Published in Exp Biol Med (Maywood) on June 20, 2014
The relevance and potential roles of microphysiological systems in biology and medicine. Exp Biol Med (Maywood) (2014) 1.74
Biology coming full circle: joining the whole and the parts. Exp Biol Med (Maywood) (2015) 1.18
TEER measurement techniques for in vitro barrier model systems. J Lab Autom (2015) 1.10
From cardiac tissue engineering to heart-on-a-chip: beating challenges. Biomed Mater (2015) 0.94
Microfluidics: reframing biological enquiry. Nat Rev Mol Cell Biol (2015) 0.87
In silico toxicology: computational methods for the prediction of chemical toxicity. Wiley Interdiscip Rev Comput Mol Sci (2016) 0.84
An in vitro method to manipulate the direction and functional strength between neural populations. Front Neural Circuits (2015) 0.84
The body-on-a-chip concept: possibilities and limitations. EXCLI J (2014) 0.84
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Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering. Sensors (Basel) (2015) 0.82
Biomarkers of treatment toxicity in combined-modality cancer therapies with radiation and systemic drugs: study design, multiplex methods, molecular networks. Int J Mol Sci (2014) 0.81
Personalized radiotherapy: concepts, biomarkers and trial design. Br J Radiol (2015) 0.77
Looking into the future: Using induced pluripotent stem cells to build two and three dimensional ocular tissue for cell therapy and disease modeling. Brain Res (2015) 0.76
A Chemical Engineer's Perspective on Health and Disease. Comput Chem Eng (2014) 0.75
Feed-Forward Propagation of Temporal and Rate Information between Cortical Populations during Coherent Activation in Engineered In Vitro Networks. Front Neural Circuits (2016) 0.75
Use of big data in drug development for precision medicine. Expert Rev Precis Med Drug Dev (2016) 0.75
Green Toxicology: a strategy for sustainable chemical and material development. Environ Sci Eur (2017) 0.75
Computationally Informed Design of a Multi-Axial Actuated Microfluidic Chip Device. Sci Rep (2017) 0.75
Cancer-on-a-chip systems at the frontier of nanomedicine. Drug Discov Today (2017) 0.75
Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol (2001) 9.62
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Engineering vascularized skeletal muscle tissue. Nat Biotechnol (2005) 7.73
The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev (2005) 7.56
Reconstituting organ-level lung functions on a chip. Science (2010) 5.75
Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature (2010) 5.47
Universal scaling of respiratory metabolism, size and nitrogen in plants. Nature (2006) 4.90
Microscale culture of human liver cells for drug development. Nat Biotechnol (2007) 4.85
In vitro microvessels for the study of angiogenesis and thrombosis. Proc Natl Acad Sci U S A (2012) 3.61
Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv Drug Deliv Rev (2001) 3.00
Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds. Proc Natl Acad Sci U S A (2003) 2.86
Allometric scaling of metabolic rate from molecules and mitochondria to cells and mammals. Proc Natl Acad Sci U S A (2002) 2.62
A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci Transl Med (2012) 2.52
Induced pluripotent stem cells: the new patient? Nat Rev Mol Cell Biol (2012) 2.50
Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet (2005) 2.49
Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures. Proc Natl Acad Sci U S A (2010) 2.44
Microengineered physiological biomimicry: organs-on-chips. Lab Chip (2012) 2.21
PCR microfluidic devices for DNA amplification. Biotechnol Adv (2005) 2.20
Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem Cell Res (2009) 2.13
Three-dimensional cellular microarray for high-throughput toxicology assays. Proc Natl Acad Sci U S A (2007) 2.09
Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol (2005) 1.96
Diversity of mechanism-based pharmacodynamic models. Drug Metab Dispos (2003) 1.93
Automated cell culture in high density tubeless microfluidic device arrays. Lab Chip (2008) 1.90
Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells. PLoS One (2009) 1.87
Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radic Biol Med (2006) 1.85
Mechanical stimulation improves tissue-engineered human skeletal muscle. Am J Physiol Cell Physiol (2002) 1.76
Design of pressure-driven microfluidic networks using electric circuit analogy. Lab Chip (2011) 1.71
The role of extracellular matrix composition in structure and function of bioengineered skeletal muscle. Biomaterials (2011) 1.68
In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes. Stem Cells Dev (2010) 1.65
Engineering of functional, perfusable 3D microvascular networks on a chip. Lab Chip (2013) 1.64
Biohybrid thin films for measuring contractility in engineered cardiovascular muscle. Biomaterials (2010) 1.61
Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells. Lab Chip (2009) 1.61
A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip. Lab Chip (2010) 1.60
Scaling and systems biology for integrating multiple organs-on-a-chip. Lab Chip (2013) 1.58
In vitro perfused human capillary networks. Tissue Eng Part C Methods (2013) 1.57
A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells. Lab Chip (2009) 1.57
Drug-screening platform based on the contractility of tissue-engineered muscle. Muscle Nerve (2008) 1.52
Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. Integr Biol (Camb) (2013) 1.52
The role of mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modelling in translational research of biologics. Drug Discov Today (2007) 1.51
Microfabricated mammalian organ systems and their integration into models of whole animals and humans. Lab Chip (2013) 1.50
A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans. Toxicol Sci (2002) 1.50
A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs. Lab Chip (2009) 1.49
Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition. J Pharm Sci (2002) 1.44
Pharmacokinetic/pharmacodynamic modelling in diabetes mellitus. Clin Pharmacokinet (2008) 1.44
The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors. Biotechnol Prog (2004) 1.41
Optimization of chemically defined cell culture media--replacing fetal bovine serum in mammalian in vitro methods. Toxicol In Vitro (2010) 1.39
Constraining the connectivity of neuronal networks cultured on microelectrode arrays with microfluidic techniques: a step towards neuron-based functional chips. Biosens Bioelectron (2005) 1.38
Organs-on-chips: breaking the in vitro impasse. Integr Biol (Camb) (2012) 1.36
Microelectrode arrays: a physiologically based neurotoxicity testing platform for the 21st century. Neurotoxicology (2010) 1.34
Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB). Lab Chip (2012) 1.32
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A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture. Lab Chip (2013) 1.27
Electrophysiological and morphological characterization of rat embryonic motoneurons in a defined system. Biotechnol Prog (2003) 1.27
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Organs-on-a-chip: a focus on compartmentalized microdevices. Ann Biomed Eng (2011) 1.25
Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments. Lab Chip (2009) 1.25
BBB on chip: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function. Biomed Microdevices (2013) 1.24
In vitro zonation and toxicity in a hepatocyte bioreactor. Toxicol Sci (2004) 1.24
Neuromuscular junction formation between human stem cell-derived motoneurons and human skeletal muscle in a defined system. Biomaterials (2011) 1.23
On being the right size: scaling effects in designing a human-on-a-chip. Integr Biol (Camb) (2013) 1.23
A defined system to allow skeletal muscle differentiation and subsequent integration with silicon microstructures. Biomaterials (2006) 1.22
Engineering challenges for instrumenting and controlling integrated organ-on-chip systems. IEEE Trans Biomed Eng (2013) 1.21
Whole body pharmacokinetic models. Clin Pharmacokinet (2003) 1.20
In vitro microelectrode array technology and neural recordings. Crit Rev Biomed Eng (2011) 1.19
Development of a microscale cell culture analog to probe naphthalene toxicity. Biotechnol Prog (2004) 1.19
A plate reader-compatible microchannel array for cell biology assays. Lab Chip (2007) 1.17
Co-culture of epithelial cells and bacteria for investigating host-pathogen interactions. Lab Chip (2009) 1.16
Three-dimensional tissue cultures: current trends and beyond. Cell Tissue Res (2012) 1.16
Modulation of adipose tissue inflammation by bioactive food compounds. J Nutr Biochem (2013) 1.15
Measurement of contractile stress generated by cultured rat muscle on silicon cantilevers for toxin detection and muscle performance enhancement. PLoS One (2010) 1.14
Force regulation by Ca2+ in skinned single cardiac myocytes of frog. Biophys J (1998) 1.13
SyM-BBB: a microfluidic Blood Brain Barrier model. Lab Chip (2013) 1.12
High-content drug screening with engineered musculoskeletal tissues. Tissue Eng Part B Rev (2010) 1.10
The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics. Anal Bioanal Chem (2010) 1.10
Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review. Clin Biochem (2010) 1.09
Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity. Biotechnol Bioeng (2009) 1.08
Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells. Mol Nutr Food Res (2010) 1.08
Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells. Integr Biol (Camb) (2010) 1.07
Force measurements from voltage-clamped guinea pig ventricular myocytes. Am J Physiol (1990) 1.07
Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip. Proc Natl Acad Sci U S A (2013) 1.07
A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices. Lab Chip (2010) 1.06
Morphological and contractile characteristics of rat cardiac myocytes from maturation to senescence. Am J Physiol (1989) 1.05
A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays. Lab Chip (2013) 1.04
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Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy. Am J Physiol Heart Circ Physiol (2002) 1.03
An on-chip cardiomyocyte cell network assay for stable drug screening regarding community effect of cell network size. Analyst (2007) 1.03
Towards monitoring real-time cellular response using an integrated microfluidics-matrix assisted laser desorption ionisation/nanoelectrospray ionisation-ion mobility-mass spectrometry platform. IET Syst Biol (2010) 1.03
Microfluidic polyacrylamide gel electrophoresis with in situ immunoblotting for native protein analysis. Anal Chem (2009) 1.02
Physiologically based pharmacokinetic modelling: a sound mechanistic basis is needed. Br J Clin Pharmacol (2005) 1.02
A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell-cell interactions. Lab Chip (2013) 1.00
Measurement of barrier tissue integrity with an organic electrochemical transistor. Adv Mater (2012) 1.00
Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform. Biomaterials (2011) 1.00
Development and progress of engineering of skeletal muscle tissue. Tissue Eng Part B Rev (2009) 0.99
Microelectrode array recordings of cardiac action potentials as a high throughput method to evaluate pesticide toxicity. Toxicol In Vitro (2005) 0.99
A low shear stress modular bioreactor for connected cell culture under high flow rates. Biotechnol Bioeng (2010) 0.98
Neuromuscular junction formation between human stem-cell-derived motoneurons and rat skeletal muscle in a defined system. Tissue Eng Part C Methods (2010) 0.97
Demonstration of a PDMS-based bio-microactuator using cultured cardiomyocytes to drive polymer micropillars. Lab Chip (2006) 0.96
A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology. PLoS One (2010) 0.96
A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers. Biotechnol Bioeng (2009) 0.96