Published in Nat Biotechnol on November 18, 2007
Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med (2010) 7.11
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Modeling hepatitis C virus infection using human induced pluripotent stem cells. Proc Natl Acad Sci U S A (2012) 2.20
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Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function. Hepatology (2009) 1.41
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A versatile valve-enabled microfluidic cell co-culture platform and demonstration of its applications to neurobiology and cancer biology. Biomed Microdevices (2011) 1.27
Accelerating drug discovery via organs-on-chips. Lab Chip (2013) 1.26
Tunable patterning of microparticles and cells using standing surface acoustic waves. Lab Chip (2012) 1.25
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Fabrication of three-dimensional porous cell-laden hydrogel for tissue engineering. Biofabrication (2010) 1.11
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog (2016) 1.11
Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions. Biochim Biophys Acta (2010) 1.10
High-content drug screening with engineered musculoskeletal tissues. Tissue Eng Part B Rev (2010) 1.10
Cell and tissue engineering for liver disease. Sci Transl Med (2014) 1.08
Laser photoablation of guidance microchannels into hydrogels directs cell growth in three dimensions. Biophys J (2009) 1.08
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems. Proc Natl Acad Sci U S A (2014) 1.07
Organ-on-a-chip platforms for studying drug delivery systems. J Control Release (2014) 1.06
Engineering a stem cell house into a home. Stem Cell Res Ther (2011) 1.04
3D hepatic cultures simultaneously maintain primary hepatocyte and liver sinusoidal endothelial cell phenotypes. PLoS One (2010) 1.03
Temperature-responsive intelligent interfaces for biomolecular separation and cell sheet engineering. J R Soc Interface (2009) 1.03
Long-term culture and coculture of primary rat and human hepatocytes. Methods Mol Biol (2013) 1.01
Magnetic manipulation and spatial patterning of multi-cellular stem cell aggregates. Integr Biol (Camb) (2011) 1.01
Generating nonlinear concentration gradients in microfluidic devices for cell studies. Anal Chem (2011) 0.98
Tissue-level modeling of xenobiotic metabolism in liver: An emerging tool for enabling clinical translational research. Clin Transl Sci (2009) 0.97
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Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers. Biomaterials (2008) 0.97
In vitro-in vivo translation of lipid nanoparticles for hepatocellular siRNA delivery. ACS Nano (2012) 0.97
The design of in vitro liver sinusoid mimics using chitosan-hyaluronic acid polyelectrolyte multilayers. Tissue Eng Part A (2010) 0.97
Digital microfabrication of user-defined 3D microstructures in cell-laden hydrogels. Biotechnol Bioeng (2013) 0.95
Automation of three-dimensional cell culture in arrayed microfluidic devices. J Lab Autom (2011) 0.95
Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues. Tissue Eng Part A (2014) 0.95
Long-term superior performance of a stem cell/hepatocyte device for the treatment of acute liver failure. Tissue Eng Part A (2009) 0.95
A cost-effective fluorescence mini-microscope for biomedical applications. Lab Chip (2015) 0.95
Engineering of an hepatic organoid to develop liver assist devices. Cell Transplant (2010) 0.93
Predicting drug metabolism: experiment and/or computation? Nat Rev Drug Discov (2015) 0.93
Using physiologically-based pharmacokinetic-guided "body-on-a-chip" systems to predict mammalian response to drug and chemical exposure. Exp Biol Med (Maywood) (2014) 0.93
Barriers of hepatitis C virus interspecies transmission. Virology (2013) 0.92
ADDME--Avoiding Drug Development Mistakes Early: central nervous system drug discovery perspective. BMC Neurol (2009) 0.92
Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro. Am J Physiol Cell Physiol (2013) 0.92
Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development. Stem Cell Res Ther (2013) 0.92
Emerging roles for extracellular vesicles in tissue engineering and regenerative medicine. Tissue Eng Part B Rev (2014) 0.92
Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform. Lab Chip (2014) 0.91
A comparative study of genome-wide transcriptional profiles of primary hepatocytes in collagen sandwich and monolayer cultures. Tissue Eng Part C Methods (2010) 0.91
A novel ultrathin collagen nanolayer assembly for 3-D microtissue engineering: Layer-by-layer collagen deposition for long-term stable microfluidic hepatocyte culture. Technology (Singap World Sci) (2014) 0.90
Hepatocyte spheroid arrays inside microwells connected with microchannels. Biomicrofluidics (2011) 0.90
Human pluripotent stem cells for modelling human liver diseases and cell therapy. Curr Gene Ther (2013) 0.90
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A microphysiological system model of therapy for liver micrometastases. Exp Biol Med (Maywood) (2014) 0.89
Layered patterning of hepatocytes in co-culture systems using microfabricated stencils. Biotechniques (2010) 0.88
Bioreactor engineering of stem cell environments. Biotechnol Adv (2013) 0.88
