Published in Antimicrob Agents Chemother on December 03, 2007
Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches. FASEB J (2011) 1.31
Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast. Antimicrob Agents Chemother (2011) 1.27
Apicoplast-targeting antibacterials inhibit the growth of Babesia parasites. Antimicrob Agents Chemother (2012) 1.00
Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin. Br J Pharmacol (2013) 0.85
In vitro and in vivo anti-malarial activity of tigecycline, a glycylcycline antibiotic, in combination with chloroquine. Malar J (2014) 0.79
Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission. PLoS One (2014) 0.77
Antibiotics in malaria therapy: which antibiotics except tetracyclines and macrolides may be used against malaria? Malar J (2016) 0.76
Ketolide agents HMR 3004 and HMR 3647 (telithromycin) inhibit the growth of Plasmodium falciparum in vitro. Afr Health Sci (2015) 0.75
A plastid of probable green algal origin in Apicomplexan parasites. Science (1997) 5.73
Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity. Am J Trop Med Hyg (1993) 4.75
Complete in vitro maturation of Plasmodium falciparum gametocytes. Nature (1981) 3.88
Measurement of the lactate dehydrogenase activity of Plasmodium falciparum as an assessment of parasitemia. Am J Trop Med Hyg (1993) 3.69
Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum. J Mol Biol (1996) 3.41
Plastid in human parasites. Nature (1996) 3.25
The effects of anti-bacterials on the malaria parasite Plasmodium falciparum. Mol Biochem Parasitol (2007) 2.47
Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. Antimicrob Agents Chemother (2007) 2.12
Malaria sporozoites actively enter and pass through rat Kupffer cells prior to hepatocyte invasion. Hepatology (2001) 2.06
Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum. Mol Microbiol (2005) 2.02
Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother (2006) 1.95
Oxygen- and time-dependent effects of antibiotics and selected mitochondrial inhibitors on Plasmodium falciparum in culture. Antimicrob Agents Chemother (1985) 1.77
Why are plastid genomes retained in non-photosynthetic organisms? Trends Plant Sci (2006) 1.74
In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin. J Biol Chem (2006) 1.65
Metabolic maps and functions of the Plasmodium mitochondrion. FEMS Microbiol Rev (2006) 1.57
The apicoplast as an antimalarial drug target. Drug Resist Updat (2001) 1.51
Plasmodium falciparum: a simple, rapid method for detecting parasite clones in microtiter plates. Exp Parasitol (1997) 1.46
Malaria chemotherapeutics part I: History of antimalarial drug development, currently used therapeutics, and drugs in clinical development. ChemMedChem (2007) 1.38
Inhibitors of nonhousekeeping functions of the apicoplast defy delayed death in Plasmodium falciparum. Antimicrob Agents Chemother (2006) 1.29
Pharmacokinetics of the new ketolide telithromycin (HMR 3647) administered in ascending single and multiple doses. Antimicrob Agents Chemother (2001) 1.15
Increased antimalarial activity of azithromycin during prolonged exposure of Plasmodium falciparum in vitro. Int J Parasitol (1995) 1.11
Fatty acid biosynthesis as a drug target in apicomplexan parasites. Curr Drug Targets (2007) 1.09
The pharmacokinetics of quinupristin/dalfopristin in laboratory animals and in humans. J Antimicrob Chemother (1997) 1.08
Enzymes for heme biosynthesis are found in both the mitochondrion and plastid of the malaria parasite Plasmodium falciparum. Protist (2004) 1.08
Isoprenoid biosynthesis of the apicoplast as drug target. Curr Drug Targets (2007) 1.03
'FAS't inhibition of malaria. Biochem J (2004) 1.01
The plastid of Plasmodium spp.: a target for inhibitors. Curr Top Microbiol Immunol (2005) 0.98
Delayed parasite elimination in human infections treated with clindamycin parallels 'delayed death' of Plasmodium falciparum in vitro. Int J Parasitol (2006) 0.93
Inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells by 11 different ketolide antibiotics. Curr Microbiol (1998) 0.93
Recently approved and investigational antibiotics for treatment of severe infections caused by Gram-positive bacteria. Curr Opin Microbiol (2005) 0.91
15-deoxyspergualin primarily targets the trafficking of apicoplast proteins in Plasmodium falciparum. J Biol Chem (2006) 0.90
Prolonged exposure of Plasmodium falciparum to ciprofloxacin increases anti-malarial activity. J Parasitol (1994) 0.86
The oxazolidinone class of drugs find their orientation on the ribosome. Mol Cell (2007) 0.78
Mechanism of translation based on intersubunit complementarities of ribosomal RNAs and tRNAs. J Theor Biol (2006) 0.77
