Published in Acta Crystallogr Sect F Struct Biol Cryst Commun on October 24, 2007
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Identification, characterization, and crystal structure of the Omega class glutathione transferases. J Biol Chem (2000) 3.17
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The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition. J Biol Chem (2003) 1.64
The glutathione transferase structural family includes a nuclear chloride channel and a ryanodine receptor calcium release channel modulator. J Biol Chem (2000) 1.62
Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution. J Biol Chem (2001) 1.49
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Gene structure, expression and chromosomal localization of murine theta class glutathione transferase mGSTT1-1. Biochem J (1999) 0.95
Trimeric structure of the wild soluble chloride intracellular ion channel CLIC4 observed in crystals. Biochem Biophys Res Commun (2006) 0.86
Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller. Mol Cell (2006) 2.46
Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling. Nat Struct Biol (2002) 2.32
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Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target? Acta Neuropathol (2014) 2.25
AMPK beta subunit targets metabolic stress sensing to glycogen. Curr Biol (2003) 2.19
Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with lipoprotein. J Immunol (2005) 1.92
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat Struct Mol Biol (2005) 1.83
The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell (2008) 1.83
Elucidation of the substrate binding site of Siah ubiquitin ligase. Structure (2006) 1.79
Anxiety over GABA(A) receptor structure relieved by AChBP. Trends Biochem Sci (2002) 1.74
Characterization of the omega class of glutathione transferases. Methods Enzymol (2005) 1.71
Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands. J Biol Chem (2007) 1.70
Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo. Breast Cancer Res Treat (2009) 1.69
The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood (2009) 1.63
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry (2006) 1.63
Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin. Proc Natl Acad Sci U S A (2005) 1.63
Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels. J Biol Chem (2005) 1.62
Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins. J Mol Biol (2007) 1.54
Structural basis for glycogen recognition by AMP-activated protein kinase. Structure (2005) 1.50
An activation-specific platelet inhibitor that can be turned on/off by medically used hypothermia. Arterioscler Thromb Vasc Biol (2011) 1.46
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Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site. Protein Sci (2004) 1.41
Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses. Drugs (2009) 1.41
Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen. J Biol Chem (2008) 1.38
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis. J Biol Chem (2003) 1.38
Nomenclature for mammalian soluble glutathione transferases. Methods Enzymol (2005) 1.36
Using deubiquitylating enzymes as research tools. Methods Enzymol (2005) 1.36
Federated repositories of X-ray diffraction images. Acta Crystallogr D Biol Crystallogr (2008) 1.33
Inhibition of skeletal muscle ClC-1 chloride channels by low intracellular pH and ATP. J Biol Chem (2007) 1.32
The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle. J Biol Chem (2008) 1.30
A rivet model for channel formation by aerolysin-like pore-forming toxins. EMBO J (2006) 1.28
Molecular determinants of ginkgolide binding in the glycine receptor pore. J Neurochem (2006) 1.28
Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. Pharmacogenetics (2003) 1.26
From glutathione transferase to pore in a CLIC. Eur Biophys J (2002) 1.23
The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin. J Biol Chem (2004) 1.22
The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling. Immunol Rev (2012) 1.20
Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases. Pharmacogenet Genomics (2005) 1.18
Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope. J Mol Biol (2008) 1.17
Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay. Virology (2003) 1.17
An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity. Hum Mol Genet (2012) 1.16
Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. Proc Natl Acad Sci U S A (2002) 1.14
Fungal effector Ecp6 outcompetes host immune receptor for chitin binding through intrachain LysM dimerization. Elife (2013) 1.14
Molecular evolution of glutathione S-transferases in the genus Drosophila. Genetics (2007) 1.14
Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. J Biol Chem (2011) 1.12
Alphavirus 6K proteins form ion channels. J Biol Chem (2002) 1.10
Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells. Mol Cancer (2011) 1.10
A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP. Biochem J (2005) 1.08
CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels. Int J Biochem Cell Biol (2004) 1.07
Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human amyloid precursor protein. J Mol Biol (2006) 1.07
Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes. PLoS Pathog (2010) 1.07
Insights into the structural basis for zinc inhibition of the glycine receptor. J Biol Chem (2003) 1.05
Contractility of single human dermal myofibroblasts and fibroblasts. Cell Motil Cytoskeleton (2002) 1.04
A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J Neurochem (2007) 1.04
Conversion of a transmembrane to a water-soluble protein complex by a single point mutation. Nat Struct Biol (2002) 1.04
S-(4-Nitrophenacyl)glutathione is a specific substrate for glutathione transferase omega 1-1. Anal Biochem (2007) 1.04
Substrate-mediated stabilization of a tetrameric drug target reveals Achilles heel in anthrax. J Biol Chem (2009) 1.03
Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation. Sci Rep (2013) 1.02
Functional characterisation of ganglioside-induced differentiation-associated protein 1 as a glutathione transferase. Biochem Biophys Res Commun (2006) 1.02
The purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Clostridium botulinum. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 1.01
Molecular basis of cytokine receptor activation. IUBMB Life (2010) 1.01
Structure of the Janus protein human CLIC2. J Mol Biol (2007) 1.01
Purification, crystallization and preliminary X-ray diffraction studies to near-atomic resolution of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.99
Direct involvement of the TEN domain at the active site of human telomerase. Nucleic Acids Res (2010) 0.98
Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins. J Biol Chem (2012) 0.97
The SARS-unique domain (SUD) of SARS coronavirus contains two macrodomains that bind G-quadruplexes. PLoS Pathog (2009) 0.96
A role for glutathione transferase Omega 1 (GSTO1-1) in the glutathionylation cycle. J Biol Chem (2013) 0.96
Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo. J Biol Chem (2005) 0.96
Hsp90 increases LIM kinase activity by promoting its homo-dimerization. FASEB J (2006) 0.96
A dihydropyridine receptor alpha1s loop region critical for skeletal muscle contraction is intrinsically unstructured and binds to a SPRY domain of the type 1 ryanodine receptor. Int J Biochem Cell Biol (2008) 0.96
GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme. J Biol Chem (2002) 0.95
TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members. PLoS One (2012) 0.95
Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription. Blood (2013) 0.94
Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways. Mol Pharmacol (2005) 0.94
The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies. Proc Natl Acad Sci U S A (2011) 0.94
Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein. J Neurosci (2002) 0.94
Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.94
Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling. J Biol Chem (2005) 0.94
Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases. J Mol Biol (2012) 0.94
The GM-CSF receptor family: mechanism of activation and implications for disease. Growth Factors (2012) 0.93
Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase. FASEB J (2008) 0.93
Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions. J Mol Biol (2006) 0.93
Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients. Respir Res (2007) 0.93
Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property. Protein Sci (2009) 0.93
Molecular determinants of common gating of a ClC chloride channel. Nat Commun (2013) 0.92
Structure of the GTPase and GDI domains of FeoB, the ferrous iron transporter of Legionella pneumophila. FEBS Lett (2009) 0.92