Long-term culture and expansion of primary human hepatocytes. Nat Biotechnol (2015) 0.87
Transwells with microstamped membranes produce micropatterned two-dimensional and three-dimensional co-cultures. Tissue Eng Part C Methods (2010) 0.87
Normal atmospheric oxygen tension and the use of antioxidants improve hepatocyte spheroid viability and function. J Cell Physiol (2011) 0.87
Nanofabricated collagen-inspired synthetic elastomers for primary rat hepatocyte culture. Tissue Eng Part A (2009) 0.86
Cellular therapy and bioartificial approaches to liver replacement. Curr Opin Organ Transplant (2012) 0.86
Weighing nanoparticles in solution at the attogram scale. Proc Natl Acad Sci U S A (2014) 0.86
Microscale technologies for regulating human stem cell differentiation. Exp Biol Med (Maywood) (2014) 0.85
Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity. Toxicol Appl Pharmacol (2010) 0.85
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Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor. Drug Metab Dispos (2015) 0.84
Microfluidics-assisted in vitro drug screening and carrier production. Adv Drug Deliv Rev (2013) 0.84
Discovering networks of perturbed biological processes in hepatocyte cultures. PLoS One (2011) 0.84
Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research. Prog Lipid Res (2015) 0.84
Nanocrystal targeting in vivo. Proc Natl Acad Sci U S A (2002) 5.35
Biodegradable luminescent porous silicon nanoparticles for in vivo applications. Nat Mater (2009) 4.77
An extracellular matrix microarray for probing cellular differentiation. Nat Methods (2005) 4.35
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proc Natl Acad Sci U S A (2011) 4.15
Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues. Nat Mater (2012) 4.10
Targeting of drugs and nanoparticles to tumors. J Cell Biol (2010) 4.07
Nanoparticles that communicate in vivo to amplify tumour targeting. Nat Mater (2011) 3.83
Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas. Cancer Res (2009) 3.77
Micromechanical control of cell-cell interactions. Proc Natl Acad Sci U S A (2007) 3.53
Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system. Nat Biotechnol (2010) 3.44
Probing the role of multicellular organization in three-dimensional microenvironments. Nat Methods (2006) 3.20
Biomolecular screening with encoded porous-silicon photonic crystals. Nat Mater (2002) 3.13
Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. FASEB J (2006) 2.95
Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures. Proc Natl Acad Sci U S A (2010) 2.44
Targeted quantum dot conjugates for siRNA delivery. Bioconjug Chem (2007) 2.31
Modeling hepatitis C virus infection using human induced pluripotent stem cells. Proc Natl Acad Sci U S A (2012) 2.20
Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting. Small (2009) 2.16
Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy. Proc Natl Acad Sci U S A (2012) 2.13
Humanized mice with ectopic artificial liver tissues. Proc Natl Acad Sci U S A (2011) 2.03
Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging. Adv Mater (2008) 2.01
In vivo tumor cell targeting with "click" nanoparticles. Bioconjug Chem (2008) 2.01
Cancer vulnerabilities unveiled by genomic loss. Cell (2012) 1.95
A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax. Cell Host Microbe (2013) 1.95
Manipulation of liquid droplets using amphiphilic, magnetic one-dimensional photonic crystal chaperones. Nat Mater (2004) 1.89
Cooperative nanomaterial system to sensitize, target, and treat tumors. Proc Natl Acad Sci U S A (2009) 1.82
SERS-Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near-Infrared Imaging and Photothermal Heating. Adv Mater (2009) 1.79
Microfabricated platform for studying stem cell fates. Biotechnol Bioeng (2004) 1.77
Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells Dev (2008) 1.76
Three-dimensional tissue fabrication. Adv Drug Deliv Rev (2004) 1.76
Polymer replicas of photonic porous silicon for sensing and drug delivery applications. Science (2003) 1.72
Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery. Angew Chem Int Ed Engl (2008) 1.71
Identification and characterization of receptor-specific peptides for siRNA delivery. ACS Nano (2012) 1.58
Formation of steady-state oxygen gradients in vitro: application to liver zonation. Biotechnol Bioeng (2003) 1.58
Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng (2003) 1.58
Single cell trapping and DNA damage analysis using microwell arrays. Proc Natl Acad Sci U S A (2010) 1.53
Engineering protein and cell adhesivity using PEO-terminated triblock polymers. J Biomed Mater Res (2002) 1.50
Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol (2013) 1.49
A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nat Commun (2012) 1.47
Photo- and electropatterning of hydrogel-encapsulated living cell arrays. Lab Chip (2004) 1.46
Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells. Hepatology (2011) 1.42
Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4. Sci Transl Med (2012) 1.42
Proteolytic actuation of nanoparticle self-assembly. Angew Chem Int Ed Engl (2006) 1.39
Tissue-specific gene delivery via nanoparticle coating. Biomaterials (2009) 1.34
Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro. Hepatology (2009) 1.33
