosphorylation of Ric-8A. J Mol Signal (2015) 0.75
Polarity and cell division orientation in the cleavage embryo: from worm to human. Mol Hum Reprod (2015) 0.75
F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo. Mol Biol Cell (2013) 0.75
A homogeneous method to measure nucleotide exchange by α-subunits of heterotrimeric G-proteins using fluorescence polarization. Assay Drug Dev Technol (2010) 0.75
Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα. Elife (2016) 0.75
Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis. PLoS One (2015) 0.75
The adhesion GPCR latrophilin - a novel signaling cascade in oriented cell division and anterior-posterior polarity. Worm (2016) 0.75
SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. Nat Cell Biol (2005) 3.37
Regulated HsSAS-6 levels ensure formation of a single procentriole per centriole during the centrosome duplication cycle. Dev Cell (2007) 3.12
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Int J Biol Sci (2005) 2.76
Structural basis of the 9-fold symmetry of centrioles. Cell (2011) 2.73
Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. Neuron (2010) 2.54
Centriolar SAS-5 is required for centrosome duplication in C. elegans. Nat Cell Biol (2004) 2.52
SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle. Dev Cell (2003) 2.50
Overly long centrioles and defective cell division upon excess of the SAS-4-related protein CPAP. Curr Biol (2009) 2.48
Regulators of G-protein signalling as new central nervous system drug targets. Nat Rev Drug Discov (2002) 2.47
Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos. Science (2003) 2.46
Sequential protein recruitment in C. elegans centriole formation. Curr Biol (2006) 2.44
A seven-transmembrane RGS protein that modulates plant cell proliferation. Science (2003) 2.41
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med (2003) 2.33
Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos. Curr Biol (2003) 2.33
Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. Nature (2002) 2.30
Mechanisms of procentriole formation. Trends Cell Biol (2008) 2.21
Structural and evolutionary division of phosphotyrosine binding (PTB) domains. J Mol Biol (2005) 2.19
Return of the GDI: the GoLoco motif in cell division. Annu Rev Biochem (2004) 2.16
Coupling of cortical dynein and G alpha proteins mediates spindle positioning in Caenorhabditis elegans. Nat Cell Biol (2007) 2.16
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat Struct Biol (2002) 2.14
The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent. J Cell Biol (2002) 2.13
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat Cell Biol (2002) 2.12
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J (2002) 2.07
Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina. Neuron (2005) 2.06
GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling. Proc Natl Acad Sci U S A (2007) 2.05
The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. Nat Cell Biol (2011) 1.99
Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets. Pharmacol Rev (2011) 1.98
Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. Structure (2005) 1.98
LGN regulates mitotic spindle orientation during epithelial morphogenesis. J Cell Biol (2010) 1.95
Receptor-mediated activation of heterotrimeric G-proteins: current structural insights. Mol Pharmacol (2007) 1.81
TAC-1 and ZYG-9 form a complex that promotes microtubule assembly in C. elegans embryos. Curr Biol (2003) 1.80
Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway. Science (2002) 1.79
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J Clin Invest (2009) 1.79
PP2A phosphatase acts upon SAS-5 to ensure centriole formation in C. elegans embryos. Dev Cell (2011) 1.77
Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins. Nat Cell Biol (2005) 1.72
The arithmetic of centrosome biogenesis. J Cell Sci (2004) 1.72
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc Natl Acad Sci U S A (2008) 1.72
Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique. Neuropsychopharmacology (2006) 1.69
Cortical dynein is critical for proper spindle positioning in human cells. J Cell Biol (2012) 1.69
NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. Nat Cell Biol (2009) 1.60
Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans. Development (2004) 1.54
Crystal structure of the multifunctional Gbeta5-RGS9 complex. Nat Struct Mol Biol (2008) 1.52
Mechanisms of spindle positioning: cortical force generators in the limelight. Curr Opin Cell Biol (2013) 1.50
Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration. Exp Cell Res (2004) 1.49
Structure-based protocol for identifying mutations that enhance protein-protein binding affinities. J Mol Biol (2007) 1.48
Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos. Dev Cell (2009) 1.47
Centrosomes promote timely mitotic entry in C. elegans embryos. Dev Cell (2007) 1.47
Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. Mol Cell Biol (2006) 1.46
The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity (2012) 1.44
Resolution doubling in 3D-STORM imaging through improved buffers. PLoS One (2013) 1.44
Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA. Mol Cell Biol (2002) 1.43
Crystal structure of the human PRMT5:MEP50 complex. Proc Natl Acad Sci U S A (2012) 1.42
Cystic fibrosis: newborn screening in America. MLO Med Lab Obs (2008) 1.42
The Fz-Dsh planar cell polarity pathway induces oriented cell division via Mud/NuMA in Drosophila and zebrafish. Dev Cell (2010) 1.42
Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division. Development (2005) 1.37
Comment on "A G protein coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid". Science (2007) 1.37
Molecular pathways regulating mitotic spindle orientation in animal cells. Development (2013) 1.33
Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism. EMBO J (2007) 1.31
Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity. Proc Natl Acad Sci U S A (2010) 1.30
A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics. J Biol Chem (2008) 1.29
The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face. Biochim Biophys Acta (2007) 1.29
Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells. J Biol Chem (2002) 1.28
Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL. J Cell Sci (2011) 1.26
PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation. J Biol Chem (2009) 1.24
Cartwheel architecture of Trichonympha basal body. Science (2012) 1.23
lis-1 is required for dynein-dependent cell division processes in C. elegans embryos. J Cell Sci (2004) 1.22
A direct fluorescence-based assay for RGS domain GTPase accelerating activity. Anal Biochem (2005) 1.22
Selective chemical crosslinking reveals a Cep57-Cep63-Cep152 centrosomal complex. Curr Biol (2013) 1.19
Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). J Biol Chem (2009) 1.16
Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation. J Cell Biol (2011) 1.14
Retracted Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity. Proc Natl Acad Sci U S A (2007) 1.14
Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets. Diabetes (2010) 1.14
Coupling the cell cycle to development. Development (2009) 1.13
Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif. Biochem J (2004) 1.13
Galpha12/13- and rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors. Mol Pharmacol (2006) 1.13
The respiratory effects of stanniocalcin-1 (STC-1) on intact mitochondria and cells: STC-1 uncouples oxidative phosphorylation and its actions are modulated by nucleotide triphosphates. Mol Cell Endocrinol (2006) 1.11
Established and emerging fluorescence-based assays for G-protein function: Ras-superfamily GTPases. Comb Chem High Throughput Screen (2003) 1.11
What is your guess? The case of the blue-green urine. Clin Chem (2011) 1.10