Published in Nature on December 06, 2007
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet (2009) 7.65
Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature (2012) 3.63
Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells. Circulation (2009) 2.93
Structural basis for calcium sensing by GCaMP2. Structure (2008) 2.52
Optogenetic control of heart muscle in vitro and in vivo. Nat Methods (2010) 2.47
c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart. Proc Natl Acad Sci U S A (2012) 2.35
c-kit expression identifies cardiovascular precursors in the neonatal heart. Proc Natl Acad Sci U S A (2009) 2.06
Stem cell therapy is proarrhythmic. Circulation (2009) 1.83
Cell therapy for the treatment of coronary heart disease: a critical appraisal. Nat Rev Cardiol (2010) 1.69
Challenges in cardiac tissue engineering. Tissue Eng Part B Rev (2010) 1.66
Epidemiology and genetics of sudden cardiac death. Circulation (2012) 1.65
Tracking chromatid segregation to identify human cardiac stem cells that regenerate extensively the infarcted myocardium. Circ Res (2012) 1.63
Cardiac cell repair therapy: a clinical perspective. Mayo Clin Proc (2009) 1.62
Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction. J Am Coll Cardiol (2012) 1.60
Sca-1+ stem cell survival and engraftment in the infarcted heart: dual role for preconditioning-induced connexin-43. Circulation (2009) 1.58
Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation. Nat Med (2010) 1.49
Engraftment of human embryonic stem cell derived cardiomyocytes improves conduction in an arrhythmogenic in vitro model. J Mol Cell Cardiol (2012) 1.45
Mechanical preconditioning enables electrophysiologic coupling of skeletal myoblast cells to myocardium. J Thorac Cardiovasc Surg (2012) 1.44
Preconditioning of skeletal myoblast-based engineered tissue constructs enables functional coupling to myocardium in vivo. J Thorac Cardiovasc Surg (2014) 1.44
Genetic enhancement of stem cell engraftment, survival, and efficacy. Circ Res (2008) 1.42
Cardiac Fibrosis: The Fibroblast Awakens. Circ Res (2016) 1.21
Stem cells in the heart: what's the buzz all about? Part 2: Arrhythmic risks and clinical studies. Heart Rhythm (2008) 1.19
Fibroblast-myocyte electrotonic coupling: does it occur in native cardiac tissue? J Mol Cell Cardiol (2014) 1.19
Cardiac conduction is required to preserve cardiac chamber morphology. Proc Natl Acad Sci U S A (2010) 1.17
Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue. Proc Natl Acad Sci U S A (2013) 1.17
Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease. Dis Model Mech (2009) 1.16
The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarction. Circ Res (2011) 1.14
Biomaterial strategies for alleviation of myocardial infarction. J R Soc Interface (2011) 1.13
Simultaneous optical mapping of intracellular free calcium and action potentials from Langendorff perfused hearts. Curr Protoc Cytom (2009) 1.12
Engineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies. Nat Commun (2011) 1.10
Induced pluripotent stem cells for post-myocardial infarction repair: remarkable opportunities and challenges. Circ Res (2014) 1.09
Combined targeting of lentiviral vectors and positioning of transduced cells by magnetic nanoparticles. Proc Natl Acad Sci U S A (2008) 1.08
Functional cardiac tissue engineering. Regen Med (2012) 1.07
Origin, development, and differentiation of cardiac fibroblasts. J Mol Cell Cardiol (2013) 1.03
Implantation of mouse embryonic stem cell-derived cardiac progenitor cells preserves function of infarcted murine hearts. PLoS One (2010) 1.01
Atrial Fibrillation and Fibrosis: Beyond the Cardiomyocyte Centric View. Biomed Res Int (2015) 0.99
PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium. Nat Commun (2015) 0.97
Cardiac applications for human pluripotent stem cells. Curr Pharm Des (2009) 0.97
Engineered early embryonic cardiac tissue increases cardiomyocyte proliferation by cyclic mechanical stretch via p38-MAP kinase phosphorylation. Tissue Eng Part A (2009) 0.96
In vitro cardiomyogenic potential of human amniotic fluid stem cells. J Tissue Eng Regen Med (2011) 0.95
Skeletal myoblasts for cardiac repair. Regen Med (2010) 0.95
Challenges in identifying the best source of stem cells for cardiac regeneration therapy. Stem Cell Res Ther (2015) 0.95
Engineered fetal cardiac graft preserves its cardiomyocyte proliferation within postinfarcted myocardium and sustains cardiac function. Tissue Eng Part A (2011) 0.94
Young developmental age cardiac extracellular matrix promotes the expansion of neonatal cardiomyocytes in vitro. Acta Biomater (2013) 0.93