Assessing porcine liver-derived biomatrix for hepatic tissue engineering. Tissue Eng (2004) 1.32
A biophysical indicator of vaso-occlusive risk in sickle cell disease. Sci Transl Med (2012) 1.32
Protease-triggered unveiling of bioactive nanoparticles. Small (2008) 1.30
Quantum dots to monitor RNAi delivery and improve gene silencing. Nucleic Acids Res (2005) 1.26
Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery. Adv Mater (2010) 1.26
Local heating of discrete droplets using magnetic porous silicon-based photonic crystals. J Am Chem Soc (2006) 1.25
In vitro zonation and toxicity in a hepatocyte bioreactor. Toxicol Sci (2004) 1.24
Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. Proc Natl Acad Sci U S A (2010) 1.20
Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics. Proc Natl Acad Sci U S A (2014) 1.20
Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling. Hepatology (2004) 1.20
Geometric control of vascular networks to enhance engineered tissue integration and function. Proc Natl Acad Sci U S A (2013) 1.19
Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance. Biomaterials (2009) 1.19
Ligand-clustered "patchy" nanoparticles for modulated cellular uptake and in vivo tumor targeting. Angew Chem Int Ed Engl (2010) 1.18
Assessment of hepatocellular function within PEG hydrogels. Biomaterials (2006) 1.18
Mitochondrial localization and the persistent migration of epithelial cancer cells. Biophys J (2013) 1.16
Bioresponsive mesoporous silica nanoparticles for triggered drug release. J Am Chem Soc (2011) 1.15
High-throughput analysis of signals regulating stem cell fate and function. Curr Opin Chem Biol (2007) 1.15
Engineering tissues for in vitro applications. Curr Opin Biotechnol (2006) 1.15
Multiphase electropatterning of cells and biomaterials. Lab Chip (2007) 1.13
Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis. ACS Nano (2013) 1.12
Effect of nanoparticle conjugation on gene silencing by RNA interference. J Am Chem Soc (2010) 1.11
Nanoparticle self-assembly gated by logical proteolytic triggers. J Am Chem Soc (2007) 1.11
Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease. Nat Biotechnol (2012) 1.10
Microscale control of cell contact and spacing via three-component surface patterning. Langmuir (2007) 1.06
The smart Petri dish: a nanostructured photonic crystal for real-time monitoring of living cells. Langmuir (2006) 1.05
The pipeline still leaks and more than you think: a status report on gender diversity in biomedical engineering. Ann Biomed Eng (2010) 1.02
Engineering liver therapies for the future. Tissue Eng (2002) 1.01
Laminin and fibronectin modulate inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay. Dev Neurobiol (2007) 0.99
Multiplexed, high-throughput analysis of 3D microtissue suspensions. Integr Biol (Camb) (2010) 0.99
The compatibility of hepatocytes with chemically modified porous silicon with reference to in vitro biosensors. Biomaterials (2008) 0.99
Statistical dynamics of flowing red blood cells by morphological image processing. PLoS Comput Biol (2009) 0.99
Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers. Biomaterials (2008) 0.97
Geometric and material determinants of patterning efficiency by dielectrophoresis. Biophys J (2004) 0.96
Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents. ACS Nano (2009) 0.95
Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues. Tissue Eng Part A (2014) 0.95
Fabrication of three-dimensional tissues. Adv Biochem Eng Biotechnol (2007) 0.94
Genetic Circuits in Salmonella typhimurium. ACS Synth Biol (2012) 0.93
Self-titrating anticoagulant nanocomplexes that restore homeostatic regulation of the coagulation cascade. ACS Nano (2014) 0.93
DNA-templated assembly of droplet-derived PEG microtissues. Lab Chip (2011) 0.93
Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers. J Am Chem Soc (2014) 0.91
Plasmonic photothermal heating of intraperitoneal tumors through the use of an implanted near-infrared source. ACS Nano (2013) 0.90
Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1alpha. Toxicol Lett (2005) 0.89
In Vivo Gene Expression Dynamics of Tumor-Targeted Bacteria. ACS Synth Biol (2012) 0.89
Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments. Lab Chip (2013) 0.88
Improving the next generation of bioartificial liver devices. Semin Cell Dev Biol (2002) 0.86
Weighing nanoparticles in solution at the attogram scale. Proc Natl Acad Sci U S A (2014) 0.86
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T-cadherin modulates hepatocyte functions in vitro. FASEB J (2008) 0.83
In-silico patterning of vascular mesenchymal cells in three dimensions. PLoS One (2011) 0.83
Patterning vascular networks in vivo for tissue engineering applications. Tissue Eng Part C Methods (2015) 0.82
Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro. Dis Model Mech (2013) 0.82
Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics. Integr Biol (Camb) (2010) 0.80
In vitro liver tissue model established from transgenic mice: role of HIF-1alpha on hypoxic gene expression. Tissue Eng (2006) 0.80
Nanoparticle amplification via photothermal unveiling of cryptic collagen binding sites. J Mater Chem B Mater Biol Med (2013) 0.79
Silicon microchips for manipulating cell-cell interaction. J Vis Exp (2007) 0.76