Michael C O'Donovan

Author PubWeight™ 320.74‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009 33.26
2 Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007 12.62
3 Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 2010 12.27
4 Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 2008 10.49
5 Wake-up call for British psychiatry. Br J Psychiatry 2008 10.30
6 Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013 8.02
7 Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet 2013 7.44
8 Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet 2003 6.63
9 Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet 2009 6.13
10 Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. Am J Hum Genet 2009 5.98
11 Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. Hum Mol Genet 2007 5.28
12 Support for the involvement of large copy number variants in the pathogenesis of schizophrenia. Hum Mol Genet 2009 4.52
13 Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophr Bull 2005 3.93
14 Discovery and statistical genotyping of copy-number variation from whole-exome sequencing depth. Am J Hum Genet 2012 3.50
15 Cis-acting variation in the expression of a high proportion of genes in human brain. Hum Genet 2003 3.07
16 Analysis of copy number variations at 15 schizophrenia-associated loci. Br J Psychiatry 2013 3.01
17 Phenotypic and genetic complexity of psychosis. Invited commentary on ... Schizophrenia: a common disease caused by multiple rare alleles. Br J Psychiatry 2007 2.97
18 Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. Am J Hum Genet 2011 2.71
19 Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genet 2013 2.68
20 Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder. Arch Gen Psychiatry 2005 2.58
21 Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS One 2010 2.57
22 Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. Am J Psychiatry 2012 2.48
23 Neurexin 1 (NRXN1) deletions in schizophrenia. Schizophr Bull 2009 2.25
24 Effects of differential genotyping error rate on the type I error probability of case-control studies. Hum Hered 2006 2.21
25 Common variants at VRK2 and TCF4 conferring risk of schizophrenia. Hum Mol Genet 2011 2.21
26 A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. BMC Med Genomics 2008 2.20
27 Polymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trial. Br J Psychiatry 2011 2.18
28 Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK. Br J Psychiatry 2006 2.16
29 A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Am J Hum Genet 2003 2.11
30 Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia. Arch Gen Psychiatry 2010 2.11
31 All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genet 2013 2.08
32 Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia. Biol Psychiatry 2010 2.07
33 Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Proc Natl Acad Sci U S A 2006 2.03
34 Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools. Hum Genet 2002 2.03
35 Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder. Br J Psychiatry 2010 1.99
36 Pooled DNA genotyping on Affymetrix SNP genotyping arrays. BMC Genomics 2006 1.96
37 Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am J Hum Genet 2013 1.96
38 Maternally derived microduplications at 15q11-q13: implication of imprinted genes in psychotic illness. Am J Psychiatry 2011 1.94
39 Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. Am J Hum Genet 2005 1.93
40 Genome-wide association study of schizophrenia in a Japanese population. Biol Psychiatry 2010 1.89
41 De novo rates and selection of schizophrenia-associated copy number variants. Biol Psychiatry 2011 1.87
42 Neurodevelopmental hypothesis of schizophrenia. Br J Psychiatry 2011 1.87
43 Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression. Hum Mol Genet 2005 1.72
44 Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. Hum Mol Genet 2010 1.72
45 Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia. Arch Gen Psychiatry 2010 1.71
46 DNA pooling as a tool for large-scale association studies in complex traits. Ann Med 2004 1.70
47 Functional analysis of human promoter polymorphisms. Hum Mol Genet 2003 1.69
48 Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2006 1.61
49 Phenotypic variations on the theme of CNVs. Nat Genet 2008 1.58
50 No major schizophrenia locus detected on chromosome 1q in a large multicenter sample. Science 2002 1.57
51 SORL1 variants and risk of late-onset Alzheimer's disease. Neurobiol Dis 2007 1.49
52 Copy number variation in schizophrenia in the Japanese population. Biol Psychiatry 2009 1.49
53 Strong bias in the location of functional promoter polymorphisms. Hum Mutat 2005 1.48
54 Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13. Arch Gen Psychiatry 2005 1.48
55 The role of the major histocompatibility complex region in cognition and brain structure: a schizophrenia GWAS follow-up. Am J Psychiatry 2013 1.48
56 Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia. Arch Gen Psychiatry 2010 1.46
57 Functional analysis of polymorphisms in the promoter regions of genes on 22q11. Hum Mutat 2004 1.43
58 A network of dopaminergic gene variations implicated as risk factors for schizophrenia. Hum Mol Genet 2007 1.43
59 Correction: Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate. PLoS Genet 2015 1.39
60 Chromosome 22 deletion syndrome and schizophrenia. Int Rev Neurobiol 2006 1.35
