Published in Toxicol Appl Pharmacol on September 24, 2010
Successful mouse hepatocyte culture with sandwich collagen gel formation. J Korean Surg Soc (2013) 0.85
Mixed learning algorithms and features ensemble in hepatotoxicity prediction. J Comput Aided Mol Des (2011) 0.80
p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo. Gene Regul Syst Bio (2015) 0.79
Challenges in using cultured primary rodent hepatocytes or cell lines to study hepatic HDL receptor SR-BI regulation by its cytoplasmic adaptor PDZK1. PLoS One (2013) 0.79
Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix. Biotechnol Bioeng (2014) 0.75
Rho GTPases in cell biology. Nature (2002) 22.81
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev (2008) 10.28
Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol (2006) 8.81
A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature (2007) 6.77
Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther (1973) 5.23
Microscale culture of human liver cells for drug development. Nat Biotechnol (2007) 4.85
In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project. Environ Health Perspect (2010) 3.84
Idiosyncratic drug hepatotoxicity. Nat Rev Drug Discov (2005) 3.23
The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol Endocrinol (2000) 2.74
The toxicity data landscape for environmental chemicals. Environ Health Perspect (2008) 2.68
Toxicity testing in the 21st century: a vision and a strategy. Reprod Toxicol (2007) 2.21
Pharmacogenomic discovery using cell-based models. Pharmacol Rev (2009) 1.96
Effect of extracellular matrix topology on cell structure, function, and physiological responsiveness: hepatocytes cultured in a sandwich configuration. FASEB J (1996) 1.90
Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis. Hepatology (2009) 1.80
Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the presence of hepatocyte growth factor and epidermal growth factor. Hepatology (1999) 1.72
A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction. Curr Drug Metab (2005) 1.61
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Res (2009) 1.60
Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation. Eur J Pharm Sci (2001) 1.59
Mechanisms of immune-mediated liver injury. Toxicol Sci (2010) 1.48
Liver myofibroblasts regulate infiltration and positioning of lymphocytes in human liver. Gastroenterology (2008) 1.39
Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity. Toxicol Appl Pharmacol (2006) 1.37
Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology (2007) 1.29
In silico pharmacogenetics of warfarin metabolism. Nat Biotechnol (2006) 1.25
Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis. Carcinogenesis (2000) 1.21
In silico and in vitro pharmacogenetic analysis in mice. Proc Natl Acad Sci U S A (2007) 1.17
Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains. Biochem Pharmacol (1997) 1.13
Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations. Xenobiotica (2007) 1.11
Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicol Sci (2009) 1.11
Reestablishment of cell polarity of rat hepatocytes in primary culture. Hepatology (1993) 1.10
Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors. Biochim Biophys Acta (2003) 1.08
Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics. Chem Biol Interact (2001) 1.06
CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor. Drug Metab Dispos (2004) 1.06
Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function. Am J Physiol Gastrointest Liver Physiol (2008) 1.04
New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures. Drug Metab Rev (2003) 1.04
In vitro models to study hepatotoxicity. Toxicol Pathol (2002) 1.03
An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity. Genome Res (2009) 0.98
Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes. Biochem Pharmacol (2002) 0.96
Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures. Toxicol Appl Pharmacol (2008) 0.96
Influence of seeding density and extracellular matrix on bile Acid transport and mrp4 expression in sandwich-cultured mouse hepatocytes. Mol Pharm (2010) 0.95
Prediction of rodent carcinogenesis: an evaluation of prechronic liver lesions as forecasters of liver tumors in NTP carcinogenicity studies. Toxicol Pathol (2004) 0.95
Cell adhesion molecules in liver function and pattern formation. FASEB J (1994) 0.95
Evaluation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepatocytes. Toxicol In Vitro (2002) 0.93
Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity. Expert Opin Drug Metab Toxicol (2008) 0.92
Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-coenzyme A oxidase gene expression by fibrates and dietary fatty acids. Eur J Biochem (1995) 0.90
Peroxisome proliferators do not increase DNA synthesis in purified rat hepatocytes. Carcinogenesis (2001) 0.88
WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase. Toxicol Sci (2007) 0.88
Cell based approaches for evaluation of drug-induced liver injury. Toxicology (2009) 0.87
Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation. Mutat Res (2000) 0.86
Role of Kupffer cells in peroxisome proliferator-induced hepatocyte proliferation. Drug Metab Rev (1999) 0.86
Differential protein binding and transcriptional activities of HNF-4 elements in three closely related CYP2C genes. DNA Cell Biol (1994) 0.85
Characterization of cytochrome P450 expression in murine embryonic stem cell-derived hepatic tissue system. Drug Metab Dispos (2006) 0.85
An in vitro approach to the study of target organ toxicity of drugs and chemicals. In Vitro Cell Dev Biol (1985) 0.83
Cell shape, cell-cell contact, cell-extracellular matrix contact and cell polarity are all required for the maximum induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes. Biochem Pharmacol (2007) 0.83
Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screening. Toxicol In Vitro (2006) 0.81
Cryopreservation of rat and mouse hepatocytes. II. Assessment of metabolic capacity using testosterone metabolism. Drug Metab Dispos (1996) 0.76
Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods (2005) 6.23
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel. J Pharmacol Exp Ther (2006) 2.49
Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. J Pharmacol Exp Ther (2006) 2.23
Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows. Bioinformatics (2007) 2.17
Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk. Blood (2010) 2.14
Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment. Toxicol Sci (2011) 2.03
