Published in Hum Mol Genet on April 28, 2004
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med (2009) 4.11
Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci U S A (2008) 3.68
Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med (2008) 2.74
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. Hum Mol Genet (2011) 1.96
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons. J Alzheimers Dis (2010) 1.84
Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease. Lancet Neurol (2010) 1.71
Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases. Brain Res Rev (2010) 1.64
Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease. Exp Neurol (2009) 1.61
Verbal paired-associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory response. Neurobiol Aging (2006) 1.58
Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2007) 1.47
In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease. Neuroimage (2007) 1.41
Oxidative stress signaling in Alzheimer's disease. Curr Alzheimer Res (2008) 1.38
Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons. Biochim Biophys Acta (2011) 1.37
The Alzheimer's disease mitochondrial cascade hypothesis: an update. Exp Neurol (2009) 1.36
Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeutics. Biochim Biophys Acta (2011) 1.32
Target identification for CNS diseases by transcriptional profiling. Neuropsychopharmacology (2008) 1.32
Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment. Mitochondrion (2006) 1.25
Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline. J Alzheimers Dis (2010) 1.24
Single cell gene expression profiling in Alzheimer's disease. NeuroRx (2006) 1.22
Mitochondrial medicine for aging and neurodegenerative diseases. Neuromolecular Med (2008) 1.22
Mitochondria and cell bioenergetics: increasingly recognized components and a possible etiologic cause of Alzheimer's disease. Antioxid Redox Signal (2011) 1.21
Mitochondria as a therapeutic target for aging and neurodegenerative diseases. Curr Alzheimer Res (2011) 1.17
Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: implications for early intervention and therapeutics. Biochim Biophys Acta (2011) 1.16
Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage. Hum Mol Genet (2012) 1.15
The neurodegenerative mitochondriopathies. J Alzheimers Dis (2009) 1.14
Identification of novel genes that modify phenotypes induced by Alzheimer's beta-amyloid overexpression in Drosophila. Genetics (2008) 1.11
Successful RNA extraction from various human postmortem tissues. Int J Legal Med (2006) 1.07
Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics. J Biomed Biotechnol (2006) 1.07
Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease. Hum Mol Genet (2012) 1.04
Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's disease. J Alzheimers Dis (2011) 1.04
Comparative analyses of genotype dependent expressed sequence tags and stress-responsive transcriptome of chickpea wilt illustrate predicted and unexpected genes and novel regulators of plant immunity. BMC Genomics (2009) 1.03
Antioxidant therapies for Alzheimer's disease. Oxid Med Cell Longev (2012) 1.03
Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease. Hum Mol Genet (2009) 1.01
Decreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria. J Alzheimers Dis (2011) 1.01
Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature. J Neurosci (2014) 1.00
Role of mitochondria in neurodegenerative diseases: mitochondria as a therapeutic target in Alzheimer's disease. CNS Spectr (2009) 0.98
Evaluation of coenzyme Q as an antioxidant strategy for Alzheimer's disease. J Alzheimers Dis (2008) 0.98
A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer. Cancer Genet (2012) 0.96
Garrison Institute on Aging: A New Hope for Elderly Individuals and Patients with Alzheimer's Disease. J Alzheimers Dis (2015) 0.95
Role of mitochondrial homeostasis and dynamics in Alzheimer's disease. Neurobiol Dis (2012) 0.93
A mitocentric view of Alzheimer's disease suggests multi-faceted treatments. J Alzheimers Dis (2010) 0.93
Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer's disease mice: Implications for impaired mitochondrial biogenesis and synaptic damage. Biochim Biophys Acta (2011) 0.93
Is the mitochondrial outermembrane protein VDAC1 therapeutic target for Alzheimer's disease? Biochim Biophys Acta (2012) 0.92
Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer's disease. Mol Neurodegener (2013) 0.92
Amyloid-β oligomers induce differential gene expression in adult human brain slices. J Biol Chem (2012) 0.91
Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice. J Bioenerg Biomembr (2007) 0.90
Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches. Int J Mol Sci (2009) 0.87
Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect. Front Physiol (2015) 0.87
Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis. Biochim Biophys Acta (2015) 0.86
Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease. Cell Cycle (2014) 0.85
Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease. Mol Neurodegener (2014) 0.85
Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: implications for synaptic dysfunction and neuronal damage. Biochim Biophys Acta (2013) 0.84
The mitochondrial epigenome: a role in Alzheimer's disease? Epigenomics (2014) 0.83
ACE inhibition with captopril retards the development of signs of neurodegeneration in an animal model of Alzheimer's disease. Int J Mol Sci (2013) 0.83
Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies. Pharmaceuticals (Basel) (2009) 0.83
Mitochondrial accumulation of APP and Abeta: significance for Alzheimer disease pathogenesis. J Cell Mol Med (2009) 0.83
Reduced VDAC1 protects against Alzheimer's disease, mitochondria, and synaptic deficiencies. J Alzheimers Dis (2013) 0.83
Dissecting gene expression at the blood-brain barrier. Front Neurosci (2014) 0.83
Oxidized cholesterol as the driving force behind the development of Alzheimer's disease. Front Aging Neurosci (2015) 0.83
Mitochondrial DNA deletions and differential mitochondrial DNA content in Rhesus monkeys: implications for aging. Biochim Biophys Acta (2011) 0.81
Amyloid beta: multiple mechanisms of toxicity and only some protective effects? Oxid Med Cell Longev (2014) 0.81
Early detection of cerebral glucose uptake changes in the 5XFAD mouse. Curr Alzheimer Res (2014) 0.81
Mitochondria-Targeted Protective Compounds in Parkinson's and Alzheimer's Diseases. Oxid Med Cell Longev (2015) 0.80
The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration. BMC Neurosci (2006) 0.80
Early-onset dysfunction of retrosplenial cortex precedes overt amyloid plaque formation in Tg2576 mice. Neuroscience (2010) 0.79
Quantitative proteomic analysis of mitochondria in aging PS-1 transgenic mice. Cell Mol Neurobiol (2009) 0.79
Changes in the expression of genes associated with intraneuronal amyloid-beta and tau in Alzheimer's disease. J Alzheimers Dis (2010) 0.79
Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPP(swe)/PS1 mice. Mol Neurodegener (2015) 0.79
The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer's disease. BMC Neurosci (2014) 0.78
FLZ inhibited γ-secretase selectively and decreased Aβ mitochondrial production in APP-SH-SY5Y cells. Naunyn Schmiedebergs Arch Pharmacol (2013) 0.78
Intracellular Calcium Dysregulation: Implications for Alzheimer's Disease. Biomed Res Int (2016) 0.77
Reduction of Glucose Metabolism in Olfactory Bulb is an Earlier Alzheimer's Disease-related Biomarker in 5XFAD Mice. Chin Med J (Engl) (2015) 0.77
Identifying Aβ-specific pathogenic mechanisms using a nematode model of Alzheimer's disease. Neurobiol Aging (2014) 0.77
RNA silencing of genes involved in Alzheimer's disease enhances mitochondrial function and synaptic activity. Biochim Biophys Acta (2013) 0.76
Regulation of global gene expression and cell proliferation by APP. Sci Rep (2016) 0.75
Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer's Disease. J Alzheimers Dis (2016) 0.75
Increased Electron Paramagnetic Resonance Signal Correlates with Mitochondrial Dysfunction and Oxidative Stress in an Alzheimer's disease Mouse Brain. J Alzheimers Dis (2016) 0.75
Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer's Disease. J Alzheimers Dis (2016) 0.75
Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets. Pharmaceuticals (Basel) (2009) 0.75
The BioPAX community standard for pathway data sharing. Nat Biotechnol (2010) 9.19
Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell (2004) 6.08
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet (2006) 3.94
Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses? Arch Neurol (2003) 3.75
Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states. Lancet (2003) 3.36
MIFlowCyt: the minimum information about a Flow Cytometry Experiment. Cytometry A (2008) 3.33
Mapping cellular transcriptosomes in autopsied Alzheimer's disease subjects and relevant animal models. Neurobiol Aging (2005) 3.09
How accurate is clinician reporting of chemotherapy adverse effects? A comparison with patient-reported symptoms from the Quality-of-Life Questionnaire C30. J Clin Oncol (2004) 2.92
Severe hepatotoxicity associated with nevirapine use in HIV-infected subjects. J Infect Dis (2005) 2.91
