Published in J Biol Chem on May 28, 2009
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature (2012) 2.96
Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets. Pharmacol Rev (2011) 1.98
Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A (2011) 1.98
Structural and functional analysis of the regulator of G protein signaling 2-gαq complex. Structure (2013) 1.55
A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. Neuropsychopharmacology (2012) 1.17
Comparative genomics uncovers novel structural and functional features of the heterotrimeric GTPase signaling system. Gene (2010) 1.08
A human homeotic transformation resulting from mutations in PLCB4 and GNAI3 causes auriculocondylar syndrome. Am J Hum Genet (2012) 1.07
β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids. Proc Natl Acad Sci U S A (2011) 0.94
Regulators of G-protein signaling in the heart and their potential as therapeutic targets. Circ Res (2011) 0.90
Regulator of G protein signaling 2 is a functionally important negative regulator of angiotensin II-induced cardiac fibroblast responses. Am J Physiol Heart Circ Physiol (2011) 0.90
Transcriptome analyses and differential gene expression in a non-model fish species with alternative mating tactics. BMC Genomics (2014) 0.89
A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis. PLoS Pathog (2012) 0.85
Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling. J Biol Chem (2012) 0.82
Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. J Biol Chem (2012) 0.80
Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters. PLoS One (2013) 0.80
A novel glucagon-related peptide (GCRP) and its receptor GCRPR account for coevolution of their family members in vertebrates. PLoS One (2013) 0.79
Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions. Nat Struct Mol Biol (2011) 0.79
Understanding how long-acting β2 -adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids in asthma - an update. Br J Pharmacol (2016) 0.77
Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: MOLECULAR BASIS FOR Gα SELECTIVITY. J Biol Chem (2016) 0.77
Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists. J Med Chem (2016) 0.76
Inhibition of the Binding between RGS2 and β-Tubulin Interferes with Spindle Formation and Chromosome Segregation during Mouse Oocyte Maturation In Vitro. PLoS One (2016) 0.75
GNAI3: Another Candidate Gene to Screen in Persons with Ocular Albinism. PLoS One (2016) 0.75
A proteomic view to characterize the effect of chitosan nanoparticle to hepatic cells: is chitosan nanoparticle an enhancer of PI3K/AKT1/mTOR pathway? Biomed Res Int (2014) 0.75
Protective Roles for RGS2 in a Mouse Model of House Dust Mite-Induced Airway Inflammation. PLoS One (2017) 0.75
RGS21, a regulator of taste and mucociliary clearance? Laryngoscope (2013) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
MrBayes 3: Bayesian phylogenetic inference under mixed models. Bioinformatics (2003) 130.85
MRBAYES: Bayesian inference of phylogenetic trees. Bioinformatics (2001) 101.31
T-Coffee: A novel method for fast and accurate multiple sequence alignment. J Mol Biol (2000) 57.88
Likelihood-enhanced fast rotation functions. Acta Crystallogr D Biol Crystallogr (2004) 23.86
SEAVIEW and PHYLO_WIN: two graphic tools for sequence alignment and molecular phylogeny. Comput Appl Biosci (1996) 20.45
Optimal description of a protein structure in terms of multiple groups undergoing TLS motion. Acta Crystallogr D Biol Crystallogr (2006) 14.21
WWW-query: an on-line retrieval system for biological sequence banks. Biochimie (1996) 11.59
Seven-transmembrane receptors. Nat Rev Mol Cell Biol (2002) 11.50
Regulation of phosphoinositide-specific phospholipase C. Annu Rev Biochem (2001) 6.42
Integration of macromolecular diffraction data. Acta Crystallogr D Biol Crystallogr (1999) 6.21
Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis. Cell (1997) 4.74
Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet (2004) 3.83
Cellular regulation of RGS proteins: modulators and integrators of G protein signaling. Pharmacol Rev (2002) 3.82
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest (2003) 2.68
Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science (1998) 2.64
Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex. Science (2005) 2.46
Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. Nat Med (2001) 2.40
G-protein signaling: back to the future. Cell Mol Life Sci (2005) 2.38
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med (2003) 2.33
Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Mol Interv (2002) 2.19
RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha. Proc Natl Acad Sci U S A (1997) 2.14
Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science (2007) 1.89
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J Clin Invest (2009) 1.79
Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci U S A (2000) 1.73
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc Natl Acad Sci U S A (2008) 1.72
G-proteins as transducers in transmembrane signalling. Prog Biophys Mol Biol (2003) 1.67
RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III. Nature (2001) 1.62
Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity. J Neurosci (1998) 1.62
A point mutation in Galphao and Galphai1 blocks interaction with regulator of G protein signaling proteins. J Biol Chem (1998) 1.60
