PubRank

William R Markesbery

Author PubWeight™ 133.32‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci U S A 2004 5.65
2 Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging 2009 4.36
3 Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants. Ann N Y Acad Sci 2002 3.11
4 TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol 2007 2.97
5 Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship. J Neuropathol Exp Neurol 2009 2.87
6 Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study. Ann Neurol 2002 2.68
7 Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity. J Neuropathol Exp Neurol 2007 2.65
8 Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons. Brain Pathol 2008 2.44
9 Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations. J Neuropathol Exp Neurol 2006 2.43
10 Association of olfactory dysfunction with incidental Lewy bodies. Mov Disord 2006 2.26
11 Age and gender effects on human brain anatomy: a voxel-based morphometric study in healthy elderly. Neurobiol Aging 2006 2.23
12 Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. Free Radic Biol Med 2002 2.10
13 Lipid peroxidation in aging brain and Alzheimer's disease. Free Radic Biol Med 2002 2.08
14 Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease. Neurobiol Dis 2006 2.04
15 Methodological Considerations in Studying Centenarians: Lessons Learned From the Georgia Centenarian Studies. Annu Rev Gerontol Geriatr 2007 1.85
16 Ribosome dysfunction is an early event in Alzheimer's disease. J Neurosci 2005 1.80
17 Head circumference, education and risk of dementia: findings from the Nun Study. J Clin Exp Neuropsychol 2003 1.73
18 Low sensitivity in clinical diagnoses of dementia with Lewy bodies. J Neurol 2009 1.73
19 Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71. J Neurochem 2002 1.73
20 Proteomic identification of nitrated proteins in Alzheimer's disease brain. J Neurochem 2003 1.70
21 Early life linguistic ability, late life cognitive function, and neuropathology: findings from the Nun Study. Neurobiol Aging 2005 1.66
22 Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease. J Neuropathol Exp Neurol 2009 1.66
23 Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease. Nucleic Acids Res 2007 1.62
24 Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease. Neurobiol Aging 2005 1.60
25 Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach. Neurobiol Dis 2005 1.58
26 Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. Exp Neurol 2008 1.58
27 Oxidative damage in mild cognitive impairment and early Alzheimer's disease. J Neurosci Res 2007 1.54
28 Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment. J Neurochem 2006 1.52
29 Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD. Neurobiol Aging 2005 1.52
30 Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis. Neurobiol Aging 2005 1.50
31 Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment. Nucleic Acids Res 2007 1.48
32 Human cerebral neuropathology of Type 2 diabetes mellitus. Biochim Biophys Acta 2008 1.46
33 Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice. Neurobiol Dis 2007 1.40
34 Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease. Neurobiol Dis 2008 1.38
35 Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease. Am J Pathol 2006 1.28
36 Designing a large prevention trial: statistical issues. Stat Med 2004 1.24
37 NOX activity is increased in mild cognitive impairment. Antioxid Redox Signal 2010 1.22
38 Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD. Brain Res 2009 1.22
39 Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease. Brain Res 2007 1.21
40 Decreased RNA, and increased RNA oxidation, in ribosomes from early Alzheimer's disease. Neurochem Res 2006 1.21
41 Proteasome inhibition induces reversible impairments in protein synthesis. FASEB J 2006 1.20
42 Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models. Free Radic Biol Med 2008 1.19
43 Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study. Neurobiol Aging 2010 1.16
44 Alzheimer's-type neuropathology in the precuneus is not increased relative to other areas of neocortex across a range of cognitive impairment. Neurosci Lett 2008 1.15
45 Kalirin is under-expressed in Alzheimer's disease hippocampus. J Alzheimers Dis 2007 1.14
46 Oxidative stress in head trauma in aging. Free Radic Biol Med 2006 1.13
47 Autoantibodies to amyloid beta-peptide (Abeta) are increased in Alzheimer's disease patients and Abeta antibodies can enhance Abeta neurotoxicity: implications for disease pathogenesis and vaccine development. Neuromolecular Med 2003 1.11
48 Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain. Free Radic Biol Med 2008 1.10
49 Healthy ageing in the Nun Study: definition and neuropathologic correlates. Age Ageing 2007 1.09
50 Comparison of recruitment efforts targeted at primary care physicians versus the community at large for participation in Alzheimer disease clinical trials. Alzheimer Dis Assoc Disord 2010 1.07
51 Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain. Mol Neurodegener 2009 1.06
52 Identification and characterization of OGG1 mutations in patients with Alzheimer's disease. Nucleic Acids Res 2007 1.06
53 Association between male gender and cortical Lewy body pathology in large autopsy series. J Neurol 2010 1.06
54 Oxidatively modified RNA in mild cognitive impairment. Neurobiol Dis 2007 1.05
55 F2-isoprostanes in Alzheimer and other neurodegenerative diseases. Antioxid Redox Signal 2005 1.04
56 Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age. Free Radic Biol Med 2008 1.02
