Published in J Biol Chem on June 16, 2010
Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors. Gastroenterology (2011) 2.63
Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR. Oncogene (2012) 1.02
Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells. J Biol Chem (2013) 0.88
ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5. Mol Biol Cell (2012) 0.84
Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3. J Biol Chem (2012) 0.82
BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration. PLoS One (2014) 0.81
Evolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapy. World J Clin Oncol (2014) 0.77
Breast tumor kinase (Brk/PTK6) plays a role in the differentiation of primary keratinocytes. Arch Dermatol Res (2011) 0.77
ArfGAPs: key regulators for receptor sorting. Receptors Clin Investig (2014) 0.75
The associated pyrazolopyrimidines PP1 and PP2 inhibit protein tyrosine kinase 6 activity and suppress breast cancer cell proliferation. Oncol Lett (2017) 0.75
Regulators and Effectors of Arf GTPases in Neutrophils. J Immunol Res (2015) 0.75
ARF proteins: roles in membrane traffic and beyond. Nat Rev Mol Cell Biol (2006) 7.75
Clathrin-independent endocytosis of ubiquitinated cargos. Proc Natl Acad Sci U S A (2005) 5.37
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature (1992) 4.46
Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation. Dev Cell (2008) 4.22
Multiple roles for Arf6: sorting, structuring, and signaling at the plasma membrane. J Biol Chem (2003) 3.53
Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis. EMBO J (1999) 2.60
The EGF receptor: a nexus for trafficking and signaling. Bioessays (2000) 2.02
ARF1 is directly involved in dynamin-independent endocytosis. Nat Cell Biol (2007) 1.91
Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin. Mol Cell Biol (2004) 1.88
Arf GAPs and membrane traffic. J Cell Sci (2006) 1.67
BRK/Sik expression in the gastrointestinal tract and in colon tumors. Clin Cancer Res (1999) 1.59
Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability. Mol Cell Biol (2000) 1.58
Stoichiometric interaction of the epidermal growth factor receptor with the clathrin-associated protein complex AP-2. J Biol Chem (1995) 1.57
Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor. J Biol Chem (1996) 1.56
ARAP1: a point of convergence for Arf and Rho signaling. Mol Cell (2002) 1.53
Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. Oncogene (2003) 1.49
Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation. Oncogene (2000) 1.48
Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides. Mol Cell Biol (1993) 1.45
A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. Oncogene (1993) 1.43
Identification of STAT3 as a specific substrate of breast tumor kinase. Oncogene (2006) 1.40
Brk is coamplified with ErbB2 to promote proliferation in breast cancer. Proc Natl Acad Sci U S A (2008) 1.36
The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2. J Biol Chem (2004) 1.36
Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor. J Biol Chem (2002) 1.28
Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6. Breast Cancer Res (2007) 1.27
Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion. Cancer Res (2008) 1.26
Regulated association of protein kinase B/Akt with breast tumor kinase. J Biol Chem (2004) 1.25
A novel intracellular epithelial cell tyrosine kinase is expressed in the skin and gastrointestinal tract. Oncogene (1995) 1.25
Tyrosine kinase gene expression in the mouse small intestine. Oncogene (1994) 1.22
The intracellular tyrosine kinase Brk sensitizes non-transformed cells to inducers of apoptosis. Cell Cycle (2005) 1.18
A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiation. Proc Natl Acad Sci U S A (1997) 1.16
Differential expression of the non-receptor tyrosine kinase BRK in oral squamous cell carcinoma and normal oral epithelium. Oral Oncol (2004) 1.15
ARAP1 regulates endocytosis of EGFR. Traffic (2008) 1.10
ARAP1 regulates EGF receptor trafficking and signalling. Traffic (2008) 1.08
A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK. Oncogene (2000) 1.07
Interaction between Brk kinase and insulin receptor substrate-4. Oncogene (2005) 1.06
Identification of tyrosine kinases overexpressed in head and neck cancer. Arch Otolaryngol Head Neck Surg (2004) 1.04
ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner. J Cell Sci (2004) 1.04
Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases. J Biol Chem (2001) 1.03
Oncogenic functions of PTK6 are enhanced by its targeting to plasma membrane but abolished by its targeting to nucleus. J Biochem (2009) 1.02
Characterisation and chromosome mapping of the human non receptor tyrosine kinase gene, brk. Oncogene (1997) 0.98
Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes. Am J Pathol (2006) 0.97
STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation. Biochem Biophys Res Commun (2009) 0.97
STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. J Biol Chem (2003) 0.94
Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration. Cell Signal (2007) 0.93