Increased Cell-Cell Coupling Increases Infarct Size and Does not Decrease Incidence of Ventricular Tachycardia in Mice. Front Physiol (2011) 0.93
Hydrogen sulfide attenuates cardiac hypertrophy and fibrosis induced by abdominal aortic coarctation in rats. Mol Med Rep (2012) 0.93
Junctional cleft [Ca²⁺]i measurements using novel cleft-targeted Ca²⁺ sensors. Circ Res (2014) 0.93
Diminished cardiac fibrosis in heart failure is associated with altered ventricular arrhythmia phenotype. J Cardiovasc Electrophysiol (2010) 0.92
Characterizing functional stem cell-cardiomyocyte interactions. Regen Med (2010) 0.92
Stem cell therapy: pieces of the puzzle. J Cardiovasc Transl Res (2009) 0.91
Cardiac cell therapy: overexpression of connexin43 in skeletal myoblasts and prevention of ventricular arrhythmias. J Cell Mol Med (2009) 0.90
Stem cell therapy for cardiac dysfunction. Springerplus (2014) 0.90
Combined vildagliptin and metformin exert better cardioprotection than monotherapy against ischemia-reperfusion injury in obese-insulin resistant rats. PLoS One (2014) 0.87
The dynamic role of cardiac fibroblasts in development and disease. J Cardiovasc Transl Res (2012) 0.87
Remodeling of cardiac fibroblasts following myocardial infarction results in increased gap junction intercellular communication. Cardiovasc Pathol (2010) 0.87
The integrative aspects of cardiac physiology and their implications for cell-based therapy. Ann N Y Acad Sci (2010) 0.87
Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes. Nat Commun (2016) 0.86
Cardiac regeneration using pluripotent stem cells--progression to large animal models. Stem Cell Res (2014) 0.86
Connexin43 knockdown or overexpression modulates cell coupling in control and failing rabbit left ventricular myocytes. Cardiovasc Res (2009) 0.86
Magnetic Resonance Imaging Tracking of Graft Survival in the Infarcted Heart: Iron Oxide Particles Versus Ferritin Overexpression Approach. J Cardiovasc Pharmacol Ther (2014) 0.85
Stem cells can form gap junctions with cardiac myocytes and exert pro-arrhythmic effects. Front Physiol (2014) 0.85
FACS-based isolation, propagation and characterization of mouse embryonic cardiomyocytes based on VCAM-1 surface marker expression. PLoS One (2013) 0.85
Enhanced gap junction expression in myoblast-containing engineered tissue. Biochem Biophys Res Commun (2012) 0.85
Cardiomyocytes from phorbol myristate acetate-activated mesenchymal stem cells restore electromechanical function in infarcted rat hearts. Proc Natl Acad Sci U S A (2010) 0.85
Stem cell therapy for ischemic heart disease. Antioxid Redox Signal (2010) 0.84
The Cardioprotective Effects of Hydrogen Sulfide in Heart Diseases: From Molecular Mechanisms to Therapeutic Potential. Oxid Med Cell Longev (2015) 0.84
Fibroblast-myocyte coupling in the heart: Potential relevance for therapeutic interventions. J Mol Cell Cardiol (2016) 0.83
Embryonic Stem Cells as a Model for Cardiac Development and Disease. Drug Discov Today Dis Models (2008) 0.83
Optical mapping of cryoinjured rat myocardium grafted with mesenchymal stem cells. Am J Physiol Heart Circ Physiol (2011) 0.83
At a crossroad: cell therapy for cardiac repair. Circ Res (2013) 0.83
Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease. Nat Rev Drug Discov (2016) 0.82
Promises and pitfalls in cell replacement therapy for heart failure. Drug Discov Today Dis Mech (2010) 0.81
Embryonic cardiomyocyte, but not autologous stem cell transplantation, restricts infarct expansion, enhances ventricular function, and improves long-term survival. PLoS One (2013) 0.81
Improved conduction and increased cell retention in healed MI using mesenchymal stem cells suspended in alginate hydrogel. J Interv Card Electrophysiol (2014) 0.81
Growth factor-induced mobilization of cardiac progenitor cells reduces the risk of arrhythmias, in a rat model of chronic myocardial infarction. PLoS One (2011) 0.81
Concise review: Engineering myocardial tissue: the convergence of stem cells biology and tissue engineering technology. Stem Cells (2013) 0.81
Titanium dioxide nanoparticles promote arrhythmias via a direct interaction with rat cardiac tissue. Part Fibre Toxicol (2014) 0.80
Reduced expression of Cx43 attenuates ventricular remodeling after myocardial infarction via impaired TGF-beta signaling. Am J Physiol Heart Circ Physiol (2009) 0.80
Concise review: skeletal muscle stem cells and cardiac lineage: potential for heart repair. Stem Cells Transl Med (2013) 0.80
The Living Scar - Cardiac Fibroblasts and the Injured Heart. Trends Mol Med (2016) 0.80
Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein. Heart Vessels (2013) 0.80
The toxic effect of R350P mutant desmin in striated muscle of man and mouse. Acta Neuropathol (2014) 0.79
Pacing lightly: optogenetics gets to the heart. Nat Methods (2010) 0.79
Cardiovascular Stem Cells in Regenerative Medicine: Ready for Prime Time? Drug Discov Today Ther Strateg (2008) 0.79
Spironolactone therapy is associated with reduced ventricular tachycardia rate in patients with cardiomyopathy. Pacing Clin Electrophysiol (2010) 0.79
Low connexin channel-dependent intercellular communication in human adult hematopoietic progenitor/stem cells: probing mechanisms of autologous stem cell therapy. Cell Commun Adhes (2009) 0.78
Genetic engineering and stem cells: combinatorial approaches for cardiac cell therapy. IEEE Eng Med Biol Mag (2008) 0.78
Regenerative therapies in electrophysiology and pacing: introducing the next steps. J Interv Card Electrophysiol (2010) 0.78
c-Src kinase inhibition reduces arrhythmia inducibility and connexin43 dysregulation after myocardial infarction. J Am Coll Cardiol (2014) 0.78
Hyperthermia differently affects connexin43 expression and gap junction permeability in skeletal myoblasts and HeLa cells. Mediators Inflamm (2014) 0.77
Progenitor/stem cell transplantation for repair of myocardial infarction: Hype or hope? Ann Palliat Med (2012) 0.77
Cardiac regeneration: different cells same goal. Med Biol Eng Comput (2011) 0.77
[Surgical intramyocardial stem cell therapy for chronic ischemic heart failure]. Herz (2010) 0.77
Hepatocyte growth factor modification enhances the anti-arrhythmic properties of human bone marrow-derived mesenchymal stem cells. PLoS One (2014) 0.77
Making better scar: Emerging approaches for modifying mechanical and electrical properties following infarction and ablation. Prog Biophys Mol Biol (2015) 0.77
Electrical and Mechanical Strategies to Enable Cardiac Repair and Regeneration. IEEE Rev Biomed Eng (2015) 0.77
"Second-generation" stem cells for cardiac repair. World J Stem Cells (2015) 0.77
Relationship of electro-mechanical remodeling to survival rates after cardiac resynchronization therapy. Tex Heart Inst J (2013) 0.77
Heart failure management: the present and the future. Antioxid Redox Signal (2009) 0.77
Oct4-induced pluripotency in adult neural stem cells. Cell (2009) 6.50
Calmodulin kinase II inhibition protects against structural heart disease. Nat Med (2005) 5.87
Imaging cellular signals in the heart in vivo: Cardiac expression of the high-signal Ca2+ indicator GCaMP2. Proc Natl Acad Sci U S A (2006) 4.71
Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med (2004) 4.59
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell (2006) 4.43
Neuronal fate determinants of adult olfactory bulb neurogenesis. Nat Neurosci (2005) 3.67
Gap junctions and the connexin protein family. Cardiovasc Res (2004) 3.66
Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature (2012) 3.63
Astroglial metabolic networks sustain hippocampal synaptic transmission. Science (2008) 3.49
Monitoring of implanted stem cell migration in vivo: a highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat. Proc Natl Acad Sci U S A (2002) 3.27
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc Natl Acad Sci U S A (2001) 3.17
Optical imaging of the heart. Circ Res (2004) 3.14
Cardiomyocyte cell cycle control and growth estimation in vivo--an analysis based on cardiomyocyte nuclei. Cardiovasc Res (2010) 3.00
Potential risks of bone marrow cell transplantation into infarcted hearts. Blood (2007) 2.97
Expression and functions of neuronal gap junctions. Nat Rev Neurosci (2005) 2.91
Whole-genome sequence of Schistosoma haematobium. Nat Genet (2012) 2.91
The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus. J Neurosci (2006) 2.85
Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death. Curr Biol (2002) 2.72
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev (2003) 2.68
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature (2002) 2.59
Structural basis for calcium sensing by GCaMP2. Structure (2008) 2.52
The Registry of the German Competence NETwork on Atrial Fibrillation: patient characteristics and initial management. Europace (2009) 2.52
Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. Science (2012) 2.48
Optogenetic control of heart muscle in vitro and in vivo. Nat Methods (2010) 2.47
Cytosolic Ca2+ triggers early afterdepolarizations and Torsade de Pointes in rabbit hearts with type 2 long QT syndrome. J Physiol (2002) 2.47
Functional architecture of inositol 1,4,5-trisphosphate signaling in restricted spaces of myoendothelial projections. Proc Natl Acad Sci U S A (2008) 2.47
Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr Biol (2010) 2.45
c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart. Proc Natl Acad Sci U S A (2012) 2.35
Fibronectin regulates Wnt7a signaling and satellite cell expansion. Cell Stem Cell (2013) 2.31
Induction of pluripotency in adult unipotent germline stem cells. Cell Stem Cell (2009) 2.26
Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release. Diabetes (2005) 2.24
Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium. J Exp Med (2006) 2.23
Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43. Circulation (2004) 2.23
Connexin30 (Gjb6)-deficiency causes severe hearing impairment and lack of endocochlear potential. Hum Mol Genet (2003) 2.17
Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion. Nat Cell Biol (2008) 2.17
Propagated endothelial Ca2+ waves and arteriolar dilation in vivo: measurements in Cx40BAC GCaMP2 transgenic mice. Circ Res (2007) 2.13
Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43. J Cell Sci (2006) 2.06
c-kit expression identifies cardiovascular precursors in the neonatal heart. Proc Natl Acad Sci U S A (2009) 2.06
Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome. J Clin Invest (2008) 1.93
Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases. Brain (2010) 1.93
Pacemaking by HCN channels requires interaction with phosphoinositides. Neuron (2006) 1.84
Cryoballoon versus RF ablation in paroxysmal atrial fibrillation: results from the German Ablation Registry. J Cardiovasc Electrophysiol (2013) 1.84
Connexin hemichannel-mediated CO2-dependent release of ATP in the medulla oblongata contributes to central respiratory chemosensitivity. J Physiol (2010) 1.81
Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells. J Neurosci (2008) 1.81
The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol (2007) 1.81
An update on connexin genes and their nomenclature in mouse and man. Cell Commun Adhes (2003) 1.77
BAC transgenic mice express enhanced green fluorescent protein in central and peripheral cholinergic neurons. Physiol Genomics (2006) 1.76
Effective engraftment but poor mid-term persistence of mononuclear and mesenchymal bone marrow cells in acute and chronic rat myocardial infarction. J Mol Cell Cardiol (2006) 1.72
Endothelial microparticle-mediated transfer of MicroRNA-126 promotes vascular endothelial cell repair via SPRED1 and is abrogated in glucose-damaged endothelial microparticles. Circulation (2013) 1.72
Efficient transgenesis in farm animals by lentiviral vectors. EMBO Rep (2003) 1.72
Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist. Sci Signal (2013) 1.71
Cardiomyocyte-restricted deletion of connexin43 during mouse development. J Mol Cell Cardiol (2006) 1.70
Pathological consequences of VCP mutations on human striated muscle. Brain (2006) 1.68
Role of olivary electrical coupling in cerebellar motor learning. Neuron (2008) 1.67
Sex modulates the arrhythmogenic substrate in prepubertal rabbit hearts with Long QT 2. J Cardiovasc Electrophysiol (2005) 1.66
Calcium oscillations and T-wave lability precede ventricular arrhythmias in acquired long QT type 2. Heart Rhythm (2010) 1.66
Spatially discordant voltage alternans cause wavebreaks in ventricular fibrillation. Heart Rhythm (2007) 1.65
Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation. Neuron (2009) 1.64
Persistence of iatrogenic atrial septal defect after pulmonary vein isolation--an underestimated risk? Am Heart J (2006) 1.63
Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protective. Heart Rhythm (2012) 1.62
Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells. J Neurosci (2002) 1.62
Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J Clin Invest (2005) 1.61
The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans. Hum Mol Genet (2007) 1.61
Influence of the bridging ligand on the substitution behaviour of dinuclear Pt(II) complexes. An experimental and theoretical approach. Dalton Trans (2007) 1.61
In vitro comparison of platinum-iridium and gold tip electrodes: lesion depth in 4 mm, 8 mm, and irrigated-tip radiofrequency ablation catheters. Europace (2009) 1.61
Cerebral diffusion-weighted magnetic resonance imaging: a tool to monitor the thrombogenicity of left atrial catheter ablation. J Cardiovasc Electrophysiol (2006) 1.60
miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit. Nat Commun (2013) 1.59
Accelerated hippocampal spreading depression and enhanced locomotory activity in mice with astrocyte-directed inactivation of connexin43. J Neurosci (2003) 1.59