Published in Gastroenterology on September 18, 2010
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell (2013) 2.10
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell (2015) 1.90
Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells. Gut (2011) 1.67
Stomach Organ and Cell Lineage Differentiation: from Embryogenesis to Adult Homeostasis. Cell Mol Gastroenterol Hepatol (2016) 1.46
Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proc Natl Acad Sci U S A (2011) 1.45
Gastric epithelial stem cells. Gastroenterology (2010) 1.39
Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract. Sci Signal (2015) 1.15
The hyaluronic acid receptor CD44 coordinates normal and metaplastic gastric epithelial progenitor cell proliferation. J Biol Chem (2013) 1.14
Pathobiology of Helicobacter pylori-Induced Gastric Cancer. Gastroenterology (2015) 1.13
Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression. Gut (2012) 1.13
The origin of pre-neoplastic metaplasia in the stomach: chief cells emerge from the Mist. Exp Cell Res (2011) 1.09
Hedgehog signalling in gut development, physiology and cancer. J Physiol (2011) 1.09
Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells. Gastroenterology (2012) 1.07
Mouse models of gastric cancer. Cancers (Basel) (2013) 1.07
Current molecular markers for gastric progenitor cells and gastric cancer stem cells. J Gastroenterol (2011) 1.05
Gastric cancer stem cells: a novel therapeutic target. Cancer Lett (2013) 1.04
Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions. Gastroenterology (2015) 1.04
Operative link for gastritis assessment vs operative link on intestinal metaplasia assessment. World J Gastroenterol (2011) 1.03
Distribution of LGR5+ cells and associated implications during the early stage of gastric tumorigenesis. PLoS One (2013) 0.99
Gastritis staging: interobserver agreement by applying OLGA and OLGIM systems. Virchows Arch (2014) 0.96
Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of parietal cells. Gastroenterology (2014) 0.93
Proteomic profiling of paraffin-embedded samples identifies metaplasia-specific and early-stage gastric cancer biomarkers. Am J Pathol (2012) 0.92
Targeted Apoptosis of Parietal Cells is Insufficient to Induce Metaplasia in Stomach. Gastroenterology (2016) 0.90
Maturity and age influence chief cell ability to transdifferentiate into metaplasia. Am J Physiol Gastrointest Liver Physiol (2016) 0.88
Oesophageal adenocarcinoma and gastric cancer: should we mind the gap? Nat Rev Cancer (2016) 0.87
Helicobacter pylori infection induced gastric cancer; advance in gastric stem cell research and the remaining challenges. Gut Pathog (2012) 0.86
Gastric stem cells and gastric cancer stem cells. Anat Cell Biol (2013) 0.86
Modeling Murine Gastric Metaplasia Through Tamoxifen-Induced Acute Parietal Cell Loss. Methods Mol Biol (2016) 0.85
Loss of anterior gradient 2 (Agr2) expression results in hyperplasia and defective lineage maturation in the murine stomach. J Biol Chem (2012) 0.85
IFNγ contributes to the development of gastric epithelial cell metaplasia in Huntingtin interacting protein 1 related (Hip1r)-deficient mice. Lab Invest (2012) 0.84
Mouse models of gastric carcinogenesis. J Gastric Cancer (2014) 0.84
Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression. J Clin Invest (2016) 0.83
Autoimmune gastritis: Pathologist's viewpoint. World J Gastroenterol (2015) 0.83
Regulation of gastric epithelial cell homeostasis by gastrin and bone morphogenetic protein signaling. Physiol Rep (2015) 0.83
Intestinal Stem Cell Markers in the Intestinal Metaplasia of Stomach and Barrett's Esophagus. PLoS One (2015) 0.82
Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of metaplasia in the stomach. Am J Physiol Gastrointest Liver Physiol (2014) 0.81
Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia. Am J Physiol Gastrointest Liver Physiol (2012) 0.80
The Development of Spasmolytic Polypeptide/TFF2-Expressing Metaplasia (SPEM) During Gastric Repair Is Absent in the Aged Stomach. Cell Mol Gastroenterol Hepatol (2016) 0.80
Murine Models of Gastric Corpus Preneoplasia. Cell Mol Gastroenterol Hepatol (2016) 0.79
Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia. J Clin Invest (2016) 0.79
Dynamic expansion of gastric mucosal doublecortin-like kinase 1-expressing cells in response to parietal cell loss is regulated by gastrin. Am J Pathol (2015) 0.79
Current Status on Stem Cells and Cancers of the Gastric Epithelium. Int J Mol Sci (2015) 0.78
Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis. PLoS One (2015) 0.78
