PubRank

Mariano Barbacid

Author PubWeight™ 134.63‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 2009 11.25
2 Tumour biology: senescence in premalignant tumours. Nature 2005 10.15
3 RAS oncogenes: the first 30 years. Nat Rev Cancer 2003 8.61
4 Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 2007 8.47
5 Mammalian cyclin-dependent kinases. Trends Biochem Sci 2005 5.54
6 Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell 2003 5.17
7 Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat Genet 2003 4.74
8 Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 2004 4.39
9 Cdk1 is sufficient to drive the mammalian cell cycle. Nature 2007 4.26
10 A pericyte origin of spinal cord scar tissue. Science 2011 4.12
11 A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell 2010 3.97
12 The European dimension for the mouse genome mutagenesis program. Nat Genet 2004 3.84
13 Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta 2002 3.77
14 p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat Genet 2007 3.30
15 EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. Cancer Cell 2012 2.59
16 Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell 2011 2.56
17 Cell cycle kinases in cancer. Curr Opin Genet Dev 2007 2.46
18 c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Cancer Cell 2011 2.28
19 Cdk2 suppresses cellular senescence induced by the c-myc oncogene. Nat Cell Biol 2009 1.99
20 CDK inhibitors in cancer therapy: what is next? Trends Pharmacol Sci 2007 1.95
21 Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proc Natl Acad Sci U S A 2006 1.93
22 What we have learned about pancreatic cancer from mouse models. Gastroenterology 2012 1.78
23 Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1). Cancer Cell 2005 1.78
24 Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival. EMBO J 2010 1.66
25 Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene 2003 1.62
26 A catalyst for change: the European cancer Patient's Bill of Rights. Oncologist 2014 1.55
27 DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. Nat Struct Mol Biol 2010 1.49
28 Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice. Hepatology 2013 1.48
29 Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Mol Cell 2011 1.44
30 A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition. J Clin Invest 2008 1.38
31 Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metab 2005 1.31
32 Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell 2005 1.23
33 The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma. J Pathol 2009 1.22
34 Genetically engineered mouse models of pancreatic adenocarcinoma. Mol Oncol 2013 1.15
35 Overall Cdk activity modulates the DNA damage response in mammalian cells. J Cell Biol 2009 1.14
36 Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma. Proc Natl Acad Sci U S A 2013 1.11
37 Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J 2012 1.08
38 Is Cyclin D1-CDK4 kinase a bona fide cancer target? Cancer Cell 2006 1.08
39 Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice. Cancer Res 2006 1.03
40 Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome. Proc Natl Acad Sci U S A 2011 1.02
41 Mice thrive without Cdk4 and Cdk2. Mol Oncol 2007 1.02
42 Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclin-dependent kinase 6. J Biol Chem 2011 1.01
43 Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity. Cancer Res 2005 0.96
44 Driving the cell cycle to cancer. Adv Exp Med Biol 2003 0.93
45 Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation. Am J Pathol 2006 0.91
46 Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas. Pigment Cell Melanoma Res 2010 0.88
47 Cdk6-dependent regulation of G(1) length controls adult neurogenesis. Stem Cells 2011 0.88
48 Postnatal Schwann cell proliferation but not myelination is strictly and uniquely dependent on cyclin-dependent kinase 4 (cdk4). Mol Cell Neurosci 2007 0.87
49 Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas. PLoS One 2013 0.82
50 Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR. Bioorg Med Chem Lett 2012 0.81
51 Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications. BMC Genomics 2013 0.80
52 Using cells devoid of RAS proteins as tools for drug discovery. Mol Carcinog 2009 0.79
53 Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor. Bioorg Med Chem Lett 2012 0.78
54 Mouse models of cancer. Mol Oncol 2013 0.76
55 Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin. Int J Cancer 2006 0.76
56 Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors. Mol Cell Biol 2014 0.76
57 Mariano Barbacid: director of Spain's first national cancer centre. Interviewed by Adrian Burton. Lancet Oncol 2002 0.75