Published in Mol Cell Neurosci on November 24, 2007
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Neuroglialpharmacology: myelination as a shared mechanism of action of psychotropic treatments. Neuropharmacology (2012) 1.00
Cdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous system. J Cell Biol (2011) 0.91
Nilotinib alone or in combination with selumetinib is a drug candidate for neurofibromatosis type 2. Neuro Oncol (2011) 0.89
SOX10 transactivates S100B to suppress Schwann cell proliferation and to promote myelination. PLoS One (2014) 0.81
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Time-dependent differential expression of long non-coding RNAs following peripheral nerve injury. Int J Mol Med (2017) 0.75
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Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell (2007) 8.47
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Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat Genet (2003) 4.74
Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell (2004) 4.39
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet (2012) 4.27
Cdk1 is sufficient to drive the mammalian cell cycle. Nature (2007) 4.26
A pericyte origin of spinal cord scar tissue. Science (2011) 4.12
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell (2010) 3.97
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta (2002) 3.77
p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat Genet (2007) 3.30
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature (2012) 3.09
Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells. Science (2004) 2.82
EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. Cancer Cell (2012) 2.59
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell (2011) 2.56
Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis. Nature (2012) 2.54
Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin. Cell (2009) 2.53
Cell cycle kinases in cancer. Curr Opin Genet Dev (2007) 2.46
Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood (2004) 2.44
CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination. Cell Stem Cell (2010) 2.40
Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development (2004) 2.39
Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin. J Cell Biol (2006) 2.32
Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network: new implications for Charcot-Marie-Tooth disease. J Cell Biol (2005) 2.32
c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Cancer Cell (2011) 2.28
Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A). Nat Med (2003) 2.17
Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance. Development (2004) 2.04
Cdk2 suppresses cellular senescence induced by the c-myc oncogene. Nat Cell Biol (2009) 1.99
Dicer in Schwann cells is required for myelination and axonal integrity. J Neurosci (2010) 1.96
CDK inhibitors in cancer therapy: what is next? Trends Pharmacol Sci (2007) 1.95
Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination. J Neurosci (2010) 1.93
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proc Natl Acad Sci U S A (2006) 1.93
Lineage-specific requirements of beta-catenin in neural crest development. J Cell Biol (2002) 1.87
Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells. Mol Cell Neurosci (2003) 1.84
Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease. Neuromolecular Med (2006) 1.79
What we have learned about pancreatic cancer from mouse models. Gastroenterology (2012) 1.78
Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1). Cancer Cell (2005) 1.78
Molecular mechanisms regulating myelination in the peripheral nervous system. Trends Neurosci (2011) 1.74
Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis. Development (2007) 1.72
Notch1 is required for neuronal and glial differentiation in the cerebellum. Development (2002) 1.69
Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development. J Cell Biol (2007) 1.69
HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells. Nat Neurosci (2011) 1.69
Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal. EMBO J (2005) 1.68
Mutations in SEPT9 cause hereditary neuralgic amyotrophy. Nat Genet (2005) 1.68
Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion. Cell Stem Cell (2008) 1.67
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival. EMBO J (2010) 1.66
Notch1 control of oligodendrocyte differentiation in the spinal cord. J Cell Biol (2002) 1.65
Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene (2003) 1.62
Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain. Mech Dev (2002) 1.56
A catalyst for change: the European cancer Patient's Bill of Rights. Oncologist (2014) 1.55
Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Science (2010) 1.53
Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4. Am J Hum Genet (2007) 1.50
Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes Dev (2005) 1.50
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. Nat Struct Mol Biol (2010) 1.49
A novel method for growing human breast epithelium in vivo using mouse and human mammary fibroblasts. Endocrinology (2002) 1.48
Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice. Hepatology (2013) 1.48
Sleep disorders in Charcot-Marie-Tooth disease type 1. J Neurol Neurosurg Psychiatry (2013) 1.47
Quantifying the early stages of remyelination following cuprizone-induced demyelination. Brain Pathol (2003) 1.47
Chlorhexidine to maintain cleanliness of laryngoscope handles: an audit and laboratory study. Eur J Anaesthesiol (2013) 1.46
Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module. Proc Natl Acad Sci U S A (2003) 1.46
Sox10 haploinsufficiency affects maintenance of progenitor cells in a mouse model of Hirschsprung disease. Hum Mol Genet (2002) 1.45
Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling. J Cell Biol (2005) 1.44
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Mol Cell (2011) 1.44
E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles. EMBO J (2003) 1.44
Schwann cells and the pathogenesis of inherited motor and sensory neuropathies (Charcot-Marie-Tooth disease). Glia (2006) 1.42
Report of a novel mutation in the PMP22 gene causing an axonal neuropathy. Muscle Nerve (2011) 1.40
SH3TC2/KIAA1985 protein is required for proper myelination and the integrity of the node of Ranvier in the peripheral nervous system. Proc Natl Acad Sci U S A (2009) 1.39
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition. J Clin Invest (2008) 1.38
Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest. Development (2012) 1.37
Regulation of neural progenitor proliferation and survival by beta1 integrins. J Cell Sci (2005) 1.34
Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system. J Cell Biol (2009) 1.33
Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1. Hum Mol Genet (2002) 1.33
Efficient isolation and gene expression profiling of small numbers of neural crest stem cells and developing Schwann cells. J Neurosci (2004) 1.33
Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination. Brain (2004) 1.33
Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metab (2005) 1.31
Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2. Hum Mol Genet (2006) 1.30
Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1. Cell Stem Cell (2009) 1.25
Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage. J Neurosci (2011) 1.24
Role of interleukin-6 in stress, sleep, and fatigue. Ann N Y Acad Sci (2012) 1.23
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell (2005) 1.23
ErbB2 signaling in Schwann cells is mostly dispensable for maintenance of myelinated peripheral nerves and proliferation of adult Schwann cells after injury. J Neurosci (2006) 1.23
Temporal control of neural crest lineage generation by Wnt/β-catenin signaling. Development (2012) 1.22
The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma. J Pathol (2009) 1.22
Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS. J Neurosci (2006) 1.22
Wnt/BMP signal integration regulates the balance between proliferation and differentiation of neuroepithelial cells in the dorsal spinal cord. Dev Biol (2006) 1.21
Molecular cell biology of Charcot-Marie-Tooth disease. Neurogenetics (2002) 1.17
Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination. J Neurosci (2006) 1.16
Conduction block in PMP22 deficiency. J Neurosci (2010) 1.16
Genetically engineered mouse models of pancreatic adenocarcinoma. Mol Oncol (2013) 1.15
The raft-associated protein MAL is required for maintenance of proper axon--glia interactions in the central nervous system. J Cell Biol (2004) 1.14
Overall Cdk activity modulates the DNA damage response in mammalian cells. J Cell Biol (2009) 1.14
The protooncogene Ski controls Schwann cell proliferation and myelination. Neuron (2004) 1.13
Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma. Proc Natl Acad Sci U S A (2013) 1.11
Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models. Neurogenetics (2009) 1.10