An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6. J Biol Chem (2005) 0.92
A PH domain in the Arf GTPase-activating protein (GAP) ARAP1 binds phosphatidylinositol 3,4,5-trisphosphate and regulates Arf GAP activity independently of recruitment to the plasma membranes. J Biol Chem (2009) 0.92
A proteomic approach to identify substrates of matrix metalloproteinase-14 in human plasma. Biochim Biophys Acta (2004) 0.91
Substrate specificities and activities of AZAP family Arf GAPs in vivo. Am J Physiol Cell Physiol (2007) 0.90
Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase. Mol Cells (1998) 0.88
Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4. EMBO J (2009) 2.34
Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR/Flk-1. J Biol Chem (2002) 1.98
Arf and its many interactors. Curr Opin Cell Biol (2003) 1.94
ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat. J Cell Biol (2002) 1.82
Arf GAPs and their interacting proteins. Traffic (2007) 1.76
Arf GAPs and membrane traffic. J Cell Sci (2006) 1.67
ARAP1: a point of convergence for Arf and Rho signaling. Mol Cell (2002) 1.53
Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. Mol Cell Biol (2010) 1.50
Src-dependent phosphorylation of ASAP1 regulates podosomes. Mol Cell Biol (2007) 1.48
Consensus nomenclature for the human ArfGAP domain-containing proteins. J Cell Biol (2008) 1.42
Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome. Mol Biol Cell (2008) 1.40
A BAR domain in the N terminus of the Arf GAP ASAP1 affects membrane structure and trafficking of epidermal growth factor receptor. Curr Biol (2006) 1.40
Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A (2007) 1.39
AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton. J Biol Chem (2002) 1.37
CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. Mol Biol Cell (2004) 1.34
Regulation of membrane trafficking and organ separation by the NEVERSHED ARF-GAP protein. Development (2009) 1.30
Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases. J Biol Chem (2005) 1.25
A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin. J Cell Biol (2006) 1.24
Identification of S100A8 and S100A9 as serological markers for colorectal cancer. J Proteome Res (2009) 1.24
Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1. Dev Cell (2003) 1.22
ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP. J Cell Sci (2006) 1.21
Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Sec14p-dependent Golgi secretory function in yeast. Mol Biol Cell (2002) 1.20
Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis. Biochem Biophys Res Commun (2008) 1.19
Modifications to the C-terminus of Arf1 alter cell functions and protein interactions. Traffic (2010) 1.17
Preparation of myristoylated Arf1 and Arf6. Methods Enzymol (2005) 1.15
The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. J Cell Sci (2005) 1.14
Kinetic analysis of GTP hydrolysis catalysed by the Arf1-GTP-ASAP1 complex. Biochem J (2007) 1.14
Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling. EMBO Rep (2010) 1.13
ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion. J Biol Chem (2008) 1.12
The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome. Blood (2010) 1.11
Nucleotide exchange factors: Kinetic analyses and the rationale for studying kinetics of GEFs. Cell Logist (2012) 1.10
ARAP1 regulates endocytosis of EGFR. Traffic (2008) 1.10
Autoinhibition of Arf GTPase-activating protein activity by the BAR domain in ASAP1. J Biol Chem (2008) 1.09
Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk. J Mol Signal (2006) 1.06
Cloning and characterization of the full-length mouse Ptk7 cDNA encoding a defective receptor protein tyrosine kinase. Gene (2004) 1.04
Arf GAPs: gatekeepers of vesicle generation. FEBS Lett (2010) 1.04
ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner. J Cell Sci (2004) 1.04
Oncogenic functions of PTK6 are enhanced by its targeting to plasma membrane but abolished by its targeting to nucleus. J Biochem (2009) 1.02
Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and Arf GAP domains. Cell Signal (2005) 1.00
Syndecan-2 functions as a docking receptor for pro-matrix metalloproteinase-7 in human colon cancer cells. J Biol Chem (2009) 1.00
Characterization of plasma gelsolin as a substrate for matrix metalloproteinases. Proteomics (2006) 0.99
Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein. J Biol Chem (2011) 0.98
An absolute role of the PKC-dependent NF-kappaB activation for induction of MMP-9 in hepatocellular carcinoma cells. Biochem Biophys Res Commun (2003) 0.96
Assays and properties of the Arf GAPs AGAP1, ASAP1, and Arf GAP1. Methods Enzymol (2005) 0.96
Mutational analysis of the Arf1*GTP/Arf GAP interface reveals an Arf1 mutant that selectively affects the Arf GAP ASAP1. Curr Biol (2005) 0.95
TIMP-1 inhibits apoptosis in breast carcinoma cells via a pathway involving pertussis toxin-sensitive G protein and c-Src. Biochem Biophys Res Commun (2003) 0.95
Release of heat shock protein 70 (Hsp70) and the effects of extracellular Hsp70 on matric metalloproteinase-9 expression in human monocytic U937 cells. Exp Mol Med (2006) 0.94