A new family of regulators of G-protein-coupled receptors? Curr Biol (1996) 1.58
RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho? Oncogene (2001) 1.55
The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro. Proc Natl Acad Sci U S A (1997) 1.46
Prototypic T cell receptor and CD4-like coreceptor are expressed by lymphocytes in the agnathan sea lamprey. Proc Natl Acad Sci U S A (2004) 1.40
G protein selectivity is a determinant of RGS2 function. J Biol Chem (1999) 1.34
The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face. Biochim Biophys Acta (2007) 1.29
A direct fluorescence-based assay for RGS domain GTPase accelerating activity. Anal Biochem (2005) 1.22
Development of Ciona intestinalis juveniles (through 2nd ascidian stage). Zoolog Sci (2004) 1.21
New vectors for co-expression of proteins: structure of Bacillus subtilis ScoAB obtained by high-throughput protocols. Protein Expr Purif (2007) 1.21
Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II. J Hypertens (2006) 1.20
Evolution of the regulators of G-protein signaling multigene family in mouse and human. Genomics (2002) 1.18
Mechanism of RGS4, a GTPase-activating protein for G protein alpha subunits. J Biol Chem (1998) 1.16
The alpha-helical domain of Galphat determines specific interaction with regulator of G protein signaling 9. J Biol Chem (1999) 1.15
Extensive gene duplication in the early evolution of animals before the parazoan-eumetazoan split demonstrated by G proteins and protein tyrosine kinases from sponge and hydra. J Mol Evol (1999) 1.14
Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation. Proc Natl Acad Sci U S A (2008) 1.10
Influence of RGS2 on anxiety-related temperament, personality, and brain function. Arch Gen Psychiatry (2008) 1.10
Ciona intestinalis as a model for cardiac development. Semin Cell Dev Biol (2006) 1.06
Differential G-alpha interaction capacities of the GoLoco motifs in Rap GTPase activating proteins. Cell Signal (2006) 1.01
Covalent immobilization of histidine-tagged proteins for surface plasmon resonance. Anal Biochem (2006) 1.01
Gq-coupled receptor agonists mediate cardiac hypertrophy via the vasculature. Hypertension (2002) 1.00
Fluorescence-based assays for RGS box function. Methods Enzymol (2004) 1.00
Association of RGS2 gene polymorphisms with suicide and increased RGS2 immunoreactivity in the postmortem brain of suicide victims. Neuropsychopharmacology (2007) 0.95
RGS proteins: Swiss army knives in seven-transmembrane domain receptor signaling networks. Sci STKE (2007) 0.95
The RGS2 gene product from a candidate hypertension allele shows decreased plasma membrane association and inhibition of Gq. Mol Pharmacol (2008) 0.92
The structure and physical properties of invertebrate and primitive vertebrate arteries. J Exp Biol (1995) 0.92
Application of RGS box proteins to evaluate G-protein selectivity in receptor-promoted signaling. Methods Enzymol (2004) 0.91
Inhibition of regulator of G protein signaling function by two mutant RGS4 proteins. Proc Natl Acad Sci U S A (1997) 0.91
Characterization and comparison of RGS2 and RGS4 as GTPase-activating proteins for m2 muscarinic receptor-stimulated G(i). Mol Pharmacol (2002) 0.88
Polarity exchange at the interface of regulators of G protein signaling with G protein alpha-subunits. J Biol Chem (2000) 0.81
Evolutionary analysis of G-proteins in early metazoans: cloning of alpha- and beta-subunits from the sponge Geodia cydonium. Biochim Biophys Acta (1998) 0.79
Selective inhibition of BET bromodomains. Nature (2010) 18.79
Predicting new molecular targets for known drugs. Nature (2009) 9.71
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc Natl Acad Sci U S A (2007) 7.96
Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther (2006) 7.03
Relating protein pharmacology by ligand chemistry. Nat Biotechnol (2007) 6.61
Structure of the human κ-opioid receptor in complex with JDTic. Nature (2012) 5.18
Histone recognition and large-scale structural analysis of the human bromodomain family. Cell (2012) 5.15
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Invest (2011) 5.12
Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron (2009) 4.98
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J Biol Chem (2003) 4.36
Protein production and purification. Nat Methods (2008) 3.97
The expanded biology of serotonin. Annu Rev Med (2009) 3.87
Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. Neuropsychopharmacology (2003) 3.78
Linear motif atlas for phosphorylation-dependent signaling. Sci Signal (2008) 3.77
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol (2011) 3.60
Generation of a synthetic memory trace. Science (2012) 3.55
Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization. Nat Neurosci (2010) 3.55
The human polyomavirus, JCV, uses serotonin receptors to infect cells. Science (2004) 3.54
Automated design of ligands to polypharmacological profiles. Nature (2012) 3.54
Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell (2009) 3.51
Small-molecule inhibition of BRDT for male contraception. Cell (2012) 3.50
G protein-coupled receptor sorting to endosomes and lysosomes. Annu Rev Pharmacol Toxicol (2008) 3.49
Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint. EMBO J (2002) 3.42