A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. J Biol Chem (2003) 1.96
Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicol Sci (2006) 1.75
Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. Drug Metab Dispos (2009) 1.67
Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab Dispos (2003) 1.66
Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metab Dispos (2003) 1.64
Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. Clin Pharmacokinet (2003) 1.60
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Res (2009) 1.60
Heading down the wrong pathway: on the influence of correlation within gene sets. BMC Genomics (2010) 1.59
Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene. Environ Health Perspect (2010) 1.59
Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest (2010) 1.59
Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology (2004) 1.51
Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes. Toxicol Appl Pharmacol (2004) 1.44
Discovery of new potentially defective alleles of human CYP2C9. Pharmacogenetics (2004) 1.42
Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol. J Pharmacol Exp Ther (2006) 1.40
Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environ Health Perspect (2015) 1.37
Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma. Cancer Lett (2012) 1.36
Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in mice. J Immunol (2002) 1.34
Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metab Dispos (2004) 1.32
Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. Mol Pharmacol (2005) 1.31
Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity. Environ Health Perspect (2010) 1.31
Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. Carcinogenesis (2004) 1.31
Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. Toxicol Sci (2010) 1.30
Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology (2007) 1.29
Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver. Hepatology (2005) 1.29
FastMap: fast eQTL mapping in homozygous populations. Bioinformatics (2008) 1.25
Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter. Mol Pharmacol (2003) 1.25
Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet. J Hepatol (2009) 1.23
Control of RNA processing by a large non-coding RNA over-expressed in carcinomas. FEBS Lett (2011) 1.21
Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma. Ann Surg Oncol (2007) 1.20
Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol Exp Ther (2003) 1.18
Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity. Environ Health Perspect (2008) 1.17
Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver. Toxicol Sci (2006) 1.16
P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide. Pharm Res (2004) 1.15
Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. Drug Metab Dispos (2004) 1.15
Standardizing benchmark dose calculations to improve science-based decisions in human health assessments. Environ Health Perspect (2014) 1.15
Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease. Toxicol Appl Pharmacol (2008) 1.14
Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage. Diabetes (2010) 1.13
In vitro models for liver toxicity testing. Toxicol Res (Camb) (2012) 1.13
Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry. Metabolomics (2008) 1.12
Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicol Sci (2012) 1.12
Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches. Chem Res Toxicol (2011) 1.11
Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicol Sci (2009) 1.11
ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence. Bioinformatics (2012) 1.09
Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes. Chem Res Toxicol (2003) 1.08
Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity. Toxicol Appl Pharmacol (2013) 1.08
Indoor air pollutants and health in the United Arab Emirates. Environ Health Perspect (2012) 1.06
The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes. Drug Metab Dispos (2002) 1.06
Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis. Environ Health Perspect (2015) 1.05
Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. Mol Pharmacol (2002) 1.04
Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol Sci (2007) 1.04
Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice. J Biol Chem (2003) 1.04
IARC monographs: 40 years of evaluating carcinogenic hazards to humans. Environ Health Perspect (2015) 1.03
Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma. Mutat Res (2010) 1.03
Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays. Toxicol Sci (2013) 1.03
Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet. Toxicol Appl Pharmacol (2012) 1.02
Human CYP2C8 is post-transcriptionally regulated by microRNAs 103 and 107 in human liver. Mol Pharmacol (2012) 1.02
Integrative chemical-biological read-across approach for chemical hazard classification. Chem Res Toxicol (2013) 1.01
The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29. Mol Pharmacol (2004) 1.01
Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma. Mol Cancer (2010) 1.01
Impaired Ras membrane association and activation in PPARalpha knockout mice after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol (2002) 1.00
In vitro screening for population variability in chemical toxicity. Toxicol Sci (2010) 1.00
Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. Toxicol Sci (2010) 1.00
Addressing human variability in next-generation human health risk assessments of environmental chemicals. Environ Health Perspect (2012) 1.00
Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals. J Toxicol Environ Health B Crit Rev (2010) 1.00
Protective effect of Juzen-taiho-to on hepatocarcinogenesis is mediated through the inhibition of Kupffer cell-induced oxidative stress. Int J Cancer (2008) 0.99
Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells. J Biomol Screen (2012) 0.99
Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci (2010) 0.99
Sex-specific gene expression in the BXD mouse liver. Physiol Genomics (2010) 0.98
Methyl deficiency, alterations in global histone modifications, and carcinogenesis. J Nutr (2007) 0.98
Three-dimensional modeling of in vitro hip kinematics under micro-separation regime for ceramic on ceramic total hip prosthesis: an analysis of vibration and noise. J Biomech (2009) 0.98
Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha. Mutat Res (2007) 0.98
Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor. Drug Metab Dispos (2006) 0.96
Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice. Exp Mol Pathol (2006) 0.96