An updated systematic overview of triple combination therapy in antiretroviral-naive HIV-infected adults. AIDS (2006) 2.74
Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage. Hum Mol Genet (2011) 2.34
Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. Proc Natl Acad Sci U S A (2006) 2.03
C-reactive protein as a prognostic marker for men with androgen-independent prostate cancer: results from the ASCENT trial. Cancer (2008) 1.92
BCR-ABL mRNA levels at and after the time of a complete cytogenetic response (CCR) predict the duration of CCR in imatinib mesylate-treated patients with CML. Blood (2006) 1.89
Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells. Proc Natl Acad Sci U S A (2007) 1.89
Poor immunogenicity of the H1N1 2009 vaccine in well controlled HIV-infected individuals. AIDS (2010) 1.87
Improved detection of prostate cancer using classification and regression tree analysis. J Clin Oncol (2005) 1.85
A viral microRNA down-regulates multiple cell cycle genes through mRNA 5'UTRs. PLoS Pathog (2010) 1.82
Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease. Hum Mol Genet (2011) 1.75
Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases. Brain Res Rev (2010) 1.64
Endoscopic measurement of cardia circumference as an indicator of GERD. Gastrointest Endosc (2006) 1.59
Geoclimatic influences on invasive aspergillosis after hematopoietic stem cell transplantation. Clin Infect Dis (2010) 1.58
Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: implications for early mitochondrial dysfunction and oxidative damage. Neuromolecular Med (2004) 1.57
In chronic myeloid leukemia white cells from cytogenetic responders and non-responders to imatinib have very similar gene expression signatures. Haematologica (2005) 1.56
Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction. J Alzheimers Dis (2005) 1.55
Dramatic increase in naive T cell turnover is linked to loss of naive T cells from old primates. Proc Natl Acad Sci U S A (2007) 1.53
Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease. Hum Mol Genet (2011) 1.48
Interest in physician-assisted suicide among Oregon cancer patients. J Clin Ethics (2006) 1.45
Flow cytometric chemosensitivity assay as a predictive tool of early clinical response in acute lymphoblastic leukemia. Pediatr Blood Cancer (2009) 1.42
Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates. J Immunol (2010) 1.41
The impact of clonal evolution on response to imatinib mesylate (STI571) in accelerated phase CML. Blood (2002) 1.39
Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse. BMC Genomics (2010) 1.38
Mitochondrial structural and functional dynamics in Huntington's disease. Brain Res Rev (2009) 1.37
Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival. Nature (2005) 1.35
Sequential immunization with a subtype B HIV-1 envelope quasispecies partially mimics the in vivo development of neutralizing antibodies. J Virol (2011) 1.33
Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeutics. Biochim Biophys Acta (2011) 1.32
Assessing the impact of indoor residual spraying on malaria morbidity using a sentinel site surveillance system in Western Uganda. Am J Trop Med Hyg (2009) 1.31
Inhaled hydrogen sulfide: a rapidly reversible inhibitor of cardiac and metabolic function in the mouse. Anesthesiology (2008) 1.30
Host regulatory network response to infection with highly pathogenic H5N1 avian influenza virus. J Virol (2011) 1.30
Androgen receptor promotes ligand-independent prostate cancer progression through c-Myc upregulation. PLoS One (2013) 1.29
Utilizing RNA-Seq data for de novo coexpression network inference. Bioinformatics (2012) 1.28
A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia. Proc Natl Acad Sci U S A (2009) 1.25
Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline. J Alzheimers Dis (2010) 1.24
Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension. Hum Mol Genet (2012) 1.22
An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4. J Biol Chem (2006) 1.21
Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. J Biol Chem (2007) 1.21
Evolving preoperative evaluation of patients with pancreatic cancer: does laparoscopy have a role in the current era? J Am Coll Surg (2009) 1.18
Time-course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging. J Neurochem (2005) 1.15
Renal gene and protein expression signatures for prediction of kidney disease progression. Am J Pathol (2009) 1.15
MET receptor sequence variants R970C and T992I lack transforming capacity. Cancer Res (2010) 1.13
On the integration of alcohol-related quantitative trait loci and gene expression analyses. Alcohol Clin Exp Res (2004) 1.11
Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates. Aging Cell (2008) 1.09
Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells. J Virol (2013) 1.08
Patient-physician disagreement regarding performance status is associated with worse survivorship in patients with advanced cancer. Cancer (2008) 1.08
Rat cytomegalovirus gene expression in cardiac allograft recipients is tissue specific and does not parallel the profiles detected in vitro. J Virol (2007) 1.05
Selection for drinking in the dark alters brain gene coexpression networks. Alcohol Clin Exp Res (2013) 1.04
Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. MBio (2013) 1.04
apoE isoforms and measures of anxiety in probable AD patients and Apoe-/- mice. Neurobiol Aging (2005) 1.03
Influence of health insurance coverage on breast, cervical, and colorectal cancer screening in rural primary care settings. Cancer (2012) 1.00
Adjuvant therapy and survival after resection of pancreatic adenocarcinoma: a population-based analysis. Cancer (2010) 1.00
Application of targeted quantitative proteomics analysis in human cerebrospinal fluid using a liquid chromatography matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometer (LC MALDI TOF/TOF) platform. J Proteome Res (2008) 0.98
Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems. BMC Syst Biol (2011) 0.97
F(2)-isoprostanes as biomarkers of late-onset Alzheimer's disease. J Mol Neurosci (2007) 0.97
Expression profiling of the ovarian surface kinome reveals candidate genes for early neoplastic changes. Transl Oncol (2009) 0.97
Using modafinil to treat fatigue in Parkinson disease: a double-blind, placebo-controlled pilot study. Clin Neuropharmacol (2009) 0.96
Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A (2012) 0.95
DNA microarray and proteomic strategies for understanding alcohol action. Alcohol Clin Exp Res (2006) 0.94
MitoQ, a mitochondria-targeted antioxidant, delays disease progression and alleviates pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. Biochim Biophys Acta (2013) 0.94
A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Invest New Drugs (2014) 0.92
Toxicity of neurons treated with herbicides and neuroprotection by mitochondria-targeted antioxidant SS31. Int J Environ Res Public Health (2011) 0.92
Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors. Aging Cell (2015) 0.92
A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease. J Alzheimers Dis (2014) 0.91
Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection. J Exp Med (2012) 0.91
Antiviral immunity following smallpox virus infection: a case-control study. J Virol (2010) 0.90
Swimmer illness associated with marine water exposure and water quality indicators: impact of widely used assumptions. Epidemiology (2013) 0.90
GABAergic system gene expression predicts clinical outcome in patients with neuroblastoma. J Clin Oncol (2004) 0.89
A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer. Epigenetics (2011) 0.89
Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugs. PLoS One (2011) 0.89
Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation. Neoplasia (2007) 0.89
Human Mycobacterium tuberculosis CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide Library. PLoS One (2013) 0.89
Clinical outcomes of androgen deprivation as the sole therapy for localized and locally advanced prostate cancer. BJU Int (2005) 0.88
Assessment of prostate-specific antigen doubling time in prediction of prostate cancer on needle biopsy. Urology (2007) 0.88
Localization of TFIIB binding regions using serial analysis of chromatin occupancy. BMC Mol Biol (2007) 0.88
Validation of a tool to measure and promote clinical teamwork. Simul Healthc (2008) 0.88
Short-term selective breeding for high and low prepulse inhibition of the acoustic startle response; pharmacological characterization and QTL mapping in the selected lines. Pharmacol Biochem Behav (2008) 0.87
Gene expression profiling of initiated epidermal cells with benign or malignant tumor fates. Carcinogenesis (2002) 0.86
Documentation and management of CKD in rural primary care. Clin J Am Soc Nephrol (2013) 0.86
Influence of mood state on capacity to consent to research in patients with bipolar disorder. Bipolar Disord (2008) 0.86
Association between documented family history of cancer and screening for breast and colorectal cancer. Prev Med (2013) 0.86
Deoxyribonucleic acid microarray analysis of gene expression pattern in the arcuate nucleus/ventromedial nucleus of hypothalamus during lactation. Endocrinology (2005) 0.86