Published in Gastroenterology on December 01, 2007
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2009) 2.17
Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol (2008) 1.96
In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia. Gastroenterology (2007) 3.41
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02
EMT and dissemination precede pancreatic tumor formation. Cell (2012) 9.27
Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell (2003) 5.36
Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development (2005) 3.57
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A (2008) 3.43
Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas. Proc Natl Acad Sci U S A (2009) 3.25
Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductase. Mech Dev (2006) 3.02
Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration. J Clin Invest (2007) 2.92
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol (2007) 2.87
Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology (2008) 2.71
Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. Cancer Res (2005) 2.64
Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafish. Dev Biol (2007) 2.62
Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas. Mech Dev (2009) 2.57
Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway. Genes Dev (2010) 2.37
Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. J Clin Invest (2002) 2.28
Nonapical symmetric divisions underlie horizontal cell layer formation in the developing retina in vivo. Neuron (2007) 2.25
Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Development (2004) 2.21
The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. Development (2007) 2.14
Viral 2A peptides allow expression of multiple proteins from a single ORF in transgenic zebrafish embryos. Genesis (2007) 2.12
Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology (2010) 2.02
Targeting of amacrine cell neurites to appropriate synaptic laminae in the developing zebrafish retina. Development (2005) 2.00
Pancreatic cancer. Curr Probl Cancer (2002) 1.92
Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia. Gastroenterology (2009) 1.89
A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology (2007) 1.88
Extensive pancreas regeneration following acinar-specific disruption of Xbp1 in mice. Gastroenterology (2011) 1.72
Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. Cancer Res (2006) 1.69
Wnt/beta-catenin signaling is required for development of the exocrine pancreas. BMC Dev Biol (2007) 1.68
Gal4/UAS transgenic tools and their application to zebrafish. Zebrafish (2008) 1.68
Results of pancreaticoduodenectomy for lymphoplasmacytic sclerosing pancreatitis. Ann Surg (2003) 1.66
The basic helix-loop-helix transcription factor E47 reprograms human pancreatic cancer cells to a quiescent acinar state with reduced tumorigenic potential. Pancreas (2015) 1.42
Zebrafish models for cancer. Annu Rev Pathol (2011) 1.41
XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum. Gastroenterology (2010) 1.37
Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology (2008) 1.36
Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas. Dev Biol (2004) 1.36
Predicting resectability of periampullary cancer with three-dimensional computed tomography. J Gastrointest Surg (2004) 1.34
Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells. Hepatology (2013) 1.34
Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia. Mol Cell Biol (2004) 1.33
A case of mistaken identity? Nonductal origins of pancreatic "ductal" cancers. Cancer Cell (2007) 1.32
Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas. Mech Dev (2004) 1.31
Aberrant localization of intracellular organelles, Ca2+ signaling, and exocytosis in Mist1 null mice. J Biol Chem (2005) 1.30
Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology (2003) 1.28
Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas. Dev Biol (2004) 1.26
Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas. Genes Dev (2008) 1.26
Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Development (2012) 1.22
Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. J Biol Chem (2004) 1.20
Exocrine specific expression of Connexin32 is dependent on the basic helix-loop-helix transcription factor Mist1. J Cell Sci (2003) 1.18
Primary explant cultures of adult and embryonic pancreas. Methods Mol Med (2005) 1.16
Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas. Dev Biol (2007) 1.15
Identification of putative mammalian D-lactate dehydrogenase enzymes. Biochem Biophys Res Commun (2002) 1.15
Evidence for repatterning of the gastric fundic epithelium associated with Ménétrier's disease and TGFalpha overexpression. Gastroenterology (2005) 1.14
