Direct involvement of the TEN domain at the active site of human telomerase.

PubWeight™: 0.98‹?› | Rank: Top 15%

🔗 View Article (PMC 3061064)

Published in Nucleic Acids Res on November 03, 2010

Authors

Julie Jurczyluk1, Amanda S Nouwens, Jessica K Holien, Timothy E Adams, George O Lovrecz, Michael W Parker, Scott B Cohen, Tracy M Bryan

Author Affiliations

1: Children's Medical Research Institute, Westmead, NSW 2145, Australia.

Articles citing this

Finding the end: recruitment of telomerase to telomeres. Nat Rev Mol Cell Biol (2013) 1.73

Telomerase recruitment requires both TCAB1 and Cajal bodies independently. Mol Cell Biol (2012) 1.28

Human telomerase: biogenesis, trafficking, recruitment, and activation. Genes Dev (2015) 1.14

Human telomerase specialization for repeat synthesis by unique handling of primer-template duplex. EMBO J (2014) 1.09

Identification of human TERT elements necessary for telomerase recruitment to telomeres. Elife (2014) 1.05

Human telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step. Proc Natl Acad Sci U S A (2011) 0.92

Telomeric G-quadruplexes are a substrate and site of localization for human telomerase. Nat Commun (2015) 0.88

The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis. BMC Mol Biol (2011) 0.88

Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase. Plant J (2014) 0.85

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. Cell Rep (2015) 0.85

The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids. Nucleic Acids Res (2015) 0.84

Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase. J Mol Biol (2015) 0.82

Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes. Elife (2015) 0.82

A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization. Mol Biol Cell (2013) 0.81

A mutation in the catalytic subunit of yeast telomerase alters primer-template alignment while promoting processivity and protein-DNA binding. J Cell Sci (2011) 0.79

A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase. PLoS Genet (2015) 0.77

Single-Molecule Studies of Telomeres and Telomerase. Annu Rev Biophys (2017) 0.75

Telomere biology and telomerase mutations in cirrhotic patients with hepatocellular carcinoma. PLoS One (2017) 0.75

Articles cited by this

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell (1985) 24.17

Telomerase catalytic subunit homologs from fission yeast and human. Science (1997) 12.35

A survey of telomerase activity in human cancer. Eur J Cancer (1997) 10.84

Reverse transcriptase motifs in the catalytic subunit of telomerase. Science (1997) 10.10

The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell (1987) 8.32

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet (1997) 6.69

Inhibition of telomerase limits the growth of human cancer cells. Nat Med (1999) 4.96

Telomeres and their control. Annu Rev Genet (2000) 4.74

Protein docking using spherical polar Fourier correlations. Proteins (2000) 3.60

Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum Mol Genet (1997) 3.56

Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev (1997) 3.47

Recognition of a chromosome truncation site associated with alpha-thalassaemia by human telomerase. Nature (1991) 3.28

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev (1999) 3.04

Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, the self-splicing rRNA intron, and U2 snRNA. RNA (1995) 2.78

Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation. Genes Dev (1993) 2.64

Telomerase primer specificity and chromosome healing. Nature (1991) 2.58

The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex. Proc Natl Acad Sci U S A (1998) 2.43

Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase. Nat Struct Mol Biol (2006) 2.32

Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants. Genes Dev (1999) 2.30

N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo. Mol Cell Biol (2001) 2.16

Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs. Mol Cell (2003) 2.07

Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition. Proc Natl Acad Sci U S A (1985) 1.97

The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit. Hum Mol Genet (1997) 1.97

Sequence-specific DNA primer effects on telomerase polymerization activity. Mol Cell Biol (1993) 1.92

Functional multimerization of the human telomerase reverse transcriptase. Mol Cell Biol (2001) 1.90

Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase. Mol Cell Biol (2000) 1.83

Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions. Mol Cell Biol (2001) 1.72

Template definition by Tetrahymena telomerase reverse transcriptase. EMBO J (2000) 1.71

Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit. Mol Cell Biol (2002) 1.71

Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer. Mol Cell Biol (2004) 1.63

A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity. J Biol Chem (2000) 1.60

The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity. Neoplasia (2001) 1.60

Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Mol Biol Cell (2000) 1.60

Two purified domains of telomerase reverse transcriptase reconstitute sequence-specific interactions with RNA. J Biol Chem (2005) 1.58