61 Clustering of metabolic comorbidity in schizophrenia: a genetic contribution? J Psychopharmacol 2005 1.31
62 Advances in genetic findings on attention deficit hyperactivity disorder. Psychol Med 2007 1.29
63 Finding schizophrenia genes. J Clin Invest 2005 1.28
64 Independent estimation of the frequency of rare CNVs in the UK population confirms their role in schizophrenia. Schizophr Res 2011 1.28
65 At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia. Biol Psychiatry 2011 1.26
66 Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria. Biol Psychiatry 2004 1.26
67 Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proc Natl Acad Sci U S A 2006 1.25
68 Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia? Schizophr Bull 2005 1.24
69 Evaluation of an approximation method for assessment of overall significance of multiple-dependent tests in a genomewide association study. Genet Epidemiol 2011 1.22
70 Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia. Biol Psychiatry 2008 1.20
71 Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Arch Gen Psychiatry 2006 1.19
72 Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use. Br J Psychiatry 2007 1.19
73 TCF4, schizophrenia, and Pitt-Hopkins Syndrome. Schizophr Bull 2010 1.15
74 A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity. Biochim Biophys Acta 2004 1.15
75 Is COMT a susceptibility gene for schizophrenia? Schizophr Bull 2007 1.14
76 CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1. Hum Mol Genet 2013 1.14
77 Schizophrenia: a genetic disorder of the synapse? BMJ 2005 1.14
78 Schizophrenia genetics: new insights from new approaches. Br Med Bull 2009 1.11
79 Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1). Biol Psychiatry 2005 1.10
80 High loading of polygenic risk for ADHD in children with comorbid aggression. Am J Psychiatry 2013 1.10
81 Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations. Schizophr Bull 2014 1.10
82 Support for RGS4 as a susceptibility gene for schizophrenia. Biol Psychiatry 2004 1.10
83 Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk. JAMA Neurol 2013 1.09
84 A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia. Hum Mol Genet 2010 1.08
85 Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. J Hum Genet 2009 1.08
86 Schizophrenia genetics: advancing on two fronts. Curr Opin Genet Dev 2009 1.08
87 Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 2003 1.08
88 Strong evidence that GNB1L is associated with schizophrenia. Hum Mol Genet 2007 1.07
89 Additive genetic variation in schizophrenia risk is shared by populations of African and European descent. Am J Hum Genet 2013 1.07
90 Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. Biol Psychiatry 2009 1.06
91 Implication of a rare deletion at distal 16p11.2 in schizophrenia. JAMA Psychiatry 2013 1.05
92 Genome-wide association study of multiplex schizophrenia pedigrees. Am J Psychiatry 2012 1.05
93 The genetics of developmental dyslexia. Eur J Hum Genet 2006 1.04
94 The effect of age and the H1c MAPT haplotype on MAPT expression in human brain. Neurobiol Aging 2008 1.04
95 Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia. Arch Gen Psychiatry 2006 1.04
96 Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Hum Mol Genet 2007 1.03
97 Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2004 1.03
98 The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. J Alzheimers Dis 2012 1.02
99 Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples. Biol Psychiatry 2006 1.00
100 No association between schizophrenia and polymorphisms in COMT in two large samples. Am J Psychiatry 2005 1.00
101 Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes. Hum Mol Genet 2004 0.99
102 Genetic differences between five European populations. Hum Hered 2010 0.98
103 Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. Pharmacogenomics 2008 0.97
104 Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease. Ann Neurol 2006 0.97
105 A neuropsychological investigation of the genome wide associated schizophrenia risk variant NRGN rs12807809. Schizophr Res 2010 0.96
106 Genetic variants in the ErbB4 gene are associated with white matter integrity. Psychiatry Res 2011 0.96
107 Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. Am J Psychiatry 2005 0.96
108 Validity of the concept of minor depression in a developing country setting. J Nerv Ment Dis 2008 0.95
109 De novo mutation in schizophrenia. Schizophr Bull 2012 0.95
110 Association analysis of AKT1 and schizophrenia in a UK case control sample. Schizophr Res 2007 0.95
111 Permutation-based approaches do not adequately allow for linkage disequilibrium in gene-wide multi-locus association analysis. Eur J Hum Genet 2012 0.95
112 Variation in tau isoform expression in different brain regions and disease states. Neurobiol Aging 2013 0.94
113 An association study of common variation at the MAPT locus with late-onset Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet 2009 0.94
114 Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects. Arch Gen Psychiatry 2009 0.94
115 Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. Am J Med Genet B Neuropsychiatr Genet 2007 0.93
116 Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. Am J Med Genet B Neuropsychiatr Genet 2005 0.92
117 Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease. Am J Psychiatry 2005 0.92
118 Association of Genetic Risk for Schizophrenia With Nonparticipation Over Time in a Population-Based Cohort Study. Am J Epidemiol 2016 0.92