57 Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease. Neurobiol Aging 2008 1.02
58 Omega-3 fatty acids: potential role in the management of early Alzheimer's disease. Clin Interv Aging 2010 1.01
59 Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice. J Neurochem 2008 1.00
60 Proteomic identification of nitrated brain proteins in early Alzheimer's disease inferior parietal lobule. J Cell Mol Med 2008 1.00
61 Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease. J Neurochem 2006 0.99
62 Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer's disease. Neurobiol Aging 2002 0.97
63 Molecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks. Neurobiol Aging 2010 0.96
64 Under-expression of Kalirin-7 Increases iNOS activity in cultured cells and correlates to elevated iNOS activity in Alzheimer's disease hippocampus. J Alzheimers Dis 2007 0.95
65 4-Hydroxynonenal oxidatively modifies histones: implications for Alzheimer's disease. Neurosci Lett 2004 0.95
66 Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain. Brain Pathol 2009 0.94
67 Acetylcholinesterase inhibitor treatment is associated with relatively slow cognitive decline in patients with Alzheimer's disease and AD + DLB. J Alzheimers Dis 2009 0.94
68 Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics. Neurobiol Dis 2010 0.93
69 Proteasome inhibition increases DNA and RNA oxidation in astrocyte and neuron cultures. J Neurochem 2004 0.91
70 The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain. Nitric Oxide 2002 0.91
71 Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression. Neurobiol Aging 2010 0.90
72 Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE. Am J Med Genet B Neuropsychiatr Genet 2003 0.90
73 3alpha,5alpha-THP: a potential plasma neurosteroid biomarker in Alzheimer's disease and perhaps non-Alzheimer's dementia. Psychopharmacology (Berl) 2005 0.89
74 Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3. J Alzheimers Dis 2004 0.89
75 Seleno-L-methionine protects against beta-amyloid and iron/hydrogen peroxide-mediated neuron death. Antioxid Redox Signal 2007 0.89
76 Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease. Aging Cell 2012 0.88
77 Redox proteomics analysis of brains from subjects with amnestic mild cognitive impairment compared to brains from subjects with preclinical Alzheimer's disease: insights into memory loss in MCI. J Alzheimers Dis 2011 0.88
78 Associations of cortical astrogliosis with cognitive performance and dementia status. J Alzheimers Dis 2004 0.87
79 Alzheimer's disease and head circumference. J Alzheimers Dis 2006 0.86
80 The effect of APOE-epsilon4 on dementia is mediated by Alzheimer neuropathology. Alzheimer Dis Assoc Disord 2009 0.86
81 Quantitative changes in the mitochondrial proteome from subjects with mild cognitive impairment, early stage, and late stage Alzheimer's disease. J Alzheimers Dis 2010 0.86
82 Neuron specific toxicity of oligomeric amyloid-β: role for JUN-kinase and oxidative stress. J Alzheimers Dis 2010 0.85
83 Organoselenium (Sel-Plex diet) decreases amyloid burden and RNA and DNA oxidative damage in APP/PS1 mice. Free Radic Biol Med 2009 0.85
84 Potential in vivo amelioration by N-acetyl-L-cysteine of oxidative stress in brain in human double mutant APP/PS-1 knock-in mice: toward therapeutic modulation of mild cognitive impairment. J Neurosci Res 2010 0.85
85 Age-related loss of phospholipid asymmetry in APP(NLh)/APP(NLh) x PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice: relevance to Alzheimer disease. Neurobiol Dis 2010 0.85
86 Quantitative proteomic analysis of mitochondria from primary neuron cultures treated with amyloid beta peptide. Neurochem Res 2005 0.84
87 Serum zinc in the progression of Alzheimer's disease. J Alzheimers Dis 2008 0.84
88 Elevated zinc transporter-6 in mild cognitive impairment, Alzheimer disease, and pick disease. J Neuropathol Exp Neurol 2006 0.84
89 Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age. J Proteomics 2011 0.83
90 Wilms' tumor suppressor (WT1) is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer's disease. Brain Res 2003 0.83
91 Protection against amyloid beta peptide and iron/hydrogen peroxide toxicity by alpha lipoic acid. J Alzheimers Dis 2003 0.82
92 Isolation of neural precursor cells from Alzheimer's disease and aged control postmortem brain. Neurobiol Aging 2005 0.82
93 Small head circumference is associated with less education in persons at risk for Alzheimer disease in later life. Alzheimer Dis Assoc Disord 2008 0.81
94 Proteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid β-peptide deposition: insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive impairment and Alzheimer's disease. Proteomics 2011 0.81
95 Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease. J Neuropathol Exp Neurol 2005 0.80
96 Amyloid beta peptide, 4-hydroxynonenal and apoptosis. Curr Alzheimer Res 2006 0.80
97 Genetic and expression profiles of cerebellar liponeurocytomas. Brain Pathol 2004 0.80
98 Increased protein hydrophobicity in response to aging and Alzheimer disease. Free Radic Biol Med 2010 0.79
99 Increased 5S rRNA oxidation in Alzheimer's disease. J Alzheimers Dis 2012 0.78
100 Biophysical and biochemical characterization of the intrinsic fluorescence from neurofibrillary tangles. Neurobiol Aging 2005 0.76
101 Cerebrospinal fluid lipoprotein delivery to human neuronal cells is increased in Alzheimer's disease and is dependent on apoE monomer concentration. J Alzheimers Dis 2002 0.75