C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity. Mol Cell Biol (2002) 1.46

Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. Mol Cell Biol (2004) 1.27

The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity. Nucleic Acids Res (2003) 1.27

N-terminal domain of yeast telomerase reverse transcriptase: recruitment of Est3p to the telomerase complex. Mol Biol Cell (2003) 1.26

Mutation in TERT separates processivity from anchor-site function. Nat Struct Mol Biol (2008) 1.24

Characterization of physical and functional anchor site interactions in human telomerase. Mol Cell Biol (2007) 1.24

High-resolution physical and functional mapping of the template adjacent DNA binding site in catalytically active telomerase. Proc Natl Acad Sci U S A (2007) 1.21

A physical and functional constituent of telomerase anchor site. J Biol Chem (2005) 1.21

Negative regulation of yeast telomerase activity through an interaction with an upstream region of the DNA primer. Nucleic Acids Res (1998) 1.19

A sensitive direct human telomerase activity assay. Nat Methods (2008) 1.19

Nucleolar localization of hTERT protein is associated with telomerase function. Exp Cell Res (2002) 1.17

Soluble domains of telomerase reverse transcriptase identified by high-throughput screening. Protein Sci (2005) 1.14

A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity. Nucleic Acids Res (2009) 1.12

Multiple DNA-binding sites in Tetrahymena telomerase. Nucleic Acids Res (2008) 1.12

An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization. Mol Biol Cell (2005) 1.11

Putative telomere-recruiting domain in the catalytic subunit of human telomerase. Mol Cell Biol (2003) 1.09

The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization. Nucleic Acids Res (2009) 1.05

Interaction of human telomerase with its primer substrate. Biochemistry (2003) 1.04

Modeling and structure function analysis of the putative anchor site of yeast telomerase. Nucleic Acids Res (2007) 0.95

Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo. PLoS One (2009) 0.88

Striking similarities in diverse telomerase proteins revealed by combining structure prediction and machine learning approaches. Pac Symp Biocomput (2008) 0.78

Articles by these authors

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha. Cell (2002) 4.92

Protein composition of catalytically active human telomerase from immortal cells. Science (2007) 3.53

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors. Mol Cell (2003) 3.20

Zanamivir-resistant influenza viruses with a novel neuraminidase mutation. J Virol (2009) 2.59

Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling. Nat Struct Biol (2002) 2.32

Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target? Acta Neuropathol (2014) 2.25

Structure of the insulin receptor ectodomain reveals a folded-over conformation. Nature (2006) 2.22

AMPK beta subunit targets metabolic stress sensing to glycogen. Curr Biol (2003) 2.19

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions. Nat Struct Mol Biol (2009) 2.08

Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with lipoprotein. J Immunol (2005) 1.92

Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat Struct Mol Biol (2005) 1.83

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell (2008) 1.83

Elucidation of the substrate binding site of Siah ubiquitin ligase. Structure (2006) 1.79

Anxiety over GABA(A) receptor structure relieved by AChBP. Trends Biochem Sci (2002) 1.74

A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition. J Exp Med (2003) 1.72

Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands. J Biol Chem (2007) 1.70

In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses. Antimicrob Agents Chemother (2009) 1.64

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood (2009) 1.63

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry (2006) 1.63

Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin. Proc Natl Acad Sci U S A (2005) 1.63

Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels. J Biol Chem (2005) 1.62

Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins. J Mol Biol (2007) 1.54

The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity. Proc Natl Acad Sci U S A (2006) 1.52

Structural basis for glycogen recognition by AMP-activated protein kinase. Structure (2005) 1.50

NS1' of flaviviruses in the Japanese encephalitis virus serogroup is a product of ribosomal frameshifting and plays a role in viral neuroinvasiveness. J Virol (2009) 1.50

Structure of stem-loop IV of Tetrahymena telomerase RNA. EMBO J (2006) 1.49

Extension of G-quadruplex DNA by ciliate telomerase. EMBO J (2006) 1.49

Physiological relevance of telomeric G-quadruplex formation: a potential drug target. Bioessays (2007) 1.47

An activation-specific platelet inhibitor that can be turned on/off by medically used hypothermia. Arterioscler Thromb Vasc Biol (2011) 1.46

CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor. J Biol Chem (2004) 1.45