Studies in human malaria. XXIX. Trials of aureomycin, chloramphenicol, penicillin, and dihydrostreptomycin against the Chesson strain of Plasmodium vivax. J Natl Malar Soc (1950) 0.77
Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum. Nat Commun (2011) 1.77
New antimalarial drugs. Angew Chem Int Ed Engl (2003) 1.68
The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host. J Exp Med (2011) 1.62
Antiplasmodial thiostrepton derivatives: proteasome inhibitors with a dual mode of action. Angew Chem Int Ed Engl (2010) 1.38
A mosquito-specific protein family includes candidate receptors for malaria sporozoite invasion of salivary glands. Cell Microbiol (2006) 1.29
Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast. Antimicrob Agents Chemother (2011) 1.27
Malaria proteases mediate inside-out egress of gametocytes from red blood cells following parasite transmission to the mosquito. Cell Microbiol (2011) 1.17
PfCCp proteins of Plasmodium falciparum: gametocyte-specific expression and role in complement-mediated inhibition of exflagellation. Int J Parasitol (2007) 1.17
The coming-out of malaria gametocytes. J Biomed Biotechnol (2010) 1.07
Sexual stage adhesion proteins form multi-protein complexes in the malaria parasite Plasmodium falciparum. J Biol Chem (2009) 1.05
Double ester prodrugs of FR900098 display enhanced in-vitro antimalarial activity. Arch Pharm (Weinheim) (2007) 1.03
Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes. Cell Microbiol (2014) 1.02
Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates. Bioorg Med Chem (2007) 1.00
A perforin-like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes. Cell Microbiol (2013) 0.99
Malaria parasites form filamentous cell-to-cell connections during reproduction in the mosquito midgut. Cell Res (2010) 0.98
Farnesyltransferase inhibitors inhibit the growth of malaria parasites in vitro and in vivo. Angew Chem Int Ed Engl (2004) 0.98
Novel deoxyxylulosephosphate-reductoisomerase inhibitors: fosmidomycin derivatives with spacious acyl residues. Arch Pharm (Weinheim) (2007) 0.96
Structure-activity relationships of novel anti-malarial agents. Part 3: N-(4-acylamino-3-benzoylphenyl)-4-propoxycinnamic acid amides. Bioorg Med Chem Lett (2002) 0.95
Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity. Bioorg Med Chem Lett (2003) 0.94
Harmonine, a defence compound from the harlequin ladybird, inhibits mycobacterial growth and demonstrates multi-stage antimalarial activity. Biol Lett (2011) 0.94
Detailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candidate PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbits. Plant Biotechnol J (2014) 0.94
Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut. Cell Host Microbe (2013) 0.93
Quaternary ammonium salts and their antimicrobial potential: targets or nonspecific interactions? ChemMedChem (2011) 0.93
Two nucleus-localized CDK-like kinases with crucial roles for malaria parasite erythrocytic replication are involved in phosphorylation of splicing factor. J Cell Biochem (2011) 0.92
Effect of protease inhibitors on exflagellation in Plasmodium falciparum. Mol Biochem Parasitol (2008) 0.90
Compounds of the upper gastrointestinal tract induce rapid and efficient excystation of Entamoeba invadens. Int J Parasitol (2009) 0.89
Molecular mechanisms of host cell egress by malaria parasites. Int J Med Microbiol (2012) 0.88
Resistance of the Burkholderia cepacia complex to fosmidomycin and fosmidomycin derivatives. Int J Antimicrob Agents (2011) 0.88
Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agents. ChemMedChem (2013) 0.87
Alkoxycarbonyloxyethyl ester prodrugs of FR900098 with improved in vivo antimalarial activity. Arch Pharm (Weinheim) (2005) 0.86
Potent antimalarial and transmission-blocking activities of centanamycin, a novel DNA-binding agent. J Infect Dis (2008) 0.86
Plant-based production of recombinant Plasmodium surface protein pf38 and evaluation of its potential as a vaccine candidate. PLoS One (2013) 0.86
Changes in the transcriptome of the malaria parasite Plasmodium falciparum during the initial phase of transmission from the human to the mosquito. BMC Genomics (2013) 0.86
Malaria vaccine candidate antigen targeting the pre-erythrocytic stage of Plasmodium falciparum produced at high level in plants. Biotechnol J (2014) 0.85
Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors. J Med Chem (2008) 0.84
Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid. Molecules (2008) 0.82
Studies addressing the importance of charge in the binding of fosmidomycin-like molecules to deoxyxylulosephosphate reductoisomerase. ChemMedChem (2008) 0.82
