Arginine methylation of the histone H3 tail impedes effector binding.

Protein arginine methylation in mammals: who, what, and why. Mol Cell (2009) 7.44

Protein arginine methyltransferases and cancer. Nat Rev Cancer (2012) 2.56

PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks. Mutat Res (2008) 2.31

Histone arginine methylation. FEBS Lett (2010) 1.95

Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation. Mol Endocrinol (2009) 1.95

TDRD3 is an effector molecule for arginine-methylated histone marks. Mol Cell (2010) 1.80

Determination of enriched histone modifications in non-genic portions of the human genome. BMC Genomics (2009) 1.80

Emerging roles for chromatin as a signal integration and storage platform. Nat Rev Mol Cell Biol (2013) 1.65

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance. Nat Struct Mol Biol (2012) 1.64

How eukaryotic genes are transcribed. Crit Rev Biochem Mol Biol (2009) 1.46

The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation. Nucleic Acids Res (2009) 1.46

Combinatorial profiling of chromatin binding modules reveals multisite discrimination. Nat Chem Biol (2010) 1.39

Human protein arginine methyltransferase 7 (PRMT7) is a type III enzyme forming ω-NG-monomethylated arginine residues. J Biol Chem (2012) 1.38

The N-terminus of histone H3 is required for de novo DNA methylation in chromatin. Proc Natl Acad Sci U S A (2009) 1.24

Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription. Genes Dev (2012) 1.21

Protein arginine methyltransferase 6 regulates multiple aspects of gene expression. Nucleic Acids Res (2010) 1.21

Enzymatic activity is required for the in vivo functions of CARM1. J Biol Chem (2009) 1.16

Thrombospondin-1 is a transcriptional repression target of PRMT6. J Biol Chem (2009) 1.12

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem J (2013) 1.12

A method for large-scale identification of protein arginine methylation. Mol Cell Proteomics (2012) 1.08

Readers of histone methylarginine marks. Biochim Biophys Acta (2014) 1.08

Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor. Nucleic Acids Res (2012) 1.07

Dynamic interplay between histone H3 modifications and protein interpreters: emerging evidence for a "histone language". Chembiochem (2010) 1.06

On WD40 proteins: propelling our knowledge of transcriptional control? Epigenetics (2012) 1.03

Histones: at the crossroads of peptide and protein chemistry. Chem Rev (2014) 1.01

p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6. Nucleic Acids Res (2012) 0.99

Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30. PLoS One (2012) 0.99

Chemical biology of protein arginine modifications in epigenetic regulation. Chem Rev (2015) 0.99

H3R42me2a is a histone modification with positive transcriptional effects. Proc Natl Acad Sci U S A (2013) 0.97

Protein arginine methylation in parasitic protozoa. Eukaryot Cell (2011) 0.97

The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes. Nucleic Acids Res (2012) 0.96

Chromatin: receiver and quarterback for cellular signals. Cell (2013) 0.95

Methylation of H2AR29 is a novel repressive PRMT6 target. Epigenetics Chromatin (2011) 0.94

Cell cycle regulation by the PRMT6 arginine methyltransferase through repression of cyclin-dependent kinase inhibitors. PLoS One (2012) 0.94

TbPRMT6 is a type I protein arginine methyltransferase that contributes to cytokinesis in Trypanosoma brucei. Eukaryot Cell (2010) 0.94

Expression and purification of full-length mouse CARM1 from transiently transfected HEK293T cells using HaloTag technology. Protein Expr Purif (2010) 0.93

Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production. FEBS J (2010) 0.91

N-alpha-terminal acetylation of histone H4 regulates arginine methylation and ribosomal DNA silencing. PLoS Genet (2013) 0.89

A gain-of-function mouse model identifies PRMT6 as a NF-κB coactivator. Nucleic Acids Res (2014) 0.86

PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation. Nat Commun (2014) 0.85

A role for CARM1-mediated histone H3 arginine methylation in protecting histone acetylation by releasing corepressors from chromatin. PLoS One (2012) 0.84

RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation. Blood (2015) 0.84

Protein Arginine Methyltransferases (PRMTs): promising targets for the treatment of pulmonary disorders. Int J Mol Sci (2012) 0.82

The application of modular protein domains in proteomics. FEBS Lett (2012) 0.82

The role of chromatin modifiers in normal and malignant hematopoiesis. Blood (2013) 0.80

Approaches to measuring the activities of protein arginine N-methyltransferases. Anal Biochem (2009) 0.80

A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72. J Biol Chem (2012) 0.79

Crystal structure of arginine methyltransferase 6 from Trypanosoma brucei. PLoS One (2014) 0.78

Identification and characterization of new molecular partners for the protein arginine methyltransferase 6 (PRMT6). PLoS One (2013) 0.77

Inhibitors of Protein Methyltransferases and Demethylases. Chem Rev (2017) 0.76

Overexpression of PRMT6 does not suppress HIV-1 Tat transactivation in cells naturally lacking PRMT6. Virol J (2013) 0.76

Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage. Sci Rep (2015) 0.76

PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3. Elife (2016) 0.76

Increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates cyclic adenosine 5'-monophosphate response element modulator alpha in systemic lupus erythematosus. Clin Epigenetics (2016) 0.75

The Histone Modification Code in the Pathogenesis of Autoimmune Diseases. Mediators Inflamm (2017) 0.75

Structural basis of arginine asymmetrical dimethylation by PRMT6. Biochem J (2016) 0.75

Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions. Epigenetics Chromatin (2017) 0.75

The Arginine Methyltransferase PRMT6 Cooperates with Polycomb Proteins in Regulating HOXA Gene Expression. PLoS One (2016) 0.75

Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. Proc Natl Acad Sci U S A (2017) 0.75

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature (2011) 13.30

Tudor, MBT and chromo domains gauge the degree of lysine methylation. EMBO Rep (2006) 5.19

Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science (2006) 4.54

p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16

Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. J Biol Chem (2006) 3.14

The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell (2007) 2.94

The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J Biol Chem (2001) 2.63

Protein arginine methyltransferases and cancer. Nat Rev Cancer (2012) 2.56

Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A (2003) 2.50

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat Struct Mol Biol (2009) 2.50

PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. EMBO Rep (2002) 2.11

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol (2010) 2.07

Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression. J Virol (2005) 2.02

Small molecule regulators of protein arginine methyltransferases. J Biol Chem (2004) 1.99

Histone arginine methylation. FEBS Lett (2010) 1.95

Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol Biol Cell (2003) 1.87

Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing. J Cell Biol (2002) 1.83

TDRD3 is an effector molecule for arginine-methylated histone marks. Mol Cell (2010) 1.80

Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase. J Biol Chem (2006) 1.79

Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol (2012) 1.77

Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. EMBO J (2004) 1.74

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol (2013) 1.72

Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene. Proc Natl Acad Sci U S A (2006) 1.69

PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. J Biol Chem (2005) 1.67

Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks. PLoS One (2009) 1.66

The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol (2006) 1.55

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics (2013) 1.53

A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Res (2009) 1.49

WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Oncogene (2004) 1.47

Normalization of nomenclature for peptide motifs as ligands of modular protein domains. FEBS Lett (2002) 1.46

Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Mol Endocrinol (2010) 1.42

A protein-domain microarray identifies novel protein-protein interactions. Biochem J (2002) 1.42

Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nat Cell Biol (2011) 1.40

Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). Biochem J (2005) 1.40

Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J Mol Biol (2010) 1.37

Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. J Biol Chem (2007) 1.35

Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development. J Biol Chem (2004) 1.35

Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT family. J Cell Sci (2009) 1.33

14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s). Cancer Res (2002) 1.33

Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. EMBO J (2010) 1.27

Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. Mol Cell Biol (2009) 1.26

Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions. Cell Stem Cell (2012) 1.23

Dynamics of human protein arginine methyltransferase 1(PRMT1) in vivo. J Biol Chem (2005) 1.22

Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs. Sci Rep (2013) 1.22

The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6. J Biol Chem (2005) 1.21

Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice. J Biol Chem (2007) 1.21

CARM1 promotes adipocyte differentiation by coactivating PPARgamma. EMBO Rep (2008) 1.21

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene. PLoS One (2009) 1.18

Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1. J Mol Biol (2008) 1.17

Enzymatic activity is required for the in vivo functions of CARM1. J Biol Chem (2009) 1.16

WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy. Genes Chromosomes Cancer (2007) 1.13

epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. J Med Chem (2008) 1.13

Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. Mol Cell (2013) 1.12

IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells. Genesis (2009) 1.12

Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Res (2010) 1.10

PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. Nat Struct Mol Biol (2012) 1.09

Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor. Nucleic Acids Res (2012) 1.07

Delphinidin, a dietary anthocyanidin, inhibits vascular endothelial growth factor receptor-2 phosphorylation. Carcinogenesis (2005) 1.06

Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. J Mol Biol (2011) 1.04

MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nat Commun (2011) 1.04

Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1. J Biol Chem (2009) 1.02

Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees. EMBO Rep (2011) 1.02

A new locus-specific database (LSDB) for mutations in the folliculin (FLCN) gene. Hum Mutat (2010) 1.02

Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions. J Biol Chem (2013) 1.02

A systematic comparison of all mutations in hereditary sensory neuropathy type I (HSAN I) reveals that the G387A mutation is not disease associated. Neurogenetics (2009) 1.01

Green tea catechins as novel antitumor and antiangiogenic compounds. Curr Med Chem Anticancer Agents (2002) 1.01

Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation. Genes Dev (2011) 1.00

CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development (2010) 0.99

Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30. PLoS One (2012) 0.99

Systematic identification of methyllysine-driven interactions for histone and nonhistone targets. J Proteome Res (2010) 0.98

Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF. J Biol Chem (2011) 0.98

Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors. ChemMedChem (2007) 0.97

Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. BMC Dev Biol (2009) 0.94

Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. J Biol Chem (2011) 0.94

Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem (2011) 0.93

Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging (Albany NY) (2012) 0.93

Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). ChemMedChem (2010) 0.90