119 Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. Eur Child Adolesc Psychiatry 2008 0.90
120 Experimental analysis of the annotation of promoters in the public database. Hum Mol Genet 2002 0.90
121 Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin. Nat Genet 2004 0.90
122 Investigating cis-acting regulatory variation using assays of relative allelic expression. Psychiatr Genet 2006 0.90
123 No evidence for association between polymorphisms in GRM3 and schizophrenia. BMC Psychiatry 2005 0.90
124 Dysbindin-1 and schizophrenia: from genetics to neuropathology. J Clin Invest 2004 0.90
125 An examination of single nucleotide polymorphism selection prioritization strategies for tests of gene-gene interaction. Biol Psychiatry 2011 0.89
126 Whole genome association study in a homogenous population in Shandong peninsula of China reveals JARID2 as a susceptibility gene for schizophrenia. J Biomed Biotechnol 2009 0.89
127 A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk. Hum Mol Genet 2012 0.89
128 No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples. Biol Psychiatry 2005 0.88
129 Schizophrenia and functional polymorphisms in the MAOA and COMT genes: no evidence for association or epistasis. Am J Med Genet 2002 0.88
130 A high proportion of chromosome 21 promoter polymorphisms influence transcriptional activity. Gene Expr 2004 0.88
131 Genotype link with extreme antisocial behavior: the contribution of cognitive pathways. Arch Gen Psychiatry 2010 0.88
132 Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatr Genet 2009 0.88
133 Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping. BMC Psychiatry 2008 0.88
134 Schizophrenia two-hit hypothesis in velo-cardio facial syndrome. Am J Med Genet B Neuropsychiatr Genet 2013 0.86
135 Reduced burden of very large and rare CNVs in bipolar affective disorder. Bipolar Disord 2013 0.86
136 Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility. Schizophr Res 2006 0.86
137 A comparison of four clustering methods for brain expression microarray data. BMC Bioinformatics 2008 0.85
138 No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study. BMC Psychiatry 2004 0.84
139 New findings from genetic association studies of schizophrenia. J Hum Genet 2009 0.84
140 Adverse effects from antidepressant treatment: randomised controlled trial of 601 depressed individuals. Psychopharmacology (Berl) 2014 0.84
141 Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples. Am J Med Genet B Neuropsychiatr Genet 2009 0.83
142 Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. J Affect Disord 2009 0.83
143 Severity of depression and response to antidepressants: GENPOD randomised controlled trial. Br J Psychiatry 2011 0.83
144 Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. Am J Med Genet B Neuropsychiatr Genet 2010 0.83
145 Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1. Hum Mol Genet 2008 0.83
146 Promoter polymorphisms in glutathione-S-transferase genes affect transcription. Pharmacogenetics 2004 0.82
147 Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia. J Psychiatr Res 2005 0.82
148 Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder. Br J Psychiatry 2009 0.82
149 A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder. Biol Psychiatry 2005 0.81
150 Mosaic copy number variation in schizophrenia. Eur J Hum Genet 2013 0.81
151 Association between TCF4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain. Am J Med Genet B Neuropsychiatr Genet 2011 0.80
152 Effects of DTNBP1 genotype on brain development in children. J Child Psychol Psychiatry 2011 0.80
153 DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder. PLoS One 2012 0.79
154 In silico discrimination of single nucleotide polymorphisms and pathological mutations in human gene promoter regions by means of local DNA sequence context and regularity. In Silico Biol 2006 0.79
155 Failure to confirm association between PIK4CA and psychosis in 22q11.2 deletion syndrome. Am J Med Genet B Neuropsychiatr Genet 2010 0.78
156 Genome scans and microarrays: converging on genes for schizophrenia? Genome Biol 2002 0.78
157 Absence of de novo point mutations in exons of GRIN2B in a large schizophrenia trio sample. Schizophr Res 2012 0.78
158 No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatr Genet 2003 0.78
159 Factor structure of autistic traits in children with ADHD. J Autism Dev Disord 2014 0.77
160 Analysis of neurogranin (NRGN) in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2011 0.77
161 Genetics and the brain: many pathways to enlightenment. Hum Genet 2009 0.76
162 Analysis of copy number variation using quantitative interspecies competitive PCR. Nucleic Acids Res 2008 0.76
163 Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 2011 0.76
164 Mutation screening of SCN2A in schizophrenia and identification of a novel loss-of-function mutation. Psychiatr Genet 2016 0.76
165 Non-random mating, parent-of-origin, and maternal-fetal incompatibility effects in schizophrenia. Schizophr Res 2012 0.76
166 No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder. Psychiatr Genet 2003 0.76
167 Genetic predictors of antidepressant side effects: a grouped candidate gene approach in the Genome-Based Therapeutic Drugs for Depression (GENDEP) study. J Psychopharmacol 2014 0.75
168 Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease. Neurosci Lett 2006 0.75