The bisnaphthalimides as new active lead compounds against Plasmodium falciparum. Bioorg Med Chem (2010) 0.81
Structure-activity relationships of novel anti-malarial agents. Part 6: N-(4-arylpropionylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides. Bioorg Med Chem Lett (2003) 0.79
A putative kinase-related protein (PKRP) from Plasmodium berghei mediates infection in the midgut and salivary glands of the mosquito. Int J Parasitol (2010) 0.79
Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity. Eur J Med Chem (2005) 0.79
Benzophenone-based farnesyltransferase inhibitors with high activity against Trypanosoma cruzi. J Med Chem (2005) 0.79
Family members stick together: multi-protein complexes of malaria parasites. Med Microbiol Immunol (2010) 0.79
Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone. Bioorg Med Chem (2009) 0.78
Broad-spectrum antimalarial activity of peptido sulfonyl fluorides, a new class of proteasome inhibitors. Antimicrob Agents Chemother (2013) 0.78
Development of benzophenone-based farnesyltransferase inhibitors as novel antimalarials. ChemMedChem (2008) 0.77
Synthesis and biological evaluation of papain-family cathepsin L-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antiprotozoal agents. ChemMedChem (2014) 0.77
Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy. Bioorg Med Chem (2012) 0.77
Structure-based optimization of aldose reductase inhibitors originating from virtual screening. ChemMedChem (2009) 0.76
[M2 inhibitors and neuraminidase inhibitors]. Pharm Unserer Zeit (2011) 0.76
Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3-benzoylphenyl)-3-arylfurylacrylic acid amides. Bioorg Med Chem (2004) 0.76
Non-thiol farnesyltransferase inhibitors: FTase-inhibition and cellular activity of benzophenone-based bisubstrate analogue farnesyltransferase inhibitors. Arch Pharm (Weinheim) (2003) 0.76
Inducible APOBEC3G-Vif double stable cell line as a high-throughput screening platform to identify antiviral compounds. Antimicrob Agents Chemother (2009) 0.76
A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages. Int J Med Microbiol (2013) 0.76
[Pharmazie in unserer Zeit 2/2011]. Pharm Unserer Zeit (2011) 0.75
[Editorial: Pharmazie in unserer Zeit 1/2012]. Pharm Unserer Zeit (2012) 0.75
[New malaria drugs: screening against the entire parasite or target-based - which is the right path?]. Pharm Unserer Zeit (2011) 0.75
[Accidental discoveries, different mechanisms of action. Active agents against Mycobacterium tuberculosis in clinical application]. Pharm Unserer Zeit (2012) 0.75
Non-thiol farnesyltransferase inhibitors: utilization of an aryl binding site by 5-arylacryloylaminobenzophenones. Bioorg Med Chem (2002) 0.75
Structure-activity relationships of novel anti-malarial agents: part 5. N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides. Bioorg Med Chem Lett (2003) 0.75
Non-thiol farnesyltransferase inhibitors: utilization of the far aryl binding site by 5-cinnamoylaminobenzophenones. Arch Pharm (Weinheim) (2004) 0.75
Non-thiol farnesyltransferase inhibitors: N-(4-Acylamino-3-benzoylphenyl)-4-nitrocinnamic acid amides. Bioorg Med Chem (2002) 0.75
Non-thiol farnesyltransferase inhibitors: N-(4-acylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides. Bioorg Med Chem (2003) 0.75
N-acyl derivatives of 4-phenoxyaniline as neuroprotective agents. ChemMedChem (2014) 0.75
[Editorial: Pharmazie in unserer Zeit 6/2009 ]. Pharm Unserer Zeit (2009) 0.75
[Selective enzyme inhibitor instead of an "iron-triggered cluster bomb"]. Pharm Unserer Zeit (2006) 0.75
The antimalarial pipeline--an update. Int J Med Microbiol (2012) 0.75
Non-thiol farnesyltransferase inhibitors: utilization of the near aryl binding site by 5-arylacetylaminobenzophenones. Arch Pharm (Weinheim) (2004) 0.75
Non-thiol farnesyltransferase inhibitors: evaluation of different AA(X)-peptidomimetic substructures in combination with arylic cysteine replacements. Arch Pharm (Weinheim) (2002) 0.75
Structure-activity relationships of novel anti-malarial agents. Part 7: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides with polar moieties. Bioorg Med Chem Lett (2003) 0.75
Non-thiol farnesyltransferase inhibitors: utilization of the far aryl binding site by arylthienylacryloylaminobenzophenones. Arch Pharm (Weinheim) (2005) 0.75
2-Acylamino-5-chlorobenzophenones with enhanced selectivity towards malaria parasites. Eur J Med Chem (2011) 0.75
Structure-activity relationships of novel anti-malarial agents. Part 4: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides. Bioorg Med Chem Lett (2002) 0.75