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology (2003) 3.35
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron (2005) 3.30
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A (2007) 3.21
Endocrine regulation of male fertility by the skeleton. Cell (2011) 3.20
Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature (2011) 3.19
Structure of the human smoothened receptor bound to an antitumour agent. Nature (2013) 3.08
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature (2012) 2.96
Critical residues for structure and catalysis in short-chain dehydrogenases/reductases. J Biol Chem (2002) 2.95
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Int J Biol Sci (2005) 2.76
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc Natl Acad Sci U S A (2006) 2.73
Remote control of neuronal signaling. Pharmacol Rev (2011) 2.66
Structural features for functional selectivity at serotonin receptors. Science (2013) 2.60
Bromodomains as therapeutic targets. Expert Rev Mol Med (2011) 2.52
Regulators of G-protein signalling as new central nervous system drug targets. Nat Rev Drug Discov (2002) 2.47
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Cell (2008) 2.46
Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos. Science (2003) 2.46
A seven-transmembrane RGS protein that modulates plant cell proliferation. Science (2003) 2.41
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation. EMBO J (2008) 2.36
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. J Med Chem (2005) 2.34
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med (2003) 2.33
Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site. Structure (2009) 2.33
The (un)targeted cancer kinome. Nat Chem Biol (2010) 2.33
Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. Nature (2002) 2.30
Engineering GPCR signaling pathways with RASSLs. Nat Methods (2008) 2.29
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol (2010) 2.26
Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol (2010) 2.22
Structural and evolutionary division of phosphotyrosine binding (PTB) domains. J Mol Biol (2005) 2.19
Return of the GDI: the GoLoco motif in cell division. Annu Rev Biochem (2004) 2.16
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat Struct Biol (2002) 2.14
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat Cell Biol (2002) 2.12
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO J (2008) 2.12
Ligand discovery from a dopamine D3 receptor homology model and crystal structure. Nat Chem Biol (2011) 2.10
RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos. Cell (2004) 2.09
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J (2002) 2.07
Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol (2011) 2.06
Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina. Neuron (2005) 2.06
GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling. Proc Natl Acad Sci U S A (2007) 2.05
Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition. Neuron (2013) 2.01
DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility. Annu Rev Pharmacol Toxicol (2014) 1.99
Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets. Pharmacol Rev (2011) 1.98
Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. Structure (2005) 1.98
Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A (2011) 1.98
Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations. J Pharmacol Exp Ther (2004) 1.97
Structure and substrate specificity of the Pim-1 kinase. J Biol Chem (2005) 1.96
LGN regulates mitotic spindle orientation during epithelial morphogenesis. J Cell Biol (2010) 1.95
Finding new tricks for old drugs: an efficient route for public-sector drug discovery. Nat Rev Drug Discov (2005) 1.93
Chemogenetic tools to interrogate brain functions. Annu Rev Neurosci (2014) 1.92
Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. J Biol Chem (2007) 1.92
G-protein-coupled receptors at a glance. J Cell Sci (2003) 1.92
The bromodomain interaction module. FEBS Lett (2012) 1.92
A chemical-genetic approach to study G protein regulation of beta cell function in vivo. Proc Natl Acad Sci U S A (2009) 1.90
An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol (2013) 1.89
Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. J Pharmacol Exp Ther (2009) 1.88
Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy. Circ Res (2008) 1.87
Structural basis for molecular recognition at serotonin receptors. Science (2013) 1.86
Structure and functional characterization of the atypical human kinase haspin. Proc Natl Acad Sci U S A (2009) 1.85
Inhibition of BET bromodomain targets genetically diverse glioblastoma. Clin Cancer Res (2013) 1.84
N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity. Neuropsychopharmacology (2007) 1.83
PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. Haematologica (2010) 1.83
Receptor-mediated activation of heterotrimeric G-proteins: current structural insights. Mol Pharmacol (2007) 1.81
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J Clin Invest (2009) 1.79
Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist. J Med Chem (2005) 1.78
Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem (2012) 1.76
Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins. Nat Cell Biol (2005) 1.72
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc Natl Acad Sci U S A (2008) 1.72