Rowe and Kahn's model of successful aging revisited: positive spirituality--the forgotten factor. Gerontologist (2002) 1.44

Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site. Protein Sci (2004) 1.41

Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses. Drugs (2009) 1.41

Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Mol Endocrinol (2002) 1.39

Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen. J Biol Chem (2008) 1.38

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis. J Biol Chem (2003) 1.38

The insulin and EGF receptor structures: new insights into ligand-induced receptor activation. Trends Biochem Sci (2007) 1.37

Federated repositories of X-ray diffraction images. Acta Crystallogr D Biol Crystallogr (2008) 1.33

Inhibition of skeletal muscle ClC-1 chloride channels by low intracellular pH and ATP. J Biol Chem (2007) 1.32

Telomerase recruitment requires both TCAB1 and Cajal bodies independently. Mol Cell Biol (2012) 1.28

A rivet model for channel formation by aerolysin-like pore-forming toxins. EMBO J (2006) 1.28

Molecular determinants of ginkgolide binding in the glycine receptor pore. J Neurochem (2006) 1.28

Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer Sci (2008) 1.28

From glutathione transferase to pore in a CLIC. Eur Biophys J (2002) 1.23

Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor. J Biol Chem (2004) 1.23

The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin. J Biol Chem (2004) 1.22

The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling. Immunol Rev (2012) 1.20

Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope. J Mol Biol (2008) 1.17

Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay. Virology (2003) 1.17

Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. Proc Natl Acad Sci U S A (2002) 1.14

Molecular evolution of glutathione S-transferases in the genus Drosophila. Genetics (2007) 1.14

Multiple DNA-binding sites in Tetrahymena telomerase. Nucleic Acids Res (2008) 1.12

Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. J Biol Chem (2011) 1.12

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR. Proc Natl Acad Sci U S A (2009) 1.07

Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human amyloid precursor protein. J Mol Biol (2006) 1.07

Insights into the structural basis for zinc inhibition of the glycine receptor. J Biol Chem (2003) 1.05

Conversion of a transmembrane to a water-soluble protein complex by a single point mutation. Nat Struct Biol (2002) 1.04

A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J Neurochem (2007) 1.04

Substrate-mediated stabilization of a tetrameric drug target reveals Achilles heel in anthrax. J Biol Chem (2009) 1.03

Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation. Sci Rep (2013) 1.02

Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. J Cell Biol (2012) 1.02

Molecular basis of cytokine receptor activation. IUBMB Life (2010) 1.01

The purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Clostridium botulinum. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 1.01

Structure of the Janus protein human CLIC2. J Mol Biol (2007) 1.01

Purification, crystallization and preliminary X-ray diffraction studies to near-atomic resolution of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.99

Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation. Cancers (Basel) (2011) 0.98

Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins. J Biol Chem (2012) 0.97

Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo. J Biol Chem (2005) 0.96

Hsp90 increases LIM kinase activity by promoting its homo-dimerization. FASEB J (2006) 0.96

GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme. J Biol Chem (2002) 0.95

TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members. PLoS One (2012) 0.95

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription. Blood (2013) 0.94

Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein. J Neurosci (2002) 0.94

Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling. J Biol Chem (2005) 0.94

Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.94

Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase. FASEB J (2008) 0.93

The GM-CSF receptor family: mechanism of activation and implications for disease. Growth Factors (2012) 0.93

Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions. J Mol Biol (2006) 0.93

A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo. Mol Cancer Ther (2010) 0.93

Molecular determinants of common gating of a ClC chloride channel. Nat Commun (2013) 0.92

Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.92

Megakaryocytes co-localise with hemopoietic stem cells and release cytokines that up-regulate stem cell proliferation. Stem Cell Res (2013) 0.92

Crystal structure of a putative methyltransferase from Mycobacterium tuberculosis: misannotation of a genome clarified by protein structural analysis. J Bacteriol (2003) 0.91

Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity. Structure (2012) 0.91

Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide. Chem Commun (Camb) (2009) 0.90

Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.90

Alternative lengthening of telomeres: dangerous road less travelled. Lancet (2003) 0.89

Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique. Biochem J (2003) 0.89

Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor. FEBS J (2013) 0.89

Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen (2012) 0.89

Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by Sortase A-mediated protein ligation. Biotechnol Bioeng (2011) 0.89