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut (2012) 1.14
Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells. Gastroenterology (2002) 1.13
Gene expression alterations in the non-neoplastic parenchyma adjacent to infiltrating pancreatic ductal adenocarcinoma. Mod Pathol (2005) 1.13
Polo-like kinase 1 facilitates loss of Pten tumor suppressor-induced prostate cancer formation. J Biol Chem (2011) 1.12
Missing pieces in understanding the intracellular trafficking of polycation/DNA complexes. J Control Release (2009) 1.12
Pancreatic ductal morphogenesis and the Pdx1 homeodomain transcription factor. Mol Biol Cell (2009) 1.09
Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays. Oncogene (2004) 1.07
Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells. Gastroenterology (2012) 1.07
Mist1 regulates pancreatic acinar cell proliferation through p21 CIP1/WAF1. Gastroenterology (2008) 1.04
Sphere-forming assays for assessment of benign and malignant pancreatic stem cells. Methods Mol Biol (2013) 1.03
Plk1 phosphorylation of orc2 and hbo1 contributes to gemcitabine resistance in pancreatic cancer. Mol Cancer Ther (2012) 1.02
Expression of the caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the ampulla of Vater. J Clin Oncol (2005) 1.02
In vivo imaging of zebrafish digestive organ function using multiple quenched fluorescent reporters. Am J Physiol Gastrointest Liver Physiol (2008) 1.02
Effects of the incorporation of a hydrophobic middle block into a PEG-polycation diblock copolymer on the physicochemical and cell interaction properties of the polymer-DNA complexes. Biomacromolecules (2008) 1.02
Influence of nano-carrier architecture on in vitro siRNA delivery performance and in vivo biodistribution: polyplexes vs micelleplexes. ACS Nano (2011) 0.98
Exocrine ontogenies: on the development of pancreatic acinar, ductal and centroacinar cells. Semin Cell Dev Biol (2012) 0.97
MIST1 regulates the pancreatic acinar cell expression of Atp2c2, the gene encoding secretory pathway calcium ATPase 2. Exp Cell Res (2010) 0.96
Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation. Cell Rep (2013) 0.96
Interactions between hairy/enhancer of split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex. Biochem J (2006) 0.96
Identification of a basic helix-loop-helix transcription factor expressed in mammary gland alveolar cells and required for maintenance of the differentiated state. Mol Endocrinol (2006) 0.96
Identification of novel MyoD gene targets in proliferating myogenic stem cells. Mol Cell Biol (2002) 0.93
Cyclic caged morpholinos: conformationally gated probes of embryonic gene function. Angew Chem Int Ed Engl (2012) 0.93
A histological survey of green fluorescent protein expression in 'green' mice: implications for stem cell research. Pathology (2007) 0.93
Characterization of Kras-mediated pancreatic tumorigenesis in zebrafish. Methods Enzymol (2008) 0.87
Aldh1-expressing endocrine progenitor cells regulate secondary islet formation in larval zebrafish pancreas. PLoS One (2013) 0.87
Screening pancreatic oncogenes in zebrafish using the Gal4/UAS system. Methods Cell Biol (2011) 0.87
Epsins' novel role in cancer cell invasion. Commun Integr Biol (2011) 0.87
Murine embryonic stem cell-derived pancreatic acinar cells recapitulate features of early pancreatic differentiation. Gastroenterology (2008) 0.86
Nonproteolytic properties of murine alternatively spliced tissue factor: implications for integrin-mediated signaling in murine models. Mol Med (2012) 0.85
RAS and the RAIN/RasIP1 effector. Methods Enzymol (2006) 0.84
Disputed paternity: the uncertain ancestry of pancreatic ductal neoplasia. Cancer Cell (2012) 0.84
The bHLH domain of Mistl is sufficient to activate gene transcription. Gene Expr (2007) 0.84
Truncal sarcomas and abdominal desmoids. Surg Clin North Am (2008) 0.84
Notch in malignancy. Cancer Treat Res (2003) 0.82
Regulation of lipid metabolism by Dicer revealed through SILAC mice. J Proteome Res (2012) 0.82
The role of PET scanning in pancreatic cancer. Adv Surg (2010) 0.82
A fast fiber enhancer exists in the muscle regulatory factor 4 gene promoter. Biochem Biophys Res Commun (2002) 0.81
Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development. Zebrafish (2013) 0.79
The tumor suppressor rpl36 restrains KRAS(G12V)-induced pancreatic cancer. Zebrafish (2014) 0.79
A photo-degradable gene delivery system for enhanced nuclear gene transcription. Biomaterials (2013) 0.78
Pisces and cancer: the stars align. Zebrafish (2009) 0.77
p53: Guardian of pancreatic epithelial identity. Cell Cycle (2011) 0.76
Current treatment of gastric cancer: is adjuvant therapy of benefit? Adv Surg (2003) 0.75