1
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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.
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Nature
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2009
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33.26
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2
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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.
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Nat Genet
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2007
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12.62
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3
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Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.
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Nature
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2010
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12.27
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4
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Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
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Nat Genet
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2008
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10.49
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5
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Wake-up call for British psychiatry.
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Br J Psychiatry
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2008
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10.30
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6
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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
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Nat Genet
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2013
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8.02
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7
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Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
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Nat Genet
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2013
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7.44
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8
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Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia.
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Am J Hum Genet
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2003
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6.63
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9
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Microduplications of 16p11.2 are associated with schizophrenia.
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Nat Genet
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2009
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6.13
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10
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Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder.
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Am J Hum Genet
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2009
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5.98
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11
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Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia.
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Hum Mol Genet
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2007
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5.28
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12
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Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.
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Hum Mol Genet
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2009
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4.52
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13
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Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology.
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2005
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3.93
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14
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Discovery and statistical genotyping of copy-number variation from whole-exome sequencing depth.
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Am J Hum Genet
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2012
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3.50
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15
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Cis-acting variation in the expression of a high proportion of genes in human brain.
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Hum Genet
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2003
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3.07
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16
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Analysis of copy number variations at 15 schizophrenia-associated loci.
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Br J Psychiatry
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2013
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3.01
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17
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Phenotypic and genetic complexity of psychosis. Invited commentary on ... Schizophrenia: a common disease caused by multiple rare alleles.
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Br J Psychiatry
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2007
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2.97
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18
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Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder.
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Am J Hum Genet
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2011
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2.71
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19
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Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate.
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PLoS Genet
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2013
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2.68
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20
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Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder.
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Arch Gen Psychiatry
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2005
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2.58
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21
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Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.
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PLoS One
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2010
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2.57
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22
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Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3.
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Am J Psychiatry
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2012
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2.48
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23
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Neurexin 1 (NRXN1) deletions in schizophrenia.
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Schizophr Bull
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2009
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2.25
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24
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Effects of differential genotyping error rate on the type I error probability of case-control studies.
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Hum Hered
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2006
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2.21
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25
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Common variants at VRK2 and TCF4 conferring risk of schizophrenia.
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Hum Mol Genet
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2011
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2.21
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26
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A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.
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BMC Med Genomics
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2008
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2.20
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27
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Polymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trial.
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Br J Psychiatry
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2011
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2.18
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28
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Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK.
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Br J Psychiatry
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2006
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2.16
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29
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A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.
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Am J Hum Genet
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2003
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2.11
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30
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Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia.
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Arch Gen Psychiatry
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2010
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2.11
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31
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All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs.
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PLoS Genet
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2013
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2.08
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32
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Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia.
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Biol Psychiatry
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2010
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2.07
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33
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Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome.
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Proc Natl Acad Sci U S A
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2006
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2.03
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34
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Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools.
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Hum Genet
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2002
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2.03
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35
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Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder.
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Br J Psychiatry
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2010
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1.99
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36
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Pooled DNA genotyping on Affymetrix SNP genotyping arrays.
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BMC Genomics
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2006
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1.96
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37
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Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors.
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Am J Hum Genet
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2013
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1.96
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38
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Maternally derived microduplications at 15q11-q13: implication of imprinted genes in psychotic illness.
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Am J Psychiatry
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2011
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1.94
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39
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Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia.
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Am J Hum Genet
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2005
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1.93
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40
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Genome-wide association study of schizophrenia in a Japanese population.
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Biol Psychiatry
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2010
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1.89
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41
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De novo rates and selection of schizophrenia-associated copy number variants.
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Biol Psychiatry
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2011
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1.87
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42
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Neurodevelopmental hypothesis of schizophrenia.
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Br J Psychiatry
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2011
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1.87
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43
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Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression.
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Hum Mol Genet
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2005
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1.72
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44
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Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries.
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Hum Mol Genet
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2010
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1.72
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45
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Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia.
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Arch Gen Psychiatry
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2010
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1.71
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46
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DNA pooling as a tool for large-scale association studies in complex traits.
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Ann Med
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2004
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1.70
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47
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Functional analysis of human promoter polymorphisms.
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Hum Mol Genet
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2003
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1.69
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48
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Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia.
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Am J Med Genet B Neuropsychiatr Genet
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2006
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1.61
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49
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Phenotypic variations on the theme of CNVs.
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Nat Genet
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2008
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1.58
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50
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No major schizophrenia locus detected on chromosome 1q in a large multicenter sample.
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2002
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1.57
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51
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SORL1 variants and risk of late-onset Alzheimer's disease.
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Neurobiol Dis
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2007
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1.49
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52
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Copy number variation in schizophrenia in the Japanese population.
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Biol Psychiatry
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2009
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1.49
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53
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Strong bias in the location of functional promoter polymorphisms.
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Hum Mutat
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2005
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1.48
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54
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Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13.