miR-30-HNF4γ and miR-194-NR2F2 regulatory networks contribute to the upregulation of metaplasia markers in the stomach. Gut (2015) 0.78
Mouse models for gastric cancer: Matching models to biological questions. J Gastroenterol Hepatol (2016) 0.77
Hepatocyte nuclear factor 4α is required for cell differentiation and homeostasis in the adult mouse gastric epithelium. Am J Physiol Gastrointest Liver Physiol (2016) 0.77
Gastric Metaplasia Induced by Helicobacter pylori Is Associated with Enhanced SOX9 Expression via Interleukin-1 Signaling. Infect Immun (2015) 0.77
Characterization of progressive metaplasia in the gastric corpus mucosa of Mongolian gerbils infected with Helicobacter pylori. J Pathol (2016) 0.77
Stomach development, stem cells and disease. Development (2016) 0.77
Identification of alanyl aminopeptidase (CD13) as a surface marker for isolation of mature gastric zymogenic chief cells. Am J Physiol Gastrointest Liver Physiol (2015) 0.77
Cellular plasticity in the adult liver and stomach. J Physiol (2016) 0.76
The role of the obestatin/GPR39 system in human gastric adenocarcinomas. Oncotarget (2016) 0.76
Metaplasia in the Stomach Arises From Gastric Chief Cells. Cell Mol Gastroenterol Hepatol (2017) 0.75
Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption. PLoS Genet (2015) 0.75
Initiation and Maintenance of Gastric Cancer: A Focus on CD44 Variant Isoforms and Cancer Stem Cells. Cell Mol Gastroenterol Hepatol (2017) 0.75
Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage. Development (2016) 0.75
Regulation of Gastric Metaplasia, Dysplasia, and Neoplasia by Bone Morphogenetic Protein Signaling. Cell Mol Gastroenterol Hepatol (2017) 0.75
Re-assessing stem cells in the stomach-one story two tales. Ann Transl Med (2017) 0.75
A unified model of the hierarchical and stochastic theories of gastric cancer. Br J Cancer (2017) 0.75
Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis. United European Gastroenterol J (2016) 0.75
Loss of HGF activator inhibits foveolar hyperplasia induced by oxyntic atrophy without altering gastrin levels. Am J Physiol Gastrointest Liver Physiol (2012) 0.75
[Continual self-renewal of the gastric epithelium by cell differentiation: implications for carcinogenesis]. Pathologe (2014) 0.75
Cytokeratin 19 promoter directs the expression of Cre recombinase in various epithelia of transgenic mice. Oncotarget (2017) 0.75
Isthmus Stem Cells Are the Origins of Metaplasia in the Gastric Corpus. Cell Mol Gastroenterol Hepatol (2017) 0.75
Increased GLP2R expression in gastric chief cells of patients with severe obesity regardless of diabetes status. Int J Obes (Lond) (2017) 0.75
A chief source of cancer and repair in stomachs. EMBO J (2017) 0.75
Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18
Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell (2010) 7.25
A human model of gastric carcinogenesis. Cancer Res (1988) 6.52
Gastric cancer originating from bone marrow-derived cells. Science (2004) 6.04
Helicobacter pylori in health and disease. Gastroenterology (2009) 3.84
Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development (2005) 3.57
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A (2008) 3.43
Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL/6 mice and p53 hemizygous transgenic mice. Gastroenterology (1996) 3.15
Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology (2000) 2.99
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol (2007) 2.87
Intestinal metaplasia types and the risk of gastric cancer: a cohort study in Slovenia. Int J Cancer (1994) 2.74
Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cell. Anat Rec (1993) 2.41
The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. Development (2007) 2.14
Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab Invest (1999) 2.10
Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection. Gastroenterology (1998) 1.96
Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology (2003) 1.96
Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild-type and gastrin-deficient mice. Am J Physiol Gastrointest Liver Physiol (2005) 1.94
Dynamics of epithelial cells in the corpus of the mouse stomach. III. Inward migration of neck cells followed by progressive transformation into zymogenic cells. Anat Rec (1993) 1.94
Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia. Gastroenterology (2009) 1.89
A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology (2007) 1.88
Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice. Gastroenterology (2007) 1.87
Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal. J Clin Invest (1989) 1.69
Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancer. Gastroenterology (2010) 1.64
The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage. Dev Biol (2008) 1.53
Reversible drug-induced oxyntic atrophy in rats. Gastroenterology (2000) 1.53
Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice. Gastroenterology (2004) 1.52
Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells. J Biol Chem (2005) 1.39
Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori. Lab Invest (2007) 1.32
Correlation between proliferation markers: PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer. Anticancer Res (2009) 1.29
Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for reevaluation of metaplasias and the origins of gastric cancer. Gastroenterology (2010) 1.28
Gastric intestinal metaplasia: subtypes and natural history. J Clin Pathol (2001) 1.17
Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. Gastroenterology (2008) 1.11
Localization of heparin-binding epidermal growth factor-like growth factor in human gastric mucosa. Gastroenterology (1995) 1.08
Immunohistochemical studies on EGF family growth factors in normal and ulcerated human gastric mucosa. Dig Dis Sci (1997) 0.98
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature (2008) 8.22
Gastric cancer originating from bone marrow-derived cells. Science (2004) 6.04
Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc Natl Acad Sci U S A (2004) 5.89
Morbidity and mortality of laparoscopic gastrectomy versus open gastrectomy for gastric cancer: an interim report--a phase III multicenter, prospective, randomized Trial (KLASS Trial). Ann Surg (2010) 4.89
Long-term results of laparoscopic gastrectomy for gastric cancer: a large-scale case-control and case-matched Korean multicenter study. J Clin Oncol (2014) 4.79
Helicobacter pylori: gastric cancer and beyond. Nat Rev Cancer (2010) 4.64
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development (2007) 3.56
Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A (2005) 3.52
Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer. Nucleic Acids Res (2009) 3.44
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A (2008) 3.43
Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE). Nat Biotechnol (2008) 3.43
Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev (2010) 3.41
Should adenocarcinoma of the esophagogastric junction be classified as esophageal cancer? A comparative analysis according to the seventh AJCC TNM classification. Ann Surg (2012) 3.15
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol (2007) 2.87
Inflammation and intestinal metaplasia of the distal esophagus are associated with alterations in the microbiome. Gastroenterology (2009) 2.55
Molecular properties of adult mouse gastric and intestinal epithelial progenitors in their niches. J Biol Chem (2006) 2.49
Molecular features of adult mouse small intestinal epithelial progenitors. Proc Natl Acad Sci U S A (2003) 2.33
The impact of comorbidity on surgical outcomes in laparoscopy-assisted distal gastrectomy: a retrospective analysis of multicenter results. Ann Surg (2008) 2.33
Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling. J Biol Chem (2002) 2.32
Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice. Gastroenterology (2009) 2.22
Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest (2011) 2.16
The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. Development (2007) 2.14
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell (2013) 2.10
Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors. Cancer Res (2008) 2.08
Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut (2011) 2.08
Helicobacter pylori protein-specific antibodies and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev (2013) 2.01
Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer Res (2003) 2.00
The pericentriolar recycling endosome plays a key role in Vpu-mediated enhancement of HIV-1 particle release. Traffic (2006) 1.97
Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology (2003) 1.96
Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3. Mol Biol Cell (2007) 1.96
Stage migration effect on survival in gastric cancer surgery with extended lymphadenectomy: the reappraisal of positive lymph node ratio as a proper N-staging. Ann Surg (2012) 1.96
Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild-type and gastrin-deficient mice. Am J Physiol Gastrointest Liver Physiol (2005) 1.94
Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation. Nat Genet (2006) 1.92
Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia. Gastroenterology (2009) 1.89
A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology (2007) 1.88
Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice. Gastroenterology (2007) 1.87
Long-term outcomes after laparoscopy-assisted gastrectomy for advanced gastric cancer: a large-scale multicenter retrospective study. Surg Endosc (2011) 1.85
Functional plasticity in the type IV secretion system of Helicobacter pylori. PLoS Pathog (2013) 1.84
Helicobacter pylori flagellin evades toll-like receptor 5-mediated innate immunity. J Infect Dis (2004) 1.83
Extensive pancreas regeneration following acinar-specific disruption of Xbp1 in mice. Gastroenterology (2011) 1.72
Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis. Mol Biol Cell (2004) 1.70
Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev (2006) 1.69
GATA2 functions at multiple steps in hemangioblast development and differentiation. Development (2006) 1.69
Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma. Cancer Res (2006) 1.69
Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells. Mol Biol Cell (2007) 1.69
The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J Cell Biol (2009) 1.68
Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells. Gut (2011) 1.67
Tamoxifen induces rapid, reversible atrophy, and metaplasia in mouse stomach. Gastroenterology (2011) 1.65
Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism. J Neurosci (2006) 1.65
Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancer. Gastroenterology (2010) 1.64
The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling. J Cell Sci (2008) 1.64
Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination. EMBO Rep (2009) 1.63
Synchronous and metachronous cancers in patients with gastric cancer. J Surg Oncol (2008) 1.62
A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle. Traffic (2006) 1.62
Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer. Cancer Res (2004) 1.62
Involvement of myosin Vb in glutamate receptor trafficking. J Biol Chem (2005) 1.61
Helicobacter pylori induces up-regulation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Infect Dis (2007) 1.60
Helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface. PLoS Pathog (2011) 1.57
Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2. Proc Natl Acad Sci U S A (2008) 1.55
Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor. J Neurosci (2002) 1.54
Implementation of Consolidated HIS: Improving Quality and Efficiency of Healthcare. Healthc Inform Res (2010) 1.54
Analysis of the lymphatic stream to predict sentinel nodes in gastric cancer patients. Ann Surg Oncol (2013) 1.53
The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage. Dev Biol (2008) 1.53
An indole-3-acetic acid carboxyl methyltransferase regulates Arabidopsis leaf development. Plant Cell (2005) 1.53
Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice. Gastroenterology (2004) 1.52
Differential involvement of endocytic compartments in the biosynthetic traffic of apical proteins. EMBO J (2007) 1.51
Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection. Cell Host Microbe (2009) 1.51
Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. Am J Physiol Gastrointest Liver Physiol (2007) 1.49
Host response to Helicobacter pylori infection before initiation of the adaptive immune response. FEMS Immunol Med Microbiol (2007) 1.49
Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Proc Natl Acad Sci U S A (2014) 1.48
Prognostic significance of p53, nm23, PCNA and c-erbB-2 in gastric cancer. Jpn J Clin Oncol (2003) 1.46
TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa. Gastroenterology (2010) 1.45
Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proc Natl Acad Sci U S A (2011) 1.45
Alternative splicing in class V myosins determines association with Rab10. J Biol Chem (2008) 1.45
Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. J Clin Invest (2012) 1.45
Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells. Gastroenterology (2010) 1.45
Chronic tamoxifen use is associated with a decreased risk of intestinal metaplasia in human gastric epithelium. Dig Dis Sci (2013) 1.43
The basic helix-loop-helix transcription factor E47 reprograms human pancreatic cancer cells to a quiescent acinar state with reduced tumorigenic potential. Pancreas (2015) 1.42
Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer. BMC Genomics (2009) 1.42
Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology (2011) 1.41
Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation. Gastroenterology (2008) 1.41
Bone morphogenetic protein signaling regulates gastric epithelial cell development and proliferation in mice. Gastroenterology (2010) 1.38