Dynamic interaction between Arf GAP and PH domains of ASAP1 in the regulation of GAP activity. Cell Signal (2008) 0.94
Profiling of differentially expressed proteins in stage IV colorectal cancers with good and poor outcomes. J Proteomics (2011) 0.93
An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6. J Biol Chem (2005) 0.92
A PH domain in the Arf GTPase-activating protein (GAP) ARAP1 binds phosphatidylinositol 3,4,5-trisphosphate and regulates Arf GAP activity independently of recruitment to the plasma membranes. J Biol Chem (2009) 0.92
Differences between AGAP1, ASAP1 and Arf GAP1 in substrate recognition: interaction with the N-terminus of Arf1. Cell Signal (2004) 0.92
Oncogenic role of protein tyrosine kinase 7 in esophageal squamous cell carcinoma. Cancer Sci (2013) 0.91
A proteomic approach to identify substrates of matrix metalloproteinase-14 in human plasma. Biochim Biophys Acta (2004) 0.91
Alteration of collapsin response mediator protein-2 expression in focal ischemic rat brain. Neuroreport (2005) 0.91
Arf1 dissociates from the clathrin adaptor GGA prior to being inactivated by Arf GTPase-activating proteins. J Biol Chem (2002) 0.89
Kinetic analysis of Arf GAP1 indicates a regulatory role for coatomer. J Biol Chem (2008) 0.88
The pleckstrin homology (PH) domain of the Arf exchange factor Brag2 is an allosteric binding site. J Biol Chem (2012) 0.88
In vitro assays of Arf1 interaction with GGA proteins. Methods Enzymol (2005) 0.87
Contribution of AZAP-Type Arf GAPs to cancer cell migration and invasion. Adv Cancer Res (2008) 0.86
Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells. Biochem J (2012) 0.86
ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking. Biol Cell (2011) 0.85
PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation. Biochem Biophys Res Commun (2013) 0.85
ArfGAP1 function in COPI mediated membrane traffic: currently debated models and comparison to other coat-binding ArfGAPs. Histol Histopathol (2012) 0.85
ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology. J Biol Chem (2013) 0.85
The presence of outer arm fucose residues on the N-glycans of tissue inhibitor of metalloproteinases-1 reduces its activity. J Proteome Res (2013) 0.84
Discovery of melanotransferrin as a serological marker of colorectal cancer by secretome analysis and quantitative proteomics. J Proteome Res (2014) 0.84
Arf GAP2 is positively regulated by coatomer and cargo. Cell Signal (2009) 0.84
Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis. J Natl Cancer Inst (2010) 0.84
Arf regulates interaction of GGA with mannose-6-phosphate receptor. Traffic (2003) 0.84
Apolipoprotein C-II is a novel substrate for matrix metalloproteinases. Biochem Biophys Res Commun (2005) 0.84
The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2. J Biol Chem (2013) 0.83
Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain. J Biol Chem (2004) 0.83
Molecular dissection of the interaction between the SH3 domain and the SH2-Kinase Linker region in PTK6. Biochem Biophys Res Commun (2007) 0.83
GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity. J Biol Chem (2012) 0.83
Fisetin inhibits matrix metalloproteinases and reduces tumor cell invasiveness and endothelial cell tube formation. Nutr Cancer (2013) 0.83
GEFH1 binds ASAP1 and regulates podosome formation. Biochem Biophys Res Commun (2011) 0.83
Novel C-terminal motif within Sec7 domain of guanine nucleotide exchange factors regulates ADP-ribosylation factor (ARF) binding and activation. J Biol Chem (2011) 0.83
Approaches to studying Arf GAPs in cells: in vitro assay with isolated focal adhesions. Curr Protoc Cell Biol (2012) 0.81
Cleavage and functional loss of human apolipoprotein E by digestion of matrix metalloproteinase-14. Proteomics (2008) 0.80
ACAP-A/B are ArfGAP homologs in dictyostelium involved in sporulation but not in chemotaxis. PLoS One (2010) 0.79
Characterization of the 5'-flanking region of the human PTK6 gene. Biochim Biophys Acta (2002) 0.79
Apolipoprotein A-IV is a novel substrate for matrix metalloproteinases. J Biochem (2011) 0.79
Genetic variation in the renin-angiotensin system and response to endurance training. Med Princ Pract (2007) 0.79
CagA phosphorylation-dependent MMP-9 expression in gastric epithelial cells. Helicobacter (2011) 0.79
Refolding of the catalytic and hinge domains of human MT1-mMP expressed in Escherichia coli and its characterization. Mol Cells (2002) 0.79
Generation of a novel proform of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein that can be reactivated by matrix metalloproteinases. Exp Cell Res (2006) 0.79
Journey to the ends of the Arf. Structure (2009) 0.78
Importance of Gly-13 for the coenzyme binding of human UDP-glucose dehydrogenase. J Biol Chem (2004) 0.78
Novel and recurrent mutations of the LDL receptor gene in Korean patients with familial hypercholesterolemia. Mol Cells (2004) 0.77
Rapid analysis of matrix metalloproteinase-3 activity by gelatin arrays using a spectral surface plasmon resonance biosensor. Analyst (2010) 0.77
ArfGAP1 promotes COPI vesicle formation by facilitating coatomer polymerization. Cell Logist (2011) 0.77