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Arch Gen Psychiatry
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2005
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1.48
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55
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The role of the major histocompatibility complex region in cognition and brain structure: a schizophrenia GWAS follow-up.
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Am J Psychiatry
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2013
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1.48
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56
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Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia.
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Arch Gen Psychiatry
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1.46
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57
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Functional analysis of polymorphisms in the promoter regions of genes on 22q11.
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Hum Mutat
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2004
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1.43
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58
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A network of dopaminergic gene variations implicated as risk factors for schizophrenia.
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Hum Mol Genet
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2007
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1.43
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59
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Correction: Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate.
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PLoS Genet
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1.39
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60
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Chromosome 22 deletion syndrome and schizophrenia.
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1.35
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Clustering of metabolic comorbidity in schizophrenia: a genetic contribution?
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J Psychopharmacol
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2005
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1.31
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Advances in genetic findings on attention deficit hyperactivity disorder.
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1.29
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Finding schizophrenia genes.
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2005
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1.28
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64
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Independent estimation of the frequency of rare CNVs in the UK population confirms their role in schizophrenia.
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Schizophr Res
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2011
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1.28
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65
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At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia.
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Biol Psychiatry
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2011
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1.26
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66
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Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria.
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Biol Psychiatry
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2004
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1.26
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67
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Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia.
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Proc Natl Acad Sci U S A
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68
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Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?
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1.24
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69
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Evaluation of an approximation method for assessment of overall significance of multiple-dependent tests in a genomewide association study.
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Genet Epidemiol
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2011
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1.22
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70
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Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia.
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Biol Psychiatry
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2008
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1.20
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71
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Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder.
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Arch Gen Psychiatry
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2006
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1.19
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72
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Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use.
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Br J Psychiatry
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2007
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1.19
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73
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TCF4, schizophrenia, and Pitt-Hopkins Syndrome.
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1.15
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74
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A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity.
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Biochim Biophys Acta
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2004
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1.15
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75
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Is COMT a susceptibility gene for schizophrenia?
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Schizophr Bull
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2007
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1.14
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76
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CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1.
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Hum Mol Genet
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1.14
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77
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Schizophrenia: a genetic disorder of the synapse?
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BMJ
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1.14
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78
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Schizophrenia genetics: new insights from new approaches.
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Br Med Bull
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1.11
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Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1).
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Biol Psychiatry
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2005
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1.10
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High loading of polygenic risk for ADHD in children with comorbid aggression.
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Am J Psychiatry
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2013
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1.10
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81
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Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations.
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Schizophr Bull
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1.10
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82
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Support for RGS4 as a susceptibility gene for schizophrenia.
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Biol Psychiatry
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2004
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1.10
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83
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Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk.
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JAMA Neurol
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2013
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1.09
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84
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A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia.
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Hum Mol Genet
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1.08
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85
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Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population.
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Schizophrenia genetics: advancing on two fronts.
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Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder.
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Am J Med Genet B Neuropsychiatr Genet
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1.08
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88
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Strong evidence that GNB1L is associated with schizophrenia.
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Hum Mol Genet
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1.07
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Additive genetic variation in schizophrenia risk is shared by populations of African and European descent.
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1.07
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Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.
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Biol Psychiatry
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Implication of a rare deletion at distal 16p11.2 in schizophrenia.
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JAMA Psychiatry
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Genome-wide association study of multiplex schizophrenia pedigrees.
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The genetics of developmental dyslexia.
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Eur J Hum Genet
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1.04
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The effect of age and the H1c MAPT haplotype on MAPT expression in human brain.
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1.04
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Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia.
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Arch Gen Psychiatry
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Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease.
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Hum Mol Genet
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Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia.
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Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples.
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Biol Psychiatry
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No association between schizophrenia and polymorphisms in COMT in two large samples.
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Am J Psychiatry
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Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes.
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Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia.
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Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease.
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A neuropsychological investigation of the genome wide associated schizophrenia risk variant NRGN rs12807809.
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Genetic variants in the ErbB4 gene are associated with white matter integrity.
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Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain.
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Variation in tau isoform expression in different brain regions and disease states.
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An association study of common variation at the MAPT locus with late-onset Alzheimer's disease.
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Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci.
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Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.
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Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease.
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Experimental analysis of the annotation of promoters in the public database.
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Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin.
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Investigating cis-acting regulatory variation using assays of relative allelic expression.
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No evidence for association between polymorphisms in GRM3 and schizophrenia.
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Dysbindin-1 and schizophrenia: from genetics to neuropathology.
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An examination of single nucleotide polymorphism selection prioritization strategies for tests of gene-gene interaction.
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Whole genome association study in a homogenous population in Shandong peninsula of China reveals JARID2 as a susceptibility gene for schizophrenia.
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A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk.
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No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples.
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A comparison of four clustering methods for